Reviewed, UniProtKB/Swiss-Prot P09021 (HXA5_MOUSE)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A5
Alternative name(s):
    Hox-1.3
    M2

Gene names

Name:	Hoxa5
Synonyms:	Hox-1.3, Hoxa-5

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
Subcellular location	Nucleus.
Developmental stage	Expressed during embryogenesis and in adult kidney.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	anterior/posterior pattern formation Inferred from mutant phenotype. Source: MGI branching involved in lung morphogenesis Inferred from mutant phenotype. Source: MGI bronchiole development Inferred from mutant phenotype. Source: MGI embryonic skeletal system morphogenesis Inferred from mutant phenotype. Source: MGI lobar bronchus epithelium development Inferred from mutant phenotype. Source: MGI lung-associated mesenchyme development Inferred from mutant phenotype. Source: MGI multicellular organism growth Inferred from mutant phenotype. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro respiratory system process Inferred from mutant phenotype. Source: MGI thyroid gland development Inferred from mutant phenotype. Source: MGI trachea cartilage morphogenesis Inferred from mutant phenotype. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Ref.1 Inferred from direct assay. Source: MGI
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Homeobox protein Hox-A5		PRO_0000200058
Regions
	DNA binding	195 – 254	60	Homeobox Ref.4
	Motif	176 – 181	6	Antp-type hexapeptide
Experimental info
	Sequence conflict	70	1	A → V in AAH11063. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P09021-1 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: DC4BDDA8FE62766E	FASTA	270	29,237
	10 20 30 40 50 60 MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG 70 80 90 100 110 120 SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP LPCSAVAPSP GSDSHHGGKN 130 140 150 160 170 180 SLGNSSGASA NAGSTHISSR EGVGTASAAE EDAPASSEQA GAQSEPSPAP PAQPQIYPWM 190 200 210 220 230 240 RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK 250 260 270 IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of a homeo domain protein in noncontact-inhibited cultured cells and postmitotic neurons." Odenwald W.F., Taylor C.F., Palmer-Hill F.J., Friedrich V. Jr., Tani M., Lazzarini R.A. Genes Dev. 1:482-496(1987) [PubMed: 2890554] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Coding sequence and expression of the homeobox gene Hox 1.3." Fibi M., Zink B., Kessel M., Colberg-Poley A.M., Labeit S., Lehrach H., Gruss P. Development 102:349-359(1988) [PubMed: 2901335] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[4]	"The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein." Odenwald W.F., Garbern J., Arnheiter H., Tournier-Lasserve E., Lazzarini R.A. Genes Dev. 3:158-172(1989) [PubMed: 2565857] [Abstract] Cited for: DNA-BINDING SPECIFICITY.
[5]	"Functional dissection of the mouse Hox-a5 gene." Zhao J.J., Lazzarini R.A., Pick L. EMBO J. 15:1313-1322(1996) [PubMed: 8635464] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M36604 mRNA. Translation: AAA37838.1. Y00208 Genomic DNA. Translation: CAA68364.1. X16840 mRNA. Translation: CAA34738.1. M28021 mRNA. Translation: AAA37837.1. BC011063 mRNA. Translation: AAH11063.1.
IPI	IPI00132371.
PIR	WJMS13. S07812.
RefSeq	NP_034583.1.
UniGene	Mm.173
3D structure databases
SMR	P09021. Positions 196-257.
ModBase	Search...
Protein-protein interaction databases
IntAct	P09021. 2 interactions.
STRING	P09021.
PTM databases
PhosphoSite	P09021.
Proteomic databases
PRIDE	P09021.
Genome annotation databases
Ensembl	ENSMUST00000048794; ENSMUSP00000039012; ENSMUSG00000038253; Mus musculus. [Genome view]
GeneID	15402.
KEGG	mmu:15402.
UCSC	uc009byh.1. mouse.
Organism-specific databases
CTD	15402.
MGI	MGI:96177. Hoxa5.
Phylogenomic databases
HOGENOM	P09021.
HOVERGEN	P09021.
OMA	TEPRYNQ
OrthoDB	EOG9PCDB9
Gene expression databases
ArrayExpress	P09021.
Bgee	P09021.
CleanEx	MM_HOXA5.
Genevestigator	P09021.
GermOnline	ENSMUSG00000038253. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	288102.
SOURCE	Search...

Entry information

Entry name

HXA5_MOUSE

Accession

Primary (citable) accession number: P09021
Secondary accession number(s): Q91VQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	November 24, 2009
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)