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Protein

Homeobox protein Hox-B4

Gene

hoxb4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi141 – 200HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B4
Alternative name(s):
Xhox-1A
Gene namesi
Name:hoxb4
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6078784. hoxb4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001271 – 232Homeobox protein Hox-B4Add BLAST232

Expressioni

Developmental stagei

Expressed early in development.

Structurei

3D structure databases

ProteinModelPortaliP09070.
SMRiP09070.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi120 – 125Antp-type hexapeptide6

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG016849.
KOiK09304.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P09070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMSSFLISS NYVDPKFPPC EEYSHSDYSP GYYGSQKRES SFQHGAPYPR
60 70 80 90 100
SVSSNSSSSA SYSSCQGSVR QSARLPHSSG LVPGEKAHLE PHMPTSSPPS
110 120 130 140 150
CSLKSSEHKH PDSPEQDPVV YPWMKKAHIS KATSTYSDGE AKRSRTAYTR
160 170 180 190 200
QQVLELEKEF HYNRYLTRRR RVEIAHTLRL SERQIKIWFQ NRRMKWKKDH
210 220 230
KLPNTKIKSN PSVNLQIAGG SPNQNKGNHV CQ
Length:232
Mass (Da):26,468
Last modified:November 1, 1988 - v1
Checksum:iE385E7C8D38FAAF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26884 Genomic DNA. Translation: AAA49756.1.
BC106429 mRNA. Translation: AAI06430.1.
PIRiA25108.
RefSeqiNP_001089733.1. NM_001096264.1.
UniGeneiXl.86704.

Genome annotation databases

GeneIDi734796.
KEGGixla:734796.

Similar proteinsi

Entry informationi

Entry nameiHXB4_XENLA
AccessioniPrimary (citable) accession number: P09070
Secondary accession number(s): Q3KQ14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: September 27, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families