SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P09105

- HBAT_HUMAN

UniProt

P09105 - HBAT_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Hemoglobin subunit theta-1
Gene
HBQ1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. oxygen transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit theta-1
Alternative name(s):
Hemoglobin theta-1 chain
Theta-1-globin
Gene namesi
Name:HBQ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:4833. HBQ1.

Subcellular locationi

GO - Cellular componenti

  1. hemoglobin complex Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29208.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Hemoglobin subunit theta-1
PRO_0000052846Add
BLAST

Proteomic databases

MaxQBiP09105.
PaxDbiP09105.
PRIDEiP09105.

PTM databases

PhosphoSiteiP09105.

Expressioni

Gene expression databases

BgeeiP09105.
CleanExiHS_HBQ1.
GenevestigatoriP09105.

Organism-specific databases

HPAiHPA049111.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000199708.

Structurei

3D structure databases

ProteinModelPortaliP09105.
SMRiP09105. Positions 3-142.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.

Phylogenomic databases

eggNOGiNOG299570.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP09105.
KOiK13827.
OMAiGVYTTEA.
OrthoDBiEOG7KH9MP.
PhylomeDBiP09105.
TreeFamiTF332328.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09105-1 [UniParc]FASTAAdd to Basket

« Hide

MALSAEDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KTYFSHLDLS    50
PGSSQVRAHG QKVADALSLA VERLDDLPHA LSALSHLHAC QLRVDPASFQ 100
LLGHCLLVTL ARHYPGDFSP ALQASLDKFL SHVISALVSE YR 142
Length:142
Mass (Da):15,508
Last modified:January 23, 2007 - v2
Checksum:i9D4F103D758694D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06482 Genomic DNA. Translation: CAA29776.1.
M33022 Genomic DNA. Translation: AAA52640.1.
DQ431198 Genomic DNA. Translation: ABD95912.1.
AE006462 Genomic DNA. Translation: AAK61217.1.
BC056686 mRNA. Translation: AAH56686.1.
M91453 Genomic DNA. Translation: AAA58362.1.
CCDSiCCDS10400.1.
PIRiI52337. HTHU.
RefSeqiNP_005322.1. NM_005331.4.
UniGeneiHs.247921.

Genome annotation databases

EnsembliENST00000199708; ENSP00000199708; ENSG00000086506.
GeneIDi3049.
KEGGihsa:3049.
UCSCiuc002cfz.3. human.

Polymorphism databases

DMDMi122330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06482 Genomic DNA. Translation: CAA29776.1 .
M33022 Genomic DNA. Translation: AAA52640.1 .
DQ431198 Genomic DNA. Translation: ABD95912.1 .
AE006462 Genomic DNA. Translation: AAK61217.1 .
BC056686 mRNA. Translation: AAH56686.1 .
M91453 Genomic DNA. Translation: AAA58362.1 .
CCDSi CCDS10400.1.
PIRi I52337. HTHU.
RefSeqi NP_005322.1. NM_005331.4.
UniGenei Hs.247921.

3D structure databases

ProteinModelPortali P09105.
SMRi P09105. Positions 3-142.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000199708.

PTM databases

PhosphoSitei P09105.

Polymorphism databases

DMDMi 122330.

Proteomic databases

MaxQBi P09105.
PaxDbi P09105.
PRIDEi P09105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000199708 ; ENSP00000199708 ; ENSG00000086506 .
GeneIDi 3049.
KEGGi hsa:3049.
UCSCi uc002cfz.3. human.

Organism-specific databases

CTDi 3049.
GeneCardsi GC16P000283.
HGNCi HGNC:4833. HBQ1.
HPAi HPA049111.
MIMi 142240. gene.
neXtProti NX_P09105.
PharmGKBi PA29208.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299570.
HOGENOMi HOG000036867.
HOVERGENi HBG009709.
InParanoidi P09105.
KOi K13827.
OMAi GVYTTEA.
OrthoDBi EOG7KH9MP.
PhylomeDBi P09105.
TreeFami TF332328.

Miscellaneous databases

GeneWikii HBQ1.
GenomeRNAii 3049.
NextBioi 12071.
PROi P09105.
SOURCEi Search...

Gene expression databases

Bgeei P09105.
CleanExi HS_HBQ1.
Genevestigatori P09105.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the human theta 1 globin gene."
    Hsu S.-L., Marks J., Shaw J.-P., Tam M., Higgs D.R., Shen C.C., Shen C.-K.J.
    Nature 331:94-96(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters."
    Kim J.H., Yu C.Y., Bailey A.D., Hardison R., Shen C.-K.J.
    Nucleic Acids Res. 17:5687-5700(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
    Tissue: Liver.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHBAT_HUMAN
AccessioniPrimary (citable) accession number: P09105
Secondary accession number(s): Q13723, Q1W6G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi