Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P09016

- HXD4_HUMAN

UniProt

P09016 - HXD4_HUMAN

Protein

Homeobox protein Hox-D4

Gene

HOXD4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 3 (23 Jan 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi154 – 21360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D4
    Alternative name(s):
    Homeobox protein HHO.C13
    Homeobox protein Hox-4B
    Homeobox protein Hox-5.1
    Gene namesi
    Name:HOXD4
    Synonyms:HOX4B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5138. HOXD4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    MIMi142981. gene+phenotype.
    PharmGKBiPA29412.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255Homeobox protein Hox-D4PRO_0000200210Add
    BLAST

    Proteomic databases

    PaxDbiP09016.
    PRIDEiP09016.

    PTM databases

    PhosphoSiteiP09016.

    Expressioni

    Gene expression databases

    BgeeiP09016.
    CleanExiHS_HOXD4.
    GenevestigatoriP09016.

    Interactioni

    Protein-protein interaction databases

    BioGridi109473. 17 interactions.
    STRINGi9606.ENSP00000302548.

    Structurei

    3D structure databases

    ProteinModelPortaliP09016.
    SMRiP09016. Positions 128-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi133 – 1386Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi222 – 23413Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314883.
    HOGENOMiHOG000231179.
    HOVERGENiHBG016849.
    InParanoidiP09016.
    KOiK09304.
    OMAiGLYPRPD.
    OrthoDBiEOG780RP4.
    PhylomeDBiP09016.
    TreeFamiTF352857.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09016-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVMSSYMVNS KYVDPKFPPC EEYLQGGYLG EQGADYYGGG AQGADFQPPG    50
    LYPRPDFGEQ PFGGSGPGPG SALPARGHGQ EPGGPGGHYA APGEPCPAPP 100
    APPPAPLPGA RAYSQSDPKQ PPSGTALKQP AVVYPWMKKV HVNSVNPNYT 150
    GGEPKRSRTA YTRQQVLELE KEFHFNRYLT RRRRIEIAHT LCLSERQIKI 200
    WFQNRRMKWK KDHKLPNTKG RSSSSSSSSS CSSSVAPSQH LQPMAKDHHT 250
    DLTTL 255
    Length:255
    Mass (Da):27,885
    Last modified:January 23, 2002 - v3
    Checksum:i39205343CDB0142F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421V → A in CAA28411. (PubMed:2879245)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti123 – 1231S → P.2 Publications
    Corresponds to variant rs34727427 [ dbSNP | Ensembl ].
    VAR_067445

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17360 Genomic DNA. Translation: CAA35237.1.
    X04706 mRNA. Translation: CAA28411.1.
    AK313885 mRNA. Translation: BAG36610.1.
    BC016763 mRNA. Translation: AAH16763.1.
    BC074797 mRNA. Translation: AAH74797.1.
    CCDSiCCDS2269.1.
    PIRiS10985. WJHU4B.
    RefSeqiNP_055436.2. NM_014621.2.
    UniGeneiHs.591609.

    Genome annotation databases

    EnsembliENST00000306324; ENSP00000302548; ENSG00000170166.
    GeneIDi3233.
    KEGGihsa:3233.
    UCSCiuc002uks.3. human.

    Polymorphism databases

    DMDMi20141491.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17360 Genomic DNA. Translation: CAA35237.1 .
    X04706 mRNA. Translation: CAA28411.1 .
    AK313885 mRNA. Translation: BAG36610.1 .
    BC016763 mRNA. Translation: AAH16763.1 .
    BC074797 mRNA. Translation: AAH74797.1 .
    CCDSi CCDS2269.1.
    PIRi S10985. WJHU4B.
    RefSeqi NP_055436.2. NM_014621.2.
    UniGenei Hs.591609.

    3D structure databases

    ProteinModelPortali P09016.
    SMRi P09016. Positions 128-214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109473. 17 interactions.
    STRINGi 9606.ENSP00000302548.

    PTM databases

    PhosphoSitei P09016.

    Polymorphism databases

    DMDMi 20141491.

    Proteomic databases

    PaxDbi P09016.
    PRIDEi P09016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306324 ; ENSP00000302548 ; ENSG00000170166 .
    GeneIDi 3233.
    KEGGi hsa:3233.
    UCSCi uc002uks.3. human.

    Organism-specific databases

    CTDi 3233.
    GeneCardsi GC02P177030.
    HGNCi HGNC:5138. HOXD4.
    MIMi 142981. gene+phenotype.
    neXtProti NX_P09016.
    PharmGKBi PA29412.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314883.
    HOGENOMi HOG000231179.
    HOVERGENi HBG016849.
    InParanoidi P09016.
    KOi K09304.
    OMAi GLYPRPD.
    OrthoDBi EOG780RP4.
    PhylomeDBi P09016.
    TreeFami TF352857.

    Miscellaneous databases

    GeneWikii HOXD4.
    GenomeRNAii 3233.
    NextBioi 12865.
    PROi P09016.
    SOURCEi Search...

    Gene expression databases

    Bgeei P09016.
    CleanExi HS_HOXD4.
    Genevestigatori P09016.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-123.
    2. "Differential and stage-related expression in embryonic tissues of a new human homoeobox gene."
      Mavilio F., Simeone A., Giampaolo A., Faiella A., Zappavigna V., Acampora D., Poiana G., Russo G., Peschle C., Boncinelli E.
      Nature 324:664-668(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-123.
      Tissue: Uterus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    5. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 154-219.

    Entry informationi

    Entry nameiHXD4_HUMAN
    AccessioniPrimary (citable) accession number: P09016
    Secondary accession number(s): B2R9R3, Q96AU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 149 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3