Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-B6

Gene

Hoxb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi146 – 20560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • erythrocyte homeostasis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B6
Alternative name(s):
Homeobox protein Hox-2.2
Homeobox protein MH-22A
Gene namesi
Name:Hoxb6
Synonyms:Hox-2.2, Hoxb-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96187. Hoxb6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Homeobox protein Hox-B6PRO_0000200136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP09023.
PaxDbiP09023.
PeptideAtlasiP09023.
PRIDEiP09023.

PTM databases

iPTMnetiP09023.
PhosphoSiteiP09023.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000690.
CleanExiMM_HOXB6.
GenevisibleiP09023. MM.

Interactioni

Protein-protein interaction databases

BioGridi200380. 1 interaction.
DIPiDIP-59870N.
STRINGi10090.ENSMUSP00000000704.

Structurei

3D structure databases

ProteinModelPortaliP09023.
SMRiP09023. Positions 150-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1326Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi216 – 2205Poly-Glu

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09023.
KOiK09306.
OMAiREKDPAC.
OrthoDBiEOG091G09XD.
PhylomeDBiP09023.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD
60 70 80 90 100
KGFAASSYYP PAGGGYGRAA PCDYGPAPAF YREKDAACAL SGADEPPPFH
110 120 130 140 150
PEPRKSDCAQ DKSVFGETEE QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR
160 170 180 190 200
QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA HALCLTERQI KIWFQNRRMK
210 220
WKKESKLLSA SQLSAEEEEE KPAE
Length:224
Mass (Da):25,310
Last modified:July 1, 1989 - v2
Checksum:iE8FC0BDEB57F5C3D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti186 – 1861T → P in AAA37844 (PubMed:2890503).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18166 Genomic DNA. Translation: AAA37844.1.
X56459 mRNA. Translation: CAA39834.1.
BC016893 mRNA. Translation: AAH16893.1.
M18401 Genomic DNA. Translation: AAC27130.1. Sequence problems.
J03782 Genomic DNA. Translation: AAA37843.1.
CCDSiCCDS25295.1.
PIRiA31324.
B29585.
C27176.
RefSeqiNP_032295.1. NM_008269.1.
UniGeneiMm.215.

Genome annotation databases

EnsembliENSMUST00000000704; ENSMUSP00000000704; ENSMUSG00000000690.
ENSMUST00000173432; ENSMUSP00000133281; ENSMUSG00000000690.
GeneIDi15414.
KEGGimmu:15414.
UCSCiuc007lbt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18166 Genomic DNA. Translation: AAA37844.1.
X56459 mRNA. Translation: CAA39834.1.
BC016893 mRNA. Translation: AAH16893.1.
M18401 Genomic DNA. Translation: AAC27130.1. Sequence problems.
J03782 Genomic DNA. Translation: AAA37843.1.
CCDSiCCDS25295.1.
PIRiA31324.
B29585.
C27176.
RefSeqiNP_032295.1. NM_008269.1.
UniGeneiMm.215.

3D structure databases

ProteinModelPortaliP09023.
SMRiP09023. Positions 150-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200380. 1 interaction.
DIPiDIP-59870N.
STRINGi10090.ENSMUSP00000000704.

PTM databases

iPTMnetiP09023.
PhosphoSiteiP09023.

Proteomic databases

MaxQBiP09023.
PaxDbiP09023.
PeptideAtlasiP09023.
PRIDEiP09023.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000704; ENSMUSP00000000704; ENSMUSG00000000690.
ENSMUST00000173432; ENSMUSP00000133281; ENSMUSG00000000690.
GeneIDi15414.
KEGGimmu:15414.
UCSCiuc007lbt.1. mouse.

Organism-specific databases

CTDi3216.
MGIiMGI:96187. Hoxb6.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP09023.
KOiK09306.
OMAiREKDPAC.
OrthoDBiEOG091G09XD.
PhylomeDBiP09023.
TreeFamiTF316310.

Miscellaneous databases

PROiP09023.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000690.
CleanExiMM_HOXB6.
GenevisibleiP09023. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXB6_MOUSE
AccessioniPrimary (citable) accession number: P09023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.