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P09022

- HXA1_MOUSE

UniProt

P09022 - HXA1_MOUSE

Protein

Homeobox protein Hox-A1

Gene

Hoxa1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.
    The homeobox domain presumably directs sequence-specific DNA binding. The N-terminal portion of ERA-1-993 may be involved in interactions with one or more other regulatory proteins. Such an interaction could regulate either the DNA-binding activity or the transcriptional regulatory activity of ERA-1-993.
    The homeoboxless ERA-1-399 protein could act as a competitive inhibitor of the ERA-1-993 protein by competing for interaction with regulatory protein(s) while being unable to bind to DNA.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi225 – 28460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. abducens nerve formation Source: Ensembl
    2. anatomical structure formation involved in morphogenesis Source: MGI
    3. anatomical structure morphogenesis Source: MGI
    4. anterior/posterior pattern specification Source: MGI
    5. artery morphogenesis Source: Ensembl
    6. central nervous system neuron differentiation Source: MGI
    7. cochlea morphogenesis Source: Ensembl
    8. cognition Source: Ensembl
    9. embryonic neurocranium morphogenesis Source: Ensembl
    10. facial nerve structural organization Source: MGI
    11. facial nucleus development Source: MGI
    12. hindbrain development Source: MGI
    13. inner ear morphogenesis Source: MGI
    14. motor neuron axon guidance Source: MGI
    15. nervous system development Source: MGI
    16. neuromuscular process Source: Ensembl
    17. optokinetic behavior Source: Ensembl
    18. outer ear morphogenesis Source: Ensembl
    19. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    20. regulation of behavior Source: Ensembl
    21. regulation of transcription from RNA polymerase II promoter Source: MGI
    22. rhombomere 3 development Source: MGI
    23. rhombomere 4 development Source: MGI
    24. rhombomere 5 development Source: MGI
    25. semicircular canal formation Source: Ensembl
    26. sensory perception of sound Source: Ensembl
    27. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A1
    Alternative name(s):
    Early retinoic acid 1
    Homeobox protein Hox-1.6
    Homeoboxless protein ERA-1-399
    Homeotic protein ERA-1-993
    Gene namesi
    Name:Hoxa1
    Synonyms:Era-1, Hox-1.6, Hoxa-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:96170. Hoxa1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Homeobox protein Hox-A1PRO_0000200031Add
    BLAST

    Proteomic databases

    PRIDEiP09022.

    PTM databases

    PhosphoSiteiP09022.

    Expressioni

    Developmental stagei

    Expressed along the entire length of the primitive streak. In early neurogenesis it is expressed in lateral and paraxial mesoderm, endoderm and superficial ectoderm or in the neural tube. From late neurogenesis to mid-embryogenesis, it presents similar spatial domains in the lateral mesoderm, endoderm and superficial ectoderm but is not detectable in any part of the hindbrain. At day 8-8.5 post-coitum found in the embryonic mesoderm, anterior to the first somite, up to the cephalic region at the level of the foregut and developing heart. At day 9 post-coitum found in an anterior part of the developing foregut and is restricted to an epithelial cell type. Expression in the gut is found at the level of the second to third branchial bars.1 Publication

    Inductioni

    By retinoic acid.

    Gene expression databases

    ArrayExpressiP09022.
    BgeeiP09022.
    CleanExiMM_HOXA1.
    GenevestigatoriP09022.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABHD17AQ96GS63EBI-3957603,EBI-2870273From a different organism.
    ADAMTSL4Q6UY143EBI-3957603,EBI-742002From a different organism.
    C1orf94Q6P1W53EBI-3957603,EBI-946029From a different organism.
    EFCAB4BQ9BSW23EBI-3957603,EBI-739773From a different organism.
    EFEMP2O959673EBI-3957603,EBI-743414From a different organism.
    FAM154AQ8IYX73EBI-3957603,EBI-3957636From a different organism.
    FHL5Q5TD973EBI-3957603,EBI-750641From a different organism.
    GRNP287992EBI-3957603,EBI-747754From a different organism.
    HOXA1P496394EBI-3957603,EBI-740785From a different organism.
    HOXD3P312493EBI-3957603,EBI-3957655From a different organism.
    IKZF2Q9UKS73EBI-3957603,EBI-3893057From a different organism.
    KRT81Q145333EBI-3957603,EBI-739648From a different organism.
    KRTAP26-1Q6PEX34EBI-3957603,EBI-3957672From a different organism.
    KRTAP3-2Q9BYR74EBI-3957603,EBI-751260From a different organism.
    KRTAP4-12Q9BQ664EBI-3957603,EBI-739863From a different organism.
    KRTAP5-9P263713EBI-3957603,EBI-3958099From a different organism.
    LGALS13Q9UHV83EBI-3957603,EBI-3957707From a different organism.
    LIMS1P480593EBI-3957603,EBI-306928From a different organism.
    LNX2Q8N4483EBI-3957603,EBI-2340947From a different organism.
    LPXNO607113EBI-3957603,EBI-744222From a different organism.
    MDFIQ997503EBI-3957603,EBI-724076From a different organism.
    MGAT5BQ3V5L53EBI-3957603,EBI-3957727From a different organism.
    N4BP2L2Q928023EBI-3957603,EBI-2514973From a different organism.
    OGTO152943EBI-3957603,EBI-539828From a different organism.
    PDCD6IPQ8WUM43EBI-3957603,EBI-310624From a different organism.
    PDLIM7Q9NR123EBI-3957603,EBI-350517From a different organism.
    PITX2Q996973EBI-3957603,EBI-1175211From a different organism.
    PLSCR1O151623EBI-3957603,EBI-740019From a different organism.
    PLSCR4Q9NRQ24EBI-3957603,EBI-769257From a different organism.
    PRDM14Q9GZV83EBI-3957603,EBI-3957793From a different organism.
    PRRC2BQ5JSZ53EBI-3957603,EBI-744891From a different organism.
    RAB33AQ140883EBI-3957603,EBI-744685From a different organism.
    RBCK1Q9BYM83EBI-3957603,EBI-2340624From a different organism.
    RBPMSQ930623EBI-3957603,EBI-740322From a different organism.
    RGS20O760813EBI-3957603,EBI-1052678From a different organism.
    SMOC1Q9H4F82EBI-3957603,EBI-2801103From a different organism.
    SPRY1O436093EBI-3957603,EBI-3866665From a different organism.
    TRAF1Q130774EBI-3957603,EBI-359224From a different organism.
    TRAF2Q129333EBI-3957603,EBI-355744From a different organism.
    TRAPPC6AO758653EBI-3957603,EBI-743573From a different organism.
    TRIM23P364062EBI-3957603,EBI-740098From a different organism.
    TRIP6Q156543EBI-3957603,EBI-742327From a different organism.
    ZBTB16Q055163EBI-3957603,EBI-711925From a different organism.
    ZBTB32Q9Y2Y43EBI-3957603,EBI-954098From a different organism.
    ZZZ3Q8IYH53EBI-3957603,EBI-2795524From a different organism.

    Protein-protein interaction databases

    DIPiDIP-59869N.
    IntActiP09022. 61 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP09022.
    SMRiP09022. Positions 198-286.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi200 – 2056Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi60 – 7011Poly-HisAdd
    BLAST
    Compositional biasi138 – 1425Poly-His

    Sequence similaritiesi

    Belongs to the Antp homeobox family. Labial subfamily.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG236971.
    HOGENOMiHOG000171545.
    HOVERGENiHBG006089.
    InParanoidiP09022.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform ERA-1-993 (identifier: P09022-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSFLEYPIL GSGDSGTCSA RAYPSDHGIT TFQSCAVSAN SCGGDDRFLV    50
    GRGVQISSPH HHHHHHHHHH PQTATYQTSG NLGISYSHSS CGPSYGAQNF 100
    SAPYGPYGLN QEADVSGGYP PCAPAVYSGN LSTPMVQHHH HHQGYAGGTV 150
    GSPQYIHHSY GQEQQTLALA TYNNSLSPLH ASHQEACRSP ASETSSPAQT 200
    FDWMKVKRNP PKTGKVGEYG YVGQPNAVRT NFTTKQLTEL EKEFHFNKYL 250
    TRARRVEIAA SLQLNETQVK IWFQNRRMKQ KKREKEGLLP ISPATPPGSD 300
    EKTEESSEKS SPSPSAPSPA SSTSDTLTTS H 331
    Length:331
    Mass (Da):36,037
    Last modified:April 1, 1990 - v2
    Checksum:iF73E4FFB1C6F15B2
    GO
    Isoform ERA-1-399 (identifier: P09022-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         115-133: VSGGYPPCAPAVYSGNLST → PPRSLSFPCFRDVFSSADL
         134-331: Missing.

    Show »
    Length:133
    Mass (Da):14,290
    Checksum:iF3A12654DA61A299
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei115 – 13319VSGGY…GNLST → PPRSLSFPCFRDVFSSADL in isoform ERA-1-399. CuratedVSP_002380Add
    BLAST
    Alternative sequencei134 – 331198Missing in isoform ERA-1-399. CuratedVSP_002381Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22115 mRNA. Translation: AAA37559.1.
    M22115 mRNA. Translation: AAA37558.1.
    X06023 Genomic DNA. Translation: CAA29426.1.
    X06024 Genomic DNA. Translation: CAA29427.1.
    M20214 Genomic DNA. No translation available.
    M20216, M20215 Genomic DNA. Translation: AAA37839.1.
    PIRiA27155.
    A30242.
    B30242.
    UniGeneiMm.197.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M22115 mRNA. Translation: AAA37559.1 .
    M22115 mRNA. Translation: AAA37558.1 .
    X06023 Genomic DNA. Translation: CAA29426.1 .
    X06024 Genomic DNA. Translation: CAA29427.1 .
    M20214 Genomic DNA. No translation available.
    M20216 , M20215 Genomic DNA. Translation: AAA37839.1 .
    PIRi A27155.
    A30242.
    B30242.
    UniGenei Mm.197.

    3D structure databases

    ProteinModelPortali P09022.
    SMRi P09022. Positions 198-286.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59869N.
    IntActi P09022. 61 interactions.

    PTM databases

    PhosphoSitei P09022.

    Proteomic databases

    PRIDEi P09022.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:96170. Hoxa1.

    Phylogenomic databases

    eggNOGi NOG236971.
    HOGENOMi HOG000171545.
    HOVERGENi HBG006089.
    InParanoidi P09022.

    Miscellaneous databases

    PROi P09022.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09022.
    Bgeei P09022.
    CleanExi MM_HOXA1.
    Genevestigatori P09022.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox."
      Larosa G.J., Gudas L.J.
      Mol. Cell. Biol. 8:3906-3917(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex."
      Baron A., Featherstone M.S., Hill R.E., Hall A., Galliott B., Duboule D.
      EMBO J. 6:2977-2986(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-331.
    3. "The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes."
      Duboule D., Dolle P.
      EMBO J. 8:1497-1505(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiHXA1_MOUSE
    AccessioniPrimary (citable) accession number: P09022
    Secondary accession number(s): P15463
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3