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P09066 (HME2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein engrailed-2

Short name=Homeobox protein en-2
Short name=Mo-En-2
Gene names
Name:En2
Synonyms:En-2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus.

Tissue specificity

Cerebellar granule cells.

Developmental stage

In the adult brain it is found in the cerebellar granule cell layer while the expression during the gestation period is region specific, at the junction of the midbrain and hindbrain.

Sequence similarities

Belongs to the engrailed homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Homeobox protein engrailed-2
PRO_0000196068

Regions

DNA binding235 – 29460Homeobox
Compositional bias24 – 307Poly-Gly
Compositional bias103 – 1108Poly-Gly

Sequences

Sequence LengthMass (Da)Tools
P09066 [UniParc].

Last modified February 1, 1994. Version 2.
Checksum: D1D9D602A1225A53

FASTA32433,817
        10         20         30         40         50         60 
MEEKDSKPSE TAAEAQRQPE PSSGGGSGGG SSPSDSDTGR RRALMLPEVL QAPGNHQHPH 

        70         80         90        100        110        120 
RITNFFIDNI LRPEFGRRKD AGTCCAGAGG ARGGEGGAGT TEGGGGGAGG AEQLLGARES 

       130        140        150        160        170        180 
RPNPACAPSA GGTLSAAAGD PAVDGEGGSK TLSLHGGAKK PGDPGGSLDG VLKARGLGGG 

       190        200        210        220        230        240 
DLSVSSDSDS SQASATLGAQ PMLWPAWVYC TRYSDRPSSG PRSRKPKKKN PNKEDKRPRT 

       250        260        270        280        290        300 
AFTAEQLQRL KAEFQTNRYL TEQRRQSLAQ ELSLNESQIK IWFQNKRAKI KKATGNKNTL 

       310        320 
AVHLMAQGLY NHSTTAKEGK SDSE 

« Hide

References

[1]"Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions."
Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., Joyner A.L.
Dev. Genet. 13:345-358(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis."
Joyner A.L., Martin G.R.
Genes Dev. 1:29-38(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 201-324.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L12704 Genomic DNA. No translation available.
L12705 mRNA. Translation: AAA53527.1.
Y00203 Genomic DNA. Translation: CAA68362.1.
CCDSCCDS19143.1.
PIRD48423.
RefSeqNP_034264.1. NM_010134.3.
UniGeneMm.4298.

3D structure databases

ProteinModelPortalP09066.
SMRP09066. Positions 214-296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000036761.

PTM databases

PhosphoSiteP09066.

Proteomic databases

PaxDbP09066.
PRIDEP09066.

Protocols and materials databases

DNASU13799.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036177; ENSMUSP00000036761; ENSMUSG00000039095.
GeneID13799.
KEGGmmu:13799.
UCSCuc008wtv.1. mouse.

Organism-specific databases

CTD2020.
MGIMGI:95390. En2.

Phylogenomic databases

eggNOGNOG306728.
HOGENOMHOG000247054.
HOVERGENHBG005975.
InParanoidP09066.
KOK09319.
OMASRPNPAC.
OrthoDBEOG7VTDN8.
PhylomeDBP09066.
TreeFamTF106461.

Gene expression databases

BgeeP09066.
CleanExMM_EN2.
GenevestigatorP09066.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000747. Homeodomain_engrailed.
IPR019737. Homoebox-engrailed_CS.
[Graphical view]
PfamPF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00026. ENGRAILED.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284554.
PROP09066.
SOURCESearch...

Entry information

Entry nameHME2_MOUSE
AccessionPrimary (citable) accession number: P09066
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot