P09071 (HXA7_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A7

Alternative name(s):
Xhox-36
XlHbox-3

Gene names

Name:

hoxa7

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Ref.1
Subcellular location	Nucleus.
Developmental stage	Expressed exclusively in the posterior mesoderm and ectoderm of early Xenopus embryos.
Induction	By derriere. Ref.3
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence CAA30124.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Homeobox protein Hox-A7		PRO_0000200079
Regions
	DNA binding	122 – 181	60	Homeobox
	Motif	111 – 116	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	P09071 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: 4EAC0A052F05D70D	FASTA	209	23,985
	10 20 30 40 50 60 MTSSYYVSAL FSKFTAGASL FPNPEPTSCS SLPNNSQRGA YGSGTGPFPS SVPSLYSSPL 70 80 90 100 110 120 YQNPFPGYSL ASDSYNLHCS SFDQNIPLLC NELPKADEAA LHHQPDSHFR IYPWMRSSGP 130 140 150 160 170 180 DRKRGRQTYT RYQTLELEKE FHFNRYLTRR RRIEIAHALC LTERQIKIWF QNRRMKWKKE 190 200 HKEESDQTPD AGEESTAPTT TADDDKDKE

References

[1]	"Posterior expression of a homeobox gene in early Xenopus embryos." Condie B.G., Harland R.M. Development 101:93-105(1987) [PubMed: 2452727] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"Xenopus homeobox-containing cDNAs expressed in early development." Fritz A., De Robertis E.M. Nucleic Acids Res. 16:1453-1469(1988) [PubMed: 2894634] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 119-209.
[3]	"derriere: a TGF-beta family member required for posterior development in Xenopus." Sun B.I., Bush S.M., Collins-Racie L.A., LaVallie E.R., DiBlasio-Smith E.A., Wolfman N.M., McCoy J.M., Sive H.L. Development 126:1467-1482(1999) [PubMed: 10068640] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M24752 mRNA. Translation: AAA49753.1. X07103 mRNA. Translation: CAA30124.1. Different initiation.
PIR	A43553.
RefSeq	NP_001082538.1. NM_001089069.1.
UniGene	Xl.12130.
3D structure databases
ProteinModelPortal	P09071.
SMR	P09071. Positions 122-186.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	398549.
KEGG	xla:398549.
Organism-specific databases
CTD	3204.
Xenbase	XB-GENE-865003. hoxa7.
Phylogenomic databases
HOVERGEN	HBG016849.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09307.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA7_XENLA

Accession

Primary (citable) accession number: P09071

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	December 14, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program