Reviewed, UniProtKB/Swiss-Prot P09092 (HXA6_MOUSE)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A6
Alternative name(s):
    Hox-1.2
    M5-4

Gene names

Name:	Hoxa6
Synonyms:	Hox-1.2, Hoxa-6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	anterior/posterior pattern formation Inferred from mutant phenotype. Source: MGI embryonic skeletal system morphogenesis Inferred from mutant phenotype. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	Homeobox protein Hox-A6		PRO_0000200068
Regions
	DNA binding	154 – 213	60	Homeobox
	Motif	135 – 140	6	Antp-type hexapeptide
Experimental info
	Sequence conflict	136 – 146	11	YPWMQRMNSCA → ASLIRTSFLPT Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P09092-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 7E29499428BBA8A7	FASTA	232	26,335
	10 20 30 40 50 60 MSSYFVNPTF PGSLPSGQDS FLGQLPLYPA GYDALRPFPA SYGASSLPDK TYTSPCFYQQ 70 80 90 100 110 120 SNSVLACNRA SYEYGASCFY SDKDLSGASP SGNNKQRGPG DYLHFSPEQQ YKPDGSVQGK 130 140 150 160 170 180 ALHEEGTDRK YTSPVYPWMQ RMNSCAGAVY GSHGRRGRQT YTRYQTLELE KEFHFNRYLT 190 200 210 220 230 RRRRIEIANA LCLTERQIKI WFQNRRMKWK KENKLINSTQ ASGEDSEAKA GE

References

[1]	"Mouse Hoxa6 gene structure and regulation." Tan D.P., Shao X., Peterkofsky A. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ICR X Swiss Webster. Tissue: Liver.
[2]	"Clustered homeo boxes are differentially expressed during murine development." Colberg-Poley A.M., Voss S.D., Chowdhury K., Stewart C.L., Wagner E.F., Gruss P. Cell 43:39-45(1985) [PubMed: 2416462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-232.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF247663 Genomic DNA. Translation: AAF97512.1. M11988 Genomic DNA. Translation: AAA37830.1.
IPI	IPI00132603.
PIR	A24779.
RefSeq	NP_034584.1.
UniGene	Mm.222030
3D structure databases
SMR	P09092. Positions 155-214.
ModBase	Search...
Protein-protein interaction databases
STRING	P09092.
Proteomic databases
PRIDE	P09092.
Genome annotation databases
Ensembl	ENSMUST00000062829; ENSMUSP00000058755; ENSMUSG00000043219; Mus musculus. [Genome view]
GeneID	15403.
KEGG	mmu:15403.
UCSC	uc009byi.1. mouse.
Organism-specific databases
CTD	15403.
MGI	MGI:96178. Hoxa6.
Phylogenomic databases
HOGENOM	P09092.
HOVERGEN	P09092.
OMA	QGKALHD
OrthoDB	EOG97H896
Gene expression databases
Bgee	P09092.
CleanEx	MM_HOXA6.
Genevestigator	P09092.
GermOnline	ENSMUSG00000043219. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	288106.
SOURCE	Search...

Entry information

Entry name

HXA6_MOUSE

Accession

Primary (citable) accession number: P09092
Secondary accession number(s): Q9JI98

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	January 23, 2002
Last modified:	November 24, 2009
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)