ID ABDB_DROME Reviewed; 493 AA. AC P09087; Q9VEQ8; Q9VEQ9; DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 3. DT 24-JAN-2024, entry version 213. DE RecName: Full=Homeobox protein abdominal-B; DE AltName: Full=Infraabdominal 7; DE Short=IAB-7; DE AltName: Full=P3; DE AltName: Full=PH189; GN Name=Abd-B; ORFNames=CG10291; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS M AND R). RC STRAIN=Canton-S; RX PubMed=7667301; DOI=10.1073/pnas.92.18.8398; RA Martin C.H., Mayeda C.A., Davis C.A., Ericsson C.L., Knafels J.D., RA Mathog D.R., Celniker S.E., Lewis E.B., Palazzolo M.J.; RT "Complete sequence of the bithorax complex of Drosophila."; RL Proc. Natl. Acad. Sci. U.S.A. 92:8398-8402(1995). RN [2] RP NUCLEOTIDE SEQUENCE (ISOFORM R), AND CHARACTERIZATION. RC TISSUE=Embryo; RX PubMed=2903049; DOI=10.1002/j.1460-2075.1988.tb03189.x; RA Delorenzi M., Ali N., Saari G., Henry C., Wilcox M., Bienz M.; RT "Evidence that the Abdominal-B r element function is conferred by a trans- RT regulatory homeoprotein."; RL EMBO J. 7:3223-3231(1988). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM M), AND CHARACTERIZATION. RC TISSUE=Embryo, and Pupae; RX PubMed=2575066; DOI=10.1101/gad.3.9.1424; RA Celniker S.E., Keelan D.J., Lewis E.B.; RT "The molecular genetics of the bithorax complex of Drosophila: RT characterization of the products of the Abdominal-B domain."; RL Genes Dev. 3:1424-1436(1989). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM M). RC STRAIN=Canton-S; TISSUE=Embryo; RX PubMed=2482824; DOI=10.1101/gad.3.12a.1969; RA Zavortink M., Sakonju S.; RT "The morphogenetic and regulatory functions of the Drosophila Abdominal-B RT gene are encoded in overlapping RNAs transcribed from separate promoters."; RL Genes Dev. 3:1969-1981(1989). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS M AND R). RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., RA Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [6] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] OF 387-447. RX PubMed=2416463; DOI=10.1016/0092-8674(85)90013-3; RA Regulski M., Harding K., Kostriken R., Karch F., Levine M., McGinnis W.; RT "Homeo box genes of the Antennapedia and bithorax complexes of RT Drosophila."; RL Cell 43:71-80(1985). RN [8] RP ALTERNATIVE SPLICING, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE. RX PubMed=2903050; DOI=10.1002/j.1460-2075.1988.tb03190.x; RA Kuziora M.A., McGinnis W.; RT "Different transcripts of the Drosophila Abd-B gene correlate with distinct RT genetic sub-functions."; RL EMBO J. 7:3233-3244(1988). CC -!- FUNCTION: Sequence-specific transcription factor which is part of a CC developmental regulatory system that provides cells with specific CC positional identities on the anterior-posterior axis. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=M; Synonyms=Morphogenetic, Abd-BI; CC IsoId=P09087-1; Sequence=Displayed; CC Name=R; Synonyms=Regulatory, Abd-BII; CC IsoId=P09087-2; Sequence=VSP_002396; CC -!- TISSUE SPECIFICITY: Isoform M and isoform R are expressed in ectodermal CC and mesodermal tissues and central nervous system of fourth to ninth CC embryonic abdominal segments. Later in embryogenesis, expression is CC seen in visceral mesoderm surrounding hindgut and in two Malpighian CC tubules. {ECO:0000269|PubMed:2903050}. CC -!- DEVELOPMENTAL STAGE: Highly expressed during embryogenesis, lower CC expression in larvae, pupae and adults. {ECO:0000269|PubMed:2903050}. CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U31961; AAA84402.1; -; Genomic_DNA. DR EMBL; U31961; AAA84403.1; -; Genomic_DNA. DR EMBL; M21173; AAA28400.1; -; mRNA. DR EMBL; X16134; CAA34260.1; -; mRNA. DR EMBL; X51663; CAB57859.1; -; mRNA. DR EMBL; AE014297; AAF55362.1; -; Genomic_DNA. DR EMBL; AE014297; AAF55363.1; -; Genomic_DNA. DR EMBL; X15080; CAA33187.1; -; mRNA. DR PIR; A32584; A32584. DR PIR; A34220; A34220. DR PIR; B24780; B24780. DR RefSeq; NP_001303471.1; NM_001316542.1. [P09087-2] DR RefSeq; NP_001303472.1; NM_001316543.1. [P09087-1] DR RefSeq; NP_001303474.1; NM_001316545.1. [P09087-2] DR RefSeq; NP_524896.2; NM_080157.3. [P09087-1] DR RefSeq; NP_650577.1; NM_142320.2. [P09087-2] DR RefSeq; NP_732180.1; NM_169735.2. [P09087-2] DR RefSeq; NP_732181.1; NM_169736.2. [P09087-2] DR RefSeq; NP_996220.1; NM_206498.2. [P09087-2] DR PDB; 5ZJQ; X-ray; 2.44 A; A=369-452. DR PDB; 5ZJR; X-ray; 3.03 A; A=369-452. DR PDB; 5ZJS; X-ray; 2.90 A; A=369-452. DR PDB; 5ZJT; X-ray; 2.40 A; A/E=369-452. DR PDBsum; 5ZJQ; -. DR PDBsum; 5ZJR; -. DR PDBsum; 5ZJS; -. DR PDBsum; 5ZJT; -. DR AlphaFoldDB; P09087; -. DR SMR; P09087; -. DR BioGRID; 70921; 61. DR DIP; DIP-19566N; -. DR IntAct; P09087; 3. DR STRING; 7227.FBpp0373669; -. DR PaxDb; 7227-FBpp0082826; -. DR DNASU; 47763; -. DR EnsemblMetazoa; FBtr0083381; FBpp0082823; FBgn0000015. [P09087-2] DR EnsemblMetazoa; FBtr0083382; FBpp0082824; FBgn0000015. [P09087-2] DR EnsemblMetazoa; FBtr0083383; FBpp0082825; FBgn0000015. [P09087-2] DR EnsemblMetazoa; FBtr0083384; FBpp0082826; FBgn0000015. [P09087-1] DR EnsemblMetazoa; FBtr0083385; FBpp0089276; FBgn0000015. [P09087-2] DR EnsemblMetazoa; FBtr0415463; FBpp0373669; FBgn0000015. [P09087-1] DR EnsemblMetazoa; FBtr0415464; FBpp0373670; FBgn0000015. [P09087-2] DR EnsemblMetazoa; FBtr0415465; FBpp0373671; FBgn0000015. [P09087-2] DR GeneID; 47763; -. DR KEGG; dme:Dmel_CG11648; -. DR AGR; FB:FBgn0000015; -. DR CTD; 47763; -. DR FlyBase; FBgn0000015; Abd-B. DR VEuPathDB; VectorBase:FBgn0000015; -. DR eggNOG; KOG0487; Eukaryota. DR GeneTree; ENSGT00940000168206; -. DR HOGENOM; CLU_545455_0_0_1; -. DR InParanoid; P09087; -. DR OMA; APWPYND; -. DR OrthoDB; 5397138at2759; -. DR PhylomeDB; P09087; -. DR SignaLink; P09087; -. DR BioGRID-ORCS; 47763; 0 hits in 3 CRISPR screens. DR GenomeRNAi; 47763; -. DR PRO; PR:P09087; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0000015; Expressed in oviduct (Drosophila) and 41 other cell types or tissues. DR ExpressionAtlas; P09087; baseline and differential. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0005704; C:polytene chromosome band; IDA:FlyBase. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:FlyBase. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:FlyBase. DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:FlyBase. DR GO; GO:0035225; P:determination of genital disc primordium; IMP:FlyBase. DR GO; GO:0035261; P:external genitalia morphogenesis; IMP:FlyBase. DR GO; GO:0030540; P:female genitalia development; IMP:FlyBase. DR GO; GO:0035224; P:genital disc anterior/posterior pattern formation; IEP:FlyBase. DR GO; GO:0035263; P:genital disc sexually dimorphic development; IMP:FlyBase. DR GO; GO:0008354; P:germ cell migration; IMP:FlyBase. DR GO; GO:0007506; P:gonadal mesoderm development; IMP:FlyBase. DR GO; GO:0007486; P:imaginal disc-derived female genitalia development; IMP:FlyBase. DR GO; GO:0030539; P:male genitalia development; IMP:FlyBase. DR GO; GO:0008584; P:male gonad development; IMP:FlyBase. DR GO; GO:0048094; P:male pigmentation; IDA:FlyBase. DR GO; GO:0007494; P:midgut development; TAS:FlyBase. DR GO; GO:0009997; P:negative regulation of cardioblast cell fate specification; IMP:FlyBase. DR GO; GO:0007621; P:negative regulation of female receptivity; IMP:FlyBase. DR GO; GO:0045705; P:negative regulation of salivary gland boundary specification; TAS:FlyBase. DR GO; GO:0045843; P:negative regulation of striated muscle tissue development; IMP:FlyBase. DR GO; GO:0061101; P:neuroendocrine cell differentiation; IMP:FlyBase. DR GO; GO:0007424; P:open tracheal system development; IMP:FlyBase. DR GO; GO:0007280; P:pole cell migration; TAS:FlyBase. DR GO; GO:1902339; P:positive regulation of apoptotic process involved in morphogenesis; IMP:FlyBase. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0007379; P:segment specification; IMP:FlyBase. DR GO; GO:0007385; P:specification of segmental identity, abdomen; IMP:FlyBase. DR GO; GO:0046693; P:sperm storage; IMP:FlyBase. DR GO; GO:0035277; P:spiracle morphogenesis, open tracheal system; IMP:FlyBase. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR020479; Homeobox_metazoa. DR InterPro; IPR046333; HXA10/ABDB-like. DR PANTHER; PTHR45874; HOMEOBOX PROTEIN ABDOMINAL-B; 1. DR PANTHER; PTHR45874:SF4; HOMEOBOX PROTEIN ABDOMINAL-B; 1. DR Pfam; PF00046; Homeodomain; 1. DR PRINTS; PR00024; HOMEOBOX. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR Genevisible; P09087; DM. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Developmental protein; DNA-binding; KW Homeobox; Nucleus; Reference proteome. FT CHAIN 1..493 FT /note="Homeobox protein abdominal-B" FT /id="PRO_0000200258" FT DNA_BIND 387..446 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 1..199 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 322..360 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 438..475 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..28 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 31..51 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 52..93 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 111..199 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 325..360 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 446..475 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 1..223 FT /note="Missing (in isoform R)" FT /evidence="ECO:0000305" FT /id="VSP_002396" FT CONFLICT 15 FT /note="Q -> H (in Ref. 4; CAB57859)" FT /evidence="ECO:0000305" FT CONFLICT 74 FT /note="Missing (in Ref. 3; CAA34260)" FT /evidence="ECO:0000305" FT CONFLICT 177..180 FT /note="ASGA -> PVR (in Ref. 3; CAA34260)" FT /evidence="ECO:0000305" FT CONFLICT 317..318 FT /note="ER -> DG (in Ref. 3; CAA34260)" FT /evidence="ECO:0000305" FT HELIX 380..382 FT /evidence="ECO:0007829|PDB:5ZJT" FT HELIX 396..408 FT /evidence="ECO:0007829|PDB:5ZJT" FT HELIX 414..423 FT /evidence="ECO:0007829|PDB:5ZJT" FT HELIX 428..444 FT /evidence="ECO:0007829|PDB:5ZJT" SQ SEQUENCE 493 AA; 55096 MW; 55A11B5E97983A5F CRC64; MQQHHLQQQQ QQQQQQEQQH LQEQQQHLQQ LHHHAHHHLP QPLHTTSHHH SAHPHLQQQQ QQQQHAVVAS SPSSVLQQQQ QQSTPTTHST PTHAVMYEDP PPVPLVAVQQ QHLPAPQQQQ QLQQQQQQQQ QQLATTPVAG ALSPAQTPTG PSAQQQQHLT SPHHQQLPQQ QTPNSVASGA SSNLQQQQQQ QNAAVAPGQT QIVAPTTASV SPSSVSSQKE DINMSIQLAP LHIPAIRAGP GFETDTSAAV KRHTAHWAYN DEGFNQHYGS GYYDRKHMFA YPYPETQFPV GQYWGPNYRP DQTTSAAAAA AYMNEAERHV SAAARQSVEG TSTSSYEPPT YSSPGGLRGY PSENYSSSGA SGGLSVGAVG PCTPNPGLHE WTGQVSVRKK RKPYSKFQTL ELEKEFLFNA YVSKQKRWEL ARNLQLTERQ VKIWFQNRRM KNKKNSQRQA NQQNNNNNSS SNHNHAQATQ QHHSGHHLNL SLNMGHHAAK MHQ //