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Protein

Homeobox protein Hox-B3

Gene

Hoxb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi191 – 250HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: Ensembl
  • anterior/posterior pattern specification Source: MGI
  • cartilage development Source: MGI
  • definitive hemopoiesis Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • face development Source: MGI
  • glossopharyngeal nerve morphogenesis Source: MGI
  • hematopoietic progenitor cell differentiation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of neurogenesis Source: MGI
  • rhombomere development Source: MGI
  • thyroid gland development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B3
Alternative name(s):
Homeobox protein Hox-2.7
Homeobox protein MH-23
Gene namesi
Name:Hoxb3
Synonyms:Hox-2.7, Hoxb-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96184. Hoxb3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001181 – 433Homeobox protein Hox-B3Add BLAST433

Proteomic databases

PaxDbiP09026.
PRIDEiP09026.

PTM databases

iPTMnetiP09026.
PhosphoSitePlusiP09026.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048763.
CleanExiMM_HOXB3.
ExpressionAtlasiP09026. baseline and differential.
GenevisibleiP09026. MM.

Interactioni

Protein-protein interaction databases

IntActiP09026. 1 interactor.
MINTiMINT-4098214.
STRINGi10090.ENSMUSP00000053426.

Structurei

3D structure databases

ProteinModelPortaliP09026.
SMRiP09026.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi129 – 134Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 181Gly-richAdd BLAST28

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00900000140772.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP09026.
KOiK09303.
OMAiEYEPHVL.
OrthoDBiEOG091G09XD.
PhylomeDBiP09026.
TreeFamiTF315938.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR025281. DUF4074.
IPR009057. Homeobox-like_sf.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P09026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKATYYDNT AAALFGGYSS YPGSNGFGYD GPPQPPFQAA THLEGDYQRS
60 70 80 90 100
ACSLQSLGNA APHAKSKELN GSCMRPGLAP EPLPAPPGSP PPSAAPTSTT
110 120 130 140 150
SNSNNGGGPS KSGPPKCGAG SNSTLTKQIF PWMKESRQTS KLKNSSPGTA
160 170 180 190 200
EGCGGGGGGG GGGGGGGGGS SGGGGGGGGG GDKSPPGSAA SKRARTAYTS
210 220 230 240 250
AQLVELEKEF HFNRYLCRPR RVEMANLLNL SERQIKIWFQ NRRMKYKKDQ
260 270 280 290 300
KAKGLASSSG GPSPAGSPPQ PMQSTAGFMN ALHSMTPSYD SPSPPAFGKG
310 320 330 340 350
HQNAYALPSN YQPPLKGCGA PQKYPPTPAS EYEPHVLQAN GGAYGTPTMQ
360 370 380 390 400
GSPVYVGGGG YADPLPPPAG PSLYGLNHLS HHPSGNLDYN GAAPMGPNQH
410 420 430
HGPCDPHPTY TDLSSHHAPP QGRIQEAPKL THL
Length:433
Mass (Da):44,353
Last modified:October 1, 1996 - v4
Checksum:i9AD3C922663612A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113G → C in CAA46951 (PubMed:1582411).Curated1
Sequence conflicti113G → C in AAA08719 (PubMed:1582411).Curated1
Sequence conflicti119A → S in CAA46951 (PubMed:1582411).Curated1
Sequence conflicti119A → S in AAA08719 (PubMed:1582411).Curated1
Sequence conflicti152 – 168GCGGG…GGGGG → RLWWWRPAVVAAAAAVR in AAA37840 (PubMed:2890503).CuratedAdd BLAST17
Sequence conflicti182D → N (PubMed:2463210).Curated1
Sequence conflicti216 – 217LC → FV in AAA37840 (PubMed:2890503).Curated2
Sequence conflicti330S → L in AAA37840 (PubMed:2890503).Curated1
Sequence conflicti342 – 361GAYGT…GGGGY → APTGRPPCRAVRCMWAGVAT (PubMed:2890503).CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66177 mRNA. Translation: CAA46951.1.
S35628 mRNA. Translation: AAA08719.1.
U02278 Genomic DNA. Translation: AAB60496.1.
M18168 Genomic DNA. Translation: AAA37840.1.
CCDSiCCDS25299.1.
PIRiS20963.
RefSeqiNP_001073338.1. NM_001079869.1.
NP_034588.2. NM_010458.2.
XP_006532346.1. XM_006532283.3.
XP_006532347.1. XM_006532284.3.
XP_006532348.1. XM_006532285.3.
XP_006532349.1. XM_006532286.3.
XP_006532351.1. XM_006532288.1.
XP_006532352.1. XM_006532289.3.
XP_006532353.1. XM_006532290.3.
XP_011247059.1. XM_011248757.2.
UniGeneiMm.342481.

Genome annotation databases

EnsembliENSMUST00000055334; ENSMUSP00000053426; ENSMUSG00000048763.
ENSMUST00000093944; ENSMUSP00000091476; ENSMUSG00000048763.
GeneIDi15410.
KEGGimmu:15410.
UCSCiuc007lbw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiHXB3_MOUSE
AccessioniPrimary (citable) accession number: P09026
Secondary accession number(s): P10285, Q4PJ06, Q61680
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 155 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families