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P09070

- HXB4_XENLA

UniProt

P09070 - HXB4_XENLA

Protein

Homeobox protein Hox-B4

Gene

hoxb4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1988)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi141 – 20060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B4
    Alternative name(s):
    Xhox-1A
    Gene namesi
    Name:hoxb4
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6078784. hoxb4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232Homeobox protein Hox-B4PRO_0000200127Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed early in development.

    Structurei

    3D structure databases

    ProteinModelPortaliP09070.
    SMRiP09070. Positions 118-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi120 – 1256Antp-type hexapeptide

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    HOVERGENiHBG016849.
    KOiK09304.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09070-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRMSSFLISS NYVDPKFPPC EEYSHSDYSP GYYGSQKRES SFQHGAPYPR    50
    SVSSNSSSSA SYSSCQGSVR QSARLPHSSG LVPGEKAHLE PHMPTSSPPS 100
    CSLKSSEHKH PDSPEQDPVV YPWMKKAHIS KATSTYSDGE AKRSRTAYTR 150
    QQVLELEKEF HYNRYLTRRR RVEIAHTLRL SERQIKIWFQ NRRMKWKKDH 200
    KLPNTKIKSN PSVNLQIAGG SPNQNKGNHV CQ 232
    Length:232
    Mass (Da):26,468
    Last modified:November 1, 1988 - v1
    Checksum:iE385E7C8D38FAAF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26884 Genomic DNA. Translation: AAA49756.1.
    BC106429 mRNA. Translation: AAI06430.1.
    PIRiA25108.
    RefSeqiNP_001089733.1. NM_001096264.1.
    UniGeneiXl.86704.

    Genome annotation databases

    GeneIDi734796.
    KEGGixla:734796.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26884 Genomic DNA. Translation: AAA49756.1 .
    BC106429 mRNA. Translation: AAI06430.1 .
    PIRi A25108.
    RefSeqi NP_001089733.1. NM_001096264.1.
    UniGenei Xl.86704.

    3D structure databases

    ProteinModelPortali P09070.
    SMRi P09070. Positions 118-201.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 734796.
    KEGGi xla:734796.

    Organism-specific databases

    CTDi 3214.
    Xenbasei XB-GENE-6078784. hoxb4.

    Phylogenomic databases

    HOVERGENi HBG016849.
    KOi K09304.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products."
      Harvey R.P., Tabin C.J., Melton D.A.
      EMBO J. 5:1237-1244(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiHXB4_XENLA
    AccessioniPrimary (citable) accession number: P09070
    Secondary accession number(s): Q3KQ14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: November 1, 1988
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3