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P09067

- HXB5_HUMAN

UniProt

P09067 - HXB5_HUMAN

Protein

Homeobox protein Hox-B5

Gene

HOXB5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 3 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi194 – 25360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. anterior/posterior pattern specification Source: Ensembl
    3. embryonic skeletal system morphogenesis Source: Ensembl
    4. endothelial cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B5
    Alternative name(s):
    Homeobox protein HHO.C10
    Homeobox protein Hox-2A
    Homeobox protein Hu-1
    Gene namesi
    Name:HOXB5
    Synonyms:HOX2A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:5116. HOXB5.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29392.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Homeobox protein Hox-B5PRO_0000200128Add
    BLAST

    Proteomic databases

    PaxDbiP09067.
    PRIDEiP09067.

    PTM databases

    PhosphoSiteiP09067.

    Expressioni

    Tissue specificityi

    Spinal cord.

    Developmental stagei

    Embryo.

    Gene expression databases

    BgeeiP09067.
    CleanExiHS_HOXB5.
    GenevestigatoriP09067.

    Interactioni

    Protein-protein interaction databases

    BioGridi109455. 1 interaction.
    IntActiP09067. 1 interaction.
    STRINGi9606.ENSP00000239151.

    Structurei

    3D structure databases

    ProteinModelPortaliP09067.
    SMRiP09067. Positions 201-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi176 – 1816Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG236516.
    HOGENOMiHOG000231178.
    HOVERGENiHBG016849.
    InParanoidiP09067.
    KOiK09305.
    OMAiCATASRE.
    OrthoDBiEOG780RP4.
    PhylomeDBiP09067.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09067-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN    50
    GMDLSVNRSS ASSSHFGAVG ESSRAFPAPA QEPRFRQAAS SCSLSSPESL 100
    PCTNGDSHGA KPSASSPSDQ ATSASSSANF TEIDEASASS EPEEAASQLS 150
    SPSLARAQPE PMATSTAAPE GQTPQIFPWM RKLHISHDMT GPDGKRARTA 200
    YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI WFQNRRMKWK 250
    KDNKLKSMSL ATAGSAFQP 269
    Length:269
    Mass (Da):29,434
    Last modified:July 1, 1993 - v3
    Checksum:i58197F105DB0F8C4
    GO

    Sequence cautioni

    The sequence AAA52681.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92299 mRNA. Translation: AAA52682.1.
    AF287967 Genomic DNA. Translation: AAG31553.1.
    AK314964 mRNA. Translation: BAG37466.1.
    BC117247 mRNA. Translation: AAI17248.1.
    X03794 mRNA. Translation: CAA27420.1.
    K02572 Genomic DNA. Translation: AAA52681.1. Different initiation.
    M86726 mRNA. Translation: AAB59430.1.
    CCDSiCCDS11530.1.
    PIRiA24777.
    A45578.
    RefSeqiNP_002138.1. NM_002147.3.
    UniGeneiHs.654456.

    Genome annotation databases

    EnsembliENST00000239151; ENSP00000239151; ENSG00000120075.
    GeneIDi3215.
    KEGGihsa:3215.
    UCSCiuc002inr.3. human.

    Polymorphism databases

    DMDMi400000.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92299 mRNA. Translation: AAA52682.1 .
    AF287967 Genomic DNA. Translation: AAG31553.1 .
    AK314964 mRNA. Translation: BAG37466.1 .
    BC117247 mRNA. Translation: AAI17248.1 .
    X03794 mRNA. Translation: CAA27420.1 .
    K02572 Genomic DNA. Translation: AAA52681.1 . Different initiation.
    M86726 mRNA. Translation: AAB59430.1 .
    CCDSi CCDS11530.1.
    PIRi A24777.
    A45578.
    RefSeqi NP_002138.1. NM_002147.3.
    UniGenei Hs.654456.

    3D structure databases

    ProteinModelPortali P09067.
    SMRi P09067. Positions 201-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109455. 1 interaction.
    IntActi P09067. 1 interaction.
    STRINGi 9606.ENSP00000239151.

    PTM databases

    PhosphoSitei P09067.

    Polymorphism databases

    DMDMi 400000.

    Proteomic databases

    PaxDbi P09067.
    PRIDEi P09067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000239151 ; ENSP00000239151 ; ENSG00000120075 .
    GeneIDi 3215.
    KEGGi hsa:3215.
    UCSCi uc002inr.3. human.

    Organism-specific databases

    CTDi 3215.
    GeneCardsi GC17M046668.
    HGNCi HGNC:5116. HOXB5.
    MIMi 142960. gene.
    neXtProti NX_P09067.
    PharmGKBi PA29392.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG236516.
    HOGENOMi HOG000231178.
    HOVERGENi HBG016849.
    InParanoidi P09067.
    KOi K09305.
    OMAi CATASRE.
    OrthoDBi EOG780RP4.
    PhylomeDBi P09067.
    TreeFami TF316310.

    Miscellaneous databases

    GeneWikii HOXB5.
    GenomeRNAii 3215.
    NextBioi 12792.
    PROi P09067.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09067.
    CleanExi HS_HOXB5.
    Genevestigatori P09067.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product."
      Galang C.K., Hauser C.A.
      New Biol. 4:558-568(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
      Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
      Am. J. Hum. Genet. 67:235-235(2000)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    5. "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos."
      Hauser C.A., Joyner A.L., Klein R.D., Learned T.K., Martin G.R., Tjian R.
      Cell 43:19-28(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-269.
    6. "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila."
      Levine M., Rubin G.M., Tjian R.
      Cell 38:667-673(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-269.
    7. "A human homoeo box gene specifically expressed in spinal cord during embryonic development."
      Simeone A., Mavilio F., Bottero L., Giampaolo A., Russo G., Faiella A., Boncinelli E., Peschle C.
      Nature 320:763-765(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 200-269.
    8. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-269.
    9. "Cloning of a homeobox-containing cDNA (HHO.c10 or Hu-1) from a gt11 cDNA library of human osteosarcoma cell MG-63."
      Waye M.M.Y.
      Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 217-269.
      Tissue: Osteosarcoma.

    Entry informationi

    Entry nameiHXB5_HUMAN
    AccessioniPrimary (citable) accession number: P09067
    Secondary accession number(s): B2RC69, P09069, Q17RP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 147 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3