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Protein

Homeobox protein engrailed-2a

Gene

eng2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi176 – 235HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: ZFIN
  • apoptotic process involved in morphogenesis Source: ZFIN
  • cell fate specification Source: ZFIN
  • midbrain development Source: ZFIN
  • midbrain-hindbrain boundary development Source: ZFIN
  • midbrain-hindbrain boundary morphogenesis Source: ZFIN
  • regulation of transcription, DNA-templated Source: InterPro

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein engrailed-2a
Short name:
Homeobox protein en-2a
Alternative name(s):
Zf-En-2
Gene namesi
Name:eng2a
Synonyms:eng-2, eng2, zf-en-2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-980526-167. eng2a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001960731 – 265Homeobox protein engrailed-2aAdd BLAST265

Proteomic databases

PaxDbiP09015.

Expressioni

Gene expression databases

BgeeiENSDARG00000026599.
ExpressionAtlasiP09015. baseline.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000028905.

Structurei

3D structure databases

ProteinModelPortaliP09015.
SMRiP09015.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the engrailed homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0493. Eukaryota.
ENOG4111P06. LUCA.
GeneTreeiENSGT00840000129733.
HOGENOMiHOG000247054.
HOVERGENiHBG005975.
InParanoidiP09015.
OMAiKDAGTCC.
OrthoDBiEOG091G0XBB.
PhylomeDBiP09015.
TreeFamiTF106461.

Family and domain databases

InterProiView protein in InterPro
IPR019549. Homeobox-engrailed_C-terminal.
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR000747. Homeobox_engrailed.
IPR020479. Homeobox_metazoa.
IPR019737. Homoebox-engrailed_CS.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00026. ENGRAILED.
PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P09015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDENEQSARD VEQRGASDES NSAIRPLLQA PGNLQLPHRI TNFFIDNILR
60 70 80 90 100
PDFGRKKEAN ITRYEDNHGA RENHNPTGPS TGQVGSTVPA EEASTTHTSS
110 120 130 140 150
GGKEAEIESE EPLKPRGENV DQCLGSESDS SQSNSNGQTG QGMLWPAWVY
160 170 180 190 200
CTRYSDRPSS GPRSRKPKKK AASKEDKRPR TAFTAEQLQR LKAEFQTNRY
210 220 230 240 250
LTEQRRQSLA QELGLNESQI KIWFQNKRAK IKKASGVKNG LAIHLMAQGL
260
YNHSTTSKED KSDSD
Length:265
Mass (Da):29,540
Last modified:October 1, 1993 - v2
Checksum:iAB4B08EF062D5AE0
GO

Sequence cautioni

The sequence CAA30471 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206R → A in CAA30471 (PubMed:2896133).Curated1
Sequence conflicti265D → H in CAA48491 (PubMed:1363539).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68151 Genomic DNA. Translation: CAA48254.1.
X68446 mRNA. Translation: CAA48491.1.
X07622 Genomic DNA. Translation: CAA30471.1. Different initiation.
X59126 Genomic DNA. No translation available.
PIRiA56557.
S00562.
RefSeqiNP_571119.2. NM_131044.2.
UniGeneiDr.162132.
Dr.162307.
Dr.75073.

Genome annotation databases

EnsembliENSDART00000031700; ENSDARP00000028905; ENSDARG00000026599.
GeneIDi30243.
KEGGidre:30243.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHME2A_DANRE
AccessioniPrimary (citable) accession number: P09015
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1993
Last modified: June 7, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families