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P09092

- HXA6_MOUSE

UniProt

P09092 - HXA6_MOUSE

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Protein

Homeobox protein Hox-A6

Gene

Hoxa6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi154 – 21360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. embryonic skeletal system development Source: MGI
  3. embryonic skeletal system morphogenesis Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A6
Alternative name(s):
Homeobox protein Hox-1.2
Homeobox protein M5-4
Gene namesi
Name:Hoxa6
Synonyms:Hox-1.2, Hoxa-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96178. Hoxa6.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Homeobox protein Hox-A6PRO_0000200068Add
BLAST

Proteomic databases

PRIDEiP09092.

PTM databases

PhosphoSiteiP09092.

Expressioni

Gene expression databases

BgeeiP09092.
CleanExiMM_HOXA6.
ExpressionAtlasiP09092. baseline.
GenevestigatoriP09092.

Interactioni

Protein-protein interaction databases

BioGridi200371. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliP09092.
SMRiP09092. Positions 158-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi135 – 1406Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG305812.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09092.
KOiK09306.
OMAiPEQQYKS.
OrthoDBiEOG780RP4.
PhylomeDBiP09092.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09092-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSYFVNPTF PGSLPSGQDS FLGQLPLYPA GYDALRPFPA SYGASSLPDK
60 70 80 90 100
TYTSPCFYQQ SNSVLACNRA SYEYGASCFY SDKDLSGASP SGNNKQRGPG
110 120 130 140 150
DYLHFSPEQQ YKPDGSVQGK ALHEEGTDRK YTSPVYPWMQ RMNSCAGAVY
160 170 180 190 200
GSHGRRGRQT YTRYQTLELE KEFHFNRYLT RRRRIEIANA LCLTERQIKI
210 220 230
WFQNRRMKWK KENKLINSTQ ASGEDSEAKA GE
Length:232
Mass (Da):26,335
Last modified:January 23, 2002 - v2
Checksum:i7E29499428BBA8A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 14611YPWMQRMNSCA → ASLIRTSFLPT(PubMed:2416462)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF247663 Genomic DNA. Translation: AAF97512.1.
M11988 Genomic DNA. Translation: AAA37830.1.
CCDSiCCDS20144.1.
PIRiA24779.
RefSeqiNP_034584.1. NM_010454.1.
UniGeneiMm.222030.

Genome annotation databases

EnsembliENSMUST00000062829; ENSMUSP00000058755; ENSMUSG00000043219.
GeneIDi15403.
KEGGimmu:15403.
UCSCiuc009byi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF247663 Genomic DNA. Translation: AAF97512.1 .
M11988 Genomic DNA. Translation: AAA37830.1 .
CCDSi CCDS20144.1.
PIRi A24779.
RefSeqi NP_034584.1. NM_010454.1.
UniGenei Mm.222030.

3D structure databases

ProteinModelPortali P09092.
SMRi P09092. Positions 158-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200371. 6 interactions.

PTM databases

PhosphoSitei P09092.

Proteomic databases

PRIDEi P09092.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062829 ; ENSMUSP00000058755 ; ENSMUSG00000043219 .
GeneIDi 15403.
KEGGi mmu:15403.
UCSCi uc009byi.1. mouse.

Organism-specific databases

CTDi 3203.
MGIi MGI:96178. Hoxa6.

Phylogenomic databases

eggNOGi NOG305812.
HOGENOMi HOG000231181.
HOVERGENi HBG016849.
InParanoidi P09092.
KOi K09306.
OMAi PEQQYKS.
OrthoDBi EOG780RP4.
PhylomeDBi P09092.
TreeFami TF316310.

Miscellaneous databases

NextBioi 288106.
PROi P09092.
SOURCEi Search...

Gene expression databases

Bgeei P09092.
CleanExi MM_HOXA6.
ExpressionAtlasi P09092. baseline.
Genevestigatori P09092.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse Hoxa6 gene structure and regulation."
    Tan D.P., Shao X., Peterkofsky A.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ICR X Swiss Webster.
    Tissue: Liver.
  2. "Clustered homeo boxes are differentially expressed during murine development."
    Colberg-Poley A.M., Voss S.D., Chowdhury K., Stewart C.L., Wagner E.F., Gruss P.
    Cell 43:39-45(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-232.

Entry informationi

Entry nameiHXA6_MOUSE
AccessioniPrimary (citable) accession number: P09092
Secondary accession number(s): Q9JI98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2002
Last modified: October 29, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3