ID   HXA6_MOUSE              Reviewed;         232 AA.
AC   P09092; Q9JI98;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   27-MAR-2024, entry version 185.
DE   RecName: Full=Homeobox protein Hox-A6;
DE   AltName: Full=Homeobox protein Hox-1.2;
DE   AltName: Full=Homeobox protein M5-4;
GN   Name=Hoxa6; Synonyms=Hox-1.2, Hoxa-6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ICR X Swiss Webster; TISSUE=Liver;
RA   Tan D.P., Shao X., Peterkofsky A.;
RT   "Mouse Hoxa6 gene structure and regulation.";
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-232.
RX   PubMed=2416462; DOI=10.1016/0092-8674(85)90010-8;
RA   Colberg-Poley A.M., Voss S.D., Chowdhury K., Stewart C.L., Wagner E.F.,
RA   Gruss P.;
RT   "Clustered homeo boxes are differentially expressed during murine
RT   development.";
RL   Cell 43:39-45(1985).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AF247663; AAF97512.1; -; Genomic_DNA.
DR   EMBL; M11988; AAA37830.1; -; Genomic_DNA.
DR   CCDS; CCDS20144.1; -.
DR   PIR; A24779; A24779.
DR   RefSeq; NP_034584.1; NM_010454.1.
DR   AlphaFoldDB; P09092; -.
DR   SMR; P09092; -.
DR   BioGRID; 200371; 6.
DR   IntAct; P09092; 6.
DR   STRING; 10090.ENSMUSP00000058755; -.
DR   PhosphoSitePlus; P09092; -.
DR   PaxDb; 10090-ENSMUSP00000058755; -.
DR   ProteomicsDB; 273058; -.
DR   Pumba; P09092; -.
DR   Antibodypedia; 1430; 285 antibodies from 29 providers.
DR   DNASU; 15403; -.
DR   Ensembl; ENSMUST00000062829.9; ENSMUSP00000058755.8; ENSMUSG00000043219.10.
DR   GeneID; 15403; -.
DR   KEGG; mmu:15403; -.
DR   UCSC; uc009byi.1; mouse.
DR   AGR; MGI:96178; -.
DR   CTD; 3203; -.
DR   MGI; MGI:96178; Hoxa6.
DR   VEuPathDB; HostDB:ENSMUSG00000043219; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000161585; -.
DR   HOGENOM; CLU_061398_1_1_1; -.
DR   InParanoid; P09092; -.
DR   OMA; YSSPCYY; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P09092; -.
DR   TreeFam; TF316310; -.
DR   BioGRID-ORCS; 15403; 3 hits in 75 CRISPR screens.
DR   PRO; PR:P09092; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; P09092; Protein.
DR   Bgee; ENSMUSG00000043219; Expressed in embryonic post-anal tail and 73 other cell types or tissues.
DR   ExpressionAtlas; P09092; baseline and differential.
DR   GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR   GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   PANTHER; PTHR45659:SF14; HOMEOBOX PROTEIN HOX-A6; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..232
FT                   /note="Homeobox protein Hox-A6"
FT                   /id="PRO_0000200068"
FT   DNA_BIND        154..213
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          88..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           135..140
FT                   /note="Antp-type hexapeptide"
FT   CONFLICT        136..146
FT                   /note="YPWMQRMNSCA -> ASLIRTSFLPT (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   232 AA;  26335 MW;  7E29499428BBA8A7 CRC64;
     MSSYFVNPTF PGSLPSGQDS FLGQLPLYPA GYDALRPFPA SYGASSLPDK TYTSPCFYQQ
     SNSVLACNRA SYEYGASCFY SDKDLSGASP SGNNKQRGPG DYLHFSPEQQ YKPDGSVQGK
     ALHEEGTDRK YTSPVYPWMQ RMNSCAGAVY GSHGRRGRQT YTRYQTLELE KEFHFNRYLT
     RRRRIEIANA LCLTERQIKI WFQNRRMKWK KENKLINSTQ ASGEDSEAKA GE
//