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P09079

- HXB5_MOUSE

UniProt

P09079 - HXB5_MOUSE

Protein

Homeobox protein Hox-B5

Gene

Hoxb5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 3 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi194 – 25360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    4. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. embryonic skeletal system development Source: MGI
    3. embryonic skeletal system morphogenesis Source: MGI
    4. endothelial cell differentiation Source: MGI
    5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    6. regulation of transcription, DNA-templated Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B5
    Alternative name(s):
    Homeobox protein H24.1
    Homeobox protein Hox-2.1
    Homeobox protein Mu-1
    Gene namesi
    Name:Hoxb5
    Synonyms:Hox-2.1, Hoxb-5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96186. Hoxb5.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Homeobox protein Hox-B5PRO_0000200129Add
    BLAST

    Proteomic databases

    PRIDEiP09079.

    PTM databases

    PhosphoSiteiP09079.

    Expressioni

    Tissue specificityi

    Expressed in a broad spectrum of tissues.

    Developmental stagei

    Embryo.

    Gene expression databases

    ArrayExpressiP09079.
    BgeeiP09079.
    CleanExiMM_HOXB5.
    GenevestigatoriP09079.

    Interactioni

    Protein-protein interaction databases

    BioGridi200379. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP09079.
    SMRiP09079. Positions 201-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi176 – 1816Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG236516.
    GeneTreeiENSGT00750000117269.
    HOGENOMiHOG000231178.
    HOVERGENiHBG016849.
    InParanoidiP09079.
    KOiK09305.
    OMAiCATASRE.
    OrthoDBiEOG780RP4.
    PhylomeDBiP09079.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09079-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN    50
    GMDLSVNRSS ASSSHFGAVG ESSRAFPASA QEPRFRQATS SCSLSSPESL 100
    PCTNGDSHGA KPSASSPSDQ ATPASSSANF TEIDEASASS EPEEAASQLS 150
    SPSLARAQPE PMATSTAAPE GQTPQIFPWM RKLHISHDMT GPDGKRARTA 200
    YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI WFQNRRMKWK 250
    KDNKLKSMSL ATAGSAFQP 269
    Length:269
    Mass (Da):29,464
    Last modified:September 5, 2006 - v3
    Checksum:iB3508345236FB6A8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811Q → K in AAA37842. (PubMed:2889591)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26283 mRNA. Translation: AAA37842.1.
    AK133512 mRNA. Translation: BAE21695.1.
    BC103595 mRNA. Translation: AAI03596.1.
    BC103596 mRNA. Translation: AAI03597.1.
    BC103604 mRNA. Translation: AAI03605.1.
    BC103607 mRNA. Translation: AAI03608.1.
    L36070 Genomic DNA. Translation: AAA50294.1.
    X03033 Genomic DNA. Translation: CAB57812.1.
    CCDSiCCDS25296.1.
    PIRiA43551.
    B24777.
    RefSeqiNP_032294.2. NM_008268.2.
    UniGeneiMm.207.

    Genome annotation databases

    EnsembliENSMUST00000049272; ENSMUSP00000035423; ENSMUSG00000038700.
    GeneIDi15413.
    KEGGimmu:15413.
    UCSCiuc007lbu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26283 mRNA. Translation: AAA37842.1 .
    AK133512 mRNA. Translation: BAE21695.1 .
    BC103595 mRNA. Translation: AAI03596.1 .
    BC103596 mRNA. Translation: AAI03597.1 .
    BC103604 mRNA. Translation: AAI03605.1 .
    BC103607 mRNA. Translation: AAI03608.1 .
    L36070 Genomic DNA. Translation: AAA50294.1 .
    X03033 Genomic DNA. Translation: CAB57812.1 .
    CCDSi CCDS25296.1.
    PIRi A43551.
    B24777.
    RefSeqi NP_032294.2. NM_008268.2.
    UniGenei Mm.207.

    3D structure databases

    ProteinModelPortali P09079.
    SMRi P09079. Positions 201-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200379. 1 interaction.

    PTM databases

    PhosphoSitei P09079.

    Proteomic databases

    PRIDEi P09079.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049272 ; ENSMUSP00000035423 ; ENSMUSG00000038700 .
    GeneIDi 15413.
    KEGGi mmu:15413.
    UCSCi uc007lbu.2. mouse.

    Organism-specific databases

    CTDi 3215.
    MGIi MGI:96186. Hoxb5.

    Phylogenomic databases

    eggNOGi NOG236516.
    GeneTreei ENSGT00750000117269.
    HOGENOMi HOG000231178.
    HOVERGENi HBG016849.
    InParanoidi P09079.
    KOi K09305.
    OMAi CATASRE.
    OrthoDBi EOG780RP4.
    PhylomeDBi P09079.
    TreeFami TF316310.

    Miscellaneous databases

    NextBioi 288138.
    PROi P09079.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09079.
    Bgeei P09079.
    CleanExi MM_HOXB5.
    Genevestigatori P09079.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1."
      Krumlauf R., Holland P.W.H., McVey J.H., Hogan B.L.M.
      Development 99:603-617(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Studies on the Hox-B5 gene."
      Arnold J.M.
      Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.
    5. "A mouse homoeo box gene is expressed during embryogenesis and in adult kidney."
      Jackson I.J., Schofield P., Hogan B.L.M.
      Nature 317:745-748(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-259.
    6. "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos."
      Hauser C.A., Joyner A.L., Klein R.D., Learned T.K., Martin G.R., Tjian R.
      Cell 43:19-28(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 194-269.

    Entry informationi

    Entry nameiHXB5_MOUSE
    AccessioniPrimary (citable) accession number: P09079
    Secondary accession number(s): Q3ZAY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3