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Protein

Homeobox protein Hox-D3

Gene

Hoxd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 254HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • cartilage development Source: MGI
  • cell-matrix adhesion Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • glossopharyngeal nerve morphogenesis Source: MGI
  • Notch signaling pathway Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • thyroid gland development Source: MGI
  • transcription, DNA-templated Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D3
Alternative name(s):
Homeobox protein Hox-4.1
Homeobox protein MH-19
Gene namesi
Name:Hoxd3
Synonyms:Hox-4.1, Hoxd-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96207 Hoxd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002051 – 433Homeobox protein Hox-D3Add BLAST433

Proteomic databases

PaxDbiP09027
PRIDEiP09027

PTM databases

PhosphoSitePlusiP09027

Expressioni

Tissue specificityi

Detected in adult kidney, but not in other adult tissues tested.1 Publication

Developmental stagei

Detected in 12-, 14-, and 17-day-old mouse embryos in the posterior half of the myelencephalon, spinal cord, dorsal root ganglia, first cervical vertebra, thyroid gland, kidney tubules, esophagus, stomach, and intestines.1 Publication

Gene expression databases

BgeeiENSMUSG00000079277
CleanExiMM_HOXD3
ExpressionAtlasiP09027 baseline and differential
GenevisibleiP09027 MM

Interactioni

Protein-protein interaction databases

BioGridi200396, 4 interactors
STRINGi10090.ENSMUSP00000044809

Structurei

3D structure databases

ProteinModelPortaliP09027
SMRiP09027
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi161 – 166Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000252944
HOVERGENiHBG107984
InParanoidiP09027
KOiK09303
OMAiYGYSTPH
OrthoDBiEOG091G0PFO
PhylomeDBiP09027
TreeFamiTF315938

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFEQGQLTL ELPECTMQKA AYYENPGLFG GYGYSKATDT YGYSTPHQPY
60 70 80 90 100
PPPAAANSLD SDYPSSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG
110 120 130 140 150
GGGGNQPPGL NSEQQPPQPP PPPPPTLPPS SPTNPGSGVP AKKTKGGLSA
160 170 180 190 200
SSSSSTISKQ IFPWMKESRQ NSKQKNSCAT SGENCEDKSP PGPASKRVRT
210 220 230 240 250
AYTSAQLVEL EKEFHFNRYL CRPRRVEMAN LLNLTERQIK IWFQNRRMKY
260 270 280 290 300
KKDQKAKGIL HSPAGQSPER SPPLGGAAGH VAYSGQLPPV PGLAYDAPSP
310 320 330 340 350
PAFAKSQPNM YGLAAYTAPL SSCLPQQKRY PAPEFEPHPM ASNGGGFASA
360 370 380 390 400
NLQGSPVYVG GNFVDSMAPT SGPVFNLGHL SHPSSASVDY SCAAQIPGNH
410 420 430
HHGPCDPHPT YTDLSAHHSS QGRLPEAPKL THL
Length:433
Mass (Da):45,976
Last modified:March 3, 2009 - v4
Checksum:i0BA0409A7F32F9E6
GO

Sequence cautioni

The sequence AAB60683 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC52779 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC52780 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE23694 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA51975 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187D → N (PubMed:2890503).Curated1
Sequence conflicti187D → N in AAA37846 (Ref. 6) Curated1
Sequence conflicti192G → D (PubMed:2890503).Curated1
Sequence conflicti192G → D in AAA37846 (Ref. 6) Curated1
Sequence conflicti201A → T (PubMed:2890503).Curated1
Sequence conflicti201A → T in AAA37846 (Ref. 6) Curated1
Sequence conflicti289Missing in CAA51975 (PubMed:7710686).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03485, U03496 Genomic DNA Translation: AAB60683.1 Different initiation.
X73573 mRNA Translation: CAA51975.1 Sequence problems.
L24363 Genomic DNA Translation: AAA37855.1
U56400 mRNA Translation: AAC52779.1 Different initiation.
U56401 Genomic DNA Translation: AAC52780.1 Different initiation.
AK138525 mRNA Translation: BAE23694.1 Different initiation.
M18169 Genomic DNA Translation: AAA37846.1 Sequence problems.
CCDSiCCDS38149.1
PIRiD29585
S34164
S47539
RefSeqiNP_034598.2, NM_010468.2
UniGeneiMm.430708

Genome annotation databases

EnsembliENSMUST00000047830; ENSMUSP00000044809; ENSMUSG00000079277
ENSMUST00000111982; ENSMUSP00000107613; ENSMUSG00000079277
ENSMUST00000111983; ENSMUSP00000107614; ENSMUSG00000079277
GeneIDi15434
KEGGimmu:15434
UCSCiuc008kee.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHXD3_MOUSE
AccessioniPrimary (citable) accession number: P09027
Secondary accession number(s): Q3UUD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 164 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health