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P09087

- ABDB_DROME

UniProt

P09087 - ABDB_DROME

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Protein
Homeobox protein abdominal-B
Gene
Abd-B, CG10291
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi387 – 44660Homeobox
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: FlyBase
  2. sequence-specific DNA binding transcription factor activity Source: FlyBase
  3. transcription regulatory region sequence-specific DNA binding Source: FlyBase
Complete GO annotation...

GO - Biological processi

  1. determination of genital disc primordium Source: FlyBase
  2. developmental pigmentation Source: FlyBase
  3. external genitalia morphogenesis Source: FlyBase
  4. female genitalia development Source: FlyBase
  5. genital disc anterior/posterior pattern formation Source: FlyBase
  6. genital disc development Source: FlyBase
  7. genital disc sexually dimorphic development Source: FlyBase
  8. germ cell migration Source: FlyBase
  9. gonadal mesoderm development Source: FlyBase
  10. heart development Source: FlyBase
  11. imaginal disc-derived female genitalia development Source: FlyBase
  12. imaginal disc-derived genitalia development Source: FlyBase
  13. male genitalia development Source: FlyBase
  14. male gonad development Source: FlyBase
  15. male pigmentation Source: FlyBase
  16. midgut development Source: FlyBase
  17. negative regulation of cardioblast cell fate specification Source: FlyBase
  18. negative regulation of female receptivity Source: FlyBase
  19. negative regulation of salivary gland boundary specification Source: FlyBase
  20. negative regulation of striated muscle tissue development Source: FlyBase
  21. open tracheal system development Source: FlyBase
  22. pole cell migration Source: FlyBase
  23. positive regulation of apoptotic process involved in morphogenesis Source: FlyBase
  24. positive regulation of developmental pigmentation Source: FlyBase
  25. positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  26. salivary gland development Source: FlyBase
  27. segment specification Source: FlyBase
  28. sex differentiation Source: FlyBase
  29. sex-specific pigmentation Source: FlyBase
  30. specification of segmental identity, abdomen Source: FlyBase
  31. sperm storage Source: FlyBase
  32. spiracle morphogenesis, open tracheal system Source: FlyBase
  33. trachea morphogenesis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein abdominal-B
Alternative name(s):
Infraabdominal 7
Short name:
IAB-7
P3
PH189
Gene namesi
Name:Abd-B
ORF Names:CG10291
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000015. Abd-B.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Homeobox protein abdominal-B
PRO_0000200258Add
BLAST

Proteomic databases

PRIDEiP09087.

Expressioni

Tissue specificityi

Isoform M and isoform R are expressed in ectodermal and mesodermal tissues and central nervous system of fourth to ninth embryonic abdominal segments. Later in embryogenesis, expression is seen in visceral mesoderm surrounding hindgut and in two Malpighian tubules.1 Publication

Developmental stagei

Highly expressed during embryogenesis, lower expression in larvae, pupae and adults.1 Publication

Gene expression databases

BgeeiP09087.

Interactioni

Protein-protein interaction databases

BioGridi70921. 20 interactions.
DIPiDIP-19566N.
IntActiP09087. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP09087.
SMRiP09087. Positions 388-444.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 192192Gln-rich
Add
BLAST
Compositional biasi306 – 3116Poly-Ala
Compositional biasi454 – 4585Poly-Asn

Sequence similaritiesi

Belongs to the Abd-B homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG286554.
GeneTreeiENSGT00730000110374.
InParanoidiP09087.
KOiK09300.
OMAiTHAVMYE.
OrthoDBiEOG7RJPTM.
PhylomeDBiP09087.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform M (identifier: P09087-1) [UniParc]FASTAAdd to Basket

Also known as: Morphogenetic, Abd-BI

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQQHHLQQQQ QQQQQQEQQH LQEQQQHLQQ LHHHAHHHLP QPLHTTSHHH    50
SAHPHLQQQQ QQQQHAVVAS SPSSVLQQQQ QQSTPTTHST PTHAVMYEDP 100
PPVPLVAVQQ QHLPAPQQQQ QLQQQQQQQQ QQLATTPVAG ALSPAQTPTG 150
PSAQQQQHLT SPHHQQLPQQ QTPNSVASGA SSNLQQQQQQ QNAAVAPGQT 200
QIVAPTTASV SPSSVSSQKE DINMSIQLAP LHIPAIRAGP GFETDTSAAV 250
KRHTAHWAYN DEGFNQHYGS GYYDRKHMFA YPYPETQFPV GQYWGPNYRP 300
DQTTSAAAAA AYMNEAERHV SAAARQSVEG TSTSSYEPPT YSSPGGLRGY 350
PSENYSSSGA SGGLSVGAVG PCTPNPGLHE WTGQVSVRKK RKPYSKFQTL 400
ELEKEFLFNA YVSKQKRWEL ARNLQLTERQ VKIWFQNRRM KNKKNSQRQA 450
NQQNNNNNSS SNHNHAQATQ QHHSGHHLNL SLNMGHHAAK MHQ 493
Length:493
Mass (Da):55,096
Last modified:October 1, 1996 - v3
Checksum:i55A11B5E97983A5F
GO
Isoform R (identifier: P09087-2) [UniParc]FASTAAdd to Basket

Also known as: Regulatory, Abd-BII

The sequence of this isoform differs from the canonical sequence as follows:
     1-223: Missing.

Show »
Length:270
Mass (Da):30,344
Checksum:i3C951B3B406F1E49
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 223223Missing in isoform R.
VSP_002396Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151Q → H in CAB57859. 1 Publication
Sequence conflicti74 – 741Missing in CAA34260. 1 Publication
Sequence conflicti177 – 1804ASGA → PVR in CAA34260. 1 Publication
Sequence conflicti317 – 3182ER → DG in CAA34260. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31961 Genomic DNA. Translation: AAA84402.1.
U31961 Genomic DNA. Translation: AAA84403.1.
M21173 mRNA. Translation: AAA28400.1.
X16134 mRNA. Translation: CAA34260.1.
X51663 mRNA. Translation: CAB57859.1.
AE014297 Genomic DNA. Translation: AAF55362.1.
AE014297 Genomic DNA. Translation: AAF55363.1.
X15080 mRNA. Translation: CAA33187.1.
PIRiA32584.
A34220.
B24780.
RefSeqiNP_524896.2. NM_080157.2. [P09087-1]
NP_650577.1. NM_142320.1. [P09087-2]
NP_732180.1. NM_169735.1. [P09087-2]
NP_732181.1. NM_169736.1. [P09087-2]
NP_996220.1. NM_206498.1. [P09087-2]
UniGeneiDm.1763.

Genome annotation databases

EnsemblMetazoaiFBtr0083384; FBpp0082826; FBgn0000015. [P09087-1]
GeneIDi47763.
KEGGidme:Dmel_CG11648.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31961 Genomic DNA. Translation: AAA84402.1 .
U31961 Genomic DNA. Translation: AAA84403.1 .
M21173 mRNA. Translation: AAA28400.1 .
X16134 mRNA. Translation: CAA34260.1 .
X51663 mRNA. Translation: CAB57859.1 .
AE014297 Genomic DNA. Translation: AAF55362.1 .
AE014297 Genomic DNA. Translation: AAF55363.1 .
X15080 mRNA. Translation: CAA33187.1 .
PIRi A32584.
A34220.
B24780.
RefSeqi NP_524896.2. NM_080157.2. [P09087-1 ]
NP_650577.1. NM_142320.1. [P09087-2 ]
NP_732180.1. NM_169735.1. [P09087-2 ]
NP_732181.1. NM_169736.1. [P09087-2 ]
NP_996220.1. NM_206498.1. [P09087-2 ]
UniGenei Dm.1763.

3D structure databases

ProteinModelPortali P09087.
SMRi P09087. Positions 388-444.
ModBasei Search...

Protein-protein interaction databases

BioGridi 70921. 20 interactions.
DIPi DIP-19566N.
IntActi P09087. 1 interaction.

Proteomic databases

PRIDEi P09087.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0083384 ; FBpp0082826 ; FBgn0000015 . [P09087-1 ]
GeneIDi 47763.
KEGGi dme:Dmel_CG11648.

Organism-specific databases

CTDi 47763.
FlyBasei FBgn0000015. Abd-B.

Phylogenomic databases

eggNOGi NOG286554.
GeneTreei ENSGT00730000110374.
InParanoidi P09087.
KOi K09300.
OMAi THAVMYE.
OrthoDBi EOG7RJPTM.
PhylomeDBi P09087.

Miscellaneous databases

GenomeRNAii 47763.
NextBioi 839106.

Gene expression databases

Bgeei P09087.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS M AND R).
    Strain: Canton-S.
  2. "Evidence that the Abdominal-B r element function is conferred by a trans-regulatory homeoprotein."
    Delorenzi M., Ali N., Saari G., Henry C., Wilcox M., Bienz M.
    EMBO J. 7:3223-3231(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM R), CHARACTERIZATION.
    Tissue: Embryo.
  3. "The molecular genetics of the bithorax complex of Drosophila: characterization of the products of the Abdominal-B domain."
    Celniker S.E., Keelan D.J., Lewis E.B.
    Genes Dev. 3:1424-1436(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM M), CHARACTERIZATION.
    Tissue: Embryo and Pupae.
  4. "The morphogenetic and regulatory functions of the Drosophila Abdominal-B gene are encoded in overlapping RNAs transcribed from separate promoters."
    Zavortink M., Sakonju S.
    Genes Dev. 3:1969-1981(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM M).
    Strain: Canton-S.
    Tissue: Embryo.
  5. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS M AND R).
    Strain: Berkeley.
  6. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  7. "Homeo box genes of the Antennapedia and bithorax complexes of Drosophila."
    Regulski M., Harding K., Kostriken R., Karch F., Levine M., McGinnis W.
    Cell 43:71-80(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 387-447.
  8. "Different transcripts of the Drosophila Abd-B gene correlate with distinct genetic sub-functions."
    Kuziora M.A., McGinnis W.
    EMBO J. 7:3233-3244(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiABDB_DROME
AccessioniPrimary (citable) accession number: P09087
Secondary accession number(s): Q9VEQ8, Q9VEQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi