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Protein

Homeobox protein Hox-D4

Gene

HOXD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi154 – 213HomeoboxAdd BLAST60

GO - Molecular functioni

  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D4
Alternative name(s):
Homeobox protein HHO.C13
Homeobox protein Hox-4B
Homeobox protein Hox-5.1
Gene namesi
Name:HOXD4
Synonyms:HOX4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000170166.5.
HGNCiHGNC:5138. HOXD4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3233.
MIMi142981. gene+phenotype.
OpenTargetsiENSG00000170166.
PharmGKBiPA29412.

Polymorphism and mutation databases

BioMutaiHOXD4.
DMDMi20141491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002101 – 255Homeobox protein Hox-D4Add BLAST255

Proteomic databases

MaxQBiP09016.
PaxDbiP09016.
PeptideAtlasiP09016.
PRIDEiP09016.

PTM databases

iPTMnetiP09016.
PhosphoSitePlusiP09016.

Expressioni

Gene expression databases

BgeeiENSG00000170166.
CleanExiHS_HOXD4.
GenevisibleiP09016. HS.

Organism-specific databases

HPAiHPA054383.
HPA070349.

Interactioni

Protein-protein interaction databases

BioGridi109473. 22 interactors.
ELMiP09016.
IntActiP09016. 2 interactors.
STRINGi9606.ENSP00000302548.

Structurei

3D structure databases

ProteinModelPortaliP09016.
SMRiP09016.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 138Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi222 – 234Poly-SerAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00900000140772.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP09016.
KOiK09304.
OMAiEQGADYY.
OrthoDBiEOG091G09XD.
PhylomeDBiP09016.
TreeFamiTF352857.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P09016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMSSYMVNS KYVDPKFPPC EEYLQGGYLG EQGADYYGGG AQGADFQPPG
60 70 80 90 100
LYPRPDFGEQ PFGGSGPGPG SALPARGHGQ EPGGPGGHYA APGEPCPAPP
110 120 130 140 150
APPPAPLPGA RAYSQSDPKQ PPSGTALKQP AVVYPWMKKV HVNSVNPNYT
160 170 180 190 200
GGEPKRSRTA YTRQQVLELE KEFHFNRYLT RRRRIEIAHT LCLSERQIKI
210 220 230 240 250
WFQNRRMKWK KDHKLPNTKG RSSSSSSSSS CSSSVAPSQH LQPMAKDHHT

DLTTL
Length:255
Mass (Da):27,885
Last modified:January 23, 2002 - v3
Checksum:i39205343CDB0142F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142V → A in CAA28411 (PubMed:2879245).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067445123S → P2 PublicationsCorresponds to variant dbSNP:rs34727427Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17360 Genomic DNA. Translation: CAA35237.1.
X04706 mRNA. Translation: CAA28411.1.
AK313885 mRNA. Translation: BAG36610.1.
BC016763 mRNA. Translation: AAH16763.1.
BC074797 mRNA. Translation: AAH74797.1.
CCDSiCCDS2269.1.
PIRiS10985. WJHU4B.
RefSeqiNP_055436.2. NM_014621.2.
UniGeneiHs.591609.

Genome annotation databases

EnsembliENST00000306324; ENSP00000302548; ENSG00000170166.
GeneIDi3233.
KEGGihsa:3233.
UCSCiuc002uks.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHXD4_HUMAN
AccessioniPrimary (citable) accession number: P09016
Secondary accession number(s): B2R9R3, Q96AU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2002
Last modified: November 22, 2017
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families