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P09025

- HXC8_MOUSE

UniProt

P09025 - HXC8_MOUSE

Protein

Homeobox protein Hox-C8

Gene

Hoxc8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi149 – 20860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    3. neuron differentiation Source: MGI
    4. skeletal system morphogenesis Source: MGI
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C8
    Alternative name(s):
    Homeobox protein Hox-3.1
    Homeobox protein M31
    Gene namesi
    Name:Hoxc8
    Synonyms:Hox-3.1, Hoxc-8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:96198. Hoxc8.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242Homeobox protein Hox-C8PRO_0000200181Add
    BLAST

    Proteomic databases

    PRIDEiP09025.

    PTM databases

    PhosphoSiteiP09025.

    Expressioni

    Developmental stagei

    Initially found in all tissues of the posterior region in 8.5 and 9.5 dpc. Embryos, it eventually become specifically located in neural tissue.

    Gene expression databases

    BgeeiP09025.
    CleanExiMM_HOXC8.
    GenevestigatoriP09025.

    Interactioni

    Subunit structurei

    Interacts with HOMEZ.By similarity

    Protein-protein interaction databases

    BioGridi200389. 2 interactions.
    IntActiP09025. 1 interaction.
    MINTiMINT-210049.

    Structurei

    3D structure databases

    ProteinModelPortaliP09025.
    SMRiP09025. Positions 153-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi138 – 1436Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314669.
    GeneTreeiENSGT00730000110212.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP09025.
    KOiK09308.
    OMAiHHGTSSI.
    OrthoDBiEOG780RP4.
    PhylomeDBiP09025.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09025-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFVNPLF SKYKGGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ    50
    HASHHVQDFF HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY 100
    GAQQEASVVQ YPDCKSSANT NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR 150
    SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALGLTE RQVKIWFQNR 200
    RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN KD 242
    Length:242
    Mass (Da):27,740
    Last modified:July 1, 1989 - v2
    Checksum:i4A2A53BDA4CFA878
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511S → T in CAA27294. (PubMed:3007994)Curated
    Sequence conflicti181 – 1811E → Q in CAA27294. (PubMed:3007994)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07439 mRNA. Translation: CAA30319.1.
    X07646 mRNA. Translation: CAA30486.1.
    M35603 Genomic DNA. Translation: AAA37857.1.
    X03659 Genomic DNA. Translation: CAA27294.1. Sequence problems.
    CCDSiCCDS27894.1.
    PIRiB25180. A25180.
    B36023. WJMSX3.
    S13785.
    RefSeqiNP_034596.1. NM_010466.2.
    UniGeneiMm.6167.

    Genome annotation databases

    EnsembliENSMUST00000001703; ENSMUSP00000001703; ENSMUSG00000001657.
    GeneIDi15426.
    KEGGimmu:15426.
    UCSCiuc012aaf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07439 mRNA. Translation: CAA30319.1 .
    X07646 mRNA. Translation: CAA30486.1 .
    M35603 Genomic DNA. Translation: AAA37857.1 .
    X03659 Genomic DNA. Translation: CAA27294.1 . Sequence problems.
    CCDSi CCDS27894.1.
    PIRi B25180. A25180.
    B36023. WJMSX3.
    S13785.
    RefSeqi NP_034596.1. NM_010466.2.
    UniGenei Mm.6167.

    3D structure databases

    ProteinModelPortali P09025.
    SMRi P09025. Positions 153-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200389. 2 interactions.
    IntActi P09025. 1 interaction.
    MINTi MINT-210049.

    PTM databases

    PhosphoSitei P09025.

    Proteomic databases

    PRIDEi P09025.

    Protocols and materials databases

    DNASUi 15426.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001703 ; ENSMUSP00000001703 ; ENSMUSG00000001657 .
    GeneIDi 15426.
    KEGGi mmu:15426.
    UCSCi uc012aaf.1. mouse.

    Organism-specific databases

    CTDi 3224.
    MGIi MGI:96198. Hoxc8.

    Phylogenomic databases

    eggNOGi NOG314669.
    GeneTreei ENSGT00730000110212.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P09025.
    KOi K09308.
    OMAi HHGTSSI.
    OrthoDBi EOG780RP4.
    PhylomeDBi P09025.
    TreeFami TF316310.

    Miscellaneous databases

    NextBioi 288178.
    PROi P09025.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09025.
    CleanExi MM_HOXC8.
    Genevestigatori P09025.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pattern of transcription of the homeo gene Hox-3.1 in the mouse embryo."
      le Mouellic H., Condamine H., Brulet P.
      Genes Dev. 2:125-135(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster."
      Breier G., Dressler G.R., Gruss P.
      EMBO J. 7:1329-1336(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox-3.1 intergenic region."
      Awgulewitsch A., Bieberich C., Bogarad L., Shashikant C., Ruddle F.H.
      Proc. Natl. Acad. Sci. U.S.A. 87:6428-6432(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CD-1.
    4. "Spatial restriction in expression of a mouse homoeo box locus within the central nervous system."
      Awgulewitsch A., Utset M.F., Hart C.P., McGinnis W., Ruddle F.H.
      Nature 320:328-335(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-216.
    5. "Sequential expression of murine homeo box genes during F9 EC cell differentiation."
      Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P.
      EMBO J. 5:2209-2215(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 149-215.

    Entry informationi

    Entry nameiHXC8_MOUSE
    AccessioniPrimary (citable) accession number: P09025
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3