Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P09024

- HXB7_MOUSE

UniProt

P09024 - HXB7_MOUSE

Protein

Homeobox protein Hox-B7

Gene

Hoxb7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi137 – 19660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. embryonic skeletal system morphogenesis Source: MGI
    3. myeloid cell differentiation Source: MGI
    4. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B7
    Alternative name(s):
    Homeobox protein Hox-2.3
    Homeobox protein MH-22B
    Homeobox protein MuB1
    Gene namesi
    Name:Hoxb7
    Synonyms:Hox-2.3, Hoxb-7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96188. Hoxb7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Homeobox protein Hox-B7PRO_0000200143Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki191 – 191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki193 – 193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiP09024.
    PRIDEiP09024.

    PTM databases

    PhosphoSiteiP09024.

    Expressioni

    Gene expression databases

    BgeeiP09024.
    CleanExiMM_HOXB7.
    GenevestigatoriP09024.

    Interactioni

    Protein-protein interaction databases

    BioGridi200381. 1 interaction.
    IntActiP09024. 1 interaction.
    MINTiMINT-1172508.
    STRINGi10090.ENSMUSP00000040121.

    Structurei

    3D structure databases

    ProteinModelPortaliP09024.
    SMRiP09024. Positions 141-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi126 – 1316Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi210 – 2178Glu-rich (acidic)

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG238660.
    GeneTreeiENSGT00730000110212.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiA2A9Z9.
    KOiK09307.
    OMAiSMQGLYP.
    OrthoDBiEOG780RP4.
    PhylomeDBiP09024.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09024-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP    50
    FSASVQGLYS GGGAMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC 100
    PGDPAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGPDRKRG RQTYTRYQTL 150
    ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ IKIWFQNRRM KWKKENKTSG 200
    PGTTGQDKAE AEEEEEE 217
    Length:217
    Mass (Da):23,967
    Last modified:September 5, 2006 - v2
    Checksum:i074AEB9D57EE88D7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1041P → A(PubMed:2889183)Curated
    Sequence conflicti104 – 1041P → A(PubMed:2896332)Curated
    Sequence conflicti108 – 1081A → G(PubMed:2889183)Curated
    Sequence conflicti108 – 1081A → G(PubMed:2896332)Curated
    Sequence conflicti144 – 1441Y → S in BAE23104. (PubMed:16141072)Curated
    Sequence conflicti206 – 2061Q → H in AAA37845. (PubMed:2890503)Curated
    Sequence conflicti211 – 2111A → G(PubMed:2889183)Curated
    Sequence conflicti211 – 2111A → G(PubMed:2896332)Curated
    Sequence conflicti211 – 2111A → R in AAA88245. (PubMed:2891608)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00436 Genomic DNA. Translation: CAA68494.1.
    X06762 mRNA. Translation: CAA29934.1.
    AK136706 mRNA. Translation: BAE23104.1.
    AL645478 Genomic DNA. Translation: CAM27142.1.
    M18167 Genomic DNA. Translation: AAA37845.1. Sequence problems.
    M18400 Genomic DNA. Translation: AAA88245.1.
    X14570 mRNA. Translation: CAA32708.1.
    CCDSiCCDS25294.1.
    PIRiA26846. WJMSX2.
    RefSeqiNP_034590.2. NM_010460.2.
    XP_006532356.1. XM_006532293.1.
    UniGeneiMm.390366.

    Genome annotation databases

    EnsembliENSMUST00000049352; ENSMUSP00000040121; ENSMUSG00000038721.
    GeneIDi15415.
    KEGGimmu:15415.
    UCSCiuc007lbr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00436 Genomic DNA. Translation: CAA68494.1 .
    X06762 mRNA. Translation: CAA29934.1 .
    AK136706 mRNA. Translation: BAE23104.1 .
    AL645478 Genomic DNA. Translation: CAM27142.1 .
    M18167 Genomic DNA. Translation: AAA37845.1 . Sequence problems.
    M18400 Genomic DNA. Translation: AAA88245.1 .
    X14570 mRNA. Translation: CAA32708.1 .
    CCDSi CCDS25294.1.
    PIRi A26846. WJMSX2.
    RefSeqi NP_034590.2. NM_010460.2.
    XP_006532356.1. XM_006532293.1.
    UniGenei Mm.390366.

    3D structure databases

    ProteinModelPortali P09024.
    SMRi P09024. Positions 141-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200381. 1 interaction.
    IntActi P09024. 1 interaction.
    MINTi MINT-1172508.
    STRINGi 10090.ENSMUSP00000040121.

    PTM databases

    PhosphoSitei P09024.

    Proteomic databases

    PaxDbi P09024.
    PRIDEi P09024.

    Protocols and materials databases

    DNASUi 15415.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049352 ; ENSMUSP00000040121 ; ENSMUSG00000038721 .
    GeneIDi 15415.
    KEGGi mmu:15415.
    UCSCi uc007lbr.1. mouse.

    Organism-specific databases

    CTDi 3217.
    MGIi MGI:96188. Hoxb7.

    Phylogenomic databases

    eggNOGi NOG238660.
    GeneTreei ENSGT00730000110212.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi A2A9Z9.
    KOi K09307.
    OMAi SMQGLYP.
    OrthoDBi EOG780RP4.
    PhylomeDBi P09024.
    TreeFami TF316310.

    Miscellaneous databases

    NextBioi 288146.
    PROi P09024.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09024.
    CleanExi MM_HOXB7.
    Genevestigatori P09024.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A mouse homeobox containing gene on chromosome 11: sequence and tissue-specific expression."
      Meijlink F., de Laaf R., Verrijzer P., Destree O., Kroezen V., Hilkens J., Deschamps J.
      Nucleic Acids Res. 15:6773-6786(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Epididymis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis."
      Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.
      DNA 6:409-418(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-217.
    6. "Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons."
      Hart C.P., Fainsod A., Ruddle F.H.
      Genomics 1:182-195(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-217.
    7. "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
      Kongsuwan K., Webb E., Housiaux P., Adams J.M.
      EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 137-196.

    Entry informationi

    Entry nameiHXB7_MOUSE
    AccessioniPrimary (citable) accession number: P09024
    Secondary accession number(s): A2A9Z9, Q3UW15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3