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Protein

Homeobox protein Hox-D3

Gene

Hoxd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 254HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • cartilage development Source: MGI
  • cell-matrix adhesion Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • glossopharyngeal nerve morphogenesis Source: MGI
  • Notch signaling pathway Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • thyroid gland development Source: MGI
  • transcription, DNA-templated Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D3
Alternative name(s):
Homeobox protein Hox-4.1
Homeobox protein MH-19
Gene namesi
Name:Hoxd3
Synonyms:Hox-4.1, Hoxd-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96207. Hoxd3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002051 – 433Homeobox protein Hox-D3Add BLAST433

Proteomic databases

PaxDbiP09027.
PRIDEiP09027.

PTM databases

PhosphoSitePlusiP09027.

Expressioni

Tissue specificityi

Detected in adult kidney, but not in other adult tissues tested.1 Publication

Developmental stagei

Detected in 12-, 14-, and 17-day-old mouse embryos in the posterior half of the myelencephalon, spinal cord, dorsal root ganglia, first cervical vertebra, thyroid gland, kidney tubules, esophagus, stomach, and intestines.1 Publication

Gene expression databases

BgeeiENSMUSG00000079277.
CleanExiMM_HOXD3.
ExpressionAtlasiP09027. baseline and differential.
GenevisibleiP09027. MM.

Interactioni

Protein-protein interaction databases

BioGridi200396. 4 interactors.
STRINGi10090.ENSMUSP00000044809.

Structurei

3D structure databases

ProteinModelPortaliP09027.
SMRiP09027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi161 – 166Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00900000140772.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP09027.
KOiK09303.
OMAiYGYSTPH.
OrthoDBiEOG091G0PFO.
PhylomeDBiP09027.
TreeFamiTF315938.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR025281. DUF4074.
IPR009057. Homeobox-like_sf.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P09027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFEQGQLTL ELPECTMQKA AYYENPGLFG GYGYSKATDT YGYSTPHQPY
60 70 80 90 100
PPPAAANSLD SDYPSSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG
110 120 130 140 150
GGGGNQPPGL NSEQQPPQPP PPPPPTLPPS SPTNPGSGVP AKKTKGGLSA
160 170 180 190 200
SSSSSTISKQ IFPWMKESRQ NSKQKNSCAT SGENCEDKSP PGPASKRVRT
210 220 230 240 250
AYTSAQLVEL EKEFHFNRYL CRPRRVEMAN LLNLTERQIK IWFQNRRMKY
260 270 280 290 300
KKDQKAKGIL HSPAGQSPER SPPLGGAAGH VAYSGQLPPV PGLAYDAPSP
310 320 330 340 350
PAFAKSQPNM YGLAAYTAPL SSCLPQQKRY PAPEFEPHPM ASNGGGFASA
360 370 380 390 400
NLQGSPVYVG GNFVDSMAPT SGPVFNLGHL SHPSSASVDY SCAAQIPGNH
410 420 430
HHGPCDPHPT YTDLSAHHSS QGRLPEAPKL THL
Length:433
Mass (Da):45,976
Last modified:March 3, 2009 - v4
Checksum:i0BA0409A7F32F9E6
GO

Sequence cautioni

The sequence AAB60683 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC52779 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC52780 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE23694 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA51975 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187D → N (PubMed:2890503).Curated1
Sequence conflicti187D → N in AAA37846 (Ref. 6) Curated1
Sequence conflicti192G → D (PubMed:2890503).Curated1
Sequence conflicti192G → D in AAA37846 (Ref. 6) Curated1
Sequence conflicti201A → T (PubMed:2890503).Curated1
Sequence conflicti201A → T in AAA37846 (Ref. 6) Curated1
Sequence conflicti289Missing in CAA51975 (PubMed:7710686).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03485, U03496 Genomic DNA. Translation: AAB60683.1. Different initiation.
X73573 mRNA. Translation: CAA51975.1. Sequence problems.
L24363 Genomic DNA. Translation: AAA37855.1.
U56400 mRNA. Translation: AAC52779.1. Different initiation.
U56401 Genomic DNA. Translation: AAC52780.1. Different initiation.
AK138525 mRNA. Translation: BAE23694.1. Different initiation.
M18169 Genomic DNA. Translation: AAA37846.1. Sequence problems.
CCDSiCCDS38149.1.
PIRiD29585.
S34164.
S47539.
RefSeqiNP_034598.2. NM_010468.2.
UniGeneiMm.430708.

Genome annotation databases

EnsembliENSMUST00000047830; ENSMUSP00000044809; ENSMUSG00000079277.
ENSMUST00000111982; ENSMUSP00000107613; ENSMUSG00000079277.
ENSMUST00000111983; ENSMUSP00000107614; ENSMUSG00000079277.
GeneIDi15434.
KEGGimmu:15434.
UCSCiuc008kee.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiHXD3_MOUSE
AccessioniPrimary (citable) accession number: P09027
Secondary accession number(s): Q3UUD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: March 3, 2009
Last modified: November 22, 2017
This is version 161 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families