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Protein

Protein zerknuellt 1

Gene

zen

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi90 – 14960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase

GO - Biological processi

  • amnioserosa formation Source: FlyBase
  • compound eye development Source: FlyBase
  • dorsal/ventral axis specification Source: FlyBase
  • dorsal/ventral pattern formation, imaginal disc Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP09089.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein zerknuellt 1
Short name:
ZEN-1
Gene namesi
Name:zen
Synonyms:z1, zen1
ORF Names:CG1046
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004053. zen.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Protein zerknuellt 1PRO_0000049112Add
BLAST

Proteomic databases

PaxDbiP09089.
PRIDEiP09089.

Expressioni

Gene expression databases

BgeeiFBgn0004053.
ExpressionAtlasiP09089. differential.
GenevisibleiP09089. DM.

Interactioni

Protein-protein interaction databases

BioGridi66026. 14 interactions.
DIPiDIP-18255N.
IntActiP09089. 2 interactions.
MINTiMINT-1547017.
STRINGi7227.FBpp0081170.

Structurei

Secondary structure

1
353
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi134 – 1429Combined sources
Turni143 – 1464Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KZ2NMR-A132-147[»]
ProteinModelPortaliP09089.
SMRiP09089. Positions 94-148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09089.

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118940.
InParanoidiP09089.
KOiK09311.
OMAiILATQSW.
OrthoDBiEOG091G0FG6.
PhylomeDBiP09089.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVMHYYPV HQAKVGSYSA DPSEVKYSDL IYGHHHDVNP IGLPPNYNQM
60 70 80 90 100
NSNPTTLNDH CSPQHVHQQH VSSDENLPSQ PNHDSQRVKL KRSRTAFTSV
110 120 130 140 150
QLVELENEFK SNMYLYRTRR IEIAQRLSLC ERQVKIWFQN RRMKFKKDIQ
160 170 180 190 200
GHREPKSNAK LAQPQAEQSA HRGIVKRLMS YSQDPREGTA AAEKRPMMAV
210 220 230 240 250
APVNPKPDYQ ASQKMKTEAS TNNGMCSSAD LSEILEHLAQ TTAAPQVSTA
260 270 280 290 300
TSSTGTSTNS ASSSSSGHYS YNVDLVLQSI KQDLEAAAQA WSKSKSAPIL
310 320 330 340 350
ATQSWHPSSQ SQVPTSVHAA PSMNLSWGEP AAKSRKLSVN HMNPCVTSYN

YPN
Length:353
Mass (Da):39,302
Last modified:November 1, 1988 - v1
Checksum:i1FA64031C160CE2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68347 mRNA. Translation: CAA48416.1.
AE001572 Genomic DNA. Translation: AAD19800.1.
AE014297 Genomic DNA. Translation: AAF54087.1.
BT028847 mRNA. Translation: ABI34228.1.
PIRiA43697.
RefSeqiNP_476793.1. NM_057445.3.
UniGeneiDm.27227.

Genome annotation databases

EnsemblMetazoaiFBtr0081670; FBpp0081170; FBgn0004053.
GeneIDi40828.
KEGGidme:Dmel_CG1046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68347 mRNA. Translation: CAA48416.1.
AE001572 Genomic DNA. Translation: AAD19800.1.
AE014297 Genomic DNA. Translation: AAF54087.1.
BT028847 mRNA. Translation: ABI34228.1.
PIRiA43697.
RefSeqiNP_476793.1. NM_057445.3.
UniGeneiDm.27227.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KZ2NMR-A132-147[»]
ProteinModelPortaliP09089.
SMRiP09089. Positions 94-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66026. 14 interactions.
DIPiDIP-18255N.
IntActiP09089. 2 interactions.
MINTiMINT-1547017.
STRINGi7227.FBpp0081170.

Proteomic databases

PaxDbiP09089.
PRIDEiP09089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081670; FBpp0081170; FBgn0004053.
GeneIDi40828.
KEGGidme:Dmel_CG1046.

Organism-specific databases

CTDi40828.
FlyBaseiFBgn0004053. zen.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118940.
InParanoidiP09089.
KOiK09311.
OMAiILATQSW.
OrthoDBiEOG091G0FG6.
PhylomeDBiP09089.

Enzyme and pathway databases

SignaLinkiP09089.

Miscellaneous databases

EvolutionaryTraceiP09089.
GenomeRNAii40828.
PROiP09089.

Gene expression databases

BgeeiFBgn0004053.
ExpressionAtlasiP09089. differential.
GenevisibleiP09089. DM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZEN1_DROME
AccessioniPrimary (citable) accession number: P09089
Secondary accession number(s): Q0IGS3, Q9VI45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: September 7, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.