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P09077

- SCR_DROME

UniProt

P09077 - SCR_DROME

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Protein

Homeotic protein Sex combs reduced

Gene

Scr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required for proper development of the sex comb and to suppress improper prothoracic wing development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi324 – 38360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. protein homodimerization activity Source: FlyBase
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase
  3. sequence-specific DNA binding Source: FlyBase
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. midgut development Source: FlyBase
  2. positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  3. salivary gland boundary specification Source: FlyBase
  4. segment specification Source: FlyBase
  5. sex comb development Source: FlyBase
  6. sex differentiation Source: FlyBase
  7. specification of segmental identity, labial segment Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein Sex combs reduced
Gene namesi
Name:Scr
ORF Names:CG1030
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003339. Scr.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Homeotic protein Sex combs reducedPRO_0000200264Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

In embryo, expressed in the labial and anterior prothoracic segments and the extreme posterior of the maxillary segment. In adult, expressed in the maxillary analgen of the eye and antennal imaginal disk and the labial and T1 leg imaginal disks.1 Publication

Gene expression databases

BgeeiP09077.
ExpressionAtlasiP09077. differential.

Interactioni

Protein-protein interaction databases

BioGridi66031. 11 interactions.
DIPiDIP-40017N.
IntActiP09077. 1 interaction.
STRINGi7227.FBpp0081163.

Structurei

Secondary structure

1
417
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi306 – 3083Combined sources
Helixi333 – 34311Combined sources
Helixi351 – 36010Combined sources
Helixi365 – 38016Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R5YX-ray2.60A298-384[»]
2R5ZX-ray2.60A298-384[»]
ProteinModelPortaliP09077.
SMRiP09077. Positions 330-384.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09077.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi303 – 3086Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 7139Gly-richAdd
BLAST
Compositional biasi114 – 16249Gln-richAdd
BLAST
Compositional biasi188 – 20013Asn-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG236516.
GeneTreeiENSGT00760000118945.
InParanoidiP09077.
KOiK09311.
OMAiISCKYAN.
OrthoDBiEOG780RP4.
PhylomeDBiP09077.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09077-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPDCFAMSS YQFVNSLASC YPQQMNPQQN HPGAGNSSAG GSGGGAGGSG
60 70 80 90 100
GVVPSGGTNG GQGSAGAATP GANDYFPAAA AYTPNLYPNT PQAHYANQAA
110 120 130 140 150
YGGQGNPDMV DYTQLQPQRL LLQQQQQQQQ QQHAHAAAAV AAQQQQQLAQ
160 170 180 190 200
QQHPQQQQQQ QQANISCKYA NDPVTPGGSG GGGVSGSNNN NNSANSNNNN
210 220 230 240 250
SQSLASPQDL STRDISPKLS PSSVVESVAR SLNKGVLGGS LAAAAAAAGL
260 270 280 290 300
NNNHSGSGVS GGPGNVNVPM HSPGGGDSDS ESDSGNEAGS SQNSGNGKKN
310 320 330 340 350
PPQIYPWMKR VHLGTSTVNA NGETKRQRTS YTRYQTLELE KEFHFNRYLT
360 370 380 390 400
RRRRIEIAHA LCLTERQIKI WFQNRRMKWK KEHKMASMNI VPYHMGPYGH
410
PYHQFDIHPS QFAHLSA
Length:417
Mass (Da):44,263
Last modified:June 21, 2005 - v5
Checksum:i8A3A58A60E0B32BE
GO

Sequence cautioni

The sequence AAA19240.1 differs from that shown. Reason: Frameshift at positions 35 and 79. Curated
The sequence CAA32637.1 differs from that shown. Reason: Frameshift at positions 93 and 141. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181Q → L in AAA19240. 1 PublicationCurated
Sequence conflicti133 – 1353HAH → LAL in AAA19240. 1 PublicationCurated
Sequence conflicti141 – 1411A → R in AAA19240. 1 PublicationCurated
Sequence conflicti258 – 2581G → R in CAA54348. (PubMed:7835693)Curated
Sequence conflicti317 – 3237TVNANGE → YCESNGQ in CAA28857. (PubMed:16453653)Curated
Sequence conflicti374 – 3741N → D in AAA19240. 1 PublicationCurated
Sequence conflicti379 – 3791W → L in CAA28857. (PubMed:16453653)Curated
Sequence conflicti393 – 3931Y → C in AAA19240. 1 PublicationCurated
Sequence conflicti402 – 4021Y → C in AAA19240. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14475 Genomic DNA. Translation: CAA32637.1. Frameshift.
X77075, X77076 Genomic DNA. Translation: CAA54348.1.
AE001572 Genomic DNA. Translation: AAD19795.1.
AE014297 Genomic DNA. Translation: AAF54082.1.
U10506 mRNA. Translation: AAA19240.1. Frameshift.
X05228 Genomic DNA. Translation: CAA28857.1.
PIRiS03631.
RefSeqiNP_524248.2. NM_079524.4.
NP_996165.1. NM_206443.2.
UniGeneiDm.2481.

Genome annotation databases

EnsemblMetazoaiFBtr0081657; FBpp0081163; FBgn0003339.
FBtr0081658; FBpp0089393; FBgn0003339.
GeneIDi40833.
KEGGidme:Dmel_CG1030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14475 Genomic DNA. Translation: CAA32637.1 . Frameshift.
X77075 , X77076 Genomic DNA. Translation: CAA54348.1 .
AE001572 Genomic DNA. Translation: AAD19795.1 .
AE014297 Genomic DNA. Translation: AAF54082.1 .
U10506 mRNA. Translation: AAA19240.1 . Frameshift.
X05228 Genomic DNA. Translation: CAA28857.1 .
PIRi S03631.
RefSeqi NP_524248.2. NM_079524.4.
NP_996165.1. NM_206443.2.
UniGenei Dm.2481.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2R5Y X-ray 2.60 A 298-384 [» ]
2R5Z X-ray 2.60 A 298-384 [» ]
ProteinModelPortali P09077.
SMRi P09077. Positions 330-384.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 66031. 11 interactions.
DIPi DIP-40017N.
IntActi P09077. 1 interaction.
STRINGi 7227.FBpp0081163.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0081657 ; FBpp0081163 ; FBgn0003339 .
FBtr0081658 ; FBpp0089393 ; FBgn0003339 .
GeneIDi 40833.
KEGGi dme:Dmel_CG1030.

Organism-specific databases

CTDi 109559.
FlyBasei FBgn0003339. Scr.

Phylogenomic databases

eggNOGi NOG236516.
GeneTreei ENSGT00760000118945.
InParanoidi P09077.
KOi K09311.
OMAi ISCKYAN.
OrthoDBi EOG780RP4.
PhylomeDBi P09077.

Miscellaneous databases

ChiTaRSi scrib. fly.
EvolutionaryTracei P09077.
GenomeRNAii 40833.
NextBioi 820837.

Gene expression databases

Bgeei P09077.
ExpressionAtlasi P09077. differential.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The homeotic gene Sex Combs Reduced of Drosophila: gene structure and embryonic expression."
    Lemotte P.K., Kuroiwa A., Fessler L.I., Gehring W.J.
    EMBO J. 8:219-227(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Baumgartner P.
    Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The sex combs reduced gene of Drosophila melanogaster has multiple transcripts."
    Andrew D.J.
    Gene 152:149-155(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequence of the Antennapedia complex of Drosophila."
    Celniker S.E., Pfeiffer B.D., Knafels J., Martin C.H., Mayeda C.A., Palazzolo M.J.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Berkeley.
  5. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  6. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  7. "Sequence of cDNA of homeodomain protein from sex combs reduced (Scr) gene."
    Kaufman T.C.
    Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  8. "Cloning of the homeotic Sex Combs Reduced gene in Drosophila and in situ localization of its transcripts."
    Kuroiwa A., Kloter U., Baumgartner P., Gehring W.J.
    EMBO J. 4:3757-3764(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 317-390.
  9. "A functional and structural analysis of the Sex combs reduced locus of Drosophila melanogaster."
    Pattatucci A.M., Otteson D.C., Kaufman T.C.
    Genetics 129:423-441(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Hox genes and the evolution of the arthropod body plan."
    Hughes C.L., Kaufman T.C.
    Evol. Dev. 4:459-499(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION, TISSUE SPECIFICITY.
  11. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiSCR_DROME
AccessioniPrimary (citable) accession number: P09077
Secondary accession number(s): Q23990, Q24508, Q9V3Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 21, 2005
Last modified: November 26, 2014
This is version 148 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3