P09105 (HBAT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemoglobin subunit theta-1

Alternative name(s):
Hemoglobin theta-1 chain
Theta-1-globin

Gene names

Name:

HBQ1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	oxygen transport Traceable author statement PubMed 7555018. Source: ProtInc
Cellular_component	hemoglobin complex Traceable author statement PubMed 7555018. Source: ProtInc
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 142	141	Hemoglobin subunit theta-1		PRO_0000052846
Sites
	Metal binding	59	1	Iron (heme distal ligand)
	Metal binding	88	1	Iron (heme proximal ligand)

Sequences

	Sequence		Length	Mass (Da)
	P09105 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 9D4F103D758694D6	FASTA	142	15,508
	10 20 30 40 50 60 MALSAEDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KTYFSHLDLS PGSSQVRAHG 70 80 90 100 110 120 QKVADALSLA VERLDDLPHA LSALSHLHAC QLRVDPASFQ LLGHCLLVTL ARHYPGDFSP 130 140 ALQASLDKFL SHVISALVSE YR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of the human theta 1 globin gene." Hsu S.-L., Marks J., Shaw J.-P., Tam M., Higgs D.R., Shen C.C., Shen C.-K.J. Nature 331:94-96(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotide sequence of the human theta 1-globin gene." Gonzalez-Redondo J.M., Han I.S., Gu Y.C., Huisman T.H.J. Biochem. Genet. 26:207-211(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter." De Gobbi M., Viprakasit V., Hughes J.R., Fisher C., Buckle V.J., Ayyub H., Gibbons R.J., Vernimmen D., Yoshinaga Y., de Jong P., Cheng J.-F., Rubin E.M., Wood W.G., Bowden D., Higgs D.R. Science 312:1215-1217(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters." Kim J.H., Yu C.Y., Bailey A.D., Hardison R., Shen C.-K.J. Nucleic Acids Res. 17:5687-5700(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14. Tissue: Liver.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X06482 Genomic DNA. Translation: CAA29776.1. M33022 Genomic DNA. Translation: AAA52640.1. DQ431198 Genomic DNA. Translation: ABD95912.1. AE006462 Genomic DNA. Translation: AAK61217.1. BC056686 mRNA. Translation: AAH56686.1. M91453 Genomic DNA. Translation: AAA58362.1.
IPI	IPI00217472.
PIR	HTHU. I52337.
RefSeq	NP_005322.1. NM_005331.4.
UniGene	Hs.247921.
3D structure databases
ProteinModelPortal	P09105.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000199708.
PTM databases
PhosphoSite	P09105.
Polymorphism databases
DMDM	122330.
Proteomic databases
PaxDb	P09105.
PRIDE	P09105.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000199708; ENSP00000199708; ENSG00000086506.
GeneID	3049.
KEGG	hsa:3049.
UCSC	uc002cfz.3. human.
Organism-specific databases
CTD	3049.
GeneCards	GC16P000264.
HGNC	HGNC:4833. HBQ1.
HPA	HPA049111.
MIM	142240. gene.
neXtProt	NX_P09105.
PharmGKB	PA29208.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG299570.
HOGENOM	HOG000036867.
HOVERGEN	HBG009709.
InParanoid	P09105.
KO	K13827.
OMA	GVYTTEA.
OrthoDB	EOG4BP1D4.
PhylomeDB	P09105.
Gene expression databases
Bgee	P09105.
CleanEx	HS_HBQ1.
Genevestigator	P09105.
GermOnline	ENSG00000086506. Homo sapiens.
Family and domain databases
Gene3D	1.10.490.10. 1 hit.
InterPro	IPR000971. Globin. IPR009050. Globin-like. IPR012292. Globin_dom. IPR002338. Haemoglobin_a. IPR002339. Haemoglobin_pi. [Graphical view]
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00612. ALPHAHAEM. PR00815. PIHAEM.
SUPFAM	SSF46458. Globin_like. 1 hit.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3049.
NextBio	12071.
SOURCE	Search...

Entry information

Entry name

HBAT_HUMAN

Accession

Primary (citable) accession number: P09105
Secondary accession number(s): Q13723, Q1W6G5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.