ID   HXB4_XENLA              Reviewed;         232 AA.
AC   P09070; Q3KQ14;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   27-MAR-2024, entry version 130.
DE   RecName: Full=Homeobox protein Hox-B4;
DE   AltName: Full=Xhox-1A;
GN   Name=hoxb4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3015593; DOI=10.1002/j.1460-2075.1986.tb04352.x;
RA   Harvey R.P., Tabin C.J., Melton D.A.;
RT   "Embryonic expression and nuclear localization of Xenopus homeobox (Xhox)
RT   gene products.";
RL   EMBO J. 5:1237-1244(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed early in development.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
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DR   EMBL; M26884; AAA49756.1; -; Genomic_DNA.
DR   EMBL; BC106429; AAI06430.1; -; mRNA.
DR   PIR; A25108; A25108.
DR   RefSeq; NP_001089733.1; NM_001096264.1.
DR   AlphaFoldDB; P09070; -.
DR   SMR; P09070; -.
DR   DNASU; 734796; -.
DR   GeneID; 734796; -.
DR   KEGG; xla:734796; -.
DR   AGR; Xenbase:XB-GENE-6078784; -.
DR   CTD; 734796; -.
DR   Xenbase; XB-GENE-6078784; hoxb4.S.
DR   OMA; PAFQHES; -.
DR   OrthoDB; 728401at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 734796; Expressed in neurula embryo and 10 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45771:SF3; HOMEOBOX PROTEIN HOX-B4; 1.
DR   PANTHER; PTHR45771; HOMEOTIC PROTEIN DEFORMED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..232
FT                   /note="Homeobox protein Hox-B4"
FT                   /id="PRO_0000200127"
FT   DNA_BIND        141..200
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          28..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           120..125
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        29..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   232 AA;  26468 MW;  E385E7C8D38FAAF9 CRC64;
     MRMSSFLISS NYVDPKFPPC EEYSHSDYSP GYYGSQKRES SFQHGAPYPR SVSSNSSSSA
     SYSSCQGSVR QSARLPHSSG LVPGEKAHLE PHMPTSSPPS CSLKSSEHKH PDSPEQDPVV
     YPWMKKAHIS KATSTYSDGE AKRSRTAYTR QQVLELEKEF HYNRYLTRRR RVEIAHTLRL
     SERQIKIWFQ NRRMKWKKDH KLPNTKIKSN PSVNLQIAGG SPNQNKGNHV CQ
//