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P09027 (HXD3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D3
Alternative name(s):
Homeobox protein Hox-4.1
Homeobox protein MH-19
Gene names
Name:Hoxd3
Synonyms:Hox-4.1, Hoxd-3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Tissue specificity

Detected in adult kidney, but not in other adult tissues tested. Ref.3

Developmental stage

Detected in 12-, 14-, and 17-day-old mouse embryos in the posterior half of the myelencephalon, spinal cord, dorsal root ganglia, first cervical vertebra, thyroid gland, kidney tubules, esophagus, stomach, and intestines. Ref.3

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.

Sequence caution

The sequence AAB60683.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAC52779.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAC52780.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAE23694.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA51975.1 differs from that shown. Reason: Frameshift at several positions.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Homeobox protein Hox-D3
PRO_0000200205

Regions

DNA binding195 – 25460Homeobox
Motif161 – 1666Antp-type hexapeptide

Experimental info

Sequence conflict1871D → N Ref.5
Sequence conflict1871D → N in AAA37846. Ref.6
Sequence conflict1921G → D Ref.5
Sequence conflict1921G → D in AAA37846. Ref.6
Sequence conflict2011A → T Ref.5
Sequence conflict2011A → T in AAA37846. Ref.6
Sequence conflict2891Missing in CAA51975. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P09027 [UniParc].

Last modified March 3, 2009. Version 4.
Checksum: 0BA0409A7F32F9E6

FASTA43345,976
        10         20         30         40         50         60 
MLFEQGQLTL ELPECTMQKA AYYENPGLFG GYGYSKATDT YGYSTPHQPY PPPAAANSLD 

        70         80         90        100        110        120 
SDYPSSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG GGGGNQPPGL NSEQQPPQPP 

       130        140        150        160        170        180 
PPPPPTLPPS SPTNPGSGVP AKKTKGGLSA SSSSSTISKQ IFPWMKESRQ NSKQKNSCAT 

       190        200        210        220        230        240 
SGENCEDKSP PGPASKRVRT AYTSAQLVEL EKEFHFNRYL CRPRRVEMAN LLNLTERQIK 

       250        260        270        280        290        300 
IWFQNRRMKY KKDQKAKGIL HSPAGQSPER SPPLGGAAGH VAYSGQLPPV PGLAYDAPSP 

       310        320        330        340        350        360 
PAFAKSQPNM YGLAAYTAPL SSCLPQQKRY PAPEFEPHPM ASNGGGFASA NLQGSPVYVG 

       370        380        390        400        410        420 
GNFVDSMAPT SGPVFNLGHL SHPSSASVDY SCAAQIPGNH HHGPCDPHPT YTDLSAHHSS 

       430 
QGRLPEAPKL THL 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of the murine Hox-D3 (Hox-4.1) gene reveals extensive identity with the human protein."
Brown W.M., Zhou L., Taylor G.R.
Biochim. Biophys. Acta 1219:219-222(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Analysis of the Hoxd-3 gene: structure and localization of its sense and natural antisense transcripts."
Bedford M., Orr-Urtreger A., Arman E., Lonai P.
DNA Cell Biol. 14:295-304(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Sequence and expression of the murine Hoxd-3 homeobox gene."
Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.
Proc. Natl. Acad. Sci. U.S.A. 93:8247-8252(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
Strain: ICR X Swiss Webster.
Tissue: Liver.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Spinal cord.
[5]"New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis."
Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.
DNA 6:409-418(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 182-303.
[6]Lonai P.
Submitted (DEC-1987) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-335.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U03485, U03496 Genomic DNA. Translation: AAB60683.1. Different initiation.
X73573 mRNA. Translation: CAA51975.1. Sequence problems.
L24363 Genomic DNA. Translation: AAA37855.1.
U56400 mRNA. Translation: AAC52779.1. Different initiation.
U56401 Genomic DNA. Translation: AAC52780.1. Different initiation.
AK138525 mRNA. Translation: BAE23694.1. Different initiation.
M18169 Genomic DNA. Translation: AAA37846.1. Sequence problems.
CCDSCCDS38149.1.
PIRD29585.
S34164.
S47539.
RefSeqNP_034598.2. NM_010468.2.
UniGeneMm.430708.

3D structure databases

ProteinModelPortalP09027.
SMRP09027. Positions 197-254.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200396. 4 interactions.

PTM databases

PhosphoSiteP09027.

Proteomic databases

PRIDEP09027.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000047830; ENSMUSP00000044809; ENSMUSG00000079277.
ENSMUST00000053932; ENSMUSP00000051355; ENSMUSG00000079277.
ENSMUST00000111982; ENSMUSP00000107613; ENSMUSG00000079277.
ENSMUST00000111983; ENSMUSP00000107614; ENSMUSG00000079277.
GeneID15434.
KEGGmmu:15434.
UCSCuc008kee.1. mouse.

Organism-specific databases

CTD3232.
MGIMGI:96207. Hoxd3.

Phylogenomic databases

eggNOGNOG284589.
HOGENOMHOG000252944.
HOVERGENHBG107984.
InParanoidP09027.
KOK09303.
OMAIFECETR.
OrthoDBEOG754HPS.
PhylomeDBP09027.
TreeFamTF315938.

Gene expression databases

ArrayExpressP09027.
BgeeP09027.
CleanExMM_HOXD3.
GenevestigatorP09027.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288206.
PROP09027.
SOURCESearch...

Entry information

Entry nameHXD3_MOUSE
AccessionPrimary (citable) accession number: P09027
Secondary accession number(s): Q3UUD3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: March 3, 2009
Last modified: July 9, 2014
This is version 136 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries