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Protein

Homeotic protein bicoid

Gene

bcd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Segment polarity protein that provides positional cues for the development of head and thoracic segments. Regulates the expression of zygotic genes, possibly through its homeodomain, and inhibits the activity of other maternal gene products. May also bind RNA. Interacts with Bin1 to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi97 – 156HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding transcription factor activity Source: FlyBase
  • morphogen activity Source: FlyBase
  • mRNA 3'-UTR binding Source: FlyBase
  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • translation regulator activity Source: FlyBase
  • translation repressor activity Source: FlyBase

GO - Biological processi

  • anterior/posterior axis specification Source: FlyBase
  • anterior/posterior axis specification, embryo Source: FlyBase
  • anterior region determination Source: FlyBase
  • maternal determination of anterior/posterior axis, embryo Source: FlyBase
  • negative regulation of translation Source: FlyBase
  • oogenesis Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • regulation of transcription by RNA polymerase II Source: FlyBase
  • regulation of translation Source: FlyBase
  • segment polarity determination Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, RNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP09081

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein bicoid
Alternative name(s):
PRD-4
Gene namesi
Name:bcd
ORF Names:CG1034
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000166 bcd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490141 – 494Homeotic protein bicoidAdd BLAST494

Proteomic databases

PaxDbiP09081
PRIDEiP09081

Expressioni

Tissue specificityi

Maternal expression is an anterior cap concentrated in the cortical cytoplasm.

Developmental stagei

Expressed both maternally and zygotically.

Gene expression databases

BgeeiFBgn0000166
GenevisibleiP09081 DM

Interactioni

Subunit structurei

Interacts with Bin1; in vitro and yeast cells. Interacts with bin3.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • morphogen activity Source: FlyBase

Protein-protein interaction databases

BioGridi66028, 79 interactors
IntActiP09081, 31 interactors
MINTiP09081
STRINGi7227.FBpp0081168

Structurei

Secondary structure

1494
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi106 – 116Combined sources11
Helixi124 – 134Combined sources11
Helixi138 – 157Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZQ3NMR-P97-163[»]
ProteinModelPortaliP09081
SMRiP09081
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09081

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni433 – 440RNA-bindingBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 40His/Pro-rich (PRD motif)Add BLAST29
Compositional biasi260 – 294Gln/His-rich (OPA repeat)Add BLAST35

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiENOG410KBMY Eukaryota
ENOG4110N46 LUCA
InParanoidiP09081
KOiK18659
OMAiGNTQFAY
OrthoDBiEOG091G0CRZ
PhylomeDBiP09081

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform G (identifier: P09081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQPPPDQNF YHHPLPHTHT HPHPHSHPHP HSHPHPHHQH PQLQLPPQFR
60 70 80 90 100
NPFDLLFDER TGAINYNYIR PYLPNQMPKP DVFPSEELPD SLVMRRPRRT
110 120 130 140 150
RTTFTSSQIA ELEQHFLQGR YLTAPRLADL SAKLALGTAQ VKIWFKNRRR
160 170 180 190 200
RHKIQSDQHK DQSYEGMPLS PGMKQSDGDP PSLQTLSLGG GATPNALTPS
210 220 230 240 250
PTPSTPTAHM TEHYSESFNA YYNYNGGHNH AQANRHMHMQ YPSGGGPGPG
260 270 280 290 300
STNVNGGQFF QQQQVHNHQQ QLHHQGNHVP HQMQQQQQQA QQQQYHHFDF
310 320 330 340 350
QQKQASACRV LVKDEPEADY NFNSSYYMRS GMSGATASAS AVARGAASPG
360 370 380 390 400
SEVYEPLTPK NDESPSLCGI GIGGPCAIAV GETEAADDMD DGTSKKTTLQ
410 420 430 440 450
ILEPLKGLDK SCDDGSSDDM STGIRALAGT GNRGAAFAKF GKPSPPQGPQ
460 470 480 490
PPLGMGGVAM GESNQYQCTM DTIMQAYNPH RNAAGNSQFA YCFN
Length:494
Mass (Da):54,511
Last modified:May 10, 2004 - v3
Checksum:i561D8509D5C11FD3
GO
Isoform A (identifier: P09081-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-400: Missing.

Show »
Length:149
Mass (Da):16,363
Checksum:i9ECE6842A7DB862A
GO
Isoform D (identifier: P09081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-85: Missing.

Show »
Length:489
Mass (Da):53,966
Checksum:i81829ACF03419B86
GO
Isoform E (identifier: P09081-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:418
Mass (Da):45,438
Checksum:i04D4C70D6750DB39
GO
Isoform F (identifier: P09081-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.
     81-85: Missing.

Note: No experimental confirmation available.
Show »
Length:413
Mass (Da):44,893
Checksum:i204670A1A666802F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298F → S in CAB37631 (PubMed:2901954).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti284Q → H in strain: Z362. 1
Natural varianti317E → K in strain: Z229. 1
Natural varianti337A → S in strain: Z95, Z197 and Z229. 1
Natural varianti438A → P in strain: Z184, Z210 and Z216. 1
Natural varianti458V → L in strain: Z157. 1
Natural varianti460M → L in strain: Oregon-R, Z145, Z266, Z346 and Z398. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0272031 – 76Missing in isoform E and isoform F. CuratedAdd BLAST76
Alternative sequenceiVSP_00223556 – 400Missing in isoform A. 1 PublicationAdd BLAST345
Alternative sequenceiVSP_00223481 – 85Missing in isoform D and isoform F. 2 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07870 Genomic DNA Translation: CAA30720.1
X14458 mRNA Translation: CAA32627.1
X14459 mRNA Translation: CAB37631.1
X14460 mRNA Translation: CAA32629.1
AF466621 Genomic DNA Translation: AAL77008.1
AF466622 Genomic DNA Translation: AAL77009.1
AF466623 Genomic DNA Translation: AAL77010.1
AF466624 Genomic DNA Translation: AAL77011.1
AF466625 Genomic DNA Translation: AAL77012.1
AF466626 Genomic DNA Translation: AAL77013.1
AF466627 Genomic DNA Translation: AAL77014.1
AF466628 Genomic DNA Translation: AAL77015.1
AF466629 Genomic DNA Translation: AAL77016.1
AF466630 Genomic DNA Translation: AAL77017.1
AF466631 Genomic DNA Translation: AAL77018.1
AF466632 Genomic DNA Translation: AAL77019.1
AF466633 Genomic DNA Translation: AAL77020.1
AF466634 Genomic DNA Translation: AAL77021.1
AF466635 Genomic DNA Translation: AAL77022.1
AF466636 Genomic DNA Translation: AAL77023.1
AF466637 Genomic DNA Translation: AAL77024.1
AF466638 Genomic DNA Translation: AAL77025.1
AF466639 Genomic DNA Translation: AAL77026.1
AF466640 Genomic DNA Translation: AAL77027.1
AF466641 Genomic DNA Translation: AAL77028.1
AF466642 Genomic DNA Translation: AAL77029.1
AF466643 Genomic DNA Translation: AAL77030.1
AF466644 Genomic DNA Translation: AAL77031.1
AF466645 Genomic DNA Translation: AAL77032.1
AE001572 Genomic DNA Translation: AAD19798.1
AE014297 Genomic DNA Translation: AAF54085.2
AE014297 Genomic DNA Translation: AAN13368.1
AE014297 Genomic DNA Translation: AAN13369.1
AE014297 Genomic DNA Translation: AAN13371.2
AE014297 Genomic DNA Translation: AAO41514.1
AY058658 mRNA Translation: AAL13887.1
BT021332 mRNA Translation: AAX33480.1
M14549 Genomic DNA Translation: AAA28385.1
K03517 mRNA Translation: AAA28391.1
PIRiS00835 WJFFBC
RefSeqiNP_476825.1, NM_057477.5 [P09081-3]
NP_731111.1, NM_169157.3 [P09081-2]
NP_731113.2, NM_169159.4 [P09081-4]
NP_788587.1, NM_176410.3 [P09081-1]
NP_788588.1, NM_176411.3 [P09081-5]
UniGeneiDm.3237

Genome annotation databases

EnsemblMetazoaiFBtr0081664; FBpp0081164; FBgn0000166 [P09081-3]
FBtr0081665; FBpp0081165; FBgn0000166 [P09081-2]
FBtr0081666; FBpp0081166; FBgn0000166 [P09081-4]
FBtr0081667; FBpp0081167; FBgn0000166 [P09081-5]
FBtr0081668; FBpp0081168; FBgn0000166 [P09081-1]
GeneIDi40830
KEGGidme:Dmel_CG1034

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBCD_DROME
AccessioniPrimary (citable) accession number: P09081
Secondary accession number(s): Q5BI92
, Q86BA9, Q86BP2, Q8INR7, Q8ST46, Q8STB1, Q8T9S9, Q8T9T0, Q8T9T1, Q95TN3, Q9UAM0, Q9VI47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: May 10, 2004
Last modified: May 23, 2018
This is version 189 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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