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Protein

Homeobox protein engrailed-1

Gene

En1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi312 – 371HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: ParkinsonsUK-UCL
  • cerebellum development Source: ParkinsonsUK-UCL
  • dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
  • dorsal/ventral pattern formation Source: MGI
  • drinking behavior Source: ParkinsonsUK-UCL
  • embryonic brain development Source: ParkinsonsUK-UCL
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: ParkinsonsUK-UCL
  • hindbrain development Source: MGI
  • limb development Source: MGI
  • midbrain development Source: ParkinsonsUK-UCL
  • midbrain-hindbrain boundary development Source: MGI
  • motor learning Source: ParkinsonsUK-UCL
  • multicellular organism growth Source: MGI
  • negative regulation of neuron apoptotic process Source: ParkinsonsUK-UCL
  • negative regulation of neuron death Source: ParkinsonsUK-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neuron development Source: MGI
  • neuron differentiation Source: MGI
  • pigmentation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • proximal/distal pattern formation Source: MGI
  • regulation of gene expression Source: MGI
  • social behavior Source: ParkinsonsUK-UCL

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein engrailed-1
Short name:
Homeobox protein en-1
Short name:
Mo-En-1
Gene namesi
Name:En1
Synonyms:En-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:95389. En1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001960631 – 401Homeobox protein engrailed-1Add BLAST401

Proteomic databases

PaxDbiP09065.
PRIDEiP09065.

PTM databases

iPTMnetiP09065.
PhosphoSitePlusiP09065.

Expressioni

Gene expression databases

BgeeiENSMUSG00000058665.
CleanExiMM_EN1.
GenevisibleiP09065. MM.

Interactioni

Protein-protein interaction databases

BioGridi199444. 2 interactors.
STRINGi10090.ENSMUSP00000078659.

Structurei

3D structure databases

ProteinModelPortaliP09065.
SMRiP09065.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi52 – 87Pro-richAdd BLAST36
Compositional biasi73 – 87Poly-ProAdd BLAST15
Compositional biasi207 – 228Poly-AlaAdd BLAST22

Sequence similaritiesi

Belongs to the engrailed homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0493. Eukaryota.
ENOG4111P06. LUCA.
GeneTreeiENSGT00900000140915.
HOGENOMiHOG000247054.
HOVERGENiHBG005975.
InParanoidiP09065.
KOiK09319.
OMAiNCGPPDG.
OrthoDBiEOG091G0XBB.
TreeFamiTF106461.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR019549. Homeobox-engrailed_C-terminal.
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR000747. Homeobox_engrailed.
IPR020479. Homeobox_metazoa.
IPR019737. Homoebox-engrailed_CS.
PfamiView protein in Pfam
PF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00026. ENGRAILED.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P09065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEQQPEPKS QRDSGLGAVA AAAPSGLSLS LSPGASGSSG SDGDSVPVSP
60 70 80 90 100
QPAPPSPPAA PCLPPLAHHP HLPPHPPPPP PPPPPPPQHL AAPAHQPQPA
110 120 130 140 150
AQLHRTTNFF IDNILRPDFG CKKEQPLPQL LVASAAAGGG AAAGGGSRVE
160 170 180 190 200
RDRGQTGAGR DPVHSLGTRA SGAASLLCAP DANCGPPDGS QPATAVSAGA
210 220 230 240 250
SKAGNPAAAA AAAAAAAAAA VAAAAAAASK PSDSGGGSGG NAGSPGAQGA
260 270 280 290 300
KFPEHNPAIL LMGSANGGPV VKTDSQQPLV WPAWVYCTRY SDRPSSGPRT
310 320 330 340 350
RKLKKKKNEK EDKRPRTAFT AEQLQRLKAE FQANRYITEQ RRQTLAQELS
360 370 380 390 400
LNESQIKIWF QNKRAKIKKA TGIKNGLALH LMAQGLYNHS TTTVQDKDES

E
Length:401
Mass (Da):40,981
Last modified:July 27, 2011 - v3
Checksum:i05456FD3815AA02A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197S → G in AAA03660 (PubMed:1363401).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12703 mRNA. Translation: AAA03660.2.
AK140408 mRNA. Translation: BAE24375.1.
Y00201 Genomic DNA. Translation: CAA68361.1.
CCDSiCCDS15235.1.
PIRiA48423.
RefSeqiNP_034263.2. NM_010133.2.
UniGeneiMm.2657.

Genome annotation databases

EnsembliENSMUST00000079721; ENSMUSP00000078659; ENSMUSG00000058665.
GeneIDi13798.
KEGGimmu:13798.
UCSCiuc007cjm.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiHME1_MOUSE
AccessioniPrimary (citable) accession number: P09065
Secondary accession number(s): Q3USF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 27, 2011
Last modified: October 25, 2017
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families