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Protein

Homeobox protein Hox-C8

Gene

Hoxc8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi149 – 20860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  3. neuron differentiation Source: MGI
  4. skeletal system morphogenesis Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C8
Alternative name(s):
Homeobox protein Hox-3.1
Homeobox protein M31
Gene namesi
Name:Hoxc8
Synonyms:Hox-3.1, Hoxc-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96198. Hoxc8.

Subcellular locationi

GO - Cellular componenti

  1. microtubule cytoskeleton Source: MGI
  2. nucleoplasm Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Homeobox protein Hox-C8PRO_0000200181Add
BLAST

Proteomic databases

MaxQBiP09025.
PRIDEiP09025.

PTM databases

PhosphoSiteiP09025.

Expressioni

Developmental stagei

Initially found in all tissues of the posterior region in 8.5 and 9.5 dpc. Embryos, it eventually become specifically located in neural tissue.

Gene expression databases

BgeeiP09025.
CleanExiMM_HOXC8.
ExpressionAtlasiP09025. baseline and differential.
GenevestigatoriP09025.

Interactioni

Subunit structurei

Interacts with HOMEZ.By similarity

Protein-protein interaction databases

BioGridi200389. 2 interactions.
IntActiP09025. 1 interaction.
MINTiMINT-210049.

Structurei

3D structure databases

ProteinModelPortaliP09025.
SMRiP09025. Positions 153-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi138 – 1436Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09025.
KOiK09308.
OMAiHHGTSSI.
OrthoDBiEOG780RP4.
PhylomeDBiP09025.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNPLF SKYKGGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ
60 70 80 90 100
HASHHVQDFF HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY
110 120 130 140 150
GAQQEASVVQ YPDCKSSANT NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR
160 170 180 190 200
SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALGLTE RQVKIWFQNR
210 220 230 240
RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN KD
Length:242
Mass (Da):27,740
Last modified:July 1, 1989 - v2
Checksum:i4A2A53BDA4CFA878
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511S → T in CAA27294 (PubMed:3007994).Curated
Sequence conflicti181 – 1811E → Q in CAA27294 (PubMed:3007994).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07439 mRNA. Translation: CAA30319.1.
X07646 mRNA. Translation: CAA30486.1.
M35603 Genomic DNA. Translation: AAA37857.1.
X03659 Genomic DNA. Translation: CAA27294.1. Sequence problems.
CCDSiCCDS27894.1.
PIRiB25180. A25180.
B36023. WJMSX3.
S13785.
RefSeqiNP_034596.1. NM_010466.2.
UniGeneiMm.6167.

Genome annotation databases

EnsembliENSMUST00000001703; ENSMUSP00000001703; ENSMUSG00000001657.
GeneIDi15426.
KEGGimmu:15426.
UCSCiuc012aaf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07439 mRNA. Translation: CAA30319.1.
X07646 mRNA. Translation: CAA30486.1.
M35603 Genomic DNA. Translation: AAA37857.1.
X03659 Genomic DNA. Translation: CAA27294.1. Sequence problems.
CCDSiCCDS27894.1.
PIRiB25180. A25180.
B36023. WJMSX3.
S13785.
RefSeqiNP_034596.1. NM_010466.2.
UniGeneiMm.6167.

3D structure databases

ProteinModelPortaliP09025.
SMRiP09025. Positions 153-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200389. 2 interactions.
IntActiP09025. 1 interaction.
MINTiMINT-210049.

PTM databases

PhosphoSiteiP09025.

Proteomic databases

MaxQBiP09025.
PRIDEiP09025.

Protocols and materials databases

DNASUi15426.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001703; ENSMUSP00000001703; ENSMUSG00000001657.
GeneIDi15426.
KEGGimmu:15426.
UCSCiuc012aaf.1. mouse.

Organism-specific databases

CTDi3224.
MGIiMGI:96198. Hoxc8.

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09025.
KOiK09308.
OMAiHHGTSSI.
OrthoDBiEOG780RP4.
PhylomeDBiP09025.
TreeFamiTF316310.

Miscellaneous databases

NextBioi288178.
PROiP09025.
SOURCEiSearch...

Gene expression databases

BgeeiP09025.
CleanExiMM_HOXC8.
ExpressionAtlasiP09025. baseline and differential.
GenevestigatoriP09025.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pattern of transcription of the homeo gene Hox-3.1 in the mouse embryo."
    le Mouellic H., Condamine H., Brulet P.
    Genes Dev. 2:125-135(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster."
    Breier G., Dressler G.R., Gruss P.
    EMBO J. 7:1329-1336(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox-3.1 intergenic region."
    Awgulewitsch A., Bieberich C., Bogarad L., Shashikant C., Ruddle F.H.
    Proc. Natl. Acad. Sci. U.S.A. 87:6428-6432(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CD-1.
  4. "Spatial restriction in expression of a mouse homoeo box locus within the central nervous system."
    Awgulewitsch A., Utset M.F., Hart C.P., McGinnis W., Ruddle F.H.
    Nature 320:328-335(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-216.
  5. "Sequential expression of murine homeo box genes during F9 EC cell differentiation."
    Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P.
    EMBO J. 5:2209-2215(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 149-215.

Entry informationi

Entry nameiHXC8_MOUSE
AccessioniPrimary (citable) accession number: P09025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: March 4, 2015
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.