UniProtKB - P09070 (HXB4_XENLA)
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Protein
Homeobox protein Hox-B4
Gene
hoxb4
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 141 – 200 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-B4Alternative name(s): Xhox-1A |
Gene namesi | Name:hoxb4 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-6078784. hoxb4. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200127 | 1 – 232 | Homeobox protein Hox-B4Add BLAST | 232 |
Expressioni
Developmental stagei
Expressed early in development.
Structurei
3D structure databases
ProteinModelPortali | P09070. |
SMRi | P09070. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 120 – 125 | Antp-type hexapeptide | 6 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
HOVERGENi | HBG016849. |
KOi | K09304. |
Family and domain databases
CDDi | cd00086. homeodomain. 1 hit. |
InterProi | View protein in InterPro IPR009057. Homeobox-like_sf. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR020479. Homeobox_metazoa. |
Pfami | View protein in Pfam PF00046. Homeobox. 1 hit. |
PRINTSi | PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX. |
SMARTi | View protein in SMART SM00389. HOX. 1 hit. |
SUPFAMi | SSF46689. SSF46689. 1 hit. |
PROSITEi | View protein in PROSITE PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
P09070-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRMSSFLISS NYVDPKFPPC EEYSHSDYSP GYYGSQKRES SFQHGAPYPR
60 70 80 90 100
SVSSNSSSSA SYSSCQGSVR QSARLPHSSG LVPGEKAHLE PHMPTSSPPS
110 120 130 140 150
CSLKSSEHKH PDSPEQDPVV YPWMKKAHIS KATSTYSDGE AKRSRTAYTR
160 170 180 190 200
QQVLELEKEF HYNRYLTRRR RVEIAHTLRL SERQIKIWFQ NRRMKWKKDH
210 220 230
KLPNTKIKSN PSVNLQIAGG SPNQNKGNHV CQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26884 Genomic DNA. Translation: AAA49756.1. BC106429 mRNA. Translation: AAI06430.1. |
PIRi | A25108. |
RefSeqi | NP_001089733.1. NM_001096264.1. |
UniGenei | Xl.86704. |
Genome annotation databases
GeneIDi | 734796. |
KEGGi | xla:734796. |
Similar proteinsi
Entry informationi
Entry namei | HXB4_XENLA | |
Accessioni | P09070Primary (citable) accession number: P09070 Secondary accession number(s): Q3KQ14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | January 31, 2018 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |