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P09105 (HBAT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemoglobin subunit theta-1
Alternative name(s):
Hemoglobin theta-1 chain
Theta-1-globin
Gene names
Name:HBQ1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 142142Hemoglobin subunit theta-1
PRO_0000052846

Sites

Metal binding591Iron (heme distal ligand)
Metal binding881Iron (heme proximal ligand)

Sequences

Sequence LengthMass (Da)Tools
P09105 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 9D4F103D758694D6

FASTA14215,508
        10         20         30         40         50         60 
MALSAEDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KTYFSHLDLS PGSSQVRAHG 

        70         80         90        100        110        120 
QKVADALSLA VERLDDLPHA LSALSHLHAC QLRVDPASFQ LLGHCLLVTL ARHYPGDFSP 

       130        140 
ALQASLDKFL SHVISALVSE YR 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of the human theta 1 globin gene."
Hsu S.-L., Marks J., Shaw J.-P., Tam M., Higgs D.R., Shen C.C., Shen C.-K.J.
Nature 331:94-96(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequence of the human theta 1-globin gene."
Gonzalez-Redondo J.M., Han I.S., Gu Y.C., Huisman T.H.J.
Biochem. Genet. 26:207-211(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter."
De Gobbi M., Viprakasit V., Hughes J.R., Fisher C., Buckle V.J., Ayyub H., Gibbons R.J., Vernimmen D., Yoshinaga Y., de Jong P., Cheng J.-F., Rubin E.M., Wood W.G., Bowden D., Higgs D.R.
Science 312:1215-1217(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters."
Kim J.H., Yu C.Y., Bailey A.D., Hardison R., Shen C.-K.J.
Nucleic Acids Res. 17:5687-5700(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
Tissue: Liver.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X06482 Genomic DNA. Translation: CAA29776.1.
M33022 Genomic DNA. Translation: AAA52640.1.
DQ431198 Genomic DNA. Translation: ABD95912.1.
AE006462 Genomic DNA. Translation: AAK61217.1.
BC056686 mRNA. Translation: AAH56686.1.
M91453 Genomic DNA. Translation: AAA58362.1.
CCDSCCDS10400.1.
PIRHTHU. I52337.
RefSeqNP_005322.1. NM_005331.4.
UniGeneHs.247921.

3D structure databases

ProteinModelPortalP09105.
SMRP09105. Positions 3-142.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000199708.

PTM databases

PhosphoSiteP09105.

Polymorphism databases

DMDM122330.

Proteomic databases

MaxQBP09105.
PaxDbP09105.
PRIDEP09105.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000199708; ENSP00000199708; ENSG00000086506.
GeneID3049.
KEGGhsa:3049.
UCSCuc002cfz.3. human.

Organism-specific databases

CTD3049.
GeneCardsGC16P000283.
HGNCHGNC:4833. HBQ1.
HPAHPA049111.
MIM142240. gene.
neXtProtNX_P09105.
PharmGKBPA29208.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299570.
HOGENOMHOG000036867.
HOVERGENHBG009709.
InParanoidP09105.
KOK13827.
OMAGVYTTEA.
OrthoDBEOG7KH9MP.
PhylomeDBP09105.
TreeFamTF332328.

Gene expression databases

BgeeP09105.
CleanExHS_HBQ1.
GenevestigatorP09105.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHBQ1.
GenomeRNAi3049.
NextBio12071.
PROP09105.
SOURCESearch...

Entry information

Entry nameHBAT_HUMAN
AccessionPrimary (citable) accession number: P09105
Secondary accession number(s): Q13723, Q1W6G5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM