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Protein

Ornithine decarboxylase

Gene

Odc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.By similarity

Catalytic activityi

L-ornithine = putrescine + CO2.

Cofactori

Enzyme regulationi

Inhibited by antizyme OAZ1, OAZ2 and OAZ3.By similarity

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine decarboxylase (Odc1)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei360 – 3601Proton donor; shared with dimeric partnerBy similarity

GO - Molecular functioni

  • ornithine decarboxylase activity Source: RGD
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.17. 5301.
ReactomeiR-RNO-350562. Regulation of ornithine decarboxylase (ODC).
R-RNO-351202. Metabolism of polyamines.
SABIO-RKP09057.
UniPathwayiUPA00535; UER00288.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase (EC:4.1.1.17)
Short name:
ODC
Gene namesi
Name:Odc1
Synonyms:Odc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3227. Odc1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • cytosol Source: Ensembl
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Ornithine decarboxylasePRO_0000149894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691N6-(pyridoxal phosphate)lysineBy similarity
Modified residuei303 – 3031Phosphoserine; by CK2By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP09057.
PRIDEiP09057.

PTM databases

PhosphoSiteiP09057.

Expressioni

Gene expression databases

ExpressionAtlasiP09057. baseline and differential.
GenevisibleiP09057. RN.

Interactioni

Subunit structurei

Monomer. Homodimer. Does not form a heterodimer with AZIN2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007259.

Chemistry

BindingDBiP09057.

Structurei

3D structure databases

ProteinModelPortaliP09057.
SMRiP09057. Positions 7-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiP09057.
KOiK01581.
OMAiCEPGEED.
OrthoDBiEOG73Z2T6.
PhylomeDBiP09057.
TreeFamiTF300760.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSFTKEEFD CHILDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDVLK
60 70 80 90 100
KHLRWLKALP RVTPFYAVKC NDSRAIVSTL AAIGTGFDCA SKTEIQLVQG
110 120 130 140 150
LGVPPERIIY ANPCKQVSQI KYAASNGVQM MTFDSEIELM KVARAHPKAK
160 170 180 190 200
LVLRIATDDS KAVCRLSVKF GATLKTSRLL LERAKELNID VIGVSFHVGS
210 220 230 240 250
GCTDPETFVQ AVSDARCVFD MGTEVGFSMY LLDIGGGFPG SEDTKLKFEE
260 270 280 290 300
ITSVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKTVWKEQ
310 320 330 340 350
TGSDDEDESN EQTLMYYVND GVYGSFNCIL YDHAHVKALL QKRPKPDEKY
360 370 380 390 400
YSSSIWGPTC DGLDRIVERC SLPEMHVGDW MLFENMGAYT VAAASTFNGF
410 420 430 440 450
QRPNIYYVMS RSMWQLMKQI QSHGFPPEVE EQDVGTLPMS CAQESGMDRH
460
PAACASASIN V
Length:461
Mass (Da):51,047
Last modified:November 1, 1988 - v1
Checksum:iCEF9D268DDDE0DA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16982 mRNA. Translation: AAA41737.1.
X07944 Genomic DNA. Translation: CAA30765.1.
J04792 Genomic DNA. Translation: AAA66286.1. Sequence problems.
J04791 mRNA. Translation: AAA66164.1.
BC078882 mRNA. Translation: AAH78882.1.
PIRiA27361. DCRTO.
RefSeqiNP_001289012.1. NM_001302083.1.
NP_036747.1. NM_012615.3.
XP_006239969.1. XM_006239907.2.
XP_006239970.1. XM_006239908.2.
UniGeneiRn.874.

Genome annotation databases

EnsembliENSRNOT00000007259; ENSRNOP00000007259; ENSRNOG00000005424.
GeneIDi24609.
KEGGirno:24609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16982 mRNA. Translation: AAA41737.1.
X07944 Genomic DNA. Translation: CAA30765.1.
J04792 Genomic DNA. Translation: AAA66286.1. Sequence problems.
J04791 mRNA. Translation: AAA66164.1.
BC078882 mRNA. Translation: AAH78882.1.
PIRiA27361. DCRTO.
RefSeqiNP_001289012.1. NM_001302083.1.
NP_036747.1. NM_012615.3.
XP_006239969.1. XM_006239907.2.
XP_006239970.1. XM_006239908.2.
UniGeneiRn.874.

3D structure databases

ProteinModelPortaliP09057.
SMRiP09057. Positions 7-421.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007259.

Chemistry

BindingDBiP09057.
ChEMBLiCHEMBL3511.

PTM databases

PhosphoSiteiP09057.

Proteomic databases

PaxDbiP09057.
PRIDEiP09057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007259; ENSRNOP00000007259; ENSRNOG00000005424.
GeneIDi24609.
KEGGirno:24609.

Organism-specific databases

CTDi4953.
RGDi3227. Odc1.

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiP09057.
KOiK01581.
OMAiCEPGEED.
OrthoDBiEOG73Z2T6.
PhylomeDBiP09057.
TreeFamiTF300760.

Enzyme and pathway databases

UniPathwayiUPA00535; UER00288.
BRENDAi4.1.1.17. 5301.
ReactomeiR-RNO-350562. Regulation of ornithine decarboxylase (ODC).
R-RNO-351202. Metabolism of polyamines.
SABIO-RKP09057.

Miscellaneous databases

NextBioi603832.
PROiP09057.

Gene expression databases

ExpressionAtlasiP09057. baseline and differential.
GenevisibleiP09057. RN.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and nucleotide sequence of rat ornithine decarboxylase cDNA."
    van Kranen H.J., van de Zande L., van Kreijl C.F., Bisschop A., Wieringa B.
    Gene 60:145-155(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Liver.
  3. "Rat ornithine decarboxylase gene. Nucleotide sequence, potential regulatory elements, and comparison to the mouse gene."
    Wen L., Huang J.K., Blackshear P.J.
    J. Biol. Chem. 264:9016-9021(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Fischer.
    Tissue: Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "The translation in vitro of rat ornithine decarboxylase mRNA is blocked by its 5' untranslated region in a polyamine-independent way."
    Van Steeg H., Van Oostrom C.T.M., Hodemaekers H.M., Peters L., Thomas A.A.
    Biochem. J. 274:521-526(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-37.

Entry informationi

Entry nameiDCOR_RAT
AccessioniPrimary (citable) accession number: P09057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: May 11, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.