Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P09066

- HME2_MOUSE

UniProt

P09066 - HME2_MOUSE

Protein

Homeobox protein engrailed-2

Gene

En2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (01 Feb 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi235 – 29460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. hindbrain development Source: MGI
    2. midbrain development Source: MGI
    3. neuron development Source: MGI
    4. neuron differentiation Source: MGI
    5. positive regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein engrailed-2
    Short name:
    Homeobox protein en-2
    Short name:
    Mo-En-2
    Gene namesi
    Name:En2
    Synonyms:En-2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:95390. En2.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Homeobox protein engrailed-2PRO_0000196068Add
    BLAST

    Proteomic databases

    PaxDbiP09066.
    PRIDEiP09066.

    PTM databases

    PhosphoSiteiP09066.

    Expressioni

    Tissue specificityi

    Cerebellar granule cells.

    Developmental stagei

    In the adult brain it is found in the cerebellar granule cell layer while the expression during the gestation period is region specific, at the junction of the midbrain and hindbrain.

    Gene expression databases

    BgeeiP09066.
    CleanExiMM_EN2.
    GenevestigatoriP09066.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000036761.

    Structurei

    3D structure databases

    ProteinModelPortaliP09066.
    SMRiP09066. Positions 214-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 307Poly-Gly
    Compositional biasi103 – 1108Poly-Gly

    Sequence similaritiesi

    Belongs to the engrailed homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG306728.
    HOGENOMiHOG000247054.
    HOVERGENiHBG005975.
    InParanoidiP09066.
    KOiK09319.
    OMAiSRPNPAC.
    OrthoDBiEOG7VTDN8.
    PhylomeDBiP09066.
    TreeFamiTF106461.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR019549. Homeobox-engrailed_C-terminal.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000747. Homeodomain_engrailed.
    IPR019737. Homoebox-engrailed_CS.
    [Graphical view]
    PfamiPF10525. Engrail_1_C_sig. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00026. ENGRAILED.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00033. ENGRAILED. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09066-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEKDSKPSE TAAEAQRQPE PSSGGGSGGG SSPSDSDTGR RRALMLPEVL    50
    QAPGNHQHPH RITNFFIDNI LRPEFGRRKD AGTCCAGAGG ARGGEGGAGT 100
    TEGGGGGAGG AEQLLGARES RPNPACAPSA GGTLSAAAGD PAVDGEGGSK 150
    TLSLHGGAKK PGDPGGSLDG VLKARGLGGG DLSVSSDSDS SQASATLGAQ 200
    PMLWPAWVYC TRYSDRPSSG PRSRKPKKKN PNKEDKRPRT AFTAEQLQRL 250
    KAEFQTNRYL TEQRRQSLAQ ELSLNESQIK IWFQNKRAKI KKATGNKNTL 300
    AVHLMAQGLY NHSTTAKEGK SDSE 324
    Length:324
    Mass (Da):33,817
    Last modified:February 1, 1994 - v2
    Checksum:iD1D9D602A1225A53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12704 Genomic DNA. No translation available.
    L12705 mRNA. Translation: AAA53527.1.
    Y00203 Genomic DNA. Translation: CAA68362.1.
    CCDSiCCDS19143.1.
    PIRiD48423.
    RefSeqiNP_034264.1. NM_010134.3.
    UniGeneiMm.4298.

    Genome annotation databases

    EnsembliENSMUST00000036177; ENSMUSP00000036761; ENSMUSG00000039095.
    GeneIDi13799.
    KEGGimmu:13799.
    UCSCiuc008wtv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12704 Genomic DNA. No translation available.
    L12705 mRNA. Translation: AAA53527.1 .
    Y00203 Genomic DNA. Translation: CAA68362.1 .
    CCDSi CCDS19143.1.
    PIRi D48423.
    RefSeqi NP_034264.1. NM_010134.3.
    UniGenei Mm.4298.

    3D structure databases

    ProteinModelPortali P09066.
    SMRi P09066. Positions 214-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000036761.

    PTM databases

    PhosphoSitei P09066.

    Proteomic databases

    PaxDbi P09066.
    PRIDEi P09066.

    Protocols and materials databases

    DNASUi 13799.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036177 ; ENSMUSP00000036761 ; ENSMUSG00000039095 .
    GeneIDi 13799.
    KEGGi mmu:13799.
    UCSCi uc008wtv.1. mouse.

    Organism-specific databases

    CTDi 2020.
    MGIi MGI:95390. En2.

    Phylogenomic databases

    eggNOGi NOG306728.
    HOGENOMi HOG000247054.
    HOVERGENi HBG005975.
    InParanoidi P09066.
    KOi K09319.
    OMAi SRPNPAC.
    OrthoDBi EOG7VTDN8.
    PhylomeDBi P09066.
    TreeFami TF106461.

    Miscellaneous databases

    NextBioi 284554.
    PROi P09066.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09066.
    CleanExi MM_EN2.
    Genevestigatori P09066.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR019549. Homeobox-engrailed_C-terminal.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000747. Homeodomain_engrailed.
    IPR019737. Homoebox-engrailed_CS.
    [Graphical view ]
    Pfami PF10525. Engrail_1_C_sig. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00026. ENGRAILED.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00033. ENGRAILED. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions."
      Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., Joyner A.L.
      Dev. Genet. 13:345-358(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis."
      Joyner A.L., Martin G.R.
      Genes Dev. 1:29-38(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 201-324.

    Entry informationi

    Entry nameiHME2_MOUSE
    AccessioniPrimary (citable) accession number: P09066
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3