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P09026 (HXB3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B3
Alternative name(s):
Homeobox protein Hox-2.7
Homeobox protein MH-23
Gene names
Name:Hoxb3
Synonyms:Hox-2.7, Hoxb-3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from electronic annotation. Source: Ensembl

anterior/posterior pattern specification

Inferred from genetic interaction PubMed 10885747PubMed 9441667. Source: MGI

cartilage development

Inferred from genetic interaction PubMed 9441667. Source: MGI

definitive hemopoiesis

Inferred from genetic interaction PubMed 17761289. Source: MGI

embryonic skeletal system morphogenesis

Inferred from mutant phenotype PubMed 9441667. Source: MGI

face development

Inferred from direct assay PubMed 21320481. Source: MGI

glossopharyngeal nerve morphogenesis

Inferred from genetic interaction PubMed 9441667. Source: MGI

hematopoietic progenitor cell differentiation

Inferred from mutant phenotype PubMed 24029230. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 21320481. Source: MGI

regulation of neurogenesis

Inferred from direct assay PubMed 21320481. Source: MGI

rhombomere development

Inferred from direct assay PubMed 21320481. Source: MGI

thyroid gland development

Inferred from genetic interaction PubMed 9520319. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA polymerase II core promoter sequence-specific DNA binding

Inferred from direct assay PubMed 21320481. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Homeobox protein Hox-B3
PRO_0000200118

Regions

DNA binding191 – 25060Homeobox
Motif129 – 1346Antp-type hexapeptide
Compositional bias154 – 18128Gly-rich

Experimental info

Sequence conflict1131G → C in CAA46951. Ref.1
Sequence conflict1131G → C in AAA08719. Ref.1
Sequence conflict1191A → S in CAA46951. Ref.1
Sequence conflict1191A → S in AAA08719. Ref.1
Sequence conflict152 – 16817GCGGG…GGGGG → RLWWWRPAVVAAAAAVR in AAA37840. Ref.3
Sequence conflict1821D → N Ref.4
Sequence conflict216 – 2172LC → FV in AAA37840. Ref.3
Sequence conflict3301S → L in AAA37840. Ref.3
Sequence conflict342 – 36120GAYGT…GGGGY → APTGRPPCRAVRCMWAGVAT Ref.3

Sequences

Sequence LengthMass (Da)Tools
P09026 [UniParc].

Last modified October 1, 1996. Version 4.
Checksum: 9AD3C922663612A6

FASTA43344,353
        10         20         30         40         50         60 
MQKATYYDNT AAALFGGYSS YPGSNGFGYD GPPQPPFQAA THLEGDYQRS ACSLQSLGNA 

        70         80         90        100        110        120 
APHAKSKELN GSCMRPGLAP EPLPAPPGSP PPSAAPTSTT SNSNNGGGPS KSGPPKCGAG 

       130        140        150        160        170        180 
SNSTLTKQIF PWMKESRQTS KLKNSSPGTA EGCGGGGGGG GGGGGGGGGS SGGGGGGGGG 

       190        200        210        220        230        240 
GDKSPPGSAA SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL SERQIKIWFQ 

       250        260        270        280        290        300 
NRRMKYKKDQ KAKGLASSSG GPSPAGSPPQ PMQSTAGFMN ALHSMTPSYD SPSPPAFGKG 

       310        320        330        340        350        360 
HQNAYALPSN YQPPLKGCGA PQKYPPTPAS EYEPHVLQAN GGAYGTPTMQ GSPVYVGGGG 

       370        380        390        400        410        420 
YADPLPPPAG PSLYGLNHLS HHPSGNLDYN GAAPMGPNQH HGPCDPHPTY TDLSSHHAPP 

       430 
QGRIQEAPKL THL 

« Hide

References

[1]"Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions."
Sham M.H., Hunt P., Nonchev S., Papalopulu N., Graham A., Boncinelli E., Krumlauf R.
EMBO J. 11:1825-1836(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The 5'-sequence of the murine Hox-b3 (Hox-2.7) gene and its intron contain multiple transcription-regulatory elements."
Brown W.M., Taylor G.R.
Int. J. Biochem. 26:1403-1409(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis."
Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.
DNA 6:409-418(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-361.
[4]"Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene."
Graham A., Papalopulu N., Lorimer J., McVey J.H., Tuddenham E.G.D., Krumlauf R.
Genes Dev. 2:1424-1438(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 181-265.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X66177 mRNA. Translation: CAA46951.1.
S35628 mRNA. Translation: AAA08719.1.
U02278 Genomic DNA. Translation: AAB60496.1.
M18168 Genomic DNA. Translation: AAA37840.1.
CCDSCCDS25299.1.
PIRS20963.
RefSeqNP_001073338.1. NM_001079869.1.
NP_034588.2. NM_010458.2.
XP_006532344.1. XM_006532281.1.
XP_006532345.1. XM_006532282.1.
XP_006532346.1. XM_006532283.1.
XP_006532347.1. XM_006532284.1.
XP_006532348.1. XM_006532285.1.
XP_006532349.1. XM_006532286.1.
XP_006532350.1. XM_006532287.1.
XP_006532351.1. XM_006532288.1.
XP_006532352.1. XM_006532289.1.
XP_006532353.1. XM_006532290.1.
UniGeneMm.342481.

3D structure databases

ProteinModelPortalP09026.
SMRP09026. Positions 193-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP09026. 1 interaction.
MINTMINT-4098214.
STRING10090.ENSMUSP00000091476.

Proteomic databases

PaxDbP09026.
PRIDEP09026.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055334; ENSMUSP00000053426; ENSMUSG00000048763.
ENSMUST00000093944; ENSMUSP00000091476; ENSMUSG00000048763.
GeneID15410.
KEGGmmu:15410.
UCSCuc007lbw.1. mouse.

Organism-specific databases

CTD3213.
MGIMGI:96184. Hoxb3.

Phylogenomic databases

eggNOGNOG284589.
GeneTreeENSGT00750000117486.
HOGENOMHOG000252944.
HOVERGENHBG107984.
InParanoidP09026.
KOK09303.
OMAATYYDNT.
OrthoDBEOG754HPS.
PhylomeDBP09026.
TreeFamTF315938.

Gene expression databases

BgeeP09026.
CleanExMM_HOXB3.
GenevestigatorP09026.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288128.
PROP09026.
SOURCESearch...

Entry information

Entry nameHXB3_MOUSE
AccessionPrimary (citable) accession number: P09026
Secondary accession number(s): P10285, Q4PJ06, Q61680
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 135 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries