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P09092 (HXA6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A6
Alternative name(s):
Homeobox protein Hox-1.2
Homeobox protein M5-4
Gene names
Name:Hoxa6
Synonyms:Hox-1.2, Hoxa-6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Homeobox protein Hox-A6
PRO_0000200068

Regions

DNA binding154 – 21360Homeobox
Motif135 – 1406Antp-type hexapeptide

Experimental info

Sequence conflict136 – 14611YPWMQRMNSCA → ASLIRTSFLPT Ref.2

Sequences

Sequence LengthMass (Da)Tools
P09092 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 7E29499428BBA8A7

FASTA23226,335
        10         20         30         40         50         60 
MSSYFVNPTF PGSLPSGQDS FLGQLPLYPA GYDALRPFPA SYGASSLPDK TYTSPCFYQQ 

        70         80         90        100        110        120 
SNSVLACNRA SYEYGASCFY SDKDLSGASP SGNNKQRGPG DYLHFSPEQQ YKPDGSVQGK 

       130        140        150        160        170        180 
ALHEEGTDRK YTSPVYPWMQ RMNSCAGAVY GSHGRRGRQT YTRYQTLELE KEFHFNRYLT 

       190        200        210        220        230 
RRRRIEIANA LCLTERQIKI WFQNRRMKWK KENKLINSTQ ASGEDSEAKA GE

« Hide

References

[1]"Mouse Hoxa6 gene structure and regulation."
Tan D.P., Shao X., Peterkofsky A.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ICR X Swiss Webster.
Tissue: Liver.
[2]"Clustered homeo boxes are differentially expressed during murine development."
Colberg-Poley A.M., Voss S.D., Chowdhury K., Stewart C.L., Wagner E.F., Gruss P.
Cell 43:39-45(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-232.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF247663 Genomic DNA. Translation: AAF97512.1.
M11988 Genomic DNA. Translation: AAA37830.1.
IPIIPI00132603.
PIRA24779.
RefSeqNP_034584.1. NM_010454.1.
UniGeneMm.222030.

3D structure databases

ProteinModelPortalP09092.
SMRP09092. Positions 158-213.
ModBaseSearch...

PTM databases

PhosphoSiteP09092.

Proteomic databases

PRIDEP09092.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000062829; ENSMUSP00000058755; ENSMUSG00000043219.
GeneID15403.
KEGGmmu:15403.

Organism-specific databases

CTD3203.
MGIMGI:96178. Hoxa6.

Phylogenomic databases

eggNOGNOG305812.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP09092.
KOK09306.
OMAPEQQYKS.
OrthoDBEOG4C5CKB.

Gene expression databases

ArrayExpressP09092.
BgeeP09092.
CleanExMM_HOXA6.
GenevestigatorP09092.
GermOnlineENSMUSG00000043219. Mus musculus.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_metazoa.
IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288106.
SOURCESearch...

Entry information

Entry nameHXA6_MOUSE
AccessionPrimary (citable) accession number: P09092
Secondary accession number(s): Q9JI98
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2002
Last modified: May 1, 2013
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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