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Protein

Homeobox protein Hox-B5

Gene

HOXB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi194 – 25360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. anterior/posterior pattern specification Source: Ensembl
  3. embryonic skeletal system morphogenesis Source: Ensembl
  4. endothelial cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B5
Alternative name(s):
Homeobox protein HHO.C10
Homeobox protein Hox-2A
Homeobox protein Hu-1
Gene namesi
Name:HOXB5
Synonyms:HOX2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5116. HOXB5.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29392.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Homeobox protein Hox-B5PRO_0000200128Add
BLAST

Proteomic databases

PaxDbiP09067.
PRIDEiP09067.

PTM databases

PhosphoSiteiP09067.

Expressioni

Tissue specificityi

Spinal cord.

Developmental stagei

Embryo.

Gene expression databases

BgeeiP09067.
CleanExiHS_HOXB5.
GenevestigatoriP09067.

Interactioni

Protein-protein interaction databases

BioGridi109455. 48 interactions.
IntActiP09067. 1 interaction.
STRINGi9606.ENSP00000239151.

Structurei

3D structure databases

ProteinModelPortaliP09067.
SMRiP09067. Positions 201-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi176 – 1816Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG236516.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP09067.
KOiK09305.
OMAiCATASRE.
OrthoDBiEOG780RP4.
PhylomeDBiP09067.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN
60 70 80 90 100
GMDLSVNRSS ASSSHFGAVG ESSRAFPAPA QEPRFRQAAS SCSLSSPESL
110 120 130 140 150
PCTNGDSHGA KPSASSPSDQ ATSASSSANF TEIDEASASS EPEEAASQLS
160 170 180 190 200
SPSLARAQPE PMATSTAAPE GQTPQIFPWM RKLHISHDMT GPDGKRARTA
210 220 230 240 250
YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI WFQNRRMKWK
260
KDNKLKSMSL ATAGSAFQP
Length:269
Mass (Da):29,434
Last modified:June 30, 1993 - v3
Checksum:i58197F105DB0F8C4
GO

Sequence cautioni

The sequence AAA52681.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92299 mRNA. Translation: AAA52682.1.
AF287967 Genomic DNA. Translation: AAG31553.1.
AK314964 mRNA. Translation: BAG37466.1.
BC117247 mRNA. Translation: AAI17248.1.
X03794 mRNA. Translation: CAA27420.1.
K02572 Genomic DNA. Translation: AAA52681.1. Different initiation.
M86726 mRNA. Translation: AAB59430.1.
CCDSiCCDS11530.1.
PIRiA24777.
A45578.
RefSeqiNP_002138.1. NM_002147.3.
UniGeneiHs.654456.

Genome annotation databases

EnsembliENST00000239151; ENSP00000239151; ENSG00000120075.
GeneIDi3215.
KEGGihsa:3215.
UCSCiuc002inr.3. human.

Polymorphism databases

DMDMi400000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92299 mRNA. Translation: AAA52682.1.
AF287967 Genomic DNA. Translation: AAG31553.1.
AK314964 mRNA. Translation: BAG37466.1.
BC117247 mRNA. Translation: AAI17248.1.
X03794 mRNA. Translation: CAA27420.1.
K02572 Genomic DNA. Translation: AAA52681.1. Different initiation.
M86726 mRNA. Translation: AAB59430.1.
CCDSiCCDS11530.1.
PIRiA24777.
A45578.
RefSeqiNP_002138.1. NM_002147.3.
UniGeneiHs.654456.

3D structure databases

ProteinModelPortaliP09067.
SMRiP09067. Positions 201-256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109455. 48 interactions.
IntActiP09067. 1 interaction.
STRINGi9606.ENSP00000239151.

PTM databases

PhosphoSiteiP09067.

Polymorphism databases

DMDMi400000.

Proteomic databases

PaxDbiP09067.
PRIDEiP09067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239151; ENSP00000239151; ENSG00000120075.
GeneIDi3215.
KEGGihsa:3215.
UCSCiuc002inr.3. human.

Organism-specific databases

CTDi3215.
GeneCardsiGC17M046668.
HGNCiHGNC:5116. HOXB5.
MIMi142960. gene.
neXtProtiNX_P09067.
PharmGKBiPA29392.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG236516.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP09067.
KOiK09305.
OMAiCATASRE.
OrthoDBiEOG780RP4.
PhylomeDBiP09067.
TreeFamiTF316310.

Miscellaneous databases

GeneWikiiHOXB5.
GenomeRNAii3215.
NextBioi12792.
PROiP09067.
SOURCEiSearch...

Gene expression databases

BgeeiP09067.
CleanExiHS_HOXB5.
GenevestigatoriP09067.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product."
    Galang C.K., Hauser C.A.
    New Biol. 4:558-568(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
    Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
    Am. J. Hum. Genet. 67:235-235(1999)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos."
    Hauser C.A., Joyner A.L., Klein R.D., Learned T.K., Martin G.R., Tjian R.
    Cell 43:19-28(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-269.
  6. "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila."
    Levine M., Rubin G.M., Tjian R.
    Cell 38:667-673(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-269.
  7. "A human homoeo box gene specifically expressed in spinal cord during embryonic development."
    Simeone A., Mavilio F., Bottero L., Giampaolo A., Russo G., Faiella A., Boncinelli E., Peschle C.
    Nature 320:763-765(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 200-269.
  8. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-269.
  9. "Cloning of a homeobox-containing cDNA (HHO.c10 or Hu-1) from a gt11 cDNA library of human osteosarcoma cell MG-63."
    Waye M.M.Y.
    Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 217-269.
    Tissue: Osteosarcoma.

Entry informationi

Entry nameiHXB5_HUMAN
AccessioniPrimary (citable) accession number: P09067
Secondary accession number(s): B2RC69, P09069, Q17RP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1988
Last sequence update: June 30, 1993
Last modified: February 3, 2015
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.