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P09017

- HXC4_HUMAN

UniProt

P09017 - HXC4_HUMAN

Protein

Homeobox protein Hox-C4

Gene

HOXC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi156 – 21560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C4
    Alternative name(s):
    Homeobox protein CP19
    Homeobox protein Hox-3E
    Gene namesi
    Name:HOXC4
    Synonyms:HOX3E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:5126. HOXC4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29401.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Homeobox protein Hox-C4PRO_0000200164Add
    BLAST

    Proteomic databases

    PaxDbiP09017.
    PRIDEiP09017.

    PTM databases

    PhosphoSiteiP09017.

    Expressioni

    Gene expression databases

    BgeeiP09017.
    GenevestigatoriP09017.

    Organism-specific databases

    HPAiHPA053910.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SUV39H1O434632EBI-3923226,EBI-349968
    WHSC1L1Q9BZ952EBI-3923226,EBI-3390132

    Protein-protein interaction databases

    BioGridi109461. 11 interactions.
    IntActiP09017. 7 interactions.
    MINTiMINT-194957.
    STRINGi9606.ENSP00000305973.

    Structurei

    3D structure databases

    ProteinModelPortaliP09017.
    SMRiP09017. Positions 163-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi135 – 1406Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi54 – 607Poly-Pro
    Compositional biasi183 – 1864Poly-Arg

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314883.
    HOGENOMiHOG000231179.
    HOVERGENiHBG016849.
    InParanoidiP09017.
    KOiK09304.
    OMAiERQYNCA.
    OrthoDBiEOG780RP4.
    PhylomeDBiP09017.
    TreeFamiTF352857.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09017-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ    50
    ELYPPPPPRP SYPERQYSCT SLQGPGNSRG HGPAQAGHHH PEKSQSLCEP 100
    APLSGASASP SPAPPACSQP APDHPSSAAS KQPIVYPWMK KIHVSTVNPN 150
    YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY LTRRRRIEIA HSLCLSERQI 200
    KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP GTSEDHSQSA 250
    TPPEQQRAED ITRL 264
    Length:264
    Mass (Da):29,811
    Last modified:December 15, 2009 - v2
    Checksum:i5CCD13995574226E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti161 – 1611T → A in CAA30376. (PubMed:2898768)Curated
    Sequence conflicti161 – 1611T → A in AAG42145. (PubMed:11857506)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti158 – 1581R → L.
    Corresponds to variant rs11835301 [ dbSNP | Ensembl ].
    VAR_055961
    Natural varianti178 – 1781N → S.
    Corresponds to variant rs35406888 [ dbSNP | Ensembl ].
    VAR_055962

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07495 mRNA. Translation: CAA30376.1.
    AY014298, AY014297 Genomic DNA. Translation: AAG42145.1.
    AC023794 Genomic DNA. No translation available.
    CCDSiCCDS8873.1.
    PIRiS01030. WJHU3E.
    RefSeqiNP_055435.2. NM_014620.5.
    NP_705897.1. NM_153633.2.
    UniGeneiHs.549040.

    Genome annotation databases

    EnsembliENST00000303406; ENSP00000305973; ENSG00000198353.
    ENST00000430889; ENSP00000399808; ENSG00000198353.
    GeneIDi3221.
    KEGGihsa:3221.
    UCSCiuc001seu.3. human.

    Polymorphism databases

    DMDMi281185468.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07495 mRNA. Translation: CAA30376.1 .
    AY014298 , AY014297 Genomic DNA. Translation: AAG42145.1 .
    AC023794 Genomic DNA. No translation available.
    CCDSi CCDS8873.1.
    PIRi S01030. WJHU3E.
    RefSeqi NP_055435.2. NM_014620.5.
    NP_705897.1. NM_153633.2.
    UniGenei Hs.549040.

    3D structure databases

    ProteinModelPortali P09017.
    SMRi P09017. Positions 163-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109461. 11 interactions.
    IntActi P09017. 7 interactions.
    MINTi MINT-194957.
    STRINGi 9606.ENSP00000305973.

    PTM databases

    PhosphoSitei P09017.

    Polymorphism databases

    DMDMi 281185468.

    Proteomic databases

    PaxDbi P09017.
    PRIDEi P09017.

    Protocols and materials databases

    DNASUi 3221.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303406 ; ENSP00000305973 ; ENSG00000198353 .
    ENST00000430889 ; ENSP00000399808 ; ENSG00000198353 .
    GeneIDi 3221.
    KEGGi hsa:3221.
    UCSCi uc001seu.3. human.

    Organism-specific databases

    CTDi 3221.
    GeneCardsi GC12P054410.
    H-InvDB HIX0079410.
    HIX0079484.
    HIX0171647.
    HGNCi HGNC:5126. HOXC4.
    HPAi HPA053910.
    MIMi 142974. gene.
    neXtProti NX_P09017.
    PharmGKBi PA29401.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314883.
    HOGENOMi HOG000231179.
    HOVERGENi HBG016849.
    InParanoidi P09017.
    KOi K09304.
    OMAi ERQYNCA.
    OrthoDBi EOG780RP4.
    PhylomeDBi P09017.
    TreeFami TF352857.

    Miscellaneous databases

    GeneWikii HOXC4.
    GenomeRNAii 3221.
    NextBioi 12814.
    PROi P09017.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09017.
    Genevestigatori P09017.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "At least three human homeoboxes on chromosome 12 belong to the same transcription unit."
      Simeone A., Pannese M., Acampora D., D'Esposito M., Boncinelli E.
      Nucleic Acids Res. 16:5379-5390(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 156-221.

    Entry informationi

    Entry nameiHXC4_HUMAN
    AccessioniPrimary (citable) accession number: P09017
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3