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P09024

- HXB7_MOUSE

UniProt

P09024 - HXB7_MOUSE

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Protein
Homeobox protein Hox-B7
Gene
Hoxb7, Hox-2.3, Hoxb-7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi137 – 19660Homeobox
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. embryonic skeletal system morphogenesis Source: MGI
  3. myeloid cell differentiation Source: MGI
  4. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B7
Alternative name(s):
Homeobox protein Hox-2.3
Homeobox protein MH-22B
Homeobox protein MuB1
Gene namesi
Name:Hoxb7
Synonyms:Hox-2.3, Hoxb-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96188. Hoxb7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Homeobox protein Hox-B7
PRO_0000200143Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki191 – 191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-linki193 – 193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP09024.
PRIDEiP09024.

PTM databases

PhosphoSiteiP09024.

Expressioni

Gene expression databases

BgeeiP09024.
CleanExiMM_HOXB7.
GenevestigatoriP09024.

Interactioni

Protein-protein interaction databases

BioGridi200381. 1 interaction.
IntActiP09024. 1 interaction.
MINTiMINT-1172508.
STRINGi10090.ENSMUSP00000040121.

Structurei

3D structure databases

ProteinModelPortaliP09024.
SMRiP09024. Positions 141-196.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi126 – 1316Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi210 – 2178Glu-rich (acidic)

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG238660.
GeneTreeiENSGT00730000110212.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiA2A9Z9.
KOiK09307.
OMAiSMQGLYP.
OrthoDBiEOG780RP4.
PhylomeDBiP09024.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09024-1 [UniParc]FASTAAdd to Basket

« Hide

MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP    50
FSASVQGLYS GGGAMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC 100
PGDPAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGPDRKRG RQTYTRYQTL 150
ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ IKIWFQNRRM KWKKENKTSG 200
PGTTGQDKAE AEEEEEE 217
Length:217
Mass (Da):23,967
Last modified:September 5, 2006 - v2
Checksum:i074AEB9D57EE88D7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041P → A1 Publication
Sequence conflicti104 – 1041P → A1 Publication
Sequence conflicti108 – 1081A → G1 Publication
Sequence conflicti108 – 1081A → G1 Publication
Sequence conflicti144 – 1441Y → S in BAE23104. 1 Publication
Sequence conflicti206 – 2061Q → H in AAA37845. 1 Publication
Sequence conflicti211 – 2111A → G1 Publication
Sequence conflicti211 – 2111A → G1 Publication
Sequence conflicti211 – 2111A → R in AAA88245. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00436 Genomic DNA. Translation: CAA68494.1.
X06762 mRNA. Translation: CAA29934.1.
AK136706 mRNA. Translation: BAE23104.1.
AL645478 Genomic DNA. Translation: CAM27142.1.
M18167 Genomic DNA. Translation: AAA37845.1. Sequence problems.
M18400 Genomic DNA. Translation: AAA88245.1.
X14570 mRNA. Translation: CAA32708.1.
CCDSiCCDS25294.1.
PIRiA26846. WJMSX2.
RefSeqiNP_034590.2. NM_010460.2.
XP_006532356.1. XM_006532293.1.
UniGeneiMm.390366.

Genome annotation databases

EnsembliENSMUST00000049352; ENSMUSP00000040121; ENSMUSG00000038721.
GeneIDi15415.
KEGGimmu:15415.
UCSCiuc007lbr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00436 Genomic DNA. Translation: CAA68494.1 .
X06762 mRNA. Translation: CAA29934.1 .
AK136706 mRNA. Translation: BAE23104.1 .
AL645478 Genomic DNA. Translation: CAM27142.1 .
M18167 Genomic DNA. Translation: AAA37845.1 . Sequence problems.
M18400 Genomic DNA. Translation: AAA88245.1 .
X14570 mRNA. Translation: CAA32708.1 .
CCDSi CCDS25294.1.
PIRi A26846. WJMSX2.
RefSeqi NP_034590.2. NM_010460.2.
XP_006532356.1. XM_006532293.1.
UniGenei Mm.390366.

3D structure databases

ProteinModelPortali P09024.
SMRi P09024. Positions 141-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200381. 1 interaction.
IntActi P09024. 1 interaction.
MINTi MINT-1172508.
STRINGi 10090.ENSMUSP00000040121.

PTM databases

PhosphoSitei P09024.

Proteomic databases

PaxDbi P09024.
PRIDEi P09024.

Protocols and materials databases

DNASUi 15415.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049352 ; ENSMUSP00000040121 ; ENSMUSG00000038721 .
GeneIDi 15415.
KEGGi mmu:15415.
UCSCi uc007lbr.1. mouse.

Organism-specific databases

CTDi 3217.
MGIi MGI:96188. Hoxb7.

Phylogenomic databases

eggNOGi NOG238660.
GeneTreei ENSGT00730000110212.
HOGENOMi HOG000231181.
HOVERGENi HBG016849.
InParanoidi A2A9Z9.
KOi K09307.
OMAi SMQGLYP.
OrthoDBi EOG780RP4.
PhylomeDBi P09024.
TreeFami TF316310.

Miscellaneous databases

NextBioi 288146.
PROi P09024.
SOURCEi Search...

Gene expression databases

Bgeei P09024.
CleanExi MM_HOXB7.
Genevestigatori P09024.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A mouse homeobox containing gene on chromosome 11: sequence and tissue-specific expression."
    Meijlink F., de Laaf R., Verrijzer P., Destree O., Kroezen V., Hilkens J., Deschamps J.
    Nucleic Acids Res. 15:6773-6786(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Epididymis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis."
    Lonai P., Arman E., Czosnek H., Ruddle F.H., Blatt C.
    DNA 6:409-418(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-217.
  6. "Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons."
    Hart C.P., Fainsod A., Ruddle F.H.
    Genomics 1:182-195(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-217.
  7. "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
    Kongsuwan K., Webb E., Housiaux P., Adams J.M.
    EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 137-196.

Entry informationi

Entry nameiHXB7_MOUSE
AccessioniPrimary (citable) accession number: P09024
Secondary accession number(s): A2A9Z9, Q3UW15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi