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P09079 (HXB5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B5
Alternative name(s):
Homeobox protein H24.1
Homeobox protein Hox-2.1
Homeobox protein Mu-1
Gene names
Name:Hoxb5
Synonyms:Hox-2.1, Hoxb-5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Tissue specificity

Expressed in a broad spectrum of tissues.

Developmental stage

Embryo.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from mutant phenotype PubMed 7828847. Source: MGI

embryonic skeletal system development

Inferred from genetic interaction PubMed 17626057. Source: MGI

embryonic skeletal system morphogenesis

Inferred from mutant phenotype PubMed 7828847. Source: MGI

endothelial cell differentiation

Inferred from direct assay PubMed 12897140. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12897140. Source: NTNU_SB

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12897140. Source: MGI

   Cellular_componentnucleus

Inferred from direct assay PubMed 10579975PubMed 1353982. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 12897140. Source: MGI

RNA polymerase II distal enhancer sequence-specific DNA binding

Inferred from direct assay PubMed 12897140. Source: NTNU_SB

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from direct assay PubMed 12897140. Source: NTNU_SB

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 12897140. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Homeobox protein Hox-B5
PRO_0000200129

Regions

DNA binding194 – 25360Homeobox
Motif176 – 1816Antp-type hexapeptide

Experimental info

Sequence conflict811Q → K in AAA37842. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P09079 [UniParc].

Last modified September 5, 2006. Version 3.
Checksum: B3508345236FB6A8

FASTA26929,464
        10         20         30         40         50         60 
MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN GMDLSVNRSS 

        70         80         90        100        110        120 
ASSSHFGAVG ESSRAFPASA QEPRFRQATS SCSLSSPESL PCTNGDSHGA KPSASSPSDQ 

       130        140        150        160        170        180 
ATPASSSANF TEIDEASASS EPEEAASQLS SPSLARAQPE PMATSTAAPE GQTPQIFPWM 

       190        200        210        220        230        240 
RKLHISHDMT GPDGKRARTA YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI 

       250        260 
WFQNRRMKWK KDNKLKSMSL ATAGSAFQP 

« Hide

References

« Hide 'large scale' references
[1]"Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1."
Krumlauf R., Holland P.W.H., McVey J.H., Hogan B.L.M.
Development 99:603-617(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Studies on the Hox-B5 gene."
Arnold J.M.
Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.
[5]"A mouse homoeo box gene is expressed during embryogenesis and in adult kidney."
Jackson I.J., Schofield P., Hogan B.L.M.
Nature 317:745-748(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-259.
[6]"Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos."
Hauser C.A., Joyner A.L., Klein R.D., Learned T.K., Martin G.R., Tjian R.
Cell 43:19-28(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 194-269.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M26283 mRNA. Translation: AAA37842.1.
AK133512 mRNA. Translation: BAE21695.1.
BC103595 mRNA. Translation: AAI03596.1.
BC103596 mRNA. Translation: AAI03597.1.
BC103604 mRNA. Translation: AAI03605.1.
BC103607 mRNA. Translation: AAI03608.1.
L36070 Genomic DNA. Translation: AAA50294.1.
X03033 Genomic DNA. Translation: CAB57812.1.
CCDSCCDS25296.1.
PIRA43551.
B24777.
RefSeqNP_032294.2. NM_008268.2.
UniGeneMm.207.

3D structure databases

ProteinModelPortalP09079.
SMRP09079. Positions 201-256.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200379. 1 interaction.

PTM databases

PhosphoSiteP09079.

Proteomic databases

PRIDEP09079.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049272; ENSMUSP00000035423; ENSMUSG00000038700.
GeneID15413.
KEGGmmu:15413.
UCSCuc007lbu.2. mouse.

Organism-specific databases

CTD3215.
MGIMGI:96186. Hoxb5.

Phylogenomic databases

eggNOGNOG236516.
GeneTreeENSGT00750000117269.
HOGENOMHOG000231178.
HOVERGENHBG016849.
InParanoidP09079.
KOK09305.
OMACATASRE.
OrthoDBEOG780RP4.
PhylomeDBP09079.
TreeFamTF316310.

Gene expression databases

ArrayExpressP09079.
BgeeP09079.
CleanExMM_HOXB5.
GenevestigatorP09079.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288138.
PROP09079.
SOURCESearch...

Entry information

Entry nameHXB5_MOUSE
AccessionPrimary (citable) accession number: P09079
Secondary accession number(s): Q3ZAY8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries