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P09025

- HXC8_MOUSE

UniProt

P09025 - HXC8_MOUSE

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Protein

Homeobox protein Hox-C8

Gene

Hoxc8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi149 – 20860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  3. neuron differentiation Source: MGI
  4. skeletal system morphogenesis Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C8
Alternative name(s):
Homeobox protein Hox-3.1
Homeobox protein M31
Gene namesi
Name:Hoxc8
Synonyms:Hox-3.1, Hoxc-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:96198. Hoxc8.

Subcellular locationi

GO - Cellular componenti

  1. microtubule cytoskeleton Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Homeobox protein Hox-C8PRO_0000200181Add
BLAST

Proteomic databases

MaxQBiP09025.
PRIDEiP09025.

PTM databases

PhosphoSiteiP09025.

Expressioni

Developmental stagei

Initially found in all tissues of the posterior region in 8.5 and 9.5 dpc. Embryos, it eventually become specifically located in neural tissue.

Gene expression databases

BgeeiP09025.
CleanExiMM_HOXC8.
ExpressionAtlasiP09025. baseline and differential.
GenevestigatoriP09025.

Interactioni

Subunit structurei

Interacts with HOMEZ.By similarity

Protein-protein interaction databases

BioGridi200389. 2 interactions.
IntActiP09025. 1 interaction.
MINTiMINT-210049.

Structurei

3D structure databases

ProteinModelPortaliP09025.
SMRiP09025. Positions 153-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi138 – 1436Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09025.
KOiK09308.
OMAiHHGTSSI.
OrthoDBiEOG780RP4.
PhylomeDBiP09025.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09025-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSYFVNPLF SKYKGGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ
60 70 80 90 100
HASHHVQDFF HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY
110 120 130 140 150
GAQQEASVVQ YPDCKSSANT NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR
160 170 180 190 200
SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALGLTE RQVKIWFQNR
210 220 230 240
RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN KD
Length:242
Mass (Da):27,740
Last modified:July 1, 1989 - v2
Checksum:i4A2A53BDA4CFA878
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511S → T in CAA27294. (PubMed:3007994)Curated
Sequence conflicti181 – 1811E → Q in CAA27294. (PubMed:3007994)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07439 mRNA. Translation: CAA30319.1.
X07646 mRNA. Translation: CAA30486.1.
M35603 Genomic DNA. Translation: AAA37857.1.
X03659 Genomic DNA. Translation: CAA27294.1. Sequence problems.
CCDSiCCDS27894.1.
PIRiB25180. A25180.
B36023. WJMSX3.
S13785.
RefSeqiNP_034596.1. NM_010466.2.
UniGeneiMm.6167.

Genome annotation databases

EnsembliENSMUST00000001703; ENSMUSP00000001703; ENSMUSG00000001657.
GeneIDi15426.
KEGGimmu:15426.
UCSCiuc012aaf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07439 mRNA. Translation: CAA30319.1 .
X07646 mRNA. Translation: CAA30486.1 .
M35603 Genomic DNA. Translation: AAA37857.1 .
X03659 Genomic DNA. Translation: CAA27294.1 . Sequence problems.
CCDSi CCDS27894.1.
PIRi B25180. A25180.
B36023. WJMSX3.
S13785.
RefSeqi NP_034596.1. NM_010466.2.
UniGenei Mm.6167.

3D structure databases

ProteinModelPortali P09025.
SMRi P09025. Positions 153-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200389. 2 interactions.
IntActi P09025. 1 interaction.
MINTi MINT-210049.

PTM databases

PhosphoSitei P09025.

Proteomic databases

MaxQBi P09025.
PRIDEi P09025.

Protocols and materials databases

DNASUi 15426.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001703 ; ENSMUSP00000001703 ; ENSMUSG00000001657 .
GeneIDi 15426.
KEGGi mmu:15426.
UCSCi uc012aaf.1. mouse.

Organism-specific databases

CTDi 3224.
MGIi MGI:96198. Hoxc8.

Phylogenomic databases

eggNOGi NOG314669.
GeneTreei ENSGT00760000118945.
HOGENOMi HOG000231181.
HOVERGENi HBG016849.
InParanoidi P09025.
KOi K09308.
OMAi HHGTSSI.
OrthoDBi EOG780RP4.
PhylomeDBi P09025.
TreeFami TF316310.

Miscellaneous databases

NextBioi 288178.
PROi P09025.
SOURCEi Search...

Gene expression databases

Bgeei P09025.
CleanExi MM_HOXC8.
ExpressionAtlasi P09025. baseline and differential.
Genevestigatori P09025.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Pattern of transcription of the homeo gene Hox-3.1 in the mouse embryo."
    le Mouellic H., Condamine H., Brulet P.
    Genes Dev. 2:125-135(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster."
    Breier G., Dressler G.R., Gruss P.
    EMBO J. 7:1329-1336(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox-3.1 intergenic region."
    Awgulewitsch A., Bieberich C., Bogarad L., Shashikant C., Ruddle F.H.
    Proc. Natl. Acad. Sci. U.S.A. 87:6428-6432(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CD-1.
  4. "Spatial restriction in expression of a mouse homoeo box locus within the central nervous system."
    Awgulewitsch A., Utset M.F., Hart C.P., McGinnis W., Ruddle F.H.
    Nature 320:328-335(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-216.
  5. "Sequential expression of murine homeo box genes during F9 EC cell differentiation."
    Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P.
    EMBO J. 5:2209-2215(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 149-215.

Entry informationi

Entry nameiHXC8_MOUSE
AccessioniPrimary (citable) accession number: P09025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3