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P09099

- XYLB_ECOLI

UniProt

P09099 - XYLB_ECOLI

Protein

Xylulose kinase

Gene

xylB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. xylulokinase activity Source: EcoCyc

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. D-xylose catabolic process Source: EcoCyc
    3. xylulose catabolic process Source: EcoCyc

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Xylose metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:XYLULOKIN-MONOMER.
    ECOL316407:JW3536-MONOMER.
    MetaCyc:XYLULOKIN-MONOMER.
    RETL1328306-WGS:GSTH-3723-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylulose kinase (EC:2.7.1.17)
    Short name:
    Xylulokinase
    Gene namesi
    Name:xylB
    Ordered Locus Names:b3564, JW3536
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11075. xylB.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Xylulose kinasePRO_0000059549Add
    BLAST

    Proteomic databases

    PRIDEiP09099.

    Expressioni

    Gene expression databases

    GenevestigatoriP09099.

    Interactioni

    Protein-protein interaction databases

    IntActiP09099. 1 interaction.
    STRINGi511145.b3564.

    Structurei

    Secondary structure

    1
    484
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 76
    Beta strandi9 – 179
    Beta strandi23 – 308
    Helixi45 – 6218
    Beta strandi70 – 756
    Beta strandi80 – 834
    Helixi102 – 11110
    Helixi115 – 1195
    Helixi128 – 13811
    Helixi140 – 1434
    Beta strandi148 – 1503
    Helixi152 – 16110
    Beta strandi165 – 1673
    Helixi168 – 1725
    Turni173 – 1753
    Turni179 – 1824
    Helixi186 – 1905
    Turni191 – 1933
    Helixi196 – 1983
    Beta strandi201 – 2033
    Beta strandi207 – 2115
    Helixi214 – 2196
    Beta strandi226 – 2283
    Helixi233 – 2419
    Beta strandi249 – 26214
    Beta strandi271 – 2733
    Beta strandi275 – 2784
    Beta strandi285 – 2917
    Helixi294 – 30411
    Helixi310 – 3167
    Helixi317 – 3193
    Beta strandi328 – 3336
    Beta strandi345 – 3539
    Helixi358 – 38124
    Turni382 – 3843
    Beta strandi390 – 3945
    Helixi395 – 3973
    Helixi400 – 41011
    Beta strandi414 – 4185
    Helixi424 – 43613
    Helixi442 – 4454
    Beta strandi451 – 4555
    Helixi459 – 47921
    Helixi480 – 4834

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ITMX-ray2.10A/B1-484[»]
    2NLXX-ray2.70A/B1-484[»]
    ProteinModelPortaliP09099.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP09099.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG1070.
    HOGENOMiHOG000222138.
    KOiK00854.
    OMAiEITGNLM.
    OrthoDBiEOG6S52KR.
    PhylomeDBiP09099.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR006000. Xylulokinase.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01312. XylB. 1 hit.
    PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09099-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYIGIDLGTS GVKVILLNEQ GEVVAAQTEK LTVSRPHPLW SEQDPEQWWQ    50
    ATDRAMKALG DQHSLQDVKA LGIAGQMHGA TLLDAQQRVL RPAILWNDGR 100
    CAQECTLLEA RVPQSRVITG NLMMPGFTAP KLLWVQRHEP EIFRQIDKVL 150
    LPKDYLRLRM TGEFASDMSD AAGTMWLDVA KRDWSDVMLQ ACDLSRDQMP 200
    ALYEGSEITG ALLPEVAKAW GMATVPVVAG GGDNAAGAVG VGMVDANQAM 250
    LSLGTSGVYF AVSEGFLSKP ESAVHSFCHA LPQRWHLMSV MLSAASCLDW 300
    AAKLTGLSNV PALIAAAQQA DESAEPVWFL PYLSGERTPH NNPQAKGVFF 350
    GLTHQHGPNE LARAVLEGVG YALADGMDVV HACGIKPQSV TLIGGGARSE 400
    YWRQMLADIS GQQLDYRTGG DVGPALGAAR LAQIAANPEK SLIELLPQLP 450
    LEQSHLPDAQ RYAAYQPRRE TFRRLYQQLL PLMA 484
    Length:484
    Mass (Da):52,618
    Last modified:July 1, 1989 - v1
    Checksum:i8CC62CBD546AFCA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01996 Genomic DNA. Translation: AAA24769.1.
    X04691 Genomic DNA. Translation: CAA28395.1.
    U00039 Genomic DNA. Translation: AAB18541.1.
    U00096 Genomic DNA. Translation: AAC76588.1.
    AP009048 Genomic DNA. Translation: BAE77729.1.
    PIRiA30266. KIECXY.
    RefSeqiNP_418021.1. NC_000913.3.
    YP_491870.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC76588; AAC76588; b3564.
    BAE77729; BAE77729; BAE77729.
    GeneIDi12933545.
    948133.
    KEGGiecj:Y75_p3611.
    eco:b3564.
    PATRICi32122604. VBIEscCol129921_3679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01996 Genomic DNA. Translation: AAA24769.1 .
    X04691 Genomic DNA. Translation: CAA28395.1 .
    U00039 Genomic DNA. Translation: AAB18541.1 .
    U00096 Genomic DNA. Translation: AAC76588.1 .
    AP009048 Genomic DNA. Translation: BAE77729.1 .
    PIRi A30266. KIECXY.
    RefSeqi NP_418021.1. NC_000913.3.
    YP_491870.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ITM X-ray 2.10 A/B 1-484 [» ]
    2NLX X-ray 2.70 A/B 1-484 [» ]
    ProteinModelPortali P09099.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P09099. 1 interaction.
    STRINGi 511145.b3564.

    Proteomic databases

    PRIDEi P09099.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC76588 ; AAC76588 ; b3564 .
    BAE77729 ; BAE77729 ; BAE77729 .
    GeneIDi 12933545.
    948133.
    KEGGi ecj:Y75_p3611.
    eco:b3564.
    PATRICi 32122604. VBIEscCol129921_3679.

    Organism-specific databases

    EchoBASEi EB1068.
    EcoGenei EG11075. xylB.

    Phylogenomic databases

    eggNOGi COG1070.
    HOGENOMi HOG000222138.
    KOi K00854.
    OMAi EITGNLM.
    OrthoDBi EOG6S52KR.
    PhylomeDBi P09099.

    Enzyme and pathway databases

    BioCyci EcoCyc:XYLULOKIN-MONOMER.
    ECOL316407:JW3536-MONOMER.
    MetaCyc:XYLULOKIN-MONOMER.
    RETL1328306-WGS:GSTH-3723-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P09099.
    PROi P09099.

    Gene expression databases

    Genevestigatori P09099.

    Family and domain databases

    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR006000. Xylulokinase.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01312. XylB. 1 hit.
    PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the xylose isomerase and xylulose kinase genes of Escherichia coli."
      Lawlis V.B., Dennis M.S., Chen E.Y., Smith D.H., Henner D.J.
      Appl. Environ. Microbiol. 47:15-21(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12 / MM294 / ATCC 33625 / DSM 5208.
    2. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
      Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
      Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "Escherichia coli proteome analysis using the gene-protein database."
      VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
      Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY 2D-GEL.

    Entry informationi

    Entry nameiXYLB_ECOLI
    AccessioniPrimary (citable) accession number: P09099
    Secondary accession number(s): Q2M7M7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3