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Protein

Protein zerknuellt 1

Gene

zen

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi90 – 149HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase

GO - Biological processi

  • amnioserosa formation Source: FlyBase
  • compound eye development Source: FlyBase
  • dorsal/ventral axis specification Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP09089

Names & Taxonomyi

Protein namesi
Recommended name:
Protein zerknuellt 1
Short name:
ZEN-1
Gene namesi
Name:zen
Synonyms:z1, zen1
ORF Names:CG1046
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004053 zen

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491121 – 353Protein zerknuellt 1Add BLAST353

Proteomic databases

PaxDbiP09089
PRIDEiP09089

Expressioni

Gene expression databases

BgeeiFBgn0004053
GenevisibleiP09089 DM

Interactioni

Protein-protein interaction databases

BioGridi6602614 interactors.
DIPiDIP-18255N
IntActiP09089 13 interactors.
STRINGi7227.FBpp0081170

Structurei

Secondary structure

1353
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi134 – 142Combined sources9
Turni143 – 146Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KZ2NMR-A132-147[»]
ProteinModelPortaliP09089
SMRiP09089
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09089

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
InParanoidiP09089
KOiK09311
OMAiILATQSW
OrthoDBiEOG091G0FG6
PhylomeDBiP09089

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVMHYYPV HQAKVGSYSA DPSEVKYSDL IYGHHHDVNP IGLPPNYNQM
60 70 80 90 100
NSNPTTLNDH CSPQHVHQQH VSSDENLPSQ PNHDSQRVKL KRSRTAFTSV
110 120 130 140 150
QLVELENEFK SNMYLYRTRR IEIAQRLSLC ERQVKIWFQN RRMKFKKDIQ
160 170 180 190 200
GHREPKSNAK LAQPQAEQSA HRGIVKRLMS YSQDPREGTA AAEKRPMMAV
210 220 230 240 250
APVNPKPDYQ ASQKMKTEAS TNNGMCSSAD LSEILEHLAQ TTAAPQVSTA
260 270 280 290 300
TSSTGTSTNS ASSSSSGHYS YNVDLVLQSI KQDLEAAAQA WSKSKSAPIL
310 320 330 340 350
ATQSWHPSSQ SQVPTSVHAA PSMNLSWGEP AAKSRKLSVN HMNPCVTSYN

YPN
Length:353
Mass (Da):39,302
Last modified:November 1, 1988 - v1
Checksum:i1FA64031C160CE2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68347 mRNA Translation: CAA48416.1
AE001572 Genomic DNA Translation: AAD19800.1
AE014297 Genomic DNA Translation: AAF54087.1
BT028847 mRNA Translation: ABI34228.1
PIRiA43697
RefSeqiNP_476793.1, NM_057445.3
UniGeneiDm.27227

Genome annotation databases

EnsemblMetazoaiFBtr0081670; FBpp0081170; FBgn0004053
GeneIDi40828
KEGGidme:Dmel_CG1046

Similar proteinsi

Entry informationi

Entry nameiZEN1_DROME
AccessioniPrimary (citable) accession number: P09089
Secondary accession number(s): Q0IGS3, Q9VI45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: March 28, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome