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P09087

- ABDB_DROME

UniProt

P09087 - ABDB_DROME

Protein

Homeobox protein abdominal-B

Gene

Abd-B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 3 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi387 – 44660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: FlyBase
    2. sequence-specific DNA binding transcription factor activity Source: FlyBase
    3. transcription regulatory region sequence-specific DNA binding Source: FlyBase

    GO - Biological processi

    1. determination of genital disc primordium Source: FlyBase
    2. developmental pigmentation Source: FlyBase
    3. external genitalia morphogenesis Source: FlyBase
    4. female genitalia development Source: FlyBase
    5. genital disc anterior/posterior pattern formation Source: FlyBase
    6. genital disc development Source: FlyBase
    7. genital disc sexually dimorphic development Source: FlyBase
    8. germ cell migration Source: FlyBase
    9. gonadal mesoderm development Source: FlyBase
    10. heart development Source: FlyBase
    11. imaginal disc-derived female genitalia development Source: FlyBase
    12. imaginal disc-derived genitalia development Source: FlyBase
    13. male genitalia development Source: FlyBase
    14. male gonad development Source: FlyBase
    15. male pigmentation Source: FlyBase
    16. midgut development Source: FlyBase
    17. negative regulation of cardioblast cell fate specification Source: FlyBase
    18. negative regulation of female receptivity Source: FlyBase
    19. negative regulation of salivary gland boundary specification Source: FlyBase
    20. negative regulation of striated muscle tissue development Source: FlyBase
    21. open tracheal system development Source: FlyBase
    22. pole cell migration Source: FlyBase
    23. positive regulation of apoptotic process involved in morphogenesis Source: FlyBase
    24. positive regulation of developmental pigmentation Source: FlyBase
    25. positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
    26. salivary gland development Source: FlyBase
    27. segment specification Source: FlyBase
    28. sex differentiation Source: FlyBase
    29. sex-specific pigmentation Source: FlyBase
    30. specification of segmental identity, abdomen Source: FlyBase
    31. sperm storage Source: FlyBase
    32. spiracle morphogenesis, open tracheal system Source: FlyBase
    33. trachea morphogenesis Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein abdominal-B
    Alternative name(s):
    Infraabdominal 7
    Short name:
    IAB-7
    P3
    PH189
    Gene namesi
    Name:Abd-B
    ORF Names:CG10291
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0000015. Abd-B.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: FlyBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Homeobox protein abdominal-BPRO_0000200258Add
    BLAST

    Proteomic databases

    PRIDEiP09087.

    Expressioni

    Tissue specificityi

    Isoform M and isoform R are expressed in ectodermal and mesodermal tissues and central nervous system of fourth to ninth embryonic abdominal segments. Later in embryogenesis, expression is seen in visceral mesoderm surrounding hindgut and in two Malpighian tubules.1 Publication

    Developmental stagei

    Highly expressed during embryogenesis, lower expression in larvae, pupae and adults.1 Publication

    Gene expression databases

    BgeeiP09087.

    Interactioni

    Protein-protein interaction databases

    BioGridi70921. 20 interactions.
    DIPiDIP-19566N.
    IntActiP09087. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP09087.
    SMRiP09087. Positions 388-444.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 192192Gln-richAdd
    BLAST
    Compositional biasi306 – 3116Poly-Ala
    Compositional biasi454 – 4585Poly-Asn

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG286554.
    GeneTreeiENSGT00730000110374.
    InParanoidiP09087.
    KOiK09300.
    OMAiTHAVMYE.
    OrthoDBiEOG7RJPTM.
    PhylomeDBiP09087.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform M (identifier: P09087-1) [UniParc]FASTAAdd to Basket

    Also known as: Morphogenetic, Abd-BI

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQQHHLQQQQ QQQQQQEQQH LQEQQQHLQQ LHHHAHHHLP QPLHTTSHHH    50
    SAHPHLQQQQ QQQQHAVVAS SPSSVLQQQQ QQSTPTTHST PTHAVMYEDP 100
    PPVPLVAVQQ QHLPAPQQQQ QLQQQQQQQQ QQLATTPVAG ALSPAQTPTG 150
    PSAQQQQHLT SPHHQQLPQQ QTPNSVASGA SSNLQQQQQQ QNAAVAPGQT 200
    QIVAPTTASV SPSSVSSQKE DINMSIQLAP LHIPAIRAGP GFETDTSAAV 250
    KRHTAHWAYN DEGFNQHYGS GYYDRKHMFA YPYPETQFPV GQYWGPNYRP 300
    DQTTSAAAAA AYMNEAERHV SAAARQSVEG TSTSSYEPPT YSSPGGLRGY 350
    PSENYSSSGA SGGLSVGAVG PCTPNPGLHE WTGQVSVRKK RKPYSKFQTL 400
    ELEKEFLFNA YVSKQKRWEL ARNLQLTERQ VKIWFQNRRM KNKKNSQRQA 450
    NQQNNNNNSS SNHNHAQATQ QHHSGHHLNL SLNMGHHAAK MHQ 493
    Length:493
    Mass (Da):55,096
    Last modified:October 1, 1996 - v3
    Checksum:i55A11B5E97983A5F
    GO
    Isoform R (identifier: P09087-2) [UniParc]FASTAAdd to Basket

    Also known as: Regulatory, Abd-BII

    The sequence of this isoform differs from the canonical sequence as follows:
         1-223: Missing.

    Show »
    Length:270
    Mass (Da):30,344
    Checksum:i3C951B3B406F1E49
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151Q → H in CAB57859. (PubMed:2482824)Curated
    Sequence conflicti74 – 741Missing in CAA34260. (PubMed:2575066)Curated
    Sequence conflicti177 – 1804ASGA → PVR in CAA34260. (PubMed:2575066)Curated
    Sequence conflicti317 – 3182ER → DG in CAA34260. (PubMed:2575066)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 223223Missing in isoform R. CuratedVSP_002396Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31961 Genomic DNA. Translation: AAA84402.1.
    U31961 Genomic DNA. Translation: AAA84403.1.
    M21173 mRNA. Translation: AAA28400.1.
    X16134 mRNA. Translation: CAA34260.1.
    X51663 mRNA. Translation: CAB57859.1.
    AE014297 Genomic DNA. Translation: AAF55362.1.
    AE014297 Genomic DNA. Translation: AAF55363.1.
    X15080 mRNA. Translation: CAA33187.1.
    PIRiA32584.
    A34220.
    B24780.
    RefSeqiNP_524896.2. NM_080157.2. [P09087-1]
    NP_650577.1. NM_142320.1. [P09087-2]
    NP_732180.1. NM_169735.1. [P09087-2]
    NP_732181.1. NM_169736.1. [P09087-2]
    NP_996220.1. NM_206498.1. [P09087-2]
    UniGeneiDm.1763.

    Genome annotation databases

    EnsemblMetazoaiFBtr0083384; FBpp0082826; FBgn0000015. [P09087-1]
    GeneIDi47763.
    KEGGidme:Dmel_CG11648.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31961 Genomic DNA. Translation: AAA84402.1 .
    U31961 Genomic DNA. Translation: AAA84403.1 .
    M21173 mRNA. Translation: AAA28400.1 .
    X16134 mRNA. Translation: CAA34260.1 .
    X51663 mRNA. Translation: CAB57859.1 .
    AE014297 Genomic DNA. Translation: AAF55362.1 .
    AE014297 Genomic DNA. Translation: AAF55363.1 .
    X15080 mRNA. Translation: CAA33187.1 .
    PIRi A32584.
    A34220.
    B24780.
    RefSeqi NP_524896.2. NM_080157.2. [P09087-1 ]
    NP_650577.1. NM_142320.1. [P09087-2 ]
    NP_732180.1. NM_169735.1. [P09087-2 ]
    NP_732181.1. NM_169736.1. [P09087-2 ]
    NP_996220.1. NM_206498.1. [P09087-2 ]
    UniGenei Dm.1763.

    3D structure databases

    ProteinModelPortali P09087.
    SMRi P09087. Positions 388-444.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 70921. 20 interactions.
    DIPi DIP-19566N.
    IntActi P09087. 1 interaction.

    Proteomic databases

    PRIDEi P09087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0083384 ; FBpp0082826 ; FBgn0000015 . [P09087-1 ]
    GeneIDi 47763.
    KEGGi dme:Dmel_CG11648.

    Organism-specific databases

    CTDi 47763.
    FlyBasei FBgn0000015. Abd-B.

    Phylogenomic databases

    eggNOGi NOG286554.
    GeneTreei ENSGT00730000110374.
    InParanoidi P09087.
    KOi K09300.
    OMAi THAVMYE.
    OrthoDBi EOG7RJPTM.
    PhylomeDBi P09087.

    Miscellaneous databases

    GenomeRNAii 47763.
    NextBioi 839106.

    Gene expression databases

    Bgeei P09087.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS M AND R).
      Strain: Canton-S.
    2. "Evidence that the Abdominal-B r element function is conferred by a trans-regulatory homeoprotein."
      Delorenzi M., Ali N., Saari G., Henry C., Wilcox M., Bienz M.
      EMBO J. 7:3223-3231(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM R), CHARACTERIZATION.
      Tissue: Embryo.
    3. "The molecular genetics of the bithorax complex of Drosophila: characterization of the products of the Abdominal-B domain."
      Celniker S.E., Keelan D.J., Lewis E.B.
      Genes Dev. 3:1424-1436(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM M), CHARACTERIZATION.
      Tissue: Embryo and Pupae.
    4. "The morphogenetic and regulatory functions of the Drosophila Abdominal-B gene are encoded in overlapping RNAs transcribed from separate promoters."
      Zavortink M., Sakonju S.
      Genes Dev. 3:1969-1981(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM M).
      Strain: Canton-S.
      Tissue: Embryo.
    5. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS M AND R).
      Strain: Berkeley.
    6. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    7. "Homeo box genes of the Antennapedia and bithorax complexes of Drosophila."
      Regulski M., Harding K., Kostriken R., Karch F., Levine M., McGinnis W.
      Cell 43:71-80(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 387-447.
    8. "Different transcripts of the Drosophila Abd-B gene correlate with distinct genetic sub-functions."
      Kuziora M.A., McGinnis W.
      EMBO J. 7:3233-3244(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiABDB_DROME
    AccessioniPrimary (citable) accession number: P09087
    Secondary accession number(s): Q9VEQ8, Q9VEQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 154 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3