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P09077

- SCR_DROME

UniProt

P09077 - SCR_DROME

Protein

Homeotic protein Sex combs reduced

Gene

Scr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 5 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required for proper development of the sex comb and to suppress improper prothoracic wing development.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi324 – 38360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein homodimerization activity Source: FlyBase
    2. RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase
    3. sequence-specific DNA binding Source: FlyBase
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. midgut development Source: FlyBase
    2. positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
    3. salivary gland boundary specification Source: FlyBase
    4. segment specification Source: FlyBase
    5. sex comb development Source: FlyBase
    6. sex differentiation Source: FlyBase
    7. specification of segmental identity, labial segment Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeotic protein Sex combs reduced
    Gene namesi
    Name:Scr
    ORF Names:CG1030
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0003339. Scr.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Homeotic protein Sex combs reducedPRO_0000200264Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei216 – 2161Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Tissue specificityi

    In embryo, expressed in the labial and anterior prothoracic segments and the extreme posterior of the maxillary segment. In adult, expressed in the maxillary analgen of the eye and antennal imaginal disk and the labial and T1 leg imaginal disks.1 Publication

    Gene expression databases

    BgeeiP09077.

    Interactioni

    Protein-protein interaction databases

    BioGridi66031. 11 interactions.
    DIPiDIP-40017N.
    IntActiP09077. 1 interaction.
    STRINGi7227.FBpp0081163.

    Structurei

    Secondary structure

    1
    417
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi306 – 3083
    Helixi333 – 34311
    Helixi351 – 36010
    Helixi365 – 38016

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2R5YX-ray2.60A298-384[»]
    2R5ZX-ray2.60A298-384[»]
    ProteinModelPortaliP09077.
    SMRiP09077. Positions 330-384.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP09077.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi303 – 3086Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi33 – 7139Gly-richAdd
    BLAST
    Compositional biasi114 – 16249Gln-richAdd
    BLAST
    Compositional biasi188 – 20013Asn-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG236516.
    GeneTreeiENSGT00750000117269.
    InParanoidiP09077.
    KOiK09311.
    OMAiISCKYAN.
    OrthoDBiEOG780RP4.
    PhylomeDBiP09077.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09077-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPDCFAMSS YQFVNSLASC YPQQMNPQQN HPGAGNSSAG GSGGGAGGSG    50
    GVVPSGGTNG GQGSAGAATP GANDYFPAAA AYTPNLYPNT PQAHYANQAA 100
    YGGQGNPDMV DYTQLQPQRL LLQQQQQQQQ QQHAHAAAAV AAQQQQQLAQ 150
    QQHPQQQQQQ QQANISCKYA NDPVTPGGSG GGGVSGSNNN NNSANSNNNN 200
    SQSLASPQDL STRDISPKLS PSSVVESVAR SLNKGVLGGS LAAAAAAAGL 250
    NNNHSGSGVS GGPGNVNVPM HSPGGGDSDS ESDSGNEAGS SQNSGNGKKN 300
    PPQIYPWMKR VHLGTSTVNA NGETKRQRTS YTRYQTLELE KEFHFNRYLT 350
    RRRRIEIAHA LCLTERQIKI WFQNRRMKWK KEHKMASMNI VPYHMGPYGH 400
    PYHQFDIHPS QFAHLSA 417
    Length:417
    Mass (Da):44,263
    Last modified:June 21, 2005 - v5
    Checksum:i8A3A58A60E0B32BE
    GO

    Sequence cautioni

    The sequence AAA19240.1 differs from that shown. Reason: Frameshift at positions 35 and 79.
    The sequence CAA32637.1 differs from that shown. Reason: Frameshift at positions 93 and 141.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti118 – 1181Q → L in AAA19240. 1 PublicationCurated
    Sequence conflicti133 – 1353HAH → LAL in AAA19240. 1 PublicationCurated
    Sequence conflicti141 – 1411A → R in AAA19240. 1 PublicationCurated
    Sequence conflicti258 – 2581G → R in CAA54348. (PubMed:7835693)Curated
    Sequence conflicti317 – 3237TVNANGE → YCESNGQ in CAA28857. (PubMed:16453653)Curated
    Sequence conflicti374 – 3741N → D in AAA19240. 1 PublicationCurated
    Sequence conflicti379 – 3791W → L in CAA28857. (PubMed:16453653)Curated
    Sequence conflicti393 – 3931Y → C in AAA19240. 1 PublicationCurated
    Sequence conflicti402 – 4021Y → C in AAA19240. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14475 Genomic DNA. Translation: CAA32637.1. Frameshift.
    X77075, X77076 Genomic DNA. Translation: CAA54348.1.
    AE001572 Genomic DNA. Translation: AAD19795.1.
    AE014297 Genomic DNA. Translation: AAF54082.1.
    U10506 mRNA. Translation: AAA19240.1. Frameshift.
    X05228 Genomic DNA. Translation: CAA28857.1.
    PIRiS03631.
    RefSeqiNP_524248.2. NM_079524.4.
    NP_996165.1. NM_206443.2.
    UniGeneiDm.2481.

    Genome annotation databases

    EnsemblMetazoaiFBtr0081657; FBpp0081163; FBgn0003339.
    FBtr0081658; FBpp0089393; FBgn0003339.
    GeneIDi40833.
    KEGGidme:Dmel_CG1030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14475 Genomic DNA. Translation: CAA32637.1 . Frameshift.
    X77075 , X77076 Genomic DNA. Translation: CAA54348.1 .
    AE001572 Genomic DNA. Translation: AAD19795.1 .
    AE014297 Genomic DNA. Translation: AAF54082.1 .
    U10506 mRNA. Translation: AAA19240.1 . Frameshift.
    X05228 Genomic DNA. Translation: CAA28857.1 .
    PIRi S03631.
    RefSeqi NP_524248.2. NM_079524.4.
    NP_996165.1. NM_206443.2.
    UniGenei Dm.2481.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2R5Y X-ray 2.60 A 298-384 [» ]
    2R5Z X-ray 2.60 A 298-384 [» ]
    ProteinModelPortali P09077.
    SMRi P09077. Positions 330-384.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 66031. 11 interactions.
    DIPi DIP-40017N.
    IntActi P09077. 1 interaction.
    STRINGi 7227.FBpp0081163.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0081657 ; FBpp0081163 ; FBgn0003339 .
    FBtr0081658 ; FBpp0089393 ; FBgn0003339 .
    GeneIDi 40833.
    KEGGi dme:Dmel_CG1030.

    Organism-specific databases

    CTDi 109559.
    FlyBasei FBgn0003339. Scr.

    Phylogenomic databases

    eggNOGi NOG236516.
    GeneTreei ENSGT00750000117269.
    InParanoidi P09077.
    KOi K09311.
    OMAi ISCKYAN.
    OrthoDBi EOG780RP4.
    PhylomeDBi P09077.

    Miscellaneous databases

    ChiTaRSi scrib. drosophila.
    EvolutionaryTracei P09077.
    GenomeRNAii 40833.
    NextBioi 820837.

    Gene expression databases

    Bgeei P09077.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The homeotic gene Sex Combs Reduced of Drosophila: gene structure and embryonic expression."
      Lemotte P.K., Kuroiwa A., Fessler L.I., Gehring W.J.
      EMBO J. 8:219-227(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Baumgartner P.
      Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "The sex combs reduced gene of Drosophila melanogaster has multiple transcripts."
      Andrew D.J.
      Gene 152:149-155(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequence of the Antennapedia complex of Drosophila."
      Celniker S.E., Pfeiffer B.D., Knafels J., Martin C.H., Mayeda C.A., Palazzolo M.J.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Berkeley.
    5. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    6. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    7. "Sequence of cDNA of homeodomain protein from sex combs reduced (Scr) gene."
      Kaufman T.C.
      Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    8. "Cloning of the homeotic Sex Combs Reduced gene in Drosophila and in situ localization of its transcripts."
      Kuroiwa A., Kloter U., Baumgartner P., Gehring W.J.
      EMBO J. 4:3757-3764(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 317-390.
    9. "A functional and structural analysis of the Sex combs reduced locus of Drosophila melanogaster."
      Pattatucci A.M., Otteson D.C., Kaufman T.C.
      Genetics 129:423-441(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Hox genes and the evolution of the arthropod body plan."
      Hughes C.L., Kaufman T.C.
      Evol. Dev. 4:459-499(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION, TISSUE SPECIFICITY.
    11. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiSCR_DROME
    AccessioniPrimary (citable) accession number: P09077
    Secondary accession number(s): Q23990, Q24508, Q9V3Q3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 146 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3