SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P09027

- HXD3_MOUSE

UniProt

P09027 - HXD3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Homeobox protein Hox-D3

Gene
Hoxd3, Hox-4.1, Hoxd-3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi195 – 25460HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cell-matrix adhesion Source: Ensembl
  2. multicellular organismal development Source: UniProtKB-KW
  3. Notch signaling pathway Source: Ensembl
  4. positive regulation of gene expression Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D3
Alternative name(s):
Homeobox protein Hox-4.1
Homeobox protein MH-19
Gene namesi
Name:Hoxd3
Synonyms:Hox-4.1, Hoxd-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96207. Hoxd3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Homeobox protein Hox-D3PRO_0000200205Add
BLAST

Proteomic databases

PRIDEiP09027.

PTM databases

PhosphoSiteiP09027.

Expressioni

Tissue specificityi

Detected in adult kidney, but not in other adult tissues tested.1 Publication

Developmental stagei

Detected in 12-, 14-, and 17-day-old mouse embryos in the posterior half of the myelencephalon, spinal cord, dorsal root ganglia, first cervical vertebra, thyroid gland, kidney tubules, esophagus, stomach, and intestines.1 Publication

Gene expression databases

ArrayExpressiP09027.
BgeeiP09027.
CleanExiMM_HOXD3.
GenevestigatoriP09027.

Interactioni

Protein-protein interaction databases

BioGridi200396. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP09027.
SMRiP09027. Positions 197-254.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi161 – 1666Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP09027.
KOiK09303.
OMAiIFECETR.
OrthoDBiEOG754HPS.
PhylomeDBiP09027.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09027-1 [UniParc]FASTAAdd to Basket

« Hide

MLFEQGQLTL ELPECTMQKA AYYENPGLFG GYGYSKATDT YGYSTPHQPY    50
PPPAAANSLD SDYPSSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG 100
GGGGNQPPGL NSEQQPPQPP PPPPPTLPPS SPTNPGSGVP AKKTKGGLSA 150
SSSSSTISKQ IFPWMKESRQ NSKQKNSCAT SGENCEDKSP PGPASKRVRT 200
AYTSAQLVEL EKEFHFNRYL CRPRRVEMAN LLNLTERQIK IWFQNRRMKY 250
KKDQKAKGIL HSPAGQSPER SPPLGGAAGH VAYSGQLPPV PGLAYDAPSP 300
PAFAKSQPNM YGLAAYTAPL SSCLPQQKRY PAPEFEPHPM ASNGGGFASA 350
NLQGSPVYVG GNFVDSMAPT SGPVFNLGHL SHPSSASVDY SCAAQIPGNH 400
HHGPCDPHPT YTDLSAHHSS QGRLPEAPKL THL 433
Length:433
Mass (Da):45,976
Last modified:March 3, 2009 - v4
Checksum:i0BA0409A7F32F9E6
GO

Sequence cautioni

The sequence CAA51975.1 differs from that shown. Reason: Frameshift at several positions.
The sequence AAB60683.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAC52779.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAC52780.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAE23694.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871D → N1 Publication
Sequence conflicti187 – 1871D → N in AAA37846. 1 Publication
Sequence conflicti192 – 1921G → D1 Publication
Sequence conflicti192 – 1921G → D in AAA37846. 1 Publication
Sequence conflicti201 – 2011A → T1 Publication
Sequence conflicti201 – 2011A → T in AAA37846. 1 Publication
Sequence conflicti289 – 2891Missing in CAA51975. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03485, U03496 Genomic DNA. Translation: AAB60683.1. Different initiation.
X73573 mRNA. Translation: CAA51975.1. Sequence problems.
L24363 Genomic DNA. Translation: AAA37855.1.
U56400 mRNA. Translation: AAC52779.1. Different initiation.
U56401 Genomic DNA. Translation: AAC52780.1. Different initiation.
AK138525 mRNA. Translation: BAE23694.1. Different initiation.
M18169 Genomic DNA. Translation: AAA37846.1. Sequence problems.
CCDSiCCDS38149.1.
PIRiD29585.
S34164.
S47539.
RefSeqiNP_034598.2. NM_010468.2.
UniGeneiMm.430708.

Genome annotation databases

EnsembliENSMUST00000047830; ENSMUSP00000044809; ENSMUSG00000079277.
ENSMUST00000053932; ENSMUSP00000051355; ENSMUSG00000079277.
ENSMUST00000111982; ENSMUSP00000107613; ENSMUSG00000079277.
ENSMUST00000111983; ENSMUSP00000107614; ENSMUSG00000079277.
GeneIDi15434.
KEGGimmu:15434.
UCSCiuc008kee.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03485 , U03496 Genomic DNA. Translation: AAB60683.1 . Different initiation.
X73573 mRNA. Translation: CAA51975.1 . Sequence problems.
L24363 Genomic DNA. Translation: AAA37855.1 .
U56400 mRNA. Translation: AAC52779.1 . Different initiation.
U56401 Genomic DNA. Translation: AAC52780.1 . Different initiation.
AK138525 mRNA. Translation: BAE23694.1 . Different initiation.
M18169 Genomic DNA. Translation: AAA37846.1 . Sequence problems.
CCDSi CCDS38149.1.
PIRi D29585.
S34164.
S47539.
RefSeqi NP_034598.2. NM_010468.2.
UniGenei Mm.430708.

3D structure databases

ProteinModelPortali P09027.
SMRi P09027. Positions 197-254.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200396. 4 interactions.

PTM databases

PhosphoSitei P09027.

Proteomic databases

PRIDEi P09027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047830 ; ENSMUSP00000044809 ; ENSMUSG00000079277 .
ENSMUST00000053932 ; ENSMUSP00000051355 ; ENSMUSG00000079277 .
ENSMUST00000111982 ; ENSMUSP00000107613 ; ENSMUSG00000079277 .
ENSMUST00000111983 ; ENSMUSP00000107614 ; ENSMUSG00000079277 .
GeneIDi 15434.
KEGGi mmu:15434.
UCSCi uc008kee.1. mouse.

Organism-specific databases

CTDi 3232.
MGIi MGI:96207. Hoxd3.

Phylogenomic databases

eggNOGi NOG284589.
HOGENOMi HOG000252944.
HOVERGENi HBG107984.
InParanoidi P09027.
KOi K09303.
OMAi IFECETR.
OrthoDBi EOG754HPS.
PhylomeDBi P09027.
TreeFami TF315938.

Miscellaneous databases

NextBioi 288206.
PROi P09027.
SOURCEi Search...

Gene expression databases

ArrayExpressi P09027.
Bgeei P09027.
CleanExi MM_HOXD3.
Genevestigatori P09027.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of the murine Hox-D3 (Hox-4.1) gene reveals extensive identity with the human protein."
    Brown W.M., Zhou L., Taylor G.R.
    Biochim. Biophys. Acta 1219:219-222(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the Hoxd-3 gene: structure and localization of its sense and natural antisense transcripts."
    Bedford M., Orr-Urtreger A., Arman E., Lonai P.
    DNA Cell Biol. 14:295-304(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Sequence and expression of the murine Hoxd-3 homeobox gene."
    Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.
    Proc. Natl. Acad. Sci. U.S.A. 93:8247-8252(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: ICR X Swiss Webster.
    Tissue: Liver.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  5. "New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis."
    Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.
    DNA 6:409-418(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 182-303.
  6. Lonai P.
    Submitted (DEC-1987) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-335.

Entry informationi

Entry nameiHXD3_MOUSE
AccessioniPrimary (citable) accession number: P09027
Secondary accession number(s): Q3UUD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: March 3, 2009
Last modified: July 9, 2014
This is version 136 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi