Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Paired box protein Pax-1

Gene

Pax1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column.

GO - Molecular functioni

  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: MGI

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • bone morphogenesis Source: MGI
  • CD4-positive, alpha-beta T cell differentiation Source: MGI
  • CD8-positive, alpha-beta T cell differentiation Source: MGI
  • cell proliferation Source: MGI
  • parathyroid gland development Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: MGI
  • sclerotome development Source: UniProtKB
  • skeletal system development Source: MGI
  • somitogenesis Source: MGI
  • thymus development Source: MGI

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-1
Gene namesi
Name:Pax1
Synonyms:Pax-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97485. Pax1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • transcription factor complex Source: MGI

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Undulated (un) homozygous mice exhibits vertebral malformations along the entire rostro-caudal axis. This is due to a single mutation in the paired box region.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501731 – 446Paired box protein Pax-1Add BLAST446

Proteomic databases

MaxQBiP09084.
PaxDbiP09084.
PRIDEiP09084.

PTM databases

PhosphoSitePlusiP09084.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037034.
CleanExiMM_PAX1.
ExpressionAtlasiP09084. baseline and differential.
GenevisibleiP09084. MM.

Interactioni

Protein-protein interaction databases

BioGridi202028. 2 interactors.
STRINGi10090.ENSMUSP00000105594.

Structurei

3D structure databases

ProteinModelPortaliP09084.
SMRiP09084.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 215PairedPROSITE-ProRule annotationAdd BLAST127

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiKOG3517. Eukaryota.
ENOG4111FI9. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230938.
HOVERGENiHBG009115.
InParanoidiP09084.
KOiK09382.
OMAiAEQTYGE.
OrthoDBiEOG091G0S4E.
PhylomeDBiP09084.
TreeFamiTF315397.

Family and domain databases

CDDicd00131. PAX. 1 hit.
Gene3Di1.10.10.10. 2 hits.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001523. Paired_dom.
IPR033206. PAX1.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR24329:SF472. PTHR24329:SF472. 1 hit.
PfamiView protein in Pfam
PF00292. PAX. 1 hit.
PRINTSiPR00027. PAIREDBOX.
SMARTiView protein in SMART
SM00351. PAX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P09084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTLGLGSR AWRVSWERAA AAAAGPGAGG ALGSGSLRVS SRRGPRLARA
60 70 80 90 100
LPLCLSGGGG ARALPDCAGP SPRRSGARQL AGPRAMEQTY GEVNQLGGVF
110 120 130 140 150
VNGRPLPNAI RLRIVELAQL GIRPCDISRQ LRVSHGCVSK ILARYNETGS
160 170 180 190 200
ILPGAIGGSK PRVTTPNVVK HIRDYKQGDP GIFAWEIRDR LLADGVCDKY
210 220 230 240 250
NVPSVSSISR ILRNKIGSLA QPGPYEASKQ PPPQPALPYN HIYQYPYPSP
260 270 280 290 300
VSPTGTKMGT HPGVPGSAGH VSIPRSWPSA HSVSNILGIR TFMEQTGALA
310 320 330 340 350
GSEGAAYSPK MEDWAGVNRA AFPTSPAVNG LEKPALEADI KYTQSASSLS
360 370 380 390 400
AVGGFLPACA YPASNQHGVY SAPAAGYLSP GPPWPPAQAP PLTPHGAGVA
410 420 430 440
VHGGELAAAM TFKHREGTDR KPPSPGGKAT DALGSLHGLP IPASTS
Length:446
Mass (Da):46,263
Last modified:May 18, 2010 - v4
Checksum:i635FE7318A946D6C
GO

Sequence cautioni

The sequence AAA37793 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAA39888 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141I → M in AAA37793 (PubMed:2453291).Curated1
Sequence conflicti300A → T in AAA39888 (PubMed:1889089).Curated1
Sequence conflicti345S → L in AAA39888 (PubMed:1889089).Curated1
Sequence conflicti367H → Q in AAA39888 (PubMed:1889089).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti103G → S in un. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133503, AJ133504, AJ133505 Genomic DNA. Translation: CAB38370.1.
AL805918 Genomic DNA. Translation: CAM17060.2.
M69222 mRNA. Translation: AAA39888.1. Different initiation.
M20978 Genomic DNA. Translation: AAA37793.1. Sequence problems.
CCDSiCCDS16835.2.
PIRiA29902.
A40023.
RefSeqiNP_032806.2. NM_008780.2.
UniGeneiMm.315502.
Mm.483524.

Genome annotation databases

EnsembliENSMUST00000109968; ENSMUSP00000105594; ENSMUSG00000037034.
GeneIDi18503.
KEGGimmu:18503.
UCSCiuc008msx.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPAX1_MOUSE
AccessioniPrimary (citable) accession number: P09084
Secondary accession number(s): A2ALJ9, Q9R2B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: May 18, 2010
Last modified: July 5, 2017
This is version 146 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot