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Protein

Mechanosensory protein 3

Gene

mec-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi217 – 276HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: WormBase
  • transcriptional activator activity, RNA polymerase II transcription factor binding Source: WormBase
  • transcription factor binding Source: WormBase

GO - Biological processi

  • mechanosensory behavior Source: WormBase
  • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: WormBase
  • neuron differentiation Source: WormBase
  • positive regulation of transcription by RNA polymerase II Source: WormBase
  • response to mechanical stimulus Source: WormBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mechanosensory protein 3
Gene namesi
Name:mec-3
ORF Names:F01D4.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF01D4.6a ; CE27422 ; WBGene00003167 ; mec-3
F01D4.6c ; CE42646 ; WBGene00003167 ; mec-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758401 – 321Mechanosensory protein 3Add BLAST321

Proteomic databases

PaxDbiP09088
PRIDEiP09088

Expressioni

Gene expression databases

BgeeiWBGene00003167

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: WormBase

Protein-protein interaction databases

IntActiP09088, 78 interactors
STRINGi6239.F01D4.6a

Structurei

3D structure databases

ProteinModelPortaliP09088
SMRiP09088
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 86LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini87 – 152LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi315 – 321Asp/Glu-rich (acidic)7

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000064530
InParanoidiP09088
OMAiSYHENCV
OrthoDBiEOG091G0BKF
PhylomeDBiP09088

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform aImported (identifier: P09088-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMLESKPLS AISMVIDSIG VDHENQNKCN CCNEQIYDRY IYRMDNRSYH
60 70 80 90 100
ENCVKCTICE SPLAEKCFWK NGRIYCSQHY YKDHSIHRCA GCKKGVSPTD
110 120 130 140 150
MVYKLKAGLV FHVECHCCSL CGRHLSPGEQ ILVDDTMMTV SCMSHYPPQM
160 170 180 190 200
DDNAPGAIGS AVDIPSCSTE NPIAPYPIDE SFSSAFQVKK EVDAYGYNFE
210 220 230 240 250
HYSFSDFCDD DSRMLKRRGP RTTIKQNQLD VLNEMFSNTP KPSKHARAKL
260 270 280 290 300
ALETGLSMRV IQVWFQNRRS KERRLKHLCN YLRHYEQRGL IPPPIHFRNE
310 320
EMDTTDFNAF CGNFEEEDDE D
Length:321
Mass (Da):37,088
Last modified:February 1, 1994 - v2
Checksum:i9231E7C3F5054853
GO
Isoform cImported (identifier: P09088-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:278
Mass (Da):32,051
Checksum:iACB8AF1608E1BF8E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0581521 – 43Missing in isoform c. CuratedAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02877 mRNA Translation: AAA50614.1
M20244 Genomic DNA Translation: AAA28108.1
Z81054 Genomic DNA Translation: CAB02885.3
BX284604 Genomic DNA Translation: CAQ58102.1
PIRiS28390
T20458
RefSeqiNP_001023111.1, NM_001027940.3 [P09088-1]
NP_001129852.1, NM_001136380.2 [P09088-3]
UniGeneiCel.19754

Genome annotation databases

EnsemblMetazoaiF01D4.6a; F01D4.6a; WBGene00003167 [P09088-1]
GeneIDi177938
UCSCiF01D4.6a c. elegans [P09088-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMEC3_CAEEL
AccessioniPrimary (citable) accession number: P09088
Secondary accession number(s): B3GWD3, O02240, Q7YTQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase

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