ID   HXB3_MOUSE              Reviewed;         433 AA.
AC   P09026; P10285; Q4PJ06; Q61680;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 4.
DT   24-JAN-2024, entry version 188.
DE   RecName: Full=Homeobox protein Hox-B3;
DE   AltName: Full=Homeobox protein Hox-2.7;
DE   AltName: Full=Homeobox protein MH-23;
GN   Name=Hoxb3; Synonyms=Hox-2.7, Hoxb-3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1582411; DOI=10.1002/j.1460-2075.1992.tb05234.x;
RA   Sham M.H., Hunt P., Nonchev S., Papalopulu N., Graham A., Boncinelli E.,
RA   Krumlauf R.;
RT   "Analysis of the murine Hox-2.7 gene: conserved alternative transcripts
RT   with differential distributions in the nervous system and the potential for
RT   shared regulatory regions.";
RL   EMBO J. 11:1825-1836(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7890121; DOI=10.1016/0020-711x(94)90184-8;
RA   Brown W.M., Taylor G.R.;
RT   "The 5'-sequence of the murine Hox-b3 (Hox-2.7) gene and its intron contain
RT   multiple transcription-regulatory elements.";
RL   Int. J. Biochem. 26:1403-1409(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-361.
RX   PubMed=2890503; DOI=10.1089/dna.1987.6.409;
RA   Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.;
RT   "New murine homeoboxes: structure, chromosomal assignment, and differential
RT   expression in adult erythropoiesis.";
RL   DNA 6:409-418(1987).
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 181-265.
RX   PubMed=2463210; DOI=10.1101/gad.2.11.1424;
RA   Graham A., Papalopulu N., Lorimer J., McVey J.H., Tuddenham E.G.D.,
RA   Krumlauf R.;
RT   "Characterization of a murine homeo box gene, Hox-2.6, related to the
RT   Drosophila Deformed gene.";
RL   Genes Dev. 2:1424-1438(1988).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X66177; CAA46951.1; -; mRNA.
DR   EMBL; S35628; AAA08719.1; -; mRNA.
DR   EMBL; U02278; AAB60496.1; -; Genomic_DNA.
DR   EMBL; M18168; AAA37840.1; -; Genomic_DNA.
DR   CCDS; CCDS25299.1; -.
DR   PIR; S20963; S20963.
DR   RefSeq; NP_001073338.1; NM_001079869.1.
DR   RefSeq; NP_034588.2; NM_010458.2.
DR   RefSeq; XP_006532346.1; XM_006532283.3.
DR   RefSeq; XP_006532347.1; XM_006532284.3.
DR   RefSeq; XP_006532348.1; XM_006532285.3.
DR   RefSeq; XP_006532349.1; XM_006532286.3.
DR   RefSeq; XP_006532351.1; XM_006532288.1.
DR   RefSeq; XP_006532352.1; XM_006532289.3.
DR   RefSeq; XP_006532353.1; XM_006532290.3.
DR   RefSeq; XP_011247059.1; XM_011248757.2.
DR   AlphaFoldDB; P09026; -.
DR   SMR; P09026; -.
DR   STRING; 10090.ENSMUSP00000091476; -.
DR   iPTMnet; P09026; -.
DR   PhosphoSitePlus; P09026; -.
DR   PaxDb; 10090-ENSMUSP00000091476; -.
DR   Antibodypedia; 4079; 162 antibodies from 23 providers.
DR   DNASU; 15410; -.
DR   Ensembl; ENSMUST00000055334.3; ENSMUSP00000053426.3; ENSMUSG00000048763.12.
DR   Ensembl; ENSMUST00000093944.10; ENSMUSP00000091476.4; ENSMUSG00000048763.12.
DR   GeneID; 15410; -.
DR   KEGG; mmu:15410; -.
DR   UCSC; uc007lbw.1; mouse.
DR   AGR; MGI:96184; -.
DR   CTD; 3213; -.
DR   MGI; MGI:96184; Hoxb3.
DR   VEuPathDB; HostDB:ENSMUSG00000048763; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000159774; -.
DR   HOGENOM; CLU_051508_1_0_1; -.
DR   InParanoid; P09026; -.
DR   OMA; GCAAPQK; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P09026; -.
DR   TreeFam; TF315938; -.
DR   BioGRID-ORCS; 15410; 1 hit in 79 CRISPR screens.
DR   ChiTaRS; Hoxb3; mouse.
DR   PRO; PR:P09026; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; P09026; Protein.
DR   Bgee; ENSMUSG00000048763; Expressed in vertebra pre-cartilage condensation and 163 other cell types or tissues.
DR   ExpressionAtlas; P09026; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR   GO; GO:0051216; P:cartilage development; IGI:MGI.
DR   GO; GO:0060216; P:definitive hemopoiesis; IGI:MGI.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
DR   GO; GO:0060324; P:face development; IDA:MGI.
DR   GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IGI:MGI.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0050767; P:regulation of neurogenesis; IDA:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021546; P:rhombomere development; IDA:MGI.
DR   GO; GO:0030878; P:thyroid gland development; IGI:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45664:SF11; HOMEOBOX PROTEIN HOX-B3; 1.
DR   PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P09026; MM.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..433
FT                   /note="Homeobox protein Hox-B3"
FT                   /id="PRO_0000200118"
FT   DNA_BIND        191..250
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          63..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          249..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          389..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           129..134
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        79..94
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..124
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        113
FT                   /note="G -> C (in Ref. 1; CAA46951/AAA08719)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        119
FT                   /note="A -> S (in Ref. 1; CAA46951/AAA08719)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        152..168
FT                   /note="GCGGGGGGGGGGGGGGG -> RLWWWRPAVVAAAAAVR (in Ref. 3;
FT                   AAA37840)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        182
FT                   /note="D -> N (in Ref. 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        216..217
FT                   /note="LC -> FV (in Ref. 3; AAA37840)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        330
FT                   /note="S -> L (in Ref. 3; AAA37840)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        342..361
FT                   /note="GAYGTPTMQGSPVYVGGGGY -> APTGRPPCRAVRCMWAGVAT (in
FT                   Ref. 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   433 AA;  44353 MW;  9AD3C922663612A6 CRC64;
     MQKATYYDNT AAALFGGYSS YPGSNGFGYD GPPQPPFQAA THLEGDYQRS ACSLQSLGNA
     APHAKSKELN GSCMRPGLAP EPLPAPPGSP PPSAAPTSTT SNSNNGGGPS KSGPPKCGAG
     SNSTLTKQIF PWMKESRQTS KLKNSSPGTA EGCGGGGGGG GGGGGGGGGS SGGGGGGGGG
     GDKSPPGSAA SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL SERQIKIWFQ
     NRRMKYKKDQ KAKGLASSSG GPSPAGSPPQ PMQSTAGFMN ALHSMTPSYD SPSPPAFGKG
     HQNAYALPSN YQPPLKGCGA PQKYPPTPAS EYEPHVLQAN GGAYGTPTMQ GSPVYVGGGG
     YADPLPPPAG PSLYGLNHLS HHPSGNLDYN GAAPMGPNQH HGPCDPHPTY TDLSSHHAPP
     QGRIQEAPKL THL
//