P09089 (ZEN1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein zerknuellt 1
Short name=ZEN-1

Gene names

Name:	zen
Synonyms:	z1, zen1
ORF Names:	CG1046

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation. Ref.1
Subcellular location	Nucleus Ref.1.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	amnioserosa formation Traceable author statement. Source: FlyBase compound eye development Inferred from mutant phenotype. Source: FlyBase dorsal/ventral axis specification Traceable author statement. Source: FlyBase transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from direct assay. Source: FlyBase sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 353

353

Protein zerknuellt 1

PRO_0000049112

Regions

DNA binding

90 – 149

60

Homeobox

Secondary structure

1

.

.

.

.

353

Helix Strand Turn

Details...

Helix

134 – 142

9

Turn

143 – 146

4

Sequences

	Sequence		Length	Mass (Da)
	P09089 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: 1FA64031C160CE2B	FASTA	353	39,302
	10 20 30 40 50 60 MSSVMHYYPV HQAKVGSYSA DPSEVKYSDL IYGHHHDVNP IGLPPNYNQM NSNPTTLNDH 70 80 90 100 110 120 CSPQHVHQQH VSSDENLPSQ PNHDSQRVKL KRSRTAFTSV QLVELENEFK SNMYLYRTRR 130 140 150 160 170 180 IEIAQRLSLC ERQVKIWFQN RRMKFKKDIQ GHREPKSNAK LAQPQAEQSA HRGIVKRLMS 190 200 210 220 230 240 YSQDPREGTA AAEKRPMMAV APVNPKPDYQ ASQKMKTEAS TNNGMCSSAD LSEILEHLAQ 250 260 270 280 290 300 TTAAPQVSTA TSSTGTSTNS ASSSSSGHYS YNVDLVLQSI KQDLEAAAQA WSKSKSAPIL 310 320 330 340 350 ATQSWHPSSQ SQVPTSVHAA PSMNLSWGEP AAKSRKLSVN HMNPCVTSYN YPN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of the zerknullt region of the Antennapedia gene complex in Drosophila." Rushlow C., Doyle H., Hoey T., Levine M. Genes Dev. 1:1268-1279(1987) [PubMed: 2892759] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
[2]	"Complete sequence of the Antennapedia complex of Drosophila." Celniker S.E., Pfeiffer B., Knafels J., Martin C.H., Mayeda C.A., Palazzolo M.J. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Berkeley.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[5]	Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Larva and Pupae.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X68347 mRNA. Translation: CAA48416.1.
AE001572 Genomic DNA. Translation: AAD19800.1.
AE014297 Genomic DNA. Translation: AAF54087.1.
BT028847 mRNA. Translation: ABI34228.1.

PIR

A43697.

RefSeq

NP_001138018.1. NM_001144546.1.
NP_476793.1. NM_057445.2.

UniGene

Dm.27227.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1KZ2	NMR	-	A	132-147	[»]

ProteinModelPortal

P09089.

SMR

P09089. Positions 94-148.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-18255N.

IntAct

P09089. 2 interactions.

MINT

MINT-1547017.

STRING

P09089.

Proteomic databases

PRIDE

P09089.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

FBtr0081670; FBpp0081170; FBgn0004053.

GeneID

40828.

KEGG

dme:Dmel_CG1046.

NMPDR

fig|7227.3.peg.11451.

Organism-specific databases

CTD

40828.

FlyBase

FBgn0004053. zen.

Phylogenomic databases

eggNOG

inNOG11990.

GeneTree

EMGT00070000025675.

InParanoid

P09089.

OMA

YRTRRIE.

OrthoDB

EOG4K3JC5.

PhylomeDB

P09089.

Gene expression databases

Bgee

P09089.

GermOnline

CG1046. Drosophila melanogaster.

Family and domain databases

InterPro

IPR001356. Homeobox.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_eu.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
[Graphical view]

Gene3D

G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.

KO

K09311.

Pfam

PF00046. Homeobox. 1 hit.
[Graphical view]

PRINTS

PR00024. HOMEOBOX.

SMART

SM00389. HOX. 1 hit.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 1 hit.

PROSITE

PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

820800.

Entry information

Entry name

ZEN1_DROME

Accession

Primary (citable) accession number: P09089
Secondary accession number(s): Q0IGS3, Q9VI45

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	January 25, 2012
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project