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P09087 (ABDB_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 153. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein abdominal-B
Alternative name(s):
Infraabdominal 7
Short name=IAB-7
P3
PH189
Gene names
Name:Abd-B
ORF Names:CG10291
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Tissue specificity

Isoform M and isoform R are expressed in ectodermal and mesodermal tissues and central nervous system of fourth to ninth embryonic abdominal segments. Later in embryogenesis, expression is seen in visceral mesoderm surrounding hindgut and in two Malpighian tubules. Ref.8

Developmental stage

Highly expressed during embryogenesis, lower expression in larvae, pupae and adults. Ref.8

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdetermination of genital disc primordium

Inferred from mutant phenotype PubMed 15893978. Source: FlyBase

developmental pigmentation

Non-traceable author statement PubMed 12459721. Source: FlyBase

external genitalia morphogenesis

Inferred from mutant phenotype PubMed 16319117. Source: FlyBase

female genitalia development

Inferred from mutant phenotype PubMed 16319117. Source: FlyBase

genital disc anterior/posterior pattern formation

Inferred from expression pattern PubMed 8798147. Source: FlyBase

genital disc development

Traceable author statement PubMed 11494318. Source: FlyBase

genital disc sexually dimorphic development

Inferred from mutant phenotype PubMed 15893978. Source: FlyBase

germ cell migration

Inferred from mutant phenotype PubMed 9435287. Source: FlyBase

gonadal mesoderm development

Inferred from mutant phenotype PubMed 15454263PubMed 9435287. Source: FlyBase

heart development

Non-traceable author statement PubMed 12837580. Source: FlyBase

imaginal disc-derived female genitalia development

Inferred from mutant phenotype PubMed 16971094. Source: FlyBase

imaginal disc-derived genitalia development

Traceable author statement PubMed 12386929. Source: FlyBase

male genitalia development

Inferred from mutant phenotype PubMed 16319117. Source: FlyBase

male gonad development

Inferred from mutant phenotype PubMed 15454263. Source: FlyBase

male pigmentation

Inferred from direct assay PubMed 16814723. Source: FlyBase

midgut development

Traceable author statement PubMed 10512197. Source: FlyBase

negative regulation of cardioblast cell fate specification

Inferred from mutant phenotype PubMed 12435360. Source: FlyBase

negative regulation of female receptivity

Inferred from mutant phenotype PubMed 23555301. Source: FlyBase

negative regulation of salivary gland boundary specification

Traceable author statement PubMed 11598957PubMed 12742168. Source: FlyBase

negative regulation of striated muscle tissue development

Inferred from mutant phenotype PubMed 12397110. Source: FlyBase

open tracheal system development

Inferred from mutant phenotype PubMed 17113384. Source: FlyBase

pole cell migration

Traceable author statement PubMed 9637912. Source: FlyBase

positive regulation of apoptotic process involved in morphogenesis

Inferred from mutant phenotype PubMed 12202035. Source: FlyBase

positive regulation of developmental pigmentation

Non-traceable author statement PubMed 12350340. Source: FlyBase

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16814723. Source: FlyBase

salivary gland development

Non-traceable author statement PubMed 14624839. Source: FlyBase

segment specification

Inferred from mutant phenotype PubMed 12202035. Source: FlyBase

sex differentiation

Non-traceable author statement PubMed 12350340. Source: FlyBase

sex-specific pigmentation

Traceable author statement PubMed 12957543. Source: FlyBase

specification of segmental identity, abdomen

Inferred from mutant phenotype PubMed 16818450PubMed 16971094. Source: FlyBase

sperm storage

Inferred from mutant phenotype PubMed 23555301. Source: FlyBase

spiracle morphogenesis, open tracheal system

Inferred from mutant phenotype PubMed 10491268. Source: FlyBase

trachea morphogenesis

Inferred from mutant phenotype PubMed 21750678. Source: FlyBase

   Cellular_componentnucleus

Inferred from direct assay PubMed 1972049Ref.3. Source: FlyBase

   Molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding

Inferred from direct assay PubMed 9491376. Source: FlyBase

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 16814723. Source: FlyBase

transcription regulatory region sequence-specific DNA binding

Inferred from direct assay PubMed 22005458. Source: FlyBase

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform M (identifier: P09087-1)

Also known as: Morphogenetic; Abd-BI;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform R (identifier: P09087-2)

Also known as: Regulatory; Abd-BII;

The sequence of this isoform differs from the canonical sequence as follows:
     1-223: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Homeobox protein abdominal-B
PRO_0000200258

Regions

DNA binding387 – 44660Homeobox
Compositional bias1 – 192192Gln-rich
Compositional bias306 – 3116Poly-Ala
Compositional bias454 – 4585Poly-Asn

Natural variations

Alternative sequence1 – 223223Missing in isoform R.
VSP_002396

Experimental info

Sequence conflict151Q → H in CAB57859. Ref.4
Sequence conflict741Missing in CAA34260. Ref.3
Sequence conflict177 – 1804ASGA → PVR in CAA34260. Ref.3
Sequence conflict317 – 3182ER → DG in CAA34260. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform M (Morphogenetic) (Abd-BI) [UniParc].

Last modified October 1, 1996. Version 3.
Checksum: 55A11B5E97983A5F

FASTA49355,096
        10         20         30         40         50         60 
MQQHHLQQQQ QQQQQQEQQH LQEQQQHLQQ LHHHAHHHLP QPLHTTSHHH SAHPHLQQQQ 

        70         80         90        100        110        120 
QQQQHAVVAS SPSSVLQQQQ QQSTPTTHST PTHAVMYEDP PPVPLVAVQQ QHLPAPQQQQ 

       130        140        150        160        170        180 
QLQQQQQQQQ QQLATTPVAG ALSPAQTPTG PSAQQQQHLT SPHHQQLPQQ QTPNSVASGA 

       190        200        210        220        230        240 
SSNLQQQQQQ QNAAVAPGQT QIVAPTTASV SPSSVSSQKE DINMSIQLAP LHIPAIRAGP 

       250        260        270        280        290        300 
GFETDTSAAV KRHTAHWAYN DEGFNQHYGS GYYDRKHMFA YPYPETQFPV GQYWGPNYRP 

       310        320        330        340        350        360 
DQTTSAAAAA AYMNEAERHV SAAARQSVEG TSTSSYEPPT YSSPGGLRGY PSENYSSSGA 

       370        380        390        400        410        420 
SGGLSVGAVG PCTPNPGLHE WTGQVSVRKK RKPYSKFQTL ELEKEFLFNA YVSKQKRWEL 

       430        440        450        460        470        480 
ARNLQLTERQ VKIWFQNRRM KNKKNSQRQA NQQNNNNNSS SNHNHAQATQ QHHSGHHLNL 

       490 
SLNMGHHAAK MHQ 

« Hide

Isoform R (Regulatory) (Abd-BII) [UniParc].

Checksum: 3C951B3B406F1E49
Show »

FASTA27030,344

References

« Hide 'large scale' references
[1]"Complete sequence of the bithorax complex of Drosophila."
Martin C.H., Mayeda C.A., Davis C.A., Ericsson C.L., Knafels J.D., Mathog D.R., Celniker S.E., Lewis E.B., Palazzolo M.J.
Proc. Natl. Acad. Sci. U.S.A. 92:8398-8402(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS M AND R).
Strain: Canton-S.
[2]"Evidence that the Abdominal-B r element function is conferred by a trans-regulatory homeoprotein."
Delorenzi M., Ali N., Saari G., Henry C., Wilcox M., Bienz M.
EMBO J. 7:3223-3231(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM R), CHARACTERIZATION.
Tissue: Embryo.
[3]"The molecular genetics of the bithorax complex of Drosophila: characterization of the products of the Abdominal-B domain."
Celniker S.E., Keelan D.J., Lewis E.B.
Genes Dev. 3:1424-1436(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM M), CHARACTERIZATION.
Tissue: Embryo and Pupae.
[4]"The morphogenetic and regulatory functions of the Drosophila Abdominal-B gene are encoded in overlapping RNAs transcribed from separate promoters."
Zavortink M., Sakonju S.
Genes Dev. 3:1969-1981(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM M).
Strain: Canton-S.
Tissue: Embryo.
[5]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS M AND R).
Strain: Berkeley.
[6]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[7]"Homeo box genes of the Antennapedia and bithorax complexes of Drosophila."
Regulski M., Harding K., Kostriken R., Karch F., Levine M., McGinnis W.
Cell 43:71-80(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 387-447.
[8]"Different transcripts of the Drosophila Abd-B gene correlate with distinct genetic sub-functions."
Kuziora M.A., McGinnis W.
EMBO J. 7:3233-3244(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31961 Genomic DNA. Translation: AAA84402.1.
U31961 Genomic DNA. Translation: AAA84403.1.
M21173 mRNA. Translation: AAA28400.1.
X16134 mRNA. Translation: CAA34260.1.
X51663 mRNA. Translation: CAB57859.1.
AE014297 Genomic DNA. Translation: AAF55362.1.
AE014297 Genomic DNA. Translation: AAF55363.1.
X15080 mRNA. Translation: CAA33187.1.
PIRA32584.
A34220.
B24780.
RefSeqNP_524896.2. NM_080157.2. [P09087-1]
NP_650577.1. NM_142320.1. [P09087-2]
NP_732180.1. NM_169735.1. [P09087-2]
NP_732181.1. NM_169736.1. [P09087-2]
NP_996220.1. NM_206498.1. [P09087-2]
UniGeneDm.1763.

3D structure databases

ProteinModelPortalP09087.
SMRP09087. Positions 388-444.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid70921. 20 interactions.
DIPDIP-19566N.
IntActP09087. 1 interaction.

Proteomic databases

PRIDEP09087.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0083384; FBpp0082826; FBgn0000015. [P09087-1]
GeneID47763.
KEGGdme:Dmel_CG11648.

Organism-specific databases

CTD47763.
FlyBaseFBgn0000015. Abd-B.

Phylogenomic databases

eggNOGNOG286554.
GeneTreeENSGT00730000110374.
InParanoidP09087.
KOK09300.
OMATHAVMYE.
OrthoDBEOG7RJPTM.
PhylomeDBP09087.

Gene expression databases

BgeeP09087.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi47763.
NextBio839106.

Entry information

Entry nameABDB_DROME
AccessionPrimary (citable) accession number: P09087
Secondary accession number(s): Q9VEQ8, Q9VEQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase