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P09077 (SCR_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 145. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeotic protein Sex combs reduced
Gene names
Name:Scr
ORF Names:CG1030
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required for proper development of the sex comb and to suppress improper prothoracic wing development. Ref.9

Subcellular location

Nucleus.

Tissue specificity

In embryo, expressed in the labial and anterior prothoracic segments and the extreme posterior of the maxillary segment. In adult, expressed in the maxillary analgen of the eye and antennal imaginal disk and the labial and T1 leg imaginal disks. Ref.10

Sequence similarities

Belongs to the Antp homeobox family. Deformed subfamily.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence AAA19240.1 differs from that shown. Reason: Frameshift at positions 35 and 79.

The sequence CAA32637.1 differs from that shown. Reason: Frameshift at positions 93 and 141.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Homeotic protein Sex combs reduced
PRO_0000200264

Regions

DNA binding324 – 38360Homeobox
Motif303 – 3086Antp-type hexapeptide
Compositional bias33 – 7139Gly-rich
Compositional bias114 – 16249Gln-rich
Compositional bias188 – 20013Asn-rich

Amino acid modifications

Modified residue2161Phosphoserine Ref.11

Experimental info

Sequence conflict1181Q → L in AAA19240. Ref.7
Sequence conflict133 – 1353HAH → LAL in AAA19240. Ref.7
Sequence conflict1411A → R in AAA19240. Ref.7
Sequence conflict2581G → R in CAA54348. Ref.3
Sequence conflict317 – 3237TVNANGE → YCESNGQ in CAA28857. Ref.8
Sequence conflict3741N → D in AAA19240. Ref.7
Sequence conflict3791W → L in CAA28857. Ref.8
Sequence conflict3931Y → C in AAA19240. Ref.7
Sequence conflict4021Y → C in AAA19240. Ref.7

Secondary structure

......... 417
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P09077 [UniParc].

Last modified June 21, 2005. Version 5.
Checksum: 8A3A58A60E0B32BE

FASTA41744,263
        10         20         30         40         50         60 
MDPDCFAMSS YQFVNSLASC YPQQMNPQQN HPGAGNSSAG GSGGGAGGSG GVVPSGGTNG 

        70         80         90        100        110        120 
GQGSAGAATP GANDYFPAAA AYTPNLYPNT PQAHYANQAA YGGQGNPDMV DYTQLQPQRL 

       130        140        150        160        170        180 
LLQQQQQQQQ QQHAHAAAAV AAQQQQQLAQ QQHPQQQQQQ QQANISCKYA NDPVTPGGSG 

       190        200        210        220        230        240 
GGGVSGSNNN NNSANSNNNN SQSLASPQDL STRDISPKLS PSSVVESVAR SLNKGVLGGS 

       250        260        270        280        290        300 
LAAAAAAAGL NNNHSGSGVS GGPGNVNVPM HSPGGGDSDS ESDSGNEAGS SQNSGNGKKN 

       310        320        330        340        350        360 
PPQIYPWMKR VHLGTSTVNA NGETKRQRTS YTRYQTLELE KEFHFNRYLT RRRRIEIAHA 

       370        380        390        400        410 
LCLTERQIKI WFQNRRMKWK KEHKMASMNI VPYHMGPYGH PYHQFDIHPS QFAHLSA 

« Hide

References

« Hide 'large scale' references
[1]"The homeotic gene Sex Combs Reduced of Drosophila: gene structure and embryonic expression."
Lemotte P.K., Kuroiwa A., Fessler L.I., Gehring W.J.
EMBO J. 8:219-227(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Baumgartner P.
Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"The sex combs reduced gene of Drosophila melanogaster has multiple transcripts."
Andrew D.J.
Gene 152:149-155(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Complete sequence of the Antennapedia complex of Drosophila."
Celniker S.E., Pfeiffer B.D., Knafels J., Martin C.H., Mayeda C.A., Palazzolo M.J.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Berkeley.
[5]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[6]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[7]"Sequence of cDNA of homeodomain protein from sex combs reduced (Scr) gene."
Kaufman T.C.
Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[8]"Cloning of the homeotic Sex Combs Reduced gene in Drosophila and in situ localization of its transcripts."
Kuroiwa A., Kloter U., Baumgartner P., Gehring W.J.
EMBO J. 4:3757-3764(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 317-390.
[9]"A functional and structural analysis of the Sex combs reduced locus of Drosophila melanogaster."
Pattatucci A.M., Otteson D.C., Kaufman T.C.
Genetics 129:423-441(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"Hox genes and the evolution of the arthropod body plan."
Hughes C.L., Kaufman T.C.
Evol. Dev. 4:459-499(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW ON FUNCTION, TISSUE SPECIFICITY.
[11]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14475 Genomic DNA. Translation: CAA32637.1. Frameshift.
X77075, X77076 Genomic DNA. Translation: CAA54348.1.
AE001572 Genomic DNA. Translation: AAD19795.1.
AE014297 Genomic DNA. Translation: AAF54082.1.
U10506 mRNA. Translation: AAA19240.1. Frameshift.
X05228 Genomic DNA. Translation: CAA28857.1.
PIRS03631.
RefSeqNP_524248.2. NM_079524.4.
NP_996165.1. NM_206443.2.
UniGeneDm.2481.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2R5YX-ray2.60A298-384[»]
2R5ZX-ray2.60A298-384[»]
ProteinModelPortalP09077.
SMRP09077. Positions 330-384.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid66031. 11 interactions.
DIPDIP-40017N.
IntActP09077. 1 interaction.
STRING7227.FBpp0081163.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0081657; FBpp0081163; FBgn0003339.
FBtr0081658; FBpp0089393; FBgn0003339.
GeneID40833.
KEGGdme:Dmel_CG1030.

Organism-specific databases

CTD109559.
FlyBaseFBgn0003339. Scr.

Phylogenomic databases

eggNOGNOG236516.
GeneTreeENSGT00750000117269.
InParanoidP09077.
KOK09311.
OMAISCKYAN.
OrthoDBEOG780RP4.
PhylomeDBP09077.

Gene expression databases

BgeeP09077.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSscrib. drosophila.
EvolutionaryTraceP09077.
GenomeRNAi40833.
NextBio820837.

Entry information

Entry nameSCR_DROME
AccessionPrimary (citable) accession number: P09077
Secondary accession number(s): Q23990, Q24508, Q9V3Q3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 21, 2005
Last modified: July 9, 2014
This is version 145 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase