P09070 (HXB4_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-B4

Alternative name(s):
Xhox-1A

Gene names

Name:

hoxb4

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Developmental stage	Expressed early in development.
Sequence similarities	Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	Homeobox protein Hox-B4		PRO_0000200127
Regions
	DNA binding	141 – 200	60	Homeobox
	Motif	120 – 125	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	P09070 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: E385E7C8D38FAAF9	FASTA	232	26,468
	10 20 30 40 50 60 MRMSSFLISS NYVDPKFPPC EEYSHSDYSP GYYGSQKRES SFQHGAPYPR SVSSNSSSSA 70 80 90 100 110 120 SYSSCQGSVR QSARLPHSSG LVPGEKAHLE PHMPTSSPPS CSLKSSEHKH PDSPEQDPVV 130 140 150 160 170 180 YPWMKKAHIS KATSTYSDGE AKRSRTAYTR QQVLELEKEF HYNRYLTRRR RVEIAHTLRL 190 200 210 220 230 SERQIKIWFQ NRRMKWKKDH KLPNTKIKSN PSVNLQIAGG SPNQNKGNHV CQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products." Harvey R.P., Tabin C.J., Melton D.A. EMBO J. 5:1237-1244(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M26884 Genomic DNA. Translation: AAA49756.1. BC106429 mRNA. Translation: AAI06430.1.
PIR	A25108.
RefSeq	NP_001089733.1. NM_001096264.1.
UniGene	Xl.86704.
3D structure databases
ProteinModelPortal	P09070.
SMR	P09070. Positions 118-201.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	734796.
KEGG	xla:734796.
Organism-specific databases
CTD	3214.
Xenbase	XB-GENE-6078784. hoxb4.
Phylogenomic databases
HOVERGEN	HBG016849.
KO	K09304.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXB4_XENLA

Accession

Primary (citable) accession number: P09070
Secondary accession number(s): Q3KQ14

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program