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P09067 (HXB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B5
Alternative name(s):
Homeobox protein HHO.C10
Homeobox protein Hox-2A
Homeobox protein Hu-1
Gene names
Name:HOXB5
Synonyms:HOX2A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Tissue specificity

Spinal cord.

Developmental stage

Embryo.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence AAA52681.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Homeobox protein Hox-B5
PRO_0000200128

Regions

DNA binding194 – 25360Homeobox
Motif176 – 1816Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
P09067 [UniParc].

Last modified July 1, 1993. Version 3.
Checksum: 58197F105DB0F8C4

FASTA26929,434
        10         20         30         40         50         60 
MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN GMDLSVNRSS 

        70         80         90        100        110        120 
ASSSHFGAVG ESSRAFPAPA QEPRFRQAAS SCSLSSPESL PCTNGDSHGA KPSASSPSDQ 

       130        140        150        160        170        180 
ATSASSSANF TEIDEASASS EPEEAASQLS SPSLARAQPE PMATSTAAPE GQTPQIFPWM 

       190        200        210        220        230        240 
RKLHISHDMT GPDGKRARTA YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI 

       250        260 
WFQNRRMKWK KDNKLKSMSL ATAGSAFQP 

« Hide

References

« Hide 'large scale' references
[1]"Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product."
Galang C.K., Hauser C.A.
New Biol. 4:558-568(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
Am. J. Hum. Genet. 67:235-235(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[5]"Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos."
Hauser C.A., Joyner A.L., Klein R.D., Learned T.K., Martin G.R., Tjian R.
Cell 43:19-28(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-269.
[6]"Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila."
Levine M., Rubin G.M., Tjian R.
Cell 38:667-673(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-269.
[7]"A human homoeo box gene specifically expressed in spinal cord during embryonic development."
Simeone A., Mavilio F., Bottero L., Giampaolo A., Russo G., Faiella A., Boncinelli E., Peschle C.
Nature 320:763-765(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 200-269.
[8]"Organization of human class I homeobox genes."
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-269.
[9]"Cloning of a homeobox-containing cDNA (HHO.c10 or Hu-1) from a gt11 cDNA library of human osteosarcoma cell MG-63."
Waye M.M.Y.
Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 217-269.
Tissue: Osteosarcoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M92299 mRNA. Translation: AAA52682.1.
AF287967 Genomic DNA. Translation: AAG31553.1.
AK314964 mRNA. Translation: BAG37466.1.
BC117247 mRNA. Translation: AAI17248.1.
X03794 mRNA. Translation: CAA27420.1.
K02572 Genomic DNA. Translation: AAA52681.1. Different initiation.
M86726 mRNA. Translation: AAB59430.1.
CCDSCCDS11530.1.
PIRA24777.
A45578.
RefSeqNP_002138.1. NM_002147.3.
UniGeneHs.654456.

3D structure databases

ProteinModelPortalP09067.
SMRP09067. Positions 201-256.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109455. 1 interaction.
IntActP09067. 1 interaction.
STRING9606.ENSP00000239151.

PTM databases

PhosphoSiteP09067.

Polymorphism databases

DMDM400000.

Proteomic databases

PaxDbP09067.
PRIDEP09067.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000239151; ENSP00000239151; ENSG00000120075.
GeneID3215.
KEGGhsa:3215.
UCSCuc002inr.3. human.

Organism-specific databases

CTD3215.
GeneCardsGC17M046668.
HGNCHGNC:5116. HOXB5.
MIM142960. gene.
neXtProtNX_P09067.
PharmGKBPA29392.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG236516.
HOGENOMHOG000231178.
HOVERGENHBG016849.
InParanoidP09067.
KOK09305.
OMACATASRE.
OrthoDBEOG780RP4.
PhylomeDBP09067.
TreeFamTF316310.

Gene expression databases

BgeeP09067.
CleanExHS_HOXB5.
GenevestigatorP09067.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOXB5.
GenomeRNAi3215.
NextBio12792.
PROP09067.
SOURCESearch...

Entry information

Entry nameHXB5_HUMAN
AccessionPrimary (citable) accession number: P09067
Secondary accession number(s): B2RC69, P09069, Q17RP4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries