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Protein

Homeobox protein Hox-B5

Gene

Hoxb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi194 – 25360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. embryonic skeletal system development Source: MGI
  3. embryonic skeletal system morphogenesis Source: MGI
  4. endothelial cell differentiation Source: MGI
  5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  6. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B5
Alternative name(s):
Homeobox protein H24.1
Homeobox protein Hox-2.1
Homeobox protein Mu-1
Gene namesi
Name:Hoxb5
Synonyms:Hox-2.1, Hoxb-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96186. Hoxb5.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Homeobox protein Hox-B5PRO_0000200129Add
BLAST

Proteomic databases

MaxQBiP09079.
PRIDEiP09079.

PTM databases

PhosphoSiteiP09079.

Expressioni

Tissue specificityi

Expressed in a broad spectrum of tissues.

Developmental stagei

Embryo.

Gene expression databases

BgeeiP09079.
CleanExiMM_HOXB5.
ExpressionAtlasiP09079. baseline and differential.
GenevestigatoriP09079.

Interactioni

Protein-protein interaction databases

BioGridi200379. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP09079.
SMRiP09079. Positions 201-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi176 – 1816Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG236516.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP09079.
KOiK09305.
OMAiCATASRE.
OrthoDBiEOG780RP4.
PhylomeDBiP09079.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN
60 70 80 90 100
GMDLSVNRSS ASSSHFGAVG ESSRAFPASA QEPRFRQATS SCSLSSPESL
110 120 130 140 150
PCTNGDSHGA KPSASSPSDQ ATPASSSANF TEIDEASASS EPEEAASQLS
160 170 180 190 200
SPSLARAQPE PMATSTAAPE GQTPQIFPWM RKLHISHDMT GPDGKRARTA
210 220 230 240 250
YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI WFQNRRMKWK
260
KDNKLKSMSL ATAGSAFQP
Length:269
Mass (Da):29,464
Last modified:September 4, 2006 - v3
Checksum:iB3508345236FB6A8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811Q → K in AAA37842 (PubMed:2889591).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26283 mRNA. Translation: AAA37842.1.
AK133512 mRNA. Translation: BAE21695.1.
BC103595 mRNA. Translation: AAI03596.1.
BC103596 mRNA. Translation: AAI03597.1.
BC103604 mRNA. Translation: AAI03605.1.
BC103607 mRNA. Translation: AAI03608.1.
L36070 Genomic DNA. Translation: AAA50294.1.
X03033 Genomic DNA. Translation: CAB57812.1.
CCDSiCCDS25296.1.
PIRiA43551.
B24777.
RefSeqiNP_032294.2. NM_008268.2.
UniGeneiMm.207.

Genome annotation databases

EnsembliENSMUST00000049272; ENSMUSP00000035423; ENSMUSG00000038700.
GeneIDi15413.
KEGGimmu:15413.
UCSCiuc007lbu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26283 mRNA. Translation: AAA37842.1.
AK133512 mRNA. Translation: BAE21695.1.
BC103595 mRNA. Translation: AAI03596.1.
BC103596 mRNA. Translation: AAI03597.1.
BC103604 mRNA. Translation: AAI03605.1.
BC103607 mRNA. Translation: AAI03608.1.
L36070 Genomic DNA. Translation: AAA50294.1.
X03033 Genomic DNA. Translation: CAB57812.1.
CCDSiCCDS25296.1.
PIRiA43551.
B24777.
RefSeqiNP_032294.2. NM_008268.2.
UniGeneiMm.207.

3D structure databases

ProteinModelPortaliP09079.
SMRiP09079. Positions 201-256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200379. 1 interaction.

PTM databases

PhosphoSiteiP09079.

Proteomic databases

MaxQBiP09079.
PRIDEiP09079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049272; ENSMUSP00000035423; ENSMUSG00000038700.
GeneIDi15413.
KEGGimmu:15413.
UCSCiuc007lbu.2. mouse.

Organism-specific databases

CTDi3215.
MGIiMGI:96186. Hoxb5.

Phylogenomic databases

eggNOGiNOG236516.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP09079.
KOiK09305.
OMAiCATASRE.
OrthoDBiEOG780RP4.
PhylomeDBiP09079.
TreeFamiTF316310.

Miscellaneous databases

NextBioi288138.
PROiP09079.
SOURCEiSearch...

Gene expression databases

BgeeiP09079.
CleanExiMM_HOXB5.
ExpressionAtlasiP09079. baseline and differential.
GenevestigatoriP09079.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1."
    Krumlauf R., Holland P.W.H., McVey J.H., Hogan B.L.M.
    Development 99:603-617(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Studies on the Hox-B5 gene."
    Arnold J.M.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.
  5. "A mouse homoeo box gene is expressed during embryogenesis and in adult kidney."
    Jackson I.J., Schofield P., Hogan B.L.M.
    Nature 317:745-748(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-259.
  6. "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos."
    Hauser C.A., Joyner A.L., Klein R.D., Learned T.K., Martin G.R., Tjian R.
    Cell 43:19-28(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 194-269.

Entry informationi

Entry nameiHXB5_MOUSE
AccessioniPrimary (citable) accession number: P09079
Secondary accession number(s): Q3ZAY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1988
Last sequence update: September 4, 2006
Last modified: January 6, 2015
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.