ID   HXB5_XENLA              Reviewed;         230 AA.
AC   P09019;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   27-MAR-2024, entry version 122.
DE   RecName: Full=Homeobox protein Hox-B5;
DE   AltName: Full=Xhox-1B;
DE   AltName: Full=XlHbox-4;
DE   Flags: Fragment;
GN   Name=hoxb5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2894634; DOI=10.1093/nar/16.4.1453;
RA   Fritz A., De Robertis E.M.;
RT   "Xenopus homeobox-containing cDNAs expressed in early development.";
RL   Nucleic Acids Res. 16:1453-1469(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-214.
RX   PubMed=3015593; DOI=10.1002/j.1460-2075.1986.tb04352.x;
RA   Harvey R.P., Tabin C.J., Melton D.A.;
RT   "Embryonic expression and nuclear localization of Xenopus homeobox (Xhox)
RT   gene products.";
RL   EMBO J. 5:1237-1244(1986).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Embryo.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X07104; CAA30125.1; -; mRNA.
DR   EMBL; M26883; AAA49755.1; -; Genomic_DNA.
DR   PIR; S00592; S00592.
DR   AlphaFoldDB; P09019; -.
DR   SMR; P09019; -.
DR   AGR; Xenbase:XB-GENE-6252645; -.
DR   Xenbase; XB-GENE-6252645; hoxb5.S.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45771; HOMEOTIC PROTEIN DEFORMED; 1.
DR   PANTHER; PTHR45771:SF6; HOMEOTIC PROTEIN SEX COMBS REDUCED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..230
FT                   /note="Homeobox protein Hox-B5"
FT                   /id="PRO_0000200134"
FT   DNA_BIND        155..214
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           137..142
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        29..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   230 AA;  25276 MW;  AD040C030F85532B CRC64;
     GGGGGNVSGS YREAGGNMQP GAYGSYNYTG MDLSISRTAA PTYGGDNSFP GQESSRFRAN
     QNCPLSTPDP LPCAKSQKSE LSPADPATSS AHFTETEETS ASSETDESTP RSGAPPRALQ
     DNCSPGAAGT DGQSPQIFPW MRKLHINHDM AGPDGKRART AYTRYQTLEL EKEFHFNRYL
     TRRRRIEIAH TLCLSERQIK IWFQNRRMKW KKDNKLKSMS LATGSSAFQP
//