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Protein

Homeobox protein Hox-B3

Gene

Hoxb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi191 – 25060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. anterior/posterior pattern specification Source: MGI
  3. cartilage development Source: MGI
  4. definitive hemopoiesis Source: MGI
  5. embryonic skeletal system morphogenesis Source: MGI
  6. face development Source: MGI
  7. glossopharyngeal nerve morphogenesis Source: MGI
  8. hematopoietic progenitor cell differentiation Source: MGI
  9. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  10. regulation of neurogenesis Source: MGI
  11. rhombomere development Source: MGI
  12. thyroid gland development Source: MGI
  13. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B3
Alternative name(s):
Homeobox protein Hox-2.7
Homeobox protein MH-23
Gene namesi
Name:Hoxb3
Synonyms:Hox-2.7, Hoxb-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96184. Hoxb3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Homeobox protein Hox-B3PRO_0000200118Add
BLAST

Proteomic databases

PaxDbiP09026.
PRIDEiP09026.

Expressioni

Gene expression databases

BgeeiP09026.
CleanExiMM_HOXB3.
GenevestigatoriP09026.

Interactioni

Protein-protein interaction databases

IntActiP09026. 1 interaction.
MINTiMINT-4098214.
STRINGi10090.ENSMUSP00000091476.

Structurei

3D structure databases

ProteinModelPortaliP09026.
SMRiP09026. Positions 193-250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi129 – 1346Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi154 – 18128Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP09026.
KOiK09303.
OMAiEYEPHVL.
OrthoDBiEOG754HPS.
PhylomeDBiP09026.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09026-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKATYYDNT AAALFGGYSS YPGSNGFGYD GPPQPPFQAA THLEGDYQRS
60 70 80 90 100
ACSLQSLGNA APHAKSKELN GSCMRPGLAP EPLPAPPGSP PPSAAPTSTT
110 120 130 140 150
SNSNNGGGPS KSGPPKCGAG SNSTLTKQIF PWMKESRQTS KLKNSSPGTA
160 170 180 190 200
EGCGGGGGGG GGGGGGGGGS SGGGGGGGGG GDKSPPGSAA SKRARTAYTS
210 220 230 240 250
AQLVELEKEF HFNRYLCRPR RVEMANLLNL SERQIKIWFQ NRRMKYKKDQ
260 270 280 290 300
KAKGLASSSG GPSPAGSPPQ PMQSTAGFMN ALHSMTPSYD SPSPPAFGKG
310 320 330 340 350
HQNAYALPSN YQPPLKGCGA PQKYPPTPAS EYEPHVLQAN GGAYGTPTMQ
360 370 380 390 400
GSPVYVGGGG YADPLPPPAG PSLYGLNHLS HHPSGNLDYN GAAPMGPNQH
410 420 430
HGPCDPHPTY TDLSSHHAPP QGRIQEAPKL THL
Length:433
Mass (Da):44,353
Last modified:October 1, 1996 - v4
Checksum:i9AD3C922663612A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131G → C in CAA46951. (PubMed:1582411)Curated
Sequence conflicti113 – 1131G → C in AAA08719. (PubMed:1582411)Curated
Sequence conflicti119 – 1191A → S in CAA46951. (PubMed:1582411)Curated
Sequence conflicti119 – 1191A → S in AAA08719. (PubMed:1582411)Curated
Sequence conflicti152 – 16817GCGGG…GGGGG → RLWWWRPAVVAAAAAVR in AAA37840. (PubMed:2890503)CuratedAdd
BLAST
Sequence conflicti182 – 1821D → N(PubMed:2463210)Curated
Sequence conflicti216 – 2172LC → FV in AAA37840. (PubMed:2890503)Curated
Sequence conflicti330 – 3301S → L in AAA37840. (PubMed:2890503)Curated
Sequence conflicti342 – 36120GAYGT…GGGGY → APTGRPPCRAVRCMWAGVAT(PubMed:2890503)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66177 mRNA. Translation: CAA46951.1.
S35628 mRNA. Translation: AAA08719.1.
U02278 Genomic DNA. Translation: AAB60496.1.
M18168 Genomic DNA. Translation: AAA37840.1.
CCDSiCCDS25299.1.
PIRiS20963.
RefSeqiNP_001073338.1. NM_001079869.1.
NP_034588.2. NM_010458.2.
XP_006532344.1. XM_006532281.1.
XP_006532345.1. XM_006532282.1.
XP_006532346.1. XM_006532283.1.
XP_006532347.1. XM_006532284.1.
XP_006532348.1. XM_006532285.1.
XP_006532349.1. XM_006532286.1.
XP_006532350.1. XM_006532287.1.
XP_006532351.1. XM_006532288.1.
XP_006532352.1. XM_006532289.1.
XP_006532353.1. XM_006532290.1.
UniGeneiMm.342481.

Genome annotation databases

EnsembliENSMUST00000055334; ENSMUSP00000053426; ENSMUSG00000048763.
ENSMUST00000093944; ENSMUSP00000091476; ENSMUSG00000048763.
GeneIDi15410.
KEGGimmu:15410.
UCSCiuc007lbw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66177 mRNA. Translation: CAA46951.1.
S35628 mRNA. Translation: AAA08719.1.
U02278 Genomic DNA. Translation: AAB60496.1.
M18168 Genomic DNA. Translation: AAA37840.1.
CCDSiCCDS25299.1.
PIRiS20963.
RefSeqiNP_001073338.1. NM_001079869.1.
NP_034588.2. NM_010458.2.
XP_006532344.1. XM_006532281.1.
XP_006532345.1. XM_006532282.1.
XP_006532346.1. XM_006532283.1.
XP_006532347.1. XM_006532284.1.
XP_006532348.1. XM_006532285.1.
XP_006532349.1. XM_006532286.1.
XP_006532350.1. XM_006532287.1.
XP_006532351.1. XM_006532288.1.
XP_006532352.1. XM_006532289.1.
XP_006532353.1. XM_006532290.1.
UniGeneiMm.342481.

3D structure databases

ProteinModelPortaliP09026.
SMRiP09026. Positions 193-250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP09026. 1 interaction.
MINTiMINT-4098214.
STRINGi10090.ENSMUSP00000091476.

Proteomic databases

PaxDbiP09026.
PRIDEiP09026.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055334; ENSMUSP00000053426; ENSMUSG00000048763.
ENSMUST00000093944; ENSMUSP00000091476; ENSMUSG00000048763.
GeneIDi15410.
KEGGimmu:15410.
UCSCiuc007lbw.1. mouse.

Organism-specific databases

CTDi3213.
MGIiMGI:96184. Hoxb3.

Phylogenomic databases

eggNOGiNOG284589.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP09026.
KOiK09303.
OMAiEYEPHVL.
OrthoDBiEOG754HPS.
PhylomeDBiP09026.
TreeFamiTF315938.

Miscellaneous databases

NextBioi288128.
PROiP09026.
SOURCEiSearch...

Gene expression databases

BgeeiP09026.
CleanExiMM_HOXB3.
GenevestigatoriP09026.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions."
    Sham M.H., Hunt P., Nonchev S., Papalopulu N., Graham A., Boncinelli E., Krumlauf R.
    EMBO J. 11:1825-1836(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The 5'-sequence of the murine Hox-b3 (Hox-2.7) gene and its intron contain multiple transcription-regulatory elements."
    Brown W.M., Taylor G.R.
    Int. J. Biochem. 26:1403-1409(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis."
    Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.
    DNA 6:409-418(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-361.
  4. "Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene."
    Graham A., Papalopulu N., Lorimer J., McVey J.H., Tuddenham E.G.D., Krumlauf R.
    Genes Dev. 2:1424-1438(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 181-265.

Entry informationi

Entry nameiHXB3_MOUSE
AccessioniPrimary (citable) accession number: P09026
Secondary accession number(s): P10285, Q4PJ06, Q61680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 138 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.