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Protein

Homeobox protein Hox-B5

Gene

HOXB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi194 – 253HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B5
Alternative name(s):
Homeobox protein HHO.C10
Homeobox protein Hox-2A
Homeobox protein Hu-1
Gene namesi
Name:HOXB5
Synonyms:HOX2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000120075.5.
HGNCiHGNC:5116. HOXB5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3215.
OpenTargetsiENSG00000120075.
PharmGKBiPA29392.

Polymorphism and mutation databases

BioMutaiHOXB5.
DMDMi400000.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001281 – 269Homeobox protein Hox-B5Add BLAST269

Proteomic databases

MaxQBiP09067.
PaxDbiP09067.
PeptideAtlasiP09067.
PRIDEiP09067.

PTM databases

iPTMnetiP09067.
PhosphoSitePlusiP09067.

Expressioni

Tissue specificityi

Spinal cord.

Developmental stagei

Embryo.

Gene expression databases

BgeeiENSG00000120075.
CleanExiHS_HOXB5.
GenevisibleiP09067. HS.

Organism-specific databases

HPAiHPA074454.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109455. 52 interactors.
ELMiP09067.
IntActiP09067. 50 interactors.
STRINGi9606.ENSP00000239151.

Structurei

3D structure databases

ProteinModelPortaliP09067.
SMRiP09067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi176 – 181Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP09067.
KOiK09305.
OMAiCATASRE.
OrthoDBiEOG091G09XD.
PhylomeDBiP09067.
TreeFamiTF316310.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P09067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN
60 70 80 90 100
GMDLSVNRSS ASSSHFGAVG ESSRAFPAPA QEPRFRQAAS SCSLSSPESL
110 120 130 140 150
PCTNGDSHGA KPSASSPSDQ ATSASSSANF TEIDEASASS EPEEAASQLS
160 170 180 190 200
SPSLARAQPE PMATSTAAPE GQTPQIFPWM RKLHISHDMT GPDGKRARTA
210 220 230 240 250
YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI WFQNRRMKWK
260
KDNKLKSMSL ATAGSAFQP
Length:269
Mass (Da):29,434
Last modified:July 1, 1993 - v3
Checksum:i58197F105DB0F8C4
GO

Sequence cautioni

The sequence AAA52681 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92299 mRNA. Translation: AAA52682.1.
AF287967 Genomic DNA. Translation: AAG31553.1.
AK314964 mRNA. Translation: BAG37466.1.
BC117247 mRNA. Translation: AAI17248.1.
X03794 mRNA. Translation: CAA27420.1.
K02572 Genomic DNA. Translation: AAA52681.1. Different initiation.
M86726 mRNA. Translation: AAB59430.1.
CCDSiCCDS11530.1.
PIRiA24777.
A45578.
RefSeqiNP_002138.1. NM_002147.3.
UniGeneiHs.654456.

Genome annotation databases

EnsembliENST00000239151; ENSP00000239151; ENSG00000120075.
GeneIDi3215.
KEGGihsa:3215.
UCSCiuc002inr.4. human.

Similar proteinsi

Entry informationi

Entry nameiHXB5_HUMAN
AccessioniPrimary (citable) accession number: P09067
Secondary accession number(s): B2RC69, P09069, Q17RP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1993
Last modified: September 27, 2017
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families