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Protein

Protein gooseberry-neuro

Gene

gsb-n

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Expressed in a segmentally repeating pattern to define the polarity of embryonic segments.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi182 – 24160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • neurogenesis Source: FlyBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • segment polarity determination Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP09083.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein gooseberry-neuro
Alternative name(s):
BSH4
Protein gooseberry proximal
Gene namesi
Name:gsb-n
Synonyms:Gsb-p, GSBA
ORF Names:CG2692
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0001147. gsb-n.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Protein gooseberry-neuroPRO_0000050169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP09083.
PRIDEiP09083.

PTM databases

iPTMnetiP09083.

Expressioni

Tissue specificityi

Expressed in a single-segment repeat in the neurectoderm during germ-band extension and later in single neurons during neuronal differentiation.1 Publication

Gene expression databases

BgeeiP09083.
GenevisibleiP09083. DM.

Interactioni

Protein-protein interaction databases

BioGridi63572. 1 interaction.
DIPiDIP-23099N.
IntActiP09083. 2 interactions.
MINTiMINT-1723154.
STRINGi7227.FBpp0072363.

Structurei

3D structure databases

ProteinModelPortaliP09083.
SMRiP09083. Positions 21-140, 181-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 143124PairedPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi302 – 32423Ala/His-richAdd
BLAST
Compositional biasi402 – 42827Ala/His-richAdd
BLAST

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000004133.
InParanoidiP09083.
KOiK09381.
OMAiHAVAQHQ.
OrthoDBiEOG7WT431.
PhylomeDBiP09083.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMSSANSLR PLFAGYPFQG QGRVNQLGGV FINGRPLPNH IRLKIVEMAA
60 70 80 90 100
SGVRPCVISR QLRVSHGCVS KILNRYQETG SIRPGVIGGS KPKVTSPEIE
110 120 130 140 150
TRIDELRKEN PSIFSWEIRE KLIKEGFADP PSTSSISRLL RGSDRGSEDG
160 170 180 190 200
RKDYTINGIL GGRDSDISDT ESEPGIPLKR KQRRSRTTFT AEQLEALERA
210 220 230 240 250
FSRTQYPDVY TREELAQTTA LTEARIQVWF SNRRARLRKH SGGSNSGLSP
260 270 280 290 300
MNSGSSNVGV GVGLSGATAP LGYGPLGVGS MAGYSPAPGT TATGAGMNDG
310 320 330 340 350
VHHAAHAPSS HHSAATAAAA AHHHTQMGGY DLVQSAAQHG FPGGFAQPGH
360 370 380 390 400
FGSQNYYHQD YSKLTIDDFS KLTADSVSKI SPSLHLSDNY SKLEAPSNWS
410 420 430 440
QAAYHAAANY NAHVAQHQLN DYAAAAAHGN PASAYSHPLP TQGQAKYWS
Length:449
Mass (Da):48,187
Last modified:January 27, 2003 - v2
Checksum:i885C618306E900F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 112RP → AA in AAA28835 (PubMed:2877747).Curated
Sequence conflicti199 – 1991R → G (PubMed:3123319).Curated
Sequence conflicti199 – 1991R → G in AAA28834 (PubMed:2877747).Curated
Sequence conflicti314 – 3141A → R (PubMed:3123319).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF47314.1.
AY071593 mRNA. Translation: AAL49215.1.
M14941 mRNA. Translation: AAA28834.1.
M14943 mRNA. Translation: AAA28835.1.
PIRiA26332.
B43698.
RefSeqiNP_523862.1. NM_079138.2.
UniGeneiDm.5850.

Genome annotation databases

EnsemblMetazoaiFBtr0072461; FBpp0072363; FBgn0001147.
GeneIDi38004.
KEGGidme:Dmel_CG2692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF47314.1.
AY071593 mRNA. Translation: AAL49215.1.
M14941 mRNA. Translation: AAA28834.1.
M14943 mRNA. Translation: AAA28835.1.
PIRiA26332.
B43698.
RefSeqiNP_523862.1. NM_079138.2.
UniGeneiDm.5850.

3D structure databases

ProteinModelPortaliP09083.
SMRiP09083. Positions 21-140, 181-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63572. 1 interaction.
DIPiDIP-23099N.
IntActiP09083. 2 interactions.
MINTiMINT-1723154.
STRINGi7227.FBpp0072363.

PTM databases

iPTMnetiP09083.

Proteomic databases

PaxDbiP09083.
PRIDEiP09083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072461; FBpp0072363; FBgn0001147.
GeneIDi38004.
KEGGidme:Dmel_CG2692.

Organism-specific databases

CTDi38004.
FlyBaseiFBgn0001147. gsb-n.

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000004133.
InParanoidiP09083.
KOiK09381.
OMAiHAVAQHQ.
OrthoDBiEOG7WT431.
PhylomeDBiP09083.

Enzyme and pathway databases

SignaLinkiP09083.

Miscellaneous databases

GenomeRNAii38004.
PROiP09083.

Gene expression databases

BgeeiP09083.
GenevisibleiP09083. DM.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis."
    Baumgartner S., Bopp D., Burri M., Noll M.
    Genes Dev. 1:1247-1267(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "A Drosophila full-length cDNA resource."
    Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
    Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila."
    Bopp D., Burri M., Baumgartner S., Frigerio G., Noll M.
    Cell 47:1033-1040(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-146 AND 162-241.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiGSBN_DROME
AccessioniPrimary (citable) accession number: P09083
Secondary accession number(s): Q9W0W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 27, 2003
Last modified: June 8, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.