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P09070 (HXB4_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B4
Alternative name(s):
Xhox-1A
Gene names
Name:hoxb4
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Developmental stage

Expressed early in development.

Sequence similarities

Belongs to the Antp homeobox family. Deformed subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Homeobox protein Hox-B4
PRO_0000200127

Regions

DNA binding141 – 20060Homeobox
Motif120 – 1256Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
P09070 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: E385E7C8D38FAAF9

FASTA23226,468
        10         20         30         40         50         60 
MRMSSFLISS NYVDPKFPPC EEYSHSDYSP GYYGSQKRES SFQHGAPYPR SVSSNSSSSA 

        70         80         90        100        110        120 
SYSSCQGSVR QSARLPHSSG LVPGEKAHLE PHMPTSSPPS CSLKSSEHKH PDSPEQDPVV 

       130        140        150        160        170        180 
YPWMKKAHIS KATSTYSDGE AKRSRTAYTR QQVLELEKEF HYNRYLTRRR RVEIAHTLRL 

       190        200        210        220        230 
SERQIKIWFQ NRRMKWKKDH KLPNTKIKSN PSVNLQIAGG SPNQNKGNHV CQ 

« Hide

References

« Hide 'large scale' references
[1]"Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products."
Harvey R.P., Tabin C.J., Melton D.A.
EMBO J. 5:1237-1244(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M26884 Genomic DNA. Translation: AAA49756.1.
BC106429 mRNA. Translation: AAI06430.1.
PIRA25108.
RefSeqNP_001089733.1. NM_001096264.1.
UniGeneXl.86704.

3D structure databases

ProteinModelPortalP09070.
SMRP09070. Positions 118-201.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID734796.
KEGGxla:734796.

Organism-specific databases

CTD3214.
XenbaseXB-GENE-6078784. hoxb4.

Phylogenomic databases

HOVERGENHBG016849.
KOK09304.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXB4_XENLA
AccessionPrimary (citable) accession number: P09070
Secondary accession number(s): Q3KQ14
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: February 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries