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P09025 (HXC8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C8
Alternative name(s):
Homeobox protein Hox-3.1
Homeobox protein M31
Gene names
Name:Hoxc8
Synonyms:Hox-3.1, Hoxc-8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subunit structure

Interacts with HOMEZ By similarity.

Subcellular location

Nucleus.

Developmental stage

Initially found in all tissues of the posterior region in 8.5 and 9.5 dpc. Embryos, it eventually become specifically located in neural tissue.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Homeobox protein Hox-C8
PRO_0000200181

Regions

DNA binding149 – 20860Homeobox
Motif138 – 1436Antp-type hexapeptide

Experimental info

Sequence conflict1511S → T in CAA27294. Ref.4
Sequence conflict1811E → Q in CAA27294. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P09025 [UniParc].

Last modified July 1, 1989. Version 2.
Checksum: 4A2A53BDA4CFA878

FASTA24227,740
        10         20         30         40         50         60 
MSSYFVNPLF SKYKGGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ HASHHVQDFF 

        70         80         90        100        110        120 
HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY GAQQEASVVQ YPDCKSSANT 

       130        140        150        160        170        180 
NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI 

       190        200        210        220        230        240 
EVSHALGLTE RQVKIWFQNR RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN 


KD

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References

[1]"Pattern of transcription of the homeo gene Hox-3.1 in the mouse embryo."
le Mouellic H., Condamine H., Brulet P.
Genes Dev. 2:125-135(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster."
Breier G., Dressler G.R., Gruss P.
EMBO J. 7:1329-1336(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2-Hox-3.1 intergenic region."
Awgulewitsch A., Bieberich C., Bogarad L., Shashikant C., Ruddle F.H.
Proc. Natl. Acad. Sci. U.S.A. 87:6428-6432(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CD-1.
[4]"Spatial restriction in expression of a mouse homoeo box locus within the central nervous system."
Awgulewitsch A., Utset M.F., Hart C.P., McGinnis W., Ruddle F.H.
Nature 320:328-335(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-216.
[5]"Sequential expression of murine homeo box genes during F9 EC cell differentiation."
Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P.
EMBO J. 5:2209-2215(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 149-215.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X07439 mRNA. Translation: CAA30319.1.
X07646 mRNA. Translation: CAA30486.1.
M35603 Genomic DNA. Translation: AAA37857.1.
X03659 Genomic DNA. Translation: CAA27294.1. Sequence problems.
IPIIPI00132381.
PIRA25180. B25180.
WJMSX3. B36023.
S13785.
RefSeqNP_034596.1. NM_010466.2.
UniGeneMm.6167.

3D structure databases

ProteinModelPortalP09025.
SMRP09025. Positions 153-208.
ModBaseSearch...

Protein-protein interaction databases

IntActP09025. 1 interaction.
MINTMINT-210049.

PTM databases

PhosphoSiteP09025.

Proteomic databases

PRIDEP09025.

Protocols and materials databases

DNASU15426.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001703; ENSMUSP00000001703; ENSMUSG00000001657.
GeneID15426.
KEGGmmu:15426.
UCSCuc012aaf.1. mouse.

Organism-specific databases

CTD3224.
MGIMGI:96198. Hoxc8.

Phylogenomic databases

eggNOGNOG314669.
GeneTreeENSGT00700000104332.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP09025.
KOK09308.
OMAHHGTSSI.
OrthoDBEOG4H464V.

Gene expression databases

ArrayExpressP09025.
BgeeP09025.
CleanExMM_HOXC8.
GenevestigatorP09025.
GermOnlineENSMUSG00000001657. Mus musculus.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_metazoa.
IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288178.
SOURCESearch...

Entry information

Entry nameHXC8_MOUSE
AccessionPrimary (citable) accession number: P09025
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: April 3, 2013
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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