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Protein

Hemoglobin subunit theta-1

Gene

HBQ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

GO - Biological processi

  • oxygen transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit theta-1
Alternative name(s):
Hemoglobin theta-1 chain
Theta-1-globin
Gene namesi
Name:HBQ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:4833. HBQ1.

Subcellular locationi

GO - Cellular componenti

  • hemoglobin complex Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29208.

Polymorphism and mutation databases

BioMutaiHBQ1.
DMDMi122330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Hemoglobin subunit theta-1PRO_0000052846Add
BLAST

Proteomic databases

MaxQBiP09105.
PaxDbiP09105.
PRIDEiP09105.

PTM databases

PhosphoSiteiP09105.

Expressioni

Gene expression databases

BgeeiP09105.
CleanExiHS_HBQ1.
GenevisibleiP09105. HS.

Organism-specific databases

HPAiHPA062473.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HBDP020423EBI-10193656,EBI-6152722
RFESDQ8TAC13EBI-10193656,EBI-10271664

Protein-protein interaction databases

BioGridi109299. 2 interactions.
IntActiP09105. 2 interactions.
STRINGi9606.ENSP00000199708.

Structurei

3D structure databases

ProteinModelPortaliP09105.
SMRiP09105. Positions 3-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG299570.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP09105.
KOiK13827.
OMAiRAHGQKV.
OrthoDBiEOG7KH9MP.
PhylomeDBiP09105.
TreeFamiTF332328.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSAEDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KTYFSHLDLS
60 70 80 90 100
PGSSQVRAHG QKVADALSLA VERLDDLPHA LSALSHLHAC QLRVDPASFQ
110 120 130 140
LLGHCLLVTL ARHYPGDFSP ALQASLDKFL SHVISALVSE YR
Length:142
Mass (Da):15,508
Last modified:January 23, 2007 - v2
Checksum:i9D4F103D758694D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06482 Genomic DNA. Translation: CAA29776.1.
M33022 Genomic DNA. Translation: AAA52640.1.
DQ431198 Genomic DNA. Translation: ABD95912.1.
AE006462 Genomic DNA. Translation: AAK61217.1.
BC056686 mRNA. Translation: AAH56686.1.
M91453 Genomic DNA. Translation: AAA58362.1.
CCDSiCCDS10400.1.
PIRiI52337. HTHU.
RefSeqiNP_005322.1. NM_005331.4.
UniGeneiHs.247921.

Genome annotation databases

EnsembliENST00000199708; ENSP00000199708; ENSG00000086506.
GeneIDi3049.
KEGGihsa:3049.
UCSCiuc002cfz.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06482 Genomic DNA. Translation: CAA29776.1.
M33022 Genomic DNA. Translation: AAA52640.1.
DQ431198 Genomic DNA. Translation: ABD95912.1.
AE006462 Genomic DNA. Translation: AAK61217.1.
BC056686 mRNA. Translation: AAH56686.1.
M91453 Genomic DNA. Translation: AAA58362.1.
CCDSiCCDS10400.1.
PIRiI52337. HTHU.
RefSeqiNP_005322.1. NM_005331.4.
UniGeneiHs.247921.

3D structure databases

ProteinModelPortaliP09105.
SMRiP09105. Positions 3-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109299. 2 interactions.
IntActiP09105. 2 interactions.
STRINGi9606.ENSP00000199708.

PTM databases

PhosphoSiteiP09105.

Polymorphism and mutation databases

BioMutaiHBQ1.
DMDMi122330.

Proteomic databases

MaxQBiP09105.
PaxDbiP09105.
PRIDEiP09105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000199708; ENSP00000199708; ENSG00000086506.
GeneIDi3049.
KEGGihsa:3049.
UCSCiuc002cfz.3. human.

Organism-specific databases

CTDi3049.
GeneCardsiGC16P000297.
HGNCiHGNC:4833. HBQ1.
HPAiHPA062473.
MIMi142240. gene.
neXtProtiNX_P09105.
PharmGKBiPA29208.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG299570.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP09105.
KOiK13827.
OMAiRAHGQKV.
OrthoDBiEOG7KH9MP.
PhylomeDBiP09105.
TreeFamiTF332328.

Miscellaneous databases

GeneWikiiHBQ1.
GenomeRNAii3049.
NextBioi12071.
PROiP09105.
SOURCEiSearch...

Gene expression databases

BgeeiP09105.
CleanExiHS_HBQ1.
GenevisibleiP09105. HS.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the human theta 1 globin gene."
    Hsu S.-L., Marks J., Shaw J.-P., Tam M., Higgs D.R., Shen C.C., Shen C.-K.J.
    Nature 331:94-96(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters."
    Kim J.H., Yu C.Y., Bailey A.D., Hardison R., Shen C.-K.J.
    Nucleic Acids Res. 17:5687-5700(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
    Tissue: Liver.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHBAT_HUMAN
AccessioniPrimary (citable) accession number: P09105
Secondary accession number(s): Q13723, Q1W6G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.