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P09017

- HXC4_HUMAN

UniProt

P09017 - HXC4_HUMAN

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Protein

Homeobox protein Hox-C4

Gene

HOXC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi156 – 21560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C4
Alternative name(s):
Homeobox protein CP19
Homeobox protein Hox-3E
Gene namesi
Name:HOXC4
Synonyms:HOX3E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:5126. HOXC4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Homeobox protein Hox-C4PRO_0000200164Add
BLAST

Proteomic databases

PaxDbiP09017.
PRIDEiP09017.

PTM databases

PhosphoSiteiP09017.

Expressioni

Gene expression databases

BgeeiP09017.
GenevestigatoriP09017.

Organism-specific databases

HPAiHPA053910.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-3923226,EBI-349968
WHSC1L1Q9BZ952EBI-3923226,EBI-3390132

Protein-protein interaction databases

BioGridi109461. 19 interactions.
IntActiP09017. 7 interactions.
MINTiMINT-194957.
STRINGi9606.ENSP00000305973.

Structurei

3D structure databases

ProteinModelPortaliP09017.
SMRiP09017. Positions 163-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi135 – 1406Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 607Poly-Pro
Compositional biasi183 – 1864Poly-Arg

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314883.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP09017.
KOiK09304.
OMAiERQYNCA.
OrthoDBiEOG780RP4.
PhylomeDBiP09017.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09017 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ
60 70 80 90 100
ELYPPPPPRP SYPERQYSCT SLQGPGNSRG HGPAQAGHHH PEKSQSLCEP
110 120 130 140 150
APLSGASASP SPAPPACSQP APDHPSSAAS KQPIVYPWMK KIHVSTVNPN
160 170 180 190 200
YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY LTRRRRIEIA HSLCLSERQI
210 220 230 240 250
KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP GTSEDHSQSA
260
TPPEQQRAED ITRL
Length:264
Mass (Da):29,811
Last modified:December 15, 2009 - v2
Checksum:i5CCD13995574226E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611T → A in CAA30376. (PubMed:2898768)Curated
Sequence conflicti161 – 1611T → A in AAG42145. (PubMed:11857506)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti158 – 1581R → L.
Corresponds to variant rs11835301 [ dbSNP | Ensembl ].
VAR_055961
Natural varianti178 – 1781N → S.
Corresponds to variant rs35406888 [ dbSNP | Ensembl ].
VAR_055962

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07495 mRNA. Translation: CAA30376.1.
AY014298, AY014297 Genomic DNA. Translation: AAG42145.1.
AC023794 Genomic DNA. No translation available.
CCDSiCCDS8873.1.
PIRiS01030. WJHU3E.
RefSeqiNP_055435.2. NM_014620.5.
NP_705897.1. NM_153633.2.
UniGeneiHs.549040.

Genome annotation databases

EnsembliENST00000303406; ENSP00000305973; ENSG00000198353.
ENST00000430889; ENSP00000399808; ENSG00000198353.
GeneIDi3221.
KEGGihsa:3221.
UCSCiuc001seu.3. human.

Polymorphism databases

DMDMi281185468.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07495 mRNA. Translation: CAA30376.1 .
AY014298 , AY014297 Genomic DNA. Translation: AAG42145.1 .
AC023794 Genomic DNA. No translation available.
CCDSi CCDS8873.1.
PIRi S01030. WJHU3E.
RefSeqi NP_055435.2. NM_014620.5.
NP_705897.1. NM_153633.2.
UniGenei Hs.549040.

3D structure databases

ProteinModelPortali P09017.
SMRi P09017. Positions 163-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109461. 19 interactions.
IntActi P09017. 7 interactions.
MINTi MINT-194957.
STRINGi 9606.ENSP00000305973.

PTM databases

PhosphoSitei P09017.

Polymorphism databases

DMDMi 281185468.

Proteomic databases

PaxDbi P09017.
PRIDEi P09017.

Protocols and materials databases

DNASUi 3221.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303406 ; ENSP00000305973 ; ENSG00000198353 .
ENST00000430889 ; ENSP00000399808 ; ENSG00000198353 .
GeneIDi 3221.
KEGGi hsa:3221.
UCSCi uc001seu.3. human.

Organism-specific databases

CTDi 3221.
GeneCardsi GC12P054410.
GC12P054485.
H-InvDB HIX0079410.
HIX0079484.
HIX0171647.
HGNCi HGNC:5126. HOXC4.
HPAi HPA053910.
MIMi 142974. gene.
neXtProti NX_P09017.
PharmGKBi PA29401.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314883.
GeneTreei ENSGT00760000118945.
HOGENOMi HOG000231179.
HOVERGENi HBG016849.
InParanoidi P09017.
KOi K09304.
OMAi ERQYNCA.
OrthoDBi EOG780RP4.
PhylomeDBi P09017.
TreeFami TF352857.

Miscellaneous databases

GeneWikii HOXC4.
GenomeRNAii 3221.
NextBioi 12814.
PROi P09017.
SOURCEi Search...

Gene expression databases

Bgeei P09017.
Genevestigatori P09017.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "At least three human homeoboxes on chromosome 12 belong to the same transcription unit."
    Simeone A., Pannese M., Acampora D., D'Esposito M., Boncinelli E.
    Nucleic Acids Res. 16:5379-5390(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 156-221.

Entry informationi

Entry nameiHXC4_HUMAN
AccessioniPrimary (citable) accession number: P09017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: December 15, 2009
Last modified: October 29, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3