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Protein

Homeobox protein abdominal-B

Gene

Abd-B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi387 – 446HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding transcription factor activity Source: FlyBase
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: FlyBase
  • transcription regulatory region sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • determination of genital disc primordium Source: FlyBase
  • developmental pigmentation Source: FlyBase
  • external genitalia morphogenesis Source: FlyBase
  • female genitalia development Source: FlyBase
  • genital disc anterior/posterior pattern formation Source: FlyBase
  • genital disc development Source: FlyBase
  • genital disc sexually dimorphic development Source: FlyBase
  • germ cell migration Source: FlyBase
  • gonadal mesoderm development Source: FlyBase
  • heart development Source: FlyBase
  • imaginal disc-derived female genitalia development Source: FlyBase
  • imaginal disc-derived genitalia development Source: FlyBase
  • male genitalia development Source: FlyBase
  • male gonad development Source: FlyBase
  • male pigmentation Source: FlyBase
  • midgut development Source: FlyBase
  • negative regulation of cardioblast cell fate specification Source: FlyBase
  • negative regulation of female receptivity Source: FlyBase
  • negative regulation of salivary gland boundary specification Source: FlyBase
  • negative regulation of striated muscle tissue development Source: FlyBase
  • neuroendocrine cell differentiation Source: FlyBase
  • open tracheal system development Source: FlyBase
  • pole cell migration Source: FlyBase
  • positive regulation of apoptotic process involved in morphogenesis Source: FlyBase
  • positive regulation of developmental pigmentation Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • salivary gland development Source: FlyBase
  • segment specification Source: FlyBase
  • sex differentiation Source: FlyBase
  • sex-specific pigmentation Source: FlyBase
  • specification of segmental identity, abdomen Source: FlyBase
  • sperm storage Source: FlyBase
  • spiracle morphogenesis, open tracheal system Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein abdominal-B
Alternative name(s):
Infraabdominal 7
Short name:
IAB-7
P3
PH189
Gene namesi
Name:Abd-B
ORF Names:CG10291
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000015 Abd-B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002581 – 493Homeobox protein abdominal-BAdd BLAST493

Proteomic databases

PaxDbiP09087
PRIDEiP09087

Expressioni

Tissue specificityi

Isoform M and isoform R are expressed in ectodermal and mesodermal tissues and central nervous system of fourth to ninth embryonic abdominal segments. Later in embryogenesis, expression is seen in visceral mesoderm surrounding hindgut and in two Malpighian tubules.1 Publication

Developmental stagei

Highly expressed during embryogenesis, lower expression in larvae, pupae and adults.1 Publication

Gene expression databases

BgeeiFBgn0000015
ExpressionAtlasiP09087 baseline and differential
GenevisibleiP09087 DM

Interactioni

Protein-protein interaction databases

BioGridi70921, 59 interactors
DIPiDIP-19566N
IntActiP09087, 2 interactors
STRINGi7227.FBpp0082826

Structurei

3D structure databases

ProteinModelPortaliP09087
SMRiP09087
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 192Gln-richAdd BLAST192
Compositional biasi306 – 311Poly-Ala6
Compositional biasi454 – 458Poly-Asn5

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
InParanoidiP09087
KOiK09300
OMAiTHAVMYE
OrthoDBiEOG091G0TNY
PhylomeDBiP09087

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform M (identifier: P09087-1) [UniParc]FASTAAdd to basket
Also known as: Morphogenetic, Abd-BI

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQHHLQQQQ QQQQQQEQQH LQEQQQHLQQ LHHHAHHHLP QPLHTTSHHH
60 70 80 90 100
SAHPHLQQQQ QQQQHAVVAS SPSSVLQQQQ QQSTPTTHST PTHAVMYEDP
110 120 130 140 150
PPVPLVAVQQ QHLPAPQQQQ QLQQQQQQQQ QQLATTPVAG ALSPAQTPTG
160 170 180 190 200
PSAQQQQHLT SPHHQQLPQQ QTPNSVASGA SSNLQQQQQQ QNAAVAPGQT
210 220 230 240 250
QIVAPTTASV SPSSVSSQKE DINMSIQLAP LHIPAIRAGP GFETDTSAAV
260 270 280 290 300
KRHTAHWAYN DEGFNQHYGS GYYDRKHMFA YPYPETQFPV GQYWGPNYRP
310 320 330 340 350
DQTTSAAAAA AYMNEAERHV SAAARQSVEG TSTSSYEPPT YSSPGGLRGY
360 370 380 390 400
PSENYSSSGA SGGLSVGAVG PCTPNPGLHE WTGQVSVRKK RKPYSKFQTL
410 420 430 440 450
ELEKEFLFNA YVSKQKRWEL ARNLQLTERQ VKIWFQNRRM KNKKNSQRQA
460 470 480 490
NQQNNNNNSS SNHNHAQATQ QHHSGHHLNL SLNMGHHAAK MHQ
Length:493
Mass (Da):55,096
Last modified:October 1, 1996 - v3
Checksum:i55A11B5E97983A5F
GO
Isoform R (identifier: P09087-2) [UniParc]FASTAAdd to basket
Also known as: Regulatory, Abd-BII

The sequence of this isoform differs from the canonical sequence as follows:
     1-223: Missing.

Show »
Length:270
Mass (Da):30,344
Checksum:i3C951B3B406F1E49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15Q → H in CAB57859 (PubMed:2482824).Curated1
Sequence conflicti74Missing in CAA34260 (PubMed:2575066).Curated1
Sequence conflicti177 – 180ASGA → PVR in CAA34260 (PubMed:2575066).Curated4
Sequence conflicti317 – 318ER → DG in CAA34260 (PubMed:2575066).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0023961 – 223Missing in isoform R. CuratedAdd BLAST223

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31961 Genomic DNA Translation: AAA84402.1
U31961 Genomic DNA Translation: AAA84403.1
M21173 mRNA Translation: AAA28400.1
X16134 mRNA Translation: CAA34260.1
X51663 mRNA Translation: CAB57859.1
AE014297 Genomic DNA Translation: AAF55362.1
AE014297 Genomic DNA Translation: AAF55363.1
X15080 mRNA Translation: CAA33187.1
PIRiA32584
A34220
B24780
RefSeqiNP_001303471.1, NM_001316542.1 [P09087-2]
NP_001303472.1, NM_001316543.1 [P09087-1]
NP_001303474.1, NM_001316545.1 [P09087-2]
NP_524896.2, NM_080157.3 [P09087-1]
NP_650577.1, NM_142320.2 [P09087-2]
NP_732180.1, NM_169735.2 [P09087-2]
NP_732181.1, NM_169736.2 [P09087-2]
NP_996220.1, NM_206498.2 [P09087-2]
UniGeneiDm.1763

Genome annotation databases

EnsemblMetazoaiFBtr0083381; FBpp0082823; FBgn0000015 [P09087-2]
FBtr0083382; FBpp0082824; FBgn0000015 [P09087-2]
FBtr0083383; FBpp0082825; FBgn0000015 [P09087-2]
FBtr0083384; FBpp0082826; FBgn0000015 [P09087-1]
FBtr0083385; FBpp0089276; FBgn0000015 [P09087-2]
FBtr0415463; FBpp0373669; FBgn0000015 [P09087-1]
FBtr0415464; FBpp0373670; FBgn0000015 [P09087-2]
FBtr0415465; FBpp0373671; FBgn0000015 [P09087-2]
GeneIDi47763
KEGGidme:Dmel_CG11648

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiABDB_DROME
AccessioniPrimary (citable) accession number: P09087
Secondary accession number(s): Q9VEQ8, Q9VEQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 188 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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