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P09026

- HXB3_MOUSE

UniProt

P09026 - HXB3_MOUSE

Protein

Homeobox protein Hox-B3

Gene

Hoxb3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 4 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi191 – 25060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. anterior/posterior pattern specification Source: MGI
    3. cartilage development Source: MGI
    4. definitive hemopoiesis Source: MGI
    5. embryonic skeletal system morphogenesis Source: MGI
    6. face development Source: MGI
    7. glossopharyngeal nerve morphogenesis Source: MGI
    8. hematopoietic progenitor cell differentiation Source: MGI
    9. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    10. regulation of neurogenesis Source: MGI
    11. rhombomere development Source: MGI
    12. thyroid gland development Source: MGI
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B3
    Alternative name(s):
    Homeobox protein Hox-2.7
    Homeobox protein MH-23
    Gene namesi
    Name:Hoxb3
    Synonyms:Hox-2.7, Hoxb-3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96184. Hoxb3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Homeobox protein Hox-B3PRO_0000200118Add
    BLAST

    Proteomic databases

    PaxDbiP09026.
    PRIDEiP09026.

    Expressioni

    Gene expression databases

    BgeeiP09026.
    CleanExiMM_HOXB3.
    GenevestigatoriP09026.

    Interactioni

    Protein-protein interaction databases

    IntActiP09026. 1 interaction.
    MINTiMINT-4098214.
    STRINGi10090.ENSMUSP00000091476.

    Structurei

    3D structure databases

    ProteinModelPortaliP09026.
    SMRiP09026. Positions 193-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi129 – 1346Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi154 – 18128Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG284589.
    GeneTreeiENSGT00750000117486.
    HOGENOMiHOG000252944.
    HOVERGENiHBG107984.
    InParanoidiP09026.
    KOiK09303.
    OMAiATYYDNT.
    OrthoDBiEOG754HPS.
    PhylomeDBiP09026.
    TreeFamiTF315938.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09026-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKATYYDNT AAALFGGYSS YPGSNGFGYD GPPQPPFQAA THLEGDYQRS    50
    ACSLQSLGNA APHAKSKELN GSCMRPGLAP EPLPAPPGSP PPSAAPTSTT 100
    SNSNNGGGPS KSGPPKCGAG SNSTLTKQIF PWMKESRQTS KLKNSSPGTA 150
    EGCGGGGGGG GGGGGGGGGS SGGGGGGGGG GDKSPPGSAA SKRARTAYTS 200
    AQLVELEKEF HFNRYLCRPR RVEMANLLNL SERQIKIWFQ NRRMKYKKDQ 250
    KAKGLASSSG GPSPAGSPPQ PMQSTAGFMN ALHSMTPSYD SPSPPAFGKG 300
    HQNAYALPSN YQPPLKGCGA PQKYPPTPAS EYEPHVLQAN GGAYGTPTMQ 350
    GSPVYVGGGG YADPLPPPAG PSLYGLNHLS HHPSGNLDYN GAAPMGPNQH 400
    HGPCDPHPTY TDLSSHHAPP QGRIQEAPKL THL 433
    Length:433
    Mass (Da):44,353
    Last modified:October 1, 1996 - v4
    Checksum:i9AD3C922663612A6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti113 – 1131G → C in CAA46951. (PubMed:1582411)Curated
    Sequence conflicti113 – 1131G → C in AAA08719. (PubMed:1582411)Curated
    Sequence conflicti119 – 1191A → S in CAA46951. (PubMed:1582411)Curated
    Sequence conflicti119 – 1191A → S in AAA08719. (PubMed:1582411)Curated
    Sequence conflicti152 – 16817GCGGG…GGGGG → RLWWWRPAVVAAAAAVR in AAA37840. (PubMed:2890503)CuratedAdd
    BLAST
    Sequence conflicti182 – 1821D → N(PubMed:2463210)Curated
    Sequence conflicti216 – 2172LC → FV in AAA37840. (PubMed:2890503)Curated
    Sequence conflicti330 – 3301S → L in AAA37840. (PubMed:2890503)Curated
    Sequence conflicti342 – 36120GAYGT…GGGGY → APTGRPPCRAVRCMWAGVAT(PubMed:2890503)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66177 mRNA. Translation: CAA46951.1.
    S35628 mRNA. Translation: AAA08719.1.
    U02278 Genomic DNA. Translation: AAB60496.1.
    M18168 Genomic DNA. Translation: AAA37840.1.
    CCDSiCCDS25299.1.
    PIRiS20963.
    RefSeqiNP_001073338.1. NM_001079869.1.
    NP_034588.2. NM_010458.2.
    XP_006532344.1. XM_006532281.1.
    XP_006532345.1. XM_006532282.1.
    XP_006532346.1. XM_006532283.1.
    XP_006532347.1. XM_006532284.1.
    XP_006532348.1. XM_006532285.1.
    XP_006532349.1. XM_006532286.1.
    XP_006532350.1. XM_006532287.1.
    XP_006532351.1. XM_006532288.1.
    XP_006532352.1. XM_006532289.1.
    XP_006532353.1. XM_006532290.1.
    UniGeneiMm.342481.

    Genome annotation databases

    EnsembliENSMUST00000055334; ENSMUSP00000053426; ENSMUSG00000048763.
    ENSMUST00000093944; ENSMUSP00000091476; ENSMUSG00000048763.
    GeneIDi15410.
    KEGGimmu:15410.
    UCSCiuc007lbw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66177 mRNA. Translation: CAA46951.1 .
    S35628 mRNA. Translation: AAA08719.1 .
    U02278 Genomic DNA. Translation: AAB60496.1 .
    M18168 Genomic DNA. Translation: AAA37840.1 .
    CCDSi CCDS25299.1.
    PIRi S20963.
    RefSeqi NP_001073338.1. NM_001079869.1.
    NP_034588.2. NM_010458.2.
    XP_006532344.1. XM_006532281.1.
    XP_006532345.1. XM_006532282.1.
    XP_006532346.1. XM_006532283.1.
    XP_006532347.1. XM_006532284.1.
    XP_006532348.1. XM_006532285.1.
    XP_006532349.1. XM_006532286.1.
    XP_006532350.1. XM_006532287.1.
    XP_006532351.1. XM_006532288.1.
    XP_006532352.1. XM_006532289.1.
    XP_006532353.1. XM_006532290.1.
    UniGenei Mm.342481.

    3D structure databases

    ProteinModelPortali P09026.
    SMRi P09026. Positions 193-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P09026. 1 interaction.
    MINTi MINT-4098214.
    STRINGi 10090.ENSMUSP00000091476.

    Proteomic databases

    PaxDbi P09026.
    PRIDEi P09026.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055334 ; ENSMUSP00000053426 ; ENSMUSG00000048763 .
    ENSMUST00000093944 ; ENSMUSP00000091476 ; ENSMUSG00000048763 .
    GeneIDi 15410.
    KEGGi mmu:15410.
    UCSCi uc007lbw.1. mouse.

    Organism-specific databases

    CTDi 3213.
    MGIi MGI:96184. Hoxb3.

    Phylogenomic databases

    eggNOGi NOG284589.
    GeneTreei ENSGT00750000117486.
    HOGENOMi HOG000252944.
    HOVERGENi HBG107984.
    InParanoidi P09026.
    KOi K09303.
    OMAi ATYYDNT.
    OrthoDBi EOG754HPS.
    PhylomeDBi P09026.
    TreeFami TF315938.

    Miscellaneous databases

    NextBioi 288128.
    PROi P09026.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09026.
    CleanExi MM_HOXB3.
    Genevestigatori P09026.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions."
      Sham M.H., Hunt P., Nonchev S., Papalopulu N., Graham A., Boncinelli E., Krumlauf R.
      EMBO J. 11:1825-1836(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The 5'-sequence of the murine Hox-b3 (Hox-2.7) gene and its intron contain multiple transcription-regulatory elements."
      Brown W.M., Taylor G.R.
      Int. J. Biochem. 26:1403-1409(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis."
      Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.
      DNA 6:409-418(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-361.
    4. "Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene."
      Graham A., Papalopulu N., Lorimer J., McVey J.H., Tuddenham E.G.D., Krumlauf R.
      Genes Dev. 2:1424-1438(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 181-265.

    Entry informationi

    Entry nameiHXB3_MOUSE
    AccessioniPrimary (citable) accession number: P09026
    Secondary accession number(s): P10285, Q4PJ06, Q61680
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 136 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3