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P09027

- HXD3_MOUSE

UniProt

P09027 - HXD3_MOUSE

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Protein

Homeobox protein Hox-D3

Gene

Hoxd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi195 – 25460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cell-matrix adhesion Source: Ensembl
  2. multicellular organismal development Source: UniProtKB-KW
  3. Notch signaling pathway Source: Ensembl
  4. positive regulation of gene expression Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D3
Alternative name(s):
Homeobox protein Hox-4.1
Homeobox protein MH-19
Gene namesi
Name:Hoxd3
Synonyms:Hox-4.1, Hoxd-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96207. Hoxd3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Homeobox protein Hox-D3PRO_0000200205Add
BLAST

Proteomic databases

PRIDEiP09027.

PTM databases

PhosphoSiteiP09027.

Expressioni

Tissue specificityi

Detected in adult kidney, but not in other adult tissues tested.1 Publication

Developmental stagei

Detected in 12-, 14-, and 17-day-old mouse embryos in the posterior half of the myelencephalon, spinal cord, dorsal root ganglia, first cervical vertebra, thyroid gland, kidney tubules, esophagus, stomach, and intestines.1 Publication

Gene expression databases

BgeeiP09027.
CleanExiMM_HOXD3.
ExpressionAtlasiP09027. baseline.
GenevestigatoriP09027.

Interactioni

Protein-protein interaction databases

BioGridi200396. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP09027.
SMRiP09027. Positions 197-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi161 – 1666Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP09027.
KOiK09303.
OMAiIFECETR.
OrthoDBiEOG754HPS.
PhylomeDBiP09027.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09027-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFEQGQLTL ELPECTMQKA AYYENPGLFG GYGYSKATDT YGYSTPHQPY
60 70 80 90 100
PPPAAANSLD SDYPSSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG
110 120 130 140 150
GGGGNQPPGL NSEQQPPQPP PPPPPTLPPS SPTNPGSGVP AKKTKGGLSA
160 170 180 190 200
SSSSSTISKQ IFPWMKESRQ NSKQKNSCAT SGENCEDKSP PGPASKRVRT
210 220 230 240 250
AYTSAQLVEL EKEFHFNRYL CRPRRVEMAN LLNLTERQIK IWFQNRRMKY
260 270 280 290 300
KKDQKAKGIL HSPAGQSPER SPPLGGAAGH VAYSGQLPPV PGLAYDAPSP
310 320 330 340 350
PAFAKSQPNM YGLAAYTAPL SSCLPQQKRY PAPEFEPHPM ASNGGGFASA
360 370 380 390 400
NLQGSPVYVG GNFVDSMAPT SGPVFNLGHL SHPSSASVDY SCAAQIPGNH
410 420 430
HHGPCDPHPT YTDLSAHHSS QGRLPEAPKL THL
Length:433
Mass (Da):45,976
Last modified:March 3, 2009 - v4
Checksum:i0BA0409A7F32F9E6
GO

Sequence cautioni

The sequence AAB60683.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAC52779.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAC52780.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE23694.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA51975.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871D → N(PubMed:2890503)Curated
Sequence conflicti187 – 1871D → N in AAA37846. 1 PublicationCurated
Sequence conflicti192 – 1921G → D(PubMed:2890503)Curated
Sequence conflicti192 – 1921G → D in AAA37846. 1 PublicationCurated
Sequence conflicti201 – 2011A → T(PubMed:2890503)Curated
Sequence conflicti201 – 2011A → T in AAA37846. 1 PublicationCurated
Sequence conflicti289 – 2891Missing in CAA51975. (PubMed:7710686)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03485, U03496 Genomic DNA. Translation: AAB60683.1. Different initiation.
X73573 mRNA. Translation: CAA51975.1. Sequence problems.
L24363 Genomic DNA. Translation: AAA37855.1.
U56400 mRNA. Translation: AAC52779.1. Different initiation.
U56401 Genomic DNA. Translation: AAC52780.1. Different initiation.
AK138525 mRNA. Translation: BAE23694.1. Different initiation.
M18169 Genomic DNA. Translation: AAA37846.1. Sequence problems.
CCDSiCCDS38149.1.
PIRiD29585.
S34164.
S47539.
RefSeqiNP_034598.2. NM_010468.2.
UniGeneiMm.430708.

Genome annotation databases

EnsembliENSMUST00000047830; ENSMUSP00000044809; ENSMUSG00000079277.
ENSMUST00000111982; ENSMUSP00000107613; ENSMUSG00000079277.
ENSMUST00000111983; ENSMUSP00000107614; ENSMUSG00000079277.
GeneIDi15434.
KEGGimmu:15434.
UCSCiuc008kee.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03485 , U03496 Genomic DNA. Translation: AAB60683.1 . Different initiation.
X73573 mRNA. Translation: CAA51975.1 . Sequence problems.
L24363 Genomic DNA. Translation: AAA37855.1 .
U56400 mRNA. Translation: AAC52779.1 . Different initiation.
U56401 Genomic DNA. Translation: AAC52780.1 . Different initiation.
AK138525 mRNA. Translation: BAE23694.1 . Different initiation.
M18169 Genomic DNA. Translation: AAA37846.1 . Sequence problems.
CCDSi CCDS38149.1.
PIRi D29585.
S34164.
S47539.
RefSeqi NP_034598.2. NM_010468.2.
UniGenei Mm.430708.

3D structure databases

ProteinModelPortali P09027.
SMRi P09027. Positions 197-254.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200396. 4 interactions.

PTM databases

PhosphoSitei P09027.

Proteomic databases

PRIDEi P09027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047830 ; ENSMUSP00000044809 ; ENSMUSG00000079277 .
ENSMUST00000111982 ; ENSMUSP00000107613 ; ENSMUSG00000079277 .
ENSMUST00000111983 ; ENSMUSP00000107614 ; ENSMUSG00000079277 .
GeneIDi 15434.
KEGGi mmu:15434.
UCSCi uc008kee.1. mouse.

Organism-specific databases

CTDi 3232.
MGIi MGI:96207. Hoxd3.

Phylogenomic databases

eggNOGi NOG284589.
HOGENOMi HOG000252944.
HOVERGENi HBG107984.
InParanoidi P09027.
KOi K09303.
OMAi IFECETR.
OrthoDBi EOG754HPS.
PhylomeDBi P09027.
TreeFami TF315938.

Miscellaneous databases

NextBioi 288206.
PROi P09027.
SOURCEi Search...

Gene expression databases

Bgeei P09027.
CleanExi MM_HOXD3.
ExpressionAtlasi P09027. baseline.
Genevestigatori P09027.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of the murine Hox-D3 (Hox-4.1) gene reveals extensive identity with the human protein."
    Brown W.M., Zhou L., Taylor G.R.
    Biochim. Biophys. Acta 1219:219-222(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the Hoxd-3 gene: structure and localization of its sense and natural antisense transcripts."
    Bedford M., Orr-Urtreger A., Arman E., Lonai P.
    DNA Cell Biol. 14:295-304(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Sequence and expression of the murine Hoxd-3 homeobox gene."
    Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.
    Proc. Natl. Acad. Sci. U.S.A. 93:8247-8252(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: ICR X Swiss Webster.
    Tissue: Liver.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  5. "New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis."
    Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.
    DNA 6:409-418(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 182-303.
  6. Lonai P.
    Submitted (DEC-1987) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-335.

Entry informationi

Entry nameiHXD3_MOUSE
AccessioniPrimary (citable) accession number: P09027
Secondary accession number(s): Q3UUD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 138 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3