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Protein

Homeobox protein Hox-A5

Gene

Hoxa5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi195 – 25460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • bronchiole development Source: MGI
  • cartilage morphogenesis Source: MGI
  • cell-cell signaling involved in mammary gland development Source: MGI
  • cell migration Source: MGI
  • embryonic skeletal system development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • epithelial tube branching involved in lung morphogenesis Source: MGI
  • intestinal epithelial cell maturation Source: MGI
  • lobar bronchus epithelium development Source: MGI
  • lung alveolus development Source: MGI
  • lung-associated mesenchyme development Source: MGI
  • lung development Source: MGI
  • lung goblet cell differentiation Source: MGI
  • mammary gland alveolus development Source: MGI
  • mammary gland epithelial cell differentiation Source: MGI
  • mesenchymal-epithelial cell signaling Source: MGI
  • morphogenesis of an epithelium Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of angiogenesis Source: MGI
  • negative regulation of erythrocyte differentiation Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of myeloid cell differentiation Source: MGI
  • positive regulation of receptor biosynthetic process Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of mammary gland epithelial cell proliferation Source: MGI
  • respiratory gaseous exchange Source: MGI
  • respiratory system process Source: MGI
  • skeletal system development Source: MGI
  • thyroid gland development Source: MGI
  • trachea cartilage morphogenesis Source: MGI
  • trachea morphogenesis Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A5
Alternative name(s):
Homeobox protein Hox-1.3
Homeobox protein M2
Gene namesi
Name:Hoxa5
Synonyms:Hox-1.3, Hoxa-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96177. Hoxa5.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Homeobox protein Hox-A5PRO_0000200058Add
BLAST

Proteomic databases

MaxQBiP09021.
PaxDbiP09021.
PRIDEiP09021.

PTM databases

PhosphoSiteiP09021.

Expressioni

Developmental stagei

Expressed during embryogenesis and in adult kidney.

Gene expression databases

BgeeiP09021.
CleanExiMM_HOXA5.
GenevisibleiP09021. MM.

Interactioni

Protein-protein interaction databases

BioGridi200370. 1 interaction.
IntActiP09021. 3 interactions.
MINTiMINT-4098192.
STRINGi10090.ENSMUSP00000039012.

Structurei

3D structure databases

ProteinModelPortaliP09021.
SMRiP09021. Positions 202-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi176 – 1816Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP09021.
KOiK09305.
OMAiQTTASHK.
OrthoDBiEOG780RP4.
PhylomeDBiP09021.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN
60 70 80 90 100
GMDLSVGRSG SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP
110 120 130 140 150
LPCSAVAPSP GSDSHHGGKN SLGNSSGASA NAGSTHISSR EGVGTASAAE
160 170 180 190 200
EDAPASSEQA GAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART
210 220 230 240 250
AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW
260 270
KKDNKLKSMS MAAAGGAFRP
Length:270
Mass (Da):29,237
Last modified:November 1, 1988 - v1
Checksum:iDC4BDDA8FE62766E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701A → V in AAH11063 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36604 mRNA. Translation: AAA37838.1.
Y00208 Genomic DNA. Translation: CAA68364.1.
X16840 mRNA. Translation: CAA34738.1.
M28021 mRNA. Translation: AAA37837.1.
BC011063 mRNA. Translation: AAH11063.1.
CCDSiCCDS20143.1.
PIRiS07812. WJMS13.
RefSeqiNP_034583.1. NM_010453.5.
UniGeneiMm.173.

Genome annotation databases

EnsembliENSMUST00000048794; ENSMUSP00000039012; ENSMUSG00000038253.
GeneIDi15402.
KEGGimmu:15402.
UCSCiuc009byh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36604 mRNA. Translation: AAA37838.1.
Y00208 Genomic DNA. Translation: CAA68364.1.
X16840 mRNA. Translation: CAA34738.1.
M28021 mRNA. Translation: AAA37837.1.
BC011063 mRNA. Translation: AAH11063.1.
CCDSiCCDS20143.1.
PIRiS07812. WJMS13.
RefSeqiNP_034583.1. NM_010453.5.
UniGeneiMm.173.

3D structure databases

ProteinModelPortaliP09021.
SMRiP09021. Positions 202-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200370. 1 interaction.
IntActiP09021. 3 interactions.
MINTiMINT-4098192.
STRINGi10090.ENSMUSP00000039012.

PTM databases

PhosphoSiteiP09021.

Proteomic databases

MaxQBiP09021.
PaxDbiP09021.
PRIDEiP09021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048794; ENSMUSP00000039012; ENSMUSG00000038253.
GeneIDi15402.
KEGGimmu:15402.
UCSCiuc009byh.1. mouse.

Organism-specific databases

CTDi3202.
MGIiMGI:96177. Hoxa5.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP09021.
KOiK09305.
OMAiQTTASHK.
OrthoDBiEOG780RP4.
PhylomeDBiP09021.
TreeFamiTF316310.

Miscellaneous databases

PROiP09021.
SOURCEiSearch...

Gene expression databases

BgeeiP09021.
CleanExiMM_HOXA5.
GenevisibleiP09021. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a homeo domain protein in noncontact-inhibited cultured cells and postmitotic neurons."
    Odenwald W.F., Taylor C.F., Palmer-Hill F.J., Friedrich V. Jr., Tani M., Lazzarini R.A.
    Genes Dev. 1:482-496(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Coding sequence and expression of the homeobox gene Hox 1.3."
    Fibi M., Zink B., Kessel M., Colberg-Poley A.M., Labeit S., Lehrach H., Gruss P.
    Development 102:349-359(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein."
    Odenwald W.F., Garbern J., Arnheiter H., Tournier-Lasserve E., Lazzarini R.A.
    Genes Dev. 3:158-172(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING SPECIFICITY.
  5. "Functional dissection of the mouse Hox-a5 gene."
    Zhao J.J., Lazzarini R.A., Pick L.
    EMBO J. 15:1313-1322(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiHXA5_MOUSE
AccessioniPrimary (citable) accession number: P09021
Secondary accession number(s): Q91VQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: June 8, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.