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P09079

- HXB5_MOUSE

UniProt

P09079 - HXB5_MOUSE

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Protein

Homeobox protein Hox-B5

Gene

Hoxb5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi194 – 25360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. embryonic skeletal system development Source: MGI
  3. embryonic skeletal system morphogenesis Source: MGI
  4. endothelial cell differentiation Source: MGI
  5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  6. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B5
Alternative name(s):
Homeobox protein H24.1
Homeobox protein Hox-2.1
Homeobox protein Mu-1
Gene namesi
Name:Hoxb5
Synonyms:Hox-2.1, Hoxb-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96186. Hoxb5.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Homeobox protein Hox-B5PRO_0000200129Add
BLAST

Proteomic databases

MaxQBiP09079.
PRIDEiP09079.

PTM databases

PhosphoSiteiP09079.

Expressioni

Tissue specificityi

Expressed in a broad spectrum of tissues.

Developmental stagei

Embryo.

Gene expression databases

BgeeiP09079.
CleanExiMM_HOXB5.
ExpressionAtlasiP09079. baseline and differential.
GenevestigatoriP09079.

Interactioni

Protein-protein interaction databases

BioGridi200379. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP09079.
SMRiP09079. Positions 201-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi176 – 1816Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG236516.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP09079.
KOiK09305.
OMAiCATASRE.
OrthoDBiEOG780RP4.
PhylomeDBiP09079.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09079-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN
60 70 80 90 100
GMDLSVNRSS ASSSHFGAVG ESSRAFPASA QEPRFRQATS SCSLSSPESL
110 120 130 140 150
PCTNGDSHGA KPSASSPSDQ ATPASSSANF TEIDEASASS EPEEAASQLS
160 170 180 190 200
SPSLARAQPE PMATSTAAPE GQTPQIFPWM RKLHISHDMT GPDGKRARTA
210 220 230 240 250
YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI WFQNRRMKWK
260
KDNKLKSMSL ATAGSAFQP
Length:269
Mass (Da):29,464
Last modified:September 5, 2006 - v3
Checksum:iB3508345236FB6A8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811Q → K in AAA37842. (PubMed:2889591)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26283 mRNA. Translation: AAA37842.1.
AK133512 mRNA. Translation: BAE21695.1.
BC103595 mRNA. Translation: AAI03596.1.
BC103596 mRNA. Translation: AAI03597.1.
BC103604 mRNA. Translation: AAI03605.1.
BC103607 mRNA. Translation: AAI03608.1.
L36070 Genomic DNA. Translation: AAA50294.1.
X03033 Genomic DNA. Translation: CAB57812.1.
CCDSiCCDS25296.1.
PIRiA43551.
B24777.
RefSeqiNP_032294.2. NM_008268.2.
UniGeneiMm.207.

Genome annotation databases

EnsembliENSMUST00000049272; ENSMUSP00000035423; ENSMUSG00000038700.
GeneIDi15413.
KEGGimmu:15413.
UCSCiuc007lbu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26283 mRNA. Translation: AAA37842.1 .
AK133512 mRNA. Translation: BAE21695.1 .
BC103595 mRNA. Translation: AAI03596.1 .
BC103596 mRNA. Translation: AAI03597.1 .
BC103604 mRNA. Translation: AAI03605.1 .
BC103607 mRNA. Translation: AAI03608.1 .
L36070 Genomic DNA. Translation: AAA50294.1 .
X03033 Genomic DNA. Translation: CAB57812.1 .
CCDSi CCDS25296.1.
PIRi A43551.
B24777.
RefSeqi NP_032294.2. NM_008268.2.
UniGenei Mm.207.

3D structure databases

ProteinModelPortali P09079.
SMRi P09079. Positions 201-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200379. 1 interaction.

PTM databases

PhosphoSitei P09079.

Proteomic databases

MaxQBi P09079.
PRIDEi P09079.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049272 ; ENSMUSP00000035423 ; ENSMUSG00000038700 .
GeneIDi 15413.
KEGGi mmu:15413.
UCSCi uc007lbu.2. mouse.

Organism-specific databases

CTDi 3215.
MGIi MGI:96186. Hoxb5.

Phylogenomic databases

eggNOGi NOG236516.
GeneTreei ENSGT00760000118945.
HOGENOMi HOG000231178.
HOVERGENi HBG016849.
InParanoidi P09079.
KOi K09305.
OMAi CATASRE.
OrthoDBi EOG780RP4.
PhylomeDBi P09079.
TreeFami TF316310.

Miscellaneous databases

NextBioi 288138.
PROi P09079.
SOURCEi Search...

Gene expression databases

Bgeei P09079.
CleanExi MM_HOXB5.
ExpressionAtlasi P09079. baseline and differential.
Genevestigatori P09079.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1."
    Krumlauf R., Holland P.W.H., McVey J.H., Hogan B.L.M.
    Development 99:603-617(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Studies on the Hox-B5 gene."
    Arnold J.M.
    Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.
  5. "A mouse homoeo box gene is expressed during embryogenesis and in adult kidney."
    Jackson I.J., Schofield P., Hogan B.L.M.
    Nature 317:745-748(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-259.
  6. "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos."
    Hauser C.A., Joyner A.L., Klein R.D., Learned T.K., Martin G.R., Tjian R.
    Cell 43:19-28(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 194-269.

Entry informationi

Entry nameiHXB5_MOUSE
AccessioniPrimary (citable) accession number: P09079
Secondary accession number(s): Q3ZAY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3