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Protein

Homeobox protein Hox-A6

Gene

Hoxa6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi154 – 21360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A6
Alternative name(s):
Homeobox protein Hox-1.2
Homeobox protein M5-4
Gene namesi
Name:Hoxa6
Synonyms:Hox-1.2, Hoxa-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96178. Hoxa6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Homeobox protein Hox-A6PRO_0000200068Add
BLAST

Proteomic databases

PRIDEiP09092.

PTM databases

PhosphoSiteiP09092.

Expressioni

Gene expression databases

BgeeiP09092.
CleanExiMM_HOXA6.
ExpressionAtlasiP09092. baseline and differential.
GenevestigatoriP09092.

Interactioni

Protein-protein interaction databases

BioGridi200371. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliP09092.
SMRiP09092. Positions 158-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi135 – 1406Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG305812.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09092.
KOiK09306.
OMAiPEQQYKS.
OrthoDBiEOG780RP4.
PhylomeDBiP09092.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNPTF PGSLPSGQDS FLGQLPLYPA GYDALRPFPA SYGASSLPDK
60 70 80 90 100
TYTSPCFYQQ SNSVLACNRA SYEYGASCFY SDKDLSGASP SGNNKQRGPG
110 120 130 140 150
DYLHFSPEQQ YKPDGSVQGK ALHEEGTDRK YTSPVYPWMQ RMNSCAGAVY
160 170 180 190 200
GSHGRRGRQT YTRYQTLELE KEFHFNRYLT RRRRIEIANA LCLTERQIKI
210 220 230
WFQNRRMKWK KENKLINSTQ ASGEDSEAKA GE
Length:232
Mass (Da):26,335
Last modified:January 23, 2002 - v2
Checksum:i7E29499428BBA8A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 14611YPWMQRMNSCA → ASLIRTSFLPT (PubMed:2416462).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247663 Genomic DNA. Translation: AAF97512.1.
M11988 Genomic DNA. Translation: AAA37830.1.
CCDSiCCDS20144.1.
PIRiA24779.
RefSeqiNP_034584.1. NM_010454.1.
UniGeneiMm.222030.

Genome annotation databases

EnsembliENSMUST00000062829; ENSMUSP00000058755; ENSMUSG00000043219.
GeneIDi15403.
KEGGimmu:15403.
UCSCiuc009byi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247663 Genomic DNA. Translation: AAF97512.1.
M11988 Genomic DNA. Translation: AAA37830.1.
CCDSiCCDS20144.1.
PIRiA24779.
RefSeqiNP_034584.1. NM_010454.1.
UniGeneiMm.222030.

3D structure databases

ProteinModelPortaliP09092.
SMRiP09092. Positions 158-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200371. 6 interactions.

PTM databases

PhosphoSiteiP09092.

Proteomic databases

PRIDEiP09092.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062829; ENSMUSP00000058755; ENSMUSG00000043219.
GeneIDi15403.
KEGGimmu:15403.
UCSCiuc009byi.1. mouse.

Organism-specific databases

CTDi3203.
MGIiMGI:96178. Hoxa6.

Phylogenomic databases

eggNOGiNOG305812.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09092.
KOiK09306.
OMAiPEQQYKS.
OrthoDBiEOG780RP4.
PhylomeDBiP09092.
TreeFamiTF316310.

Miscellaneous databases

NextBioi288106.
PROiP09092.
SOURCEiSearch...

Gene expression databases

BgeeiP09092.
CleanExiMM_HOXA6.
ExpressionAtlasiP09092. baseline and differential.
GenevestigatoriP09092.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mouse Hoxa6 gene structure and regulation."
    Tan D.P., Shao X., Peterkofsky A.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ICR X Swiss Webster.
    Tissue: Liver.
  2. "Clustered homeo boxes are differentially expressed during murine development."
    Colberg-Poley A.M., Voss S.D., Chowdhury K., Stewart C.L., Wagner E.F., Gruss P.
    Cell 43:39-45(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-232.

Entry informationi

Entry nameiHXA6_MOUSE
AccessioniPrimary (citable) accession number: P09092
Secondary accession number(s): Q9JI98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2002
Last modified: May 27, 2015
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.