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Protein

Homeotic protein Sex combs reduced

Gene

Scr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required for proper development of the sex comb and to suppress improper prothoracic wing development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi324 – 383HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding transcription factor activity Source: InterPro
  • protein homodimerization activity Source: FlyBase
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • midgut development Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • salivary gland boundary specification Source: FlyBase
  • sex comb development Source: FlyBase
  • sex differentiation Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein Sex combs reduced
Gene namesi
Name:Scr
ORF Names:CG1030
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003339 Scr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002641 – 417Homeotic protein Sex combs reducedAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP09077
PRIDEiP09077

PTM databases

iPTMnetiP09077

Expressioni

Tissue specificityi

In embryo, expressed in the labial and anterior prothoracic segments and the extreme posterior of the maxillary segment. In adult, expressed in the maxillary analgen of the eye and antennal imaginal disk and the labial and T1 leg imaginal disks.1 Publication

Gene expression databases

BgeeiFBgn0003339
ExpressionAtlasiP09077 baseline and differential
GenevisibleiP09077 DM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
exdP404273EBI-666569,EBI-101537

GO - Molecular functioni

  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi66031, 43 interactors
DIPiDIP-40017N
IntActiP09077, 1 interactor
STRINGi7227.FBpp0089393

Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi306 – 308Combined sources3
Helixi333 – 343Combined sources11
Helixi351 – 360Combined sources10
Helixi365 – 380Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R5YX-ray2.60A298-384[»]
2R5ZX-ray2.60A298-384[»]
ProteinModelPortaliP09077
SMRiP09077
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09077

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi303 – 308Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 71Gly-richAdd BLAST39
Compositional biasi114 – 162Gln-richAdd BLAST49
Compositional biasi188 – 200Asn-richAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
InParanoidiP09077
KOiK09311
OMAiGANDYFP
OrthoDBiEOG091G09XD
PhylomeDBiP09077

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPDCFAMSS YQFVNSLASC YPQQMNPQQN HPGAGNSSAG GSGGGAGGSG
60 70 80 90 100
GVVPSGGTNG GQGSAGAATP GANDYFPAAA AYTPNLYPNT PQAHYANQAA
110 120 130 140 150
YGGQGNPDMV DYTQLQPQRL LLQQQQQQQQ QQHAHAAAAV AAQQQQQLAQ
160 170 180 190 200
QQHPQQQQQQ QQANISCKYA NDPVTPGGSG GGGVSGSNNN NNSANSNNNN
210 220 230 240 250
SQSLASPQDL STRDISPKLS PSSVVESVAR SLNKGVLGGS LAAAAAAAGL
260 270 280 290 300
NNNHSGSGVS GGPGNVNVPM HSPGGGDSDS ESDSGNEAGS SQNSGNGKKN
310 320 330 340 350
PPQIYPWMKR VHLGTSTVNA NGETKRQRTS YTRYQTLELE KEFHFNRYLT
360 370 380 390 400
RRRRIEIAHA LCLTERQIKI WFQNRRMKWK KEHKMASMNI VPYHMGPYGH
410
PYHQFDIHPS QFAHLSA
Length:417
Mass (Da):44,263
Last modified:June 21, 2005 - v5
Checksum:i8A3A58A60E0B32BE
GO

Sequence cautioni

The sequence AAA19240 differs from that shown. Reason: Frameshift at positions 35 and 79.Curated
The sequence CAA32637 differs from that shown. Reason: Frameshift at positions 93 and 141.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118Q → L in AAA19240 (Ref. 7) Curated1
Sequence conflicti133 – 135HAH → LAL in AAA19240 (Ref. 7) Curated3
Sequence conflicti141A → R in AAA19240 (Ref. 7) Curated1
Sequence conflicti258G → R in CAA54348 (PubMed:7835693).Curated1
Sequence conflicti317 – 323TVNANGE → YCESNGQ in CAA28857 (PubMed:16453653).Curated7
Sequence conflicti374N → D in AAA19240 (Ref. 7) Curated1
Sequence conflicti379W → L in CAA28857 (PubMed:16453653).Curated1
Sequence conflicti393Y → C in AAA19240 (Ref. 7) Curated1
Sequence conflicti402Y → C in AAA19240 (Ref. 7) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14475 Genomic DNA Translation: CAA32637.1 Frameshift.
X77075, X77076 Genomic DNA Translation: CAA54348.1
AE001572 Genomic DNA Translation: AAD19795.1
AE014297 Genomic DNA Translation: AAF54082.1
U10506 mRNA Translation: AAA19240.1 Frameshift.
X05228 Genomic DNA Translation: CAA28857.1
PIRiS03631
RefSeqiNP_524248.2, NM_079524.4
NP_996165.1, NM_206443.2
UniGeneiDm.2481

Genome annotation databases

EnsemblMetazoaiFBtr0081657; FBpp0081163; FBgn0003339
FBtr0081658; FBpp0089393; FBgn0003339
GeneIDi40833
KEGGidme:Dmel_CG1030

Similar proteinsi

Entry informationi

Entry nameiSCR_DROME
AccessioniPrimary (citable) accession number: P09077
Secondary accession number(s): Q23990, Q24508, Q9V3Q3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 21, 2005
Last modified: May 23, 2018
This is version 177 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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