ID   HXB7_MOUSE              Reviewed;         217 AA.
AC   P09024; A2A9Z9; Q3UW15;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   27-MAR-2024, entry version 193.
DE   RecName: Full=Homeobox protein Hox-B7;
DE   AltName: Full=Homeobox protein Hox-2.3;
DE   AltName: Full=Homeobox protein MH-22B;
DE   AltName: Full=Homeobox protein MuB1;
GN   Name=Hoxb7; Synonyms=Hox-2.3, Hoxb-7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2889183; DOI=10.1093/nar/15.17.6773;
RA   Meijlink F., de Laaf R., Verrijzer P., Destree O., Kroezen V., Hilkens J.,
RA   Deschamps J.;
RT   "A mouse homeobox containing gene on chromosome 11: sequence and tissue-
RT   specific expression.";
RL   Nucleic Acids Res. 15:6773-6786(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2896332; DOI=10.1093/nar/16.6.2729;
RA   Verrijzer P., de Graaff W., Deschamps J., Meijlink F.;
RT   "Nucleotide sequence of the Hox2.3 gene region.";
RL   Nucleic Acids Res. 16:2729-2729(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Epididymis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-217.
RX   PubMed=2890503; DOI=10.1089/dna.1987.6.409;
RA   Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.;
RT   "New murine homeoboxes: structure, chromosomal assignment, and differential
RT   expression in adult erythropoiesis.";
RL   DNA 6:409-418(1987).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-217.
RX   PubMed=2891608; DOI=10.1016/0888-7543(87)90011-5;
RA   Hart C.P., Fainsod A., Ruddle F.H.;
RT   "Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes:
RT   evolutionary and structural comparisons.";
RL   Genomics 1:182-195(1987).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 137-196.
RX   PubMed=2901346; DOI=10.1002/j.1460-2075.1988.tb03052.x;
RA   Kongsuwan K., Webb E., Housiaux P., Adams J.M.;
RT   "Expression of multiple homeobox genes within diverse mammalian
RT   haemopoietic lineages.";
RL   EMBO J. 7:2131-2138(1988).
RN   [8]
RP   INTERACTION WITH PBX1.
RX   PubMed=7791786; DOI=10.1128/mcb.15.7.3786;
RA   Lu Q., Knoepfler P.S., Scheele J., Wright D.D., Kamps M.P.;
RT   "Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the
RT   products of multiple murine Hox genes, some of which are themselves
RT   oncogenes.";
RL   Mol. Cell. Biol. 15:3786-3795(1995).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC       PBX1. {ECO:0000269|PubMed:7791786}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; Y00436; CAA68494.1; -; Genomic_DNA.
DR   EMBL; X06762; CAA29934.1; -; mRNA.
DR   EMBL; AK136706; BAE23104.1; -; mRNA.
DR   EMBL; AL645478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M18167; AAA37845.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; M18400; AAA88245.1; -; Genomic_DNA.
DR   EMBL; X14570; CAA32708.1; -; mRNA.
DR   CCDS; CCDS25294.1; -.
DR   PIR; A26846; WJMSX2.
DR   RefSeq; NP_034590.2; NM_010460.2.
DR   AlphaFoldDB; P09024; -.
DR   SMR; P09024; -.
DR   BioGRID; 200381; 1.
DR   IntAct; P09024; 1.
DR   STRING; 10090.ENSMUSP00000040121; -.
DR   iPTMnet; P09024; -.
DR   PhosphoSitePlus; P09024; -.
DR   SwissPalm; P09024; -.
DR   MaxQB; P09024; -.
DR   PaxDb; 10090-ENSMUSP00000040121; -.
DR   ProteomicsDB; 273230; -.
DR   Antibodypedia; 68878; 404 antibodies from 32 providers.
DR   DNASU; 15415; -.
DR   Ensembl; ENSMUST00000049352.8; ENSMUSP00000040121.7; ENSMUSG00000038721.9.
DR   GeneID; 15415; -.
DR   KEGG; mmu:15415; -.
DR   UCSC; uc007lbr.1; mouse.
DR   AGR; MGI:96188; -.
DR   CTD; 3217; -.
DR   MGI; MGI:96188; Hoxb7.
DR   VEuPathDB; HostDB:ENSMUSG00000038721; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000161230; -.
DR   HOGENOM; CLU_061398_1_1_1; -.
DR   InParanoid; P09024; -.
DR   OMA; QNCNKTD; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P09024; -.
DR   TreeFam; TF316310; -.
DR   BioGRID-ORCS; 15415; 1 hit in 79 CRISPR screens.
DR   PRO; PR:P09024; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; P09024; Protein.
DR   Bgee; ENSMUSG00000038721; Expressed in embryonic post-anal tail and 86 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0016604; C:nuclear body; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IDA:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
DR   GO; GO:0030099; P:myeloid cell differentiation; IMP:MGI.
DR   GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR46166:SF5; HOMEOBOX B7; 1.
DR   PANTHER; PTHR46166; HOMEOBOX DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P09024; MM.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..217
FT                   /note="Homeobox protein Hox-B7"
FT                   /id="PRO_0000200143"
FT   DNA_BIND        137..196
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          192..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           126..131
FT                   /note="Antp-type hexapeptide"
FT   CONFLICT        104
FT                   /note="P -> A (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        108
FT                   /note="A -> G (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        144
FT                   /note="Y -> S (in Ref. 3; BAE23104)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        206
FT                   /note="Q -> H (in Ref. 5; AAA37845)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        211
FT                   /note="A -> G (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        211
FT                   /note="A -> R (in Ref. 6; AAA88245)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   217 AA;  23967 MW;  074AEB9D57EE88D7 CRC64;
     MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP FSASVQGLYS
     GGGAMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDPAKAAGA KEQRDSDLAA
     ESNFRIYPWM RSSGPDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ
     IKIWFQNRRM KWKKENKTSG PGTTGQDKAE AEEEEEE
//