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P09086

- PO2F2_HUMAN

UniProt

P09086 - PO2F2_HUMAN

Protein

POU domain, class 2, transcription factor 2

Gene

POU2F2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 170 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.4 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi297 – 35660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: MGI
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cell maturation Source: Ensembl
    2. humoral immune response Source: ProtInc
    3. immunoglobulin secretion involved in immune response Source: Ensembl
    4. mature B cell differentiation Source: Ensembl
    5. positive regulation of transcription, DNA-templated Source: Ensembl
    6. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 2, transcription factor 2
    Alternative name(s):
    Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
    Octamer-binding protein 2
    Short name:
    Oct-2
    Octamer-binding transcription factor 2
    Short name:
    OTF-2
    Gene namesi
    Name:POU2F2
    Synonyms:OCT2, OTF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:9213. POU2F2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi340 – 3423VIR → FNP: Suppresses DNA-binding ability.

    Organism-specific databases

    PharmGKBiPA33537.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479POU domain, class 2, transcription factor 2PRO_0000100714Add
    BLAST

    Proteomic databases

    MaxQBiP09086.
    PaxDbiP09086.
    PRIDEiP09086.

    PTM databases

    PhosphoSiteiP09086.

    Expressioni

    Tissue specificityi

    Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.2 Publications

    Gene expression databases

    ArrayExpressiP09086.
    BgeeiP09086.
    CleanExiHS_POU2F2.
    GenevestigatoriP09086.

    Organism-specific databases

    HPAiCAB002513.

    Interactioni

    Subunit structurei

    Interacts with NR3C1, AR and PGR.1 Publication

    Protein-protein interaction databases

    BioGridi111448. 15 interactions.
    DIPiDIP-51N.
    MINTiMINT-194986.
    STRINGi9606.ENSP00000373992.

    Structurei

    Secondary structure

    1
    479
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi307 – 31812
    Helixi324 – 3318
    Turni332 – 3354
    Helixi338 – 35013
    Turni356 – 3583

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HDPNMR-A297-359[»]
    ProteinModelPortaliP09086.
    SMRiP09086. Positions 199-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP09086.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini195 – 26975POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni389 – 41022Leucine-zipperAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi417 – 4248Gly-rich

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG267922.
    HOGENOMiHOG000220842.
    HOVERGENiHBG052783.
    InParanoidiP09086.
    KOiK09364.
    PhylomeDBiP09086.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P09086-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVHSSMGAPE IRMSKPLEAE KQGLDSPSEH TDTERNGPDT NHQNPQNKTS    50
    PFSVSPTGPS TKIKAEDPSG DSAPAAPLPP QPAQPHLPQA QLMLTGSQLA 100
    GDIQQLLQLQ QLVLVPGHHL QPPAQFLLPQ AQQSQPGLLP TPNLFQLPQQ 150
    TQGALLTSQP RAGLPTQAVT RPTLPDPHLS HPQPPKCLEP PSHPEEPSDL 200
    EELEQFARTF KQRRIKLGFT QGDVGLAMGK LYGNDFSQTT ISRFEALNLS 250
    FKNMCKLKPL LEKWLNDAET MSVDSSLPSP NQLSSPSLGF DGLPGRRRKK 300
    RTSIETNVRF ALEKSFLANQ KPTSEEILLI AEQLHMEKEV IRVWFCNRRQ 350
    KEKRINPCSA APMLPSPGKP ASYSPHMVTP QGGAGTLPLS QASSSLSTTV 400
    TTLSSAVGTL HPSRTAGGGG GGGGAAPPLN SIPSVTPPPP ATTNSTNPSP 450
    QGSHSAIGLS GLNPSTGPGL WWNPAPYQP 479
    Length:479
    Mass (Da):51,209
    Last modified:January 23, 2007 - v3
    Checksum:i8DA661DC07644D43
    GO
    Isoform 2 (identifier: P09086-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         468-479: Missing.

    Show »
    Length:467
    Mass (Da):49,801
    Checksum:i444B5AB65B950050
    GO
    Isoform 3 (identifier: P09086-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         168-183: Missing.

    Show »
    Length:463
    Mass (Da):49,461
    Checksum:i5DCCA37A76A65AB9
    GO
    Isoform 4 (identifier: P09086-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         168-183: Missing.
         400-416: VTTLSSAVGTLHPSRTA → AQTPALKAATRLSACQA
         417-479: Missing.

    Show »
    Length:400
    Mass (Da):43,528
    Checksum:i074B384660350FCE
    GO
    Isoform 5 (identifier: P09086-5) [UniParc]FASTAAdd to Basket

    Also known as: Oct-2B

    The sequence of this isoform differs from the canonical sequence as follows:
         468-479: PGLWWNPAPYQP → STMVGLSSGL...GGPEAGSKAE

    Note: Incomplete sequence.

    Show »
    Length:602
    Mass (Da):62,172
    Checksum:iF5E4E2B0D206FC15
    GO

    Sequence cautioni

    The sequence CAA32039.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei168 – 18316Missing in isoform 3 and isoform 4. 3 PublicationsVSP_002324Add
    BLAST
    Alternative sequencei400 – 41617VTTLS…PSRTA → AQTPALKAATRLSACQA in isoform 4. 2 PublicationsVSP_007848Add
    BLAST
    Alternative sequencei417 – 47963Missing in isoform 4. 2 PublicationsVSP_007849Add
    BLAST
    Alternative sequencei468 – 47912Missing in isoform 2. 1 PublicationVSP_002325Add
    BLAST
    Alternative sequencei468 – 47912PGLWW…APYQP → STMVGLSSGLSPALMSNNPL ATIQALASGGTLPLTSLDGS GNLVLGAAGAAPGSPSLVTS PLFLNHTGLPLLSAPPGVGL VSAAAAAVAASISSKSPGLS SSSSSSSSSSSSTCSDVAAQ TPGGPGGPEAGSKAE in isoform 5. 1 PublicationVSP_032187Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36653 mRNA. Translation: AAA36389.1.
    X53468 mRNA. Translation: CAA37562.1.
    X53469 mRNA. Translation: CAA37565.1.
    M36542 mRNA. Translation: AAA36732.1.
    X13810 mRNA. Translation: CAA32040.1.
    BT007438 mRNA. Translation: AAP36106.1.
    BC006101 mRNA. Translation: AAH06101.1.
    M36718 mRNA. Translation: AAA59978.1.
    X13809 mRNA. Translation: CAA32039.1. Different initiation.
    X81030 Genomic DNA. Translation: CAA56933.1.
    CCDSiCCDS33035.1. [P09086-3]
    CCDS56094.1. [P09086-2]
    CCDS56095.1. [P09086-1]
    CCDS58665.1. [P09086-4]
    PIRiA31753.
    A42098.
    RefSeqiNP_001193954.1. NM_001207025.2. [P09086-1]
    NP_001193955.1. NM_001207026.1. [P09086-2]
    NP_001234923.1. NM_001247994.1. [P09086-4]
    NP_002689.1. NM_002698.4. [P09086-3]
    UniGeneiHs.147381.

    Genome annotation databases

    EnsembliENST00000389341; ENSP00000373992; ENSG00000028277. [P09086-3]
    ENST00000526816; ENSP00000431603; ENSG00000028277. [P09086-1]
    ENST00000529067; ENSP00000437224; ENSG00000028277. [P09086-4]
    ENST00000529952; ENSP00000436988; ENSG00000028277. [P09086-2]
    GeneIDi5452.
    KEGGihsa:5452.
    UCSCiuc002osn.3. human. [P09086-3]
    uc002osp.3. human. [P09086-1]
    uc002osq.3. human. [P09086-4]

    Polymorphism databases

    DMDMi123402.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36653 mRNA. Translation: AAA36389.1 .
    X53468 mRNA. Translation: CAA37562.1 .
    X53469 mRNA. Translation: CAA37565.1 .
    M36542 mRNA. Translation: AAA36732.1 .
    X13810 mRNA. Translation: CAA32040.1 .
    BT007438 mRNA. Translation: AAP36106.1 .
    BC006101 mRNA. Translation: AAH06101.1 .
    M36718 mRNA. Translation: AAA59978.1 .
    X13809 mRNA. Translation: CAA32039.1 . Different initiation.
    X81030 Genomic DNA. Translation: CAA56933.1 .
    CCDSi CCDS33035.1. [P09086-3 ]
    CCDS56094.1. [P09086-2 ]
    CCDS56095.1. [P09086-1 ]
    CCDS58665.1. [P09086-4 ]
    PIRi A31753.
    A42098.
    RefSeqi NP_001193954.1. NM_001207025.2. [P09086-1 ]
    NP_001193955.1. NM_001207026.1. [P09086-2 ]
    NP_001234923.1. NM_001247994.1. [P09086-4 ]
    NP_002689.1. NM_002698.4. [P09086-3 ]
    UniGenei Hs.147381.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HDP NMR - A 297-359 [» ]
    ProteinModelPortali P09086.
    SMRi P09086. Positions 199-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111448. 15 interactions.
    DIPi DIP-51N.
    MINTi MINT-194986.
    STRINGi 9606.ENSP00000373992.

    PTM databases

    PhosphoSitei P09086.

    Polymorphism databases

    DMDMi 123402.

    Proteomic databases

    MaxQBi P09086.
    PaxDbi P09086.
    PRIDEi P09086.

    Protocols and materials databases

    DNASUi 5452.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000389341 ; ENSP00000373992 ; ENSG00000028277 . [P09086-3 ]
    ENST00000526816 ; ENSP00000431603 ; ENSG00000028277 . [P09086-1 ]
    ENST00000529067 ; ENSP00000437224 ; ENSG00000028277 . [P09086-4 ]
    ENST00000529952 ; ENSP00000436988 ; ENSG00000028277 . [P09086-2 ]
    GeneIDi 5452.
    KEGGi hsa:5452.
    UCSCi uc002osn.3. human. [P09086-3 ]
    uc002osp.3. human. [P09086-1 ]
    uc002osq.3. human. [P09086-4 ]

    Organism-specific databases

    CTDi 5452.
    GeneCardsi GC19M042592.
    HGNCi HGNC:9213. POU2F2.
    HPAi CAB002513.
    MIMi 164176. gene.
    neXtProti NX_P09086.
    PharmGKBi PA33537.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267922.
    HOGENOMi HOG000220842.
    HOVERGENi HBG052783.
    InParanoidi P09086.
    KOi K09364.
    PhylomeDBi P09086.
    TreeFami TF316413.

    Miscellaneous databases

    EvolutionaryTracei P09086.
    GenomeRNAii 5452.
    NextBioi 21101.
    PROi P09086.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09086.
    Bgeei P09086.
    CleanExi HS_POU2F2.
    Genevestigatori P09086.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains."
      Clerc R.G., Corcoran L.M., Lebowitz J.H., Baltimore D., Sharp P.A.
      Genes Dev. 2:1570-1581(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 450-479 (ISOFORM 1).
    2. "A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein."
      Scheidereit C., Cromlish J.A., Gerster T., Kawakami K., Balmaceda C.-G., Currie R.A., Roder R.G.
      Nature 336:551-557(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY.
      Tissue: B-cell lymphoma.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Lymph.
    5. "A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells."
      Mueller M.M., Ruppert S., Schaffner W., Matthias P.
      Nature 336:544-551(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-479 (ISOFORM 1).
      Tissue: B-cell.
    6. "Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells."
      Muller-Immergluck M.M., Schaffner W., Matthias P.
      EMBO J. 9:1625-1634(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-161, FUNCTION.
    7. "Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution."
      Matsuo K., Clay O., Kuenzler P., Georgiev O., Urbanek P., Schaffner W.
      Biol. Chem. Hoppe-Seyler 375:675-683(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 168-377.
    8. "A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain."
      Ko H.-S., Fast P., McBride W., Staudt L.M.
      Cell 55:135-144(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 240-387, FUNCTION.
    9. "Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter."
      Tanaka M., Lai J.-S., Herr W.
      Cell 68:755-767(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 468-479 (ISOFORM 5), FUNCTION.
    10. "Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA)."
      Schreiber E., Matthias P., Mueller M.M., Schaffner W.
      EMBO J. 7:4221-4229(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION (ISOFORM 5), TISSUE SPECIFICITY.
    11. "Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter."
      Prefontaine G.G., Walther R., Giffin W., Lemieux M.E., Pope L., Hache R.J.G.
      J. Biol. Chem. 274:26713-26719(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NR3C1; AR AND PGR.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2."
      Sivaraja M., Botfield M.C., Mueller M., Jancso A., Weiss M.A.
      Biochemistry 33:9845-9855(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 297-359.

    Entry informationi

    Entry nameiPO2F2_HUMAN
    AccessioniPrimary (citable) accession number: P09086
    Secondary accession number(s): Q16648, Q7M4M8, Q9BRS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 170 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3