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P09105

- HBAT_HUMAN

UniProt

P09105 - HBAT_HUMAN

Protein

Hemoglobin subunit theta-1

Gene

HBQ1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Iron (heme distal ligand)
    Metal bindingi88 – 881Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. oxygen transport Source: ProtInc

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemoglobin subunit theta-1
    Alternative name(s):
    Hemoglobin theta-1 chain
    Theta-1-globin
    Gene namesi
    Name:HBQ1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:4833. HBQ1.

    Subcellular locationi

    GO - Cellular componenti

    1. hemoglobin complex Source: ProtInc

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29208.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 142142Hemoglobin subunit theta-1PRO_0000052846Add
    BLAST

    Proteomic databases

    MaxQBiP09105.
    PaxDbiP09105.
    PRIDEiP09105.

    PTM databases

    PhosphoSiteiP09105.

    Expressioni

    Gene expression databases

    BgeeiP09105.
    CleanExiHS_HBQ1.
    GenevestigatoriP09105.

    Organism-specific databases

    HPAiHPA049111.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000199708.

    Structurei

    3D structure databases

    ProteinModelPortaliP09105.
    SMRiP09105. Positions 3-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG299570.
    HOGENOMiHOG000036867.
    HOVERGENiHBG009709.
    InParanoidiP09105.
    KOiK13827.
    OMAiGVYTTEA.
    OrthoDBiEOG7KH9MP.
    PhylomeDBiP09105.
    TreeFamiTF332328.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002338. Haemoglobin_a.
    IPR002339. Haemoglobin_pi.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00612. ALPHAHAEM.
    PR00815. PIHAEM.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09105-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSAEDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KTYFSHLDLS    50
    PGSSQVRAHG QKVADALSLA VERLDDLPHA LSALSHLHAC QLRVDPASFQ 100
    LLGHCLLVTL ARHYPGDFSP ALQASLDKFL SHVISALVSE YR 142
    Length:142
    Mass (Da):15,508
    Last modified:January 23, 2007 - v2
    Checksum:i9D4F103D758694D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06482 Genomic DNA. Translation: CAA29776.1.
    M33022 Genomic DNA. Translation: AAA52640.1.
    DQ431198 Genomic DNA. Translation: ABD95912.1.
    AE006462 Genomic DNA. Translation: AAK61217.1.
    BC056686 mRNA. Translation: AAH56686.1.
    M91453 Genomic DNA. Translation: AAA58362.1.
    CCDSiCCDS10400.1.
    PIRiI52337. HTHU.
    RefSeqiNP_005322.1. NM_005331.4.
    UniGeneiHs.247921.

    Genome annotation databases

    EnsembliENST00000199708; ENSP00000199708; ENSG00000086506.
    GeneIDi3049.
    KEGGihsa:3049.
    UCSCiuc002cfz.3. human.

    Polymorphism databases

    DMDMi122330.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06482 Genomic DNA. Translation: CAA29776.1 .
    M33022 Genomic DNA. Translation: AAA52640.1 .
    DQ431198 Genomic DNA. Translation: ABD95912.1 .
    AE006462 Genomic DNA. Translation: AAK61217.1 .
    BC056686 mRNA. Translation: AAH56686.1 .
    M91453 Genomic DNA. Translation: AAA58362.1 .
    CCDSi CCDS10400.1.
    PIRi I52337. HTHU.
    RefSeqi NP_005322.1. NM_005331.4.
    UniGenei Hs.247921.

    3D structure databases

    ProteinModelPortali P09105.
    SMRi P09105. Positions 3-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000199708.

    PTM databases

    PhosphoSitei P09105.

    Polymorphism databases

    DMDMi 122330.

    Proteomic databases

    MaxQBi P09105.
    PaxDbi P09105.
    PRIDEi P09105.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000199708 ; ENSP00000199708 ; ENSG00000086506 .
    GeneIDi 3049.
    KEGGi hsa:3049.
    UCSCi uc002cfz.3. human.

    Organism-specific databases

    CTDi 3049.
    GeneCardsi GC16P000283.
    HGNCi HGNC:4833. HBQ1.
    HPAi HPA049111.
    MIMi 142240. gene.
    neXtProti NX_P09105.
    PharmGKBi PA29208.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299570.
    HOGENOMi HOG000036867.
    HOVERGENi HBG009709.
    InParanoidi P09105.
    KOi K13827.
    OMAi GVYTTEA.
    OrthoDBi EOG7KH9MP.
    PhylomeDBi P09105.
    TreeFami TF332328.

    Miscellaneous databases

    GeneWikii HBQ1.
    GenomeRNAii 3049.
    NextBioi 12071.
    PROi P09105.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09105.
    CleanExi HS_HBQ1.
    Genevestigatori P09105.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002338. Haemoglobin_a.
    IPR002339. Haemoglobin_pi.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00612. ALPHAHAEM.
    PR00815. PIHAEM.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the human theta 1 globin gene."
      Hsu S.-L., Marks J., Shaw J.-P., Tam M., Higgs D.R., Shen C.C., Shen C.-K.J.
      Nature 331:94-96(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters."
      Kim J.H., Yu C.Y., Bailey A.D., Hardison R., Shen C.-K.J.
      Nucleic Acids Res. 17:5687-5700(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
      Tissue: Liver.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHBAT_HUMAN
    AccessioniPrimary (citable) accession number: P09105
    Secondary accession number(s): Q13723, Q1W6G5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3