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P09024 (HXB7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B7
Alternative name(s):
Homeobox protein Hox-2.3
Homeobox protein MH-22B
Homeobox protein MuB1
Gene names
Name:Hoxb7
Synonyms:Hox-2.3, Hoxb-7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Homeobox protein Hox-B7
PRO_0000200143

Regions

DNA binding137 – 19660Homeobox
Motif126 – 1316Antp-type hexapeptide
Compositional bias210 – 2178Glu-rich (acidic)

Amino acid modifications

Cross-link191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-link193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Experimental info

Sequence conflict1041P → A Ref.1
Sequence conflict1041P → A Ref.2
Sequence conflict1081A → G Ref.1
Sequence conflict1081A → G Ref.2
Sequence conflict1441Y → S in BAE23104. Ref.3
Sequence conflict2061Q → H in AAA37845. Ref.5
Sequence conflict2111A → G Ref.1
Sequence conflict2111A → G Ref.2
Sequence conflict2111A → R in AAA88245. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P09024 [UniParc].

Last modified September 5, 2006. Version 2.
Checksum: 074AEB9D57EE88D7

FASTA21723,967
        10         20         30         40         50         60 
MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP FSASVQGLYS 

        70         80         90        100        110        120 
GGGAMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDPAKAAGA KEQRDSDLAA 

       130        140        150        160        170        180 
ESNFRIYPWM RSSGPDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ 

       190        200        210 
IKIWFQNRRM KWKKENKTSG PGTTGQDKAE AEEEEEE 

« Hide

References

« Hide 'large scale' references
[1]"A mouse homeobox containing gene on chromosome 11: sequence and tissue-specific expression."
Meijlink F., de Laaf R., Verrijzer P., Destree O., Kroezen V., Hilkens J., Deschamps J.
Nucleic Acids Res. 15:6773-6786(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequence of the Hox2.3 gene region."
Verrijzer P., de Graaff W., Deschamps J., Meijlink F.
Nucleic Acids Res. 16:2729-2729(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Epididymis.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis."
Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.
DNA 6:409-418(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-217.
[6]"Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons."
Hart C.P., Fainsod A., Ruddle F.H.
Genomics 1:182-195(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-217.
[7]"Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
Kongsuwan K., Webb E., Housiaux P., Adams J.M.
EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 137-196.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00436 Genomic DNA. Translation: CAA68494.1.
X06762 mRNA. Translation: CAA29934.1.
AK136706 mRNA. Translation: BAE23104.1.
AL645478 Genomic DNA. Translation: CAM27142.1.
M18167 Genomic DNA. Translation: AAA37845.1. Sequence problems.
M18400 Genomic DNA. Translation: AAA88245.1.
X14570 mRNA. Translation: CAA32708.1.
CCDSCCDS25294.1.
PIRWJMSX2. A26846.
RefSeqNP_034590.2. NM_010460.2.
XP_006532356.1. XM_006532293.1.
UniGeneMm.390366.

3D structure databases

ProteinModelPortalP09024.
SMRP09024. Positions 141-196.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200381. 1 interaction.
IntActP09024. 1 interaction.
MINTMINT-1172508.
STRING10090.ENSMUSP00000040121.

PTM databases

PhosphoSiteP09024.

Proteomic databases

PaxDbP09024.
PRIDEP09024.

Protocols and materials databases

DNASU15415.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049352; ENSMUSP00000040121; ENSMUSG00000038721.
GeneID15415.
KEGGmmu:15415.
UCSCuc007lbr.1. mouse.

Organism-specific databases

CTD3217.
MGIMGI:96188. Hoxb7.

Phylogenomic databases

eggNOGNOG238660.
GeneTreeENSGT00730000110212.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidA2A9Z9.
KOK09307.
OMASMQGLYP.
OrthoDBEOG780RP4.
PhylomeDBP09024.
TreeFamTF316310.

Gene expression databases

BgeeP09024.
CleanExMM_HOXB7.
GenevestigatorP09024.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288146.
PROP09024.
SOURCESearch...

Entry information

Entry nameHXB7_MOUSE
AccessionPrimary (citable) accession number: P09024
Secondary accession number(s): A2A9Z9, Q3UW15
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries