ID   HXB5_HUMAN              Reviewed;         269 AA.
AC   P09067; B2RC69; P09069; Q17RP4;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 3.
DT   24-JAN-2024, entry version 211.
DE   RecName: Full=Homeobox protein Hox-B5;
DE   AltName: Full=Homeobox protein HHO.C10;
DE   AltName: Full=Homeobox protein Hox-2A;
DE   AltName: Full=Homeobox protein Hu-1;
GN   Name=HOXB5; Synonyms=HOX2A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1355360;
RA   Galang C.K., Hauser C.A.;
RT   "Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain
RT   gene product.";
RL   New Biol. 4:558-568(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R.,
RA   Pakstis A.J.;
RT   "Overall linkage disequilibrium in 33 populations for highly informative
RT   multisite haplotypes spanning the HOXB gene cluster.";
RL   Am. J. Hum. Genet. 67:235-235(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-269.
RX   PubMed=4075393; DOI=10.1016/0092-8674(85)90008-x;
RA   Hauser C.A., Joyner A.L., Klein R.D., Learned T.K., Martin G.R., Tjian R.;
RT   "Expression of homologous homeo-box-containing genes in differentiated
RT   human teratocarcinoma cells and mouse embryos.";
RL   Cell 43:19-28(1985).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-269.
RX   PubMed=6091895; DOI=10.1016/0092-8674(84)90261-7;
RA   Levine M., Rubin G.M., Tjian R.;
RT   "Human DNA sequences homologous to a protein coding region conserved
RT   between homeotic genes of Drosophila.";
RL   Cell 38:667-673(1984).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 200-269.
RX   PubMed=3453105; DOI=10.1038/320763a0;
RA   Simeone A., Mavilio F., Bottero L., Giampaolo A., Russo G., Faiella A.,
RA   Boncinelli E., Peschle C.;
RT   "A human homoeo box gene specifically expressed in spinal cord during
RT   embryonic development.";
RL   Nature 320:763-765(1986).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-269.
RX   PubMed=2576652; DOI=10.1139/g89-133;
RA   Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA   Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT   "Organization of human class I homeobox genes.";
RL   Genome 31:745-756(1989).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 217-269.
RC   TISSUE=Osteosarcoma;
RA   Waye M.M.Y.;
RT   "Cloning of a homeobox-containing cDNA (HHO.c10 or Hu-1) from a gt11 cDNA
RT   library of human osteosarcoma cell MG-63.";
RL   Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- INTERACTION:
CC       P09067; Q9NWX5: ASB6; NbExp=3; IntAct=EBI-3893317, EBI-6425205;
CC       P09067; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-3893317, EBI-4400025;
CC       P09067; A2RRN7: CADPS; NbExp=3; IntAct=EBI-3893317, EBI-10179719;
CC       P09067; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-3893317, EBI-739580;
CC       P09067; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-3893317, EBI-11530605;
CC       P09067; A6NC98: CCDC88B; NbExp=3; IntAct=EBI-3893317, EBI-347573;
CC       P09067; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-3893317, EBI-739624;
CC       P09067; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-3893317, EBI-12819063;
CC       P09067; P67870: CSNK2B; NbExp=3; IntAct=EBI-3893317, EBI-348169;
CC       P09067; Q13363-2: CTBP1; NbExp=3; IntAct=EBI-3893317, EBI-10171858;
CC       P09067; P56545-3: CTBP2; NbExp=8; IntAct=EBI-3893317, EBI-10171902;
CC       P09067; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-3893317, EBI-3867333;
CC       P09067; Q08379: GOLGA2; NbExp=3; IntAct=EBI-3893317, EBI-618309;
CC       P09067; Q9NYA3: GOLGA6A; NbExp=3; IntAct=EBI-3893317, EBI-11163335;
CC       P09067; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-3893317, EBI-5916454;
CC       P09067; P54257: HAP1; NbExp=3; IntAct=EBI-3893317, EBI-712814;
CC       P09067; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-3893317, EBI-748420;
CC       P09067; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-3893317, EBI-10961706;
CC       P09067; O75031: HSF2BP; NbExp=3; IntAct=EBI-3893317, EBI-7116203;
CC       P09067; Q92845: KIFAP3; NbExp=3; IntAct=EBI-3893317, EBI-954040;
CC       P09067; Q15323: KRT31; NbExp=3; IntAct=EBI-3893317, EBI-948001;
CC       P09067; O76011: KRT34; NbExp=3; IntAct=EBI-3893317, EBI-1047093;
CC       P09067; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-3893317, EBI-11959885;
CC       P09067; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-3893317, EBI-12012928;
CC       P09067; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-3893317, EBI-10171774;
CC       P09067; O95751: LDOC1; NbExp=3; IntAct=EBI-3893317, EBI-740738;
CC       P09067; P43364: MAGEA11; NbExp=3; IntAct=EBI-3893317, EBI-739552;
CC       P09067; P43364-2: MAGEA11; NbExp=3; IntAct=EBI-3893317, EBI-10178634;
CC       P09067; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-3893317, EBI-16439278;
CC       P09067; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-3893317, EBI-10172526;
CC       P09067; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-3893317, EBI-11522433;
CC       P09067; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-3893317, EBI-10271199;
CC       P09067; O43482: OIP5; NbExp=3; IntAct=EBI-3893317, EBI-536879;
CC       P09067; P40424: PBX1; NbExp=3; IntAct=EBI-3893317, EBI-301611;
CC       P09067; P40425: PBX2; NbExp=3; IntAct=EBI-3893317, EBI-348489;
CC       P09067; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-3893317, EBI-10302990;
CC       P09067; Q5VU43-2: PDE4DIP; NbExp=3; IntAct=EBI-3893317, EBI-9640281;
CC       P09067; Q5T6S3: PHF19; NbExp=3; IntAct=EBI-3893317, EBI-2339674;
CC       P09067; Q9Y4D7: PLXND1; NbExp=3; IntAct=EBI-3893317, EBI-310731;
CC       P09067; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-3893317, EBI-3957793;
CC       P09067; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-3893317, EBI-750487;
CC       P09067; Q8IYF3-3: TEX11; NbExp=3; IntAct=EBI-3893317, EBI-11523345;
CC       P09067; Q08117-2: TLE5; NbExp=5; IntAct=EBI-3893317, EBI-11741437;
CC       P09067; Q13077: TRAF1; NbExp=3; IntAct=EBI-3893317, EBI-359224;
CC       P09067; Q12933: TRAF2; NbExp=3; IntAct=EBI-3893317, EBI-355744;
CC       P09067; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-3893317, EBI-3650647;
CC       P09067; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-3893317, EBI-492476;
CC       P09067; P36406: TRIM23; NbExp=6; IntAct=EBI-3893317, EBI-740098;
CC       P09067; P14373: TRIM27; NbExp=3; IntAct=EBI-3893317, EBI-719493;
CC       P09067; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-3893317, EBI-2130429;
CC       P09067; Q495M9: USH1G; NbExp=3; IntAct=EBI-3893317, EBI-8601749;
CC       P09067; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-3893317, EBI-2799833;
CC       P09067; Q9NQZ6: ZC4H2; NbExp=3; IntAct=EBI-3893317, EBI-747993;
CC       P09067; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-3893317, EBI-12030590;
CC       P09067; Q9HBT8: ZNF286A; NbExp=3; IntAct=EBI-3893317, EBI-10754950;
CC       P09067; Q9H707: ZNF552; NbExp=3; IntAct=EBI-3893317, EBI-2555731;
CC       P09067; Q8N720: ZNF655; NbExp=3; IntAct=EBI-3893317, EBI-625509;
CC       P09067; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-3893317, EBI-10251462;
CC       P09067; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-3893317, EBI-527853;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Spinal cord.
CC   -!- DEVELOPMENTAL STAGE: Embryo.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA52681.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M92299; AAA52682.1; -; mRNA.
DR   EMBL; AF287967; AAG31553.1; -; Genomic_DNA.
DR   EMBL; AK314964; BAG37466.1; -; mRNA.
DR   EMBL; BC117247; AAI17248.1; -; mRNA.
DR   EMBL; X03794; CAA27420.1; -; mRNA.
DR   EMBL; K02572; AAA52681.1; ALT_INIT; Genomic_DNA.
DR   EMBL; M86726; AAB59430.1; -; mRNA.
DR   CCDS; CCDS11530.1; -.
DR   PIR; A24777; A24777.
DR   PIR; A45578; A45578.
DR   RefSeq; NP_002138.1; NM_002147.3.
DR   AlphaFoldDB; P09067; -.
DR   SMR; P09067; -.
DR   BioGRID; 109455; 110.
DR   ELM; P09067; -.
DR   IntAct; P09067; 91.
DR   STRING; 9606.ENSP00000239151; -.
DR   iPTMnet; P09067; -.
DR   PhosphoSitePlus; P09067; -.
DR   BioMuta; HOXB5; -.
DR   DMDM; 400000; -.
DR   jPOST; P09067; -.
DR   MassIVE; P09067; -.
DR   MaxQB; P09067; -.
DR   PaxDb; 9606-ENSP00000239151; -.
DR   PeptideAtlas; P09067; -.
DR   ProteomicsDB; 52191; -.
DR   ABCD; P09067; 2 sequenced antibodies.
DR   Antibodypedia; 17850; 288 antibodies from 30 providers.
DR   DNASU; 3215; -.
DR   Ensembl; ENST00000239151.6; ENSP00000239151.4; ENSG00000120075.6.
DR   GeneID; 3215; -.
DR   KEGG; hsa:3215; -.
DR   MANE-Select; ENST00000239151.6; ENSP00000239151.4; NM_002147.4; NP_002138.1.
DR   UCSC; uc002inr.4; human.
DR   AGR; HGNC:5116; -.
DR   CTD; 3215; -.
DR   DisGeNET; 3215; -.
DR   GeneCards; HOXB5; -.
DR   HGNC; HGNC:5116; HOXB5.
DR   HPA; ENSG00000120075; Tissue enhanced (epididymis, intestine, kidney).
DR   MIM; 142960; gene.
DR   neXtProt; NX_P09067; -.
DR   OpenTargets; ENSG00000120075; -.
DR   PharmGKB; PA29392; -.
DR   VEuPathDB; HostDB:ENSG00000120075; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000158354; -.
DR   HOGENOM; CLU_061398_2_1_1; -.
DR   InParanoid; P09067; -.
DR   OMA; TNGESHG; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P09067; -.
DR   TreeFam; TF316310; -.
DR   PathwayCommons; P09067; -.
DR   SignaLink; P09067; -.
DR   BioGRID-ORCS; 3215; 19 hits in 1183 CRISPR screens.
DR   ChiTaRS; HOXB5; human.
DR   GeneWiki; HOXB5; -.
DR   GenomeRNAi; 3215; -.
DR   Pharos; P09067; Tbio.
DR   PRO; PR:P09067; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P09067; Protein.
DR   Bgee; ENSG00000120075; Expressed in mucosa of transverse colon and 119 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0001650; C:fibrillar center; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR   GO; GO:0045446; P:endothelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   PANTHER; PTHR45659:SF2; HOMEOBOX PROTEIN HOX-B5; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P09067; HS.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..269
FT                   /note="Homeobox protein Hox-B5"
FT                   /id="PRO_0000200128"
FT   DNA_BIND        194..253
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          77..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           176..181
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        86..172
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   269 AA;  29434 MW;  58197F105DB0F8C4 CRC64;
     MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN GMDLSVNRSS
     ASSSHFGAVG ESSRAFPAPA QEPRFRQAAS SCSLSSPESL PCTNGDSHGA KPSASSPSDQ
     ATSASSSANF TEIDEASASS EPEEAASQLS SPSLARAQPE PMATSTAAPE GQTPQIFPWM
     RKLHISHDMT GPDGKRARTA YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI
     WFQNRRMKWK KDNKLKSMSL ATAGSAFQP
//