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Protein

Homeobox protein Hox-B7

Gene

Hoxb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi137 – 196HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • myeloid cell differentiation Source: MGI
  • positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B7
Alternative name(s):
Homeobox protein Hox-2.3
Homeobox protein MH-22B
Homeobox protein MuB1
Gene namesi
Name:Hoxb7
Synonyms:Hox-2.3, Hoxb-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96188. Hoxb7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001431 – 217Homeobox protein Hox-B7Add BLAST217

Proteomic databases

MaxQBiP09024.
PaxDbiP09024.
PRIDEiP09024.

PTM databases

iPTMnetiP09024.
PhosphoSitePlusiP09024.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038721.
CleanExiMM_HOXB7.
GenevisibleiP09024. MM.

Interactioni

Protein-protein interaction databases

BioGridi200381. 1 interactor.
IntActiP09024. 1 interactor.
MINTiMINT-1172508.
STRINGi10090.ENSMUSP00000040121.

Structurei

3D structure databases

ProteinModelPortaliP09024.
SMRiP09024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi126 – 131Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi210 – 217Glu-rich (acidic)8

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00900000140772.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09024.
KOiK09307.
OMAiCAPFEQN.
OrthoDBiEOG091G09XD.
PhylomeDBiP09024.
TreeFamiTF316310.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P09024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP
60 70 80 90 100
FSASVQGLYS GGGAMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC
110 120 130 140 150
PGDPAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGPDRKRG RQTYTRYQTL
160 170 180 190 200
ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ IKIWFQNRRM KWKKENKTSG
210
PGTTGQDKAE AEEEEEE
Length:217
Mass (Da):23,967
Last modified:September 5, 2006 - v2
Checksum:i074AEB9D57EE88D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104P → A (PubMed:2889183).Curated1
Sequence conflicti104P → A (PubMed:2896332).Curated1
Sequence conflicti108A → G (PubMed:2889183).Curated1
Sequence conflicti108A → G (PubMed:2896332).Curated1
Sequence conflicti144Y → S in BAE23104 (PubMed:16141072).Curated1
Sequence conflicti206Q → H in AAA37845 (PubMed:2890503).Curated1
Sequence conflicti211A → G (PubMed:2889183).Curated1
Sequence conflicti211A → G (PubMed:2896332).Curated1
Sequence conflicti211A → R in AAA88245 (PubMed:2891608).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00436 Genomic DNA. Translation: CAA68494.1.
X06762 mRNA. Translation: CAA29934.1.
AK136706 mRNA. Translation: BAE23104.1.
AL645478 Genomic DNA. Translation: CAM27142.1.
M18167 Genomic DNA. Translation: AAA37845.1. Sequence problems.
M18400 Genomic DNA. Translation: AAA88245.1.
X14570 mRNA. Translation: CAA32708.1.
CCDSiCCDS25294.1.
PIRiA26846. WJMSX2.
RefSeqiNP_034590.2. NM_010460.2.
UniGeneiMm.390366.

Genome annotation databases

EnsembliENSMUST00000049352; ENSMUSP00000040121; ENSMUSG00000038721.
GeneIDi15415.
KEGGimmu:15415.
UCSCiuc007lbr.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiHXB7_MOUSE
AccessioniPrimary (citable) accession number: P09024
Secondary accession number(s): A2A9Z9, Q3UW15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: September 5, 2006
Last modified: November 22, 2017
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families