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P09015 (HME2A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homeobox protein engrailed-2a

Short name=Homeobox protein en-2a
Alternative name(s):
Zf-En-2
Gene names
Name:eng2a
Synonyms:eng-2, eng2, zf-en-2
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus.

Sequence similarities

Belongs to the engrailed homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence CAA30471.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Homeobox protein engrailed-2a
PRO_0000196073

Regions

DNA binding176 – 23560Homeobox

Experimental info

Sequence conflict2061R → A in CAA30471. Ref.3
Sequence conflict2651D → H in CAA48491. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P09015 [UniParc].

Last modified October 1, 1993. Version 2.
Checksum: AB4B08EF062D5AE0

FASTA26529,540
        10         20         30         40         50         60 
MDENEQSARD VEQRGASDES NSAIRPLLQA PGNLQLPHRI TNFFIDNILR PDFGRKKEAN 

        70         80         90        100        110        120 
ITRYEDNHGA RENHNPTGPS TGQVGSTVPA EEASTTHTSS GGKEAEIESE EPLKPRGENV 

       130        140        150        160        170        180 
DQCLGSESDS SQSNSNGQTG QGMLWPAWVY CTRYSDRPSS GPRSRKPKKK AASKEDKRPR 

       190        200        210        220        230        240 
TAFTAEQLQR LKAEFQTNRY LTEQRRQSLA QELGLNESQI KIWFQNKRAK IKKASGVKNG 

       250        260 
LAIHLMAQGL YNHSTTSKED KSDSD 

« Hide

References

[1]"Structure and early embryonic expression of the zebrafish engrailed-2 gene."
Fjose A., Njolstad P.R., Nornes S., Molven A., Krauss S.
Mech. Dev. 39:51-62(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Coordinate embryonic expression of three zebrafish engrailed genes."
Ekker M., Wegner J., Akimenko M.-A., Westerfield M.
Development 116:1001-1010(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"A zebrafish engrailed-like homeobox sequence expressed during embryogenesis."
Fjose A., Eiken H.G., Njolstad P.R., Molven A., Hordvik I.
FEBS Lett. 231:355-360(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 162-265.
[4]"Conservation of engrailed-like homeobox sequences during vertebrate evolution."
Holland P.W.H., Williams N.A.
FEBS Lett. 277:250-252(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 182-244.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68151 Genomic DNA. Translation: CAA48254.1.
X68446 mRNA. Translation: CAA48491.1.
X07622 Genomic DNA. Translation: CAA30471.1. Different initiation.
X59126 Genomic DNA. No translation available.
PIRA56557.
S00562.
RefSeqNP_571119.2. NM_131044.2.
UniGeneDr.162132.
Dr.162307.
Dr.75073.

3D structure databases

ProteinModelPortalP09015.
SMRP09015. Positions 175-234.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000031700; ENSDARP00000028905; ENSDARG00000026599.
GeneID30243.
KEGGdre:30243.

Organism-specific databases

CTD30243.
ZFINZDB-GENE-980526-167. eng2a.

Phylogenomic databases

eggNOGNOG306728.
GeneTreeENSGT00750000117439.
HOGENOMHOG000247054.
HOVERGENHBG005975.
InParanoidP09015.
OMAERHEECE.
OrthoDBEOG7VTDN8.
PhylomeDBP09015.
TreeFamTF106461.

Gene expression databases

BgeeP09015.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000747. Homeodomain_engrailed.
IPR019737. Homoebox-engrailed_CS.
IPR000047. HTH_motif.
[Graphical view]
PfamPF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00026. ENGRAILED.
PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806696.
PROP09015.

Entry information

Entry nameHME2A_DANRE
AccessionPrimary (citable) accession number: P09015
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families