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P09015

- HME2A_DANRE

UniProt

P09015 - HME2A_DANRE

Protein

Homeobox protein engrailed-2a

Gene

eng2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi176 – 23560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: ZFIN
    2. apoptotic process involved in morphogenesis Source: ZFIN
    3. cell fate specification Source: ZFIN
    4. midbrain development Source: ZFIN
    5. midbrain-hindbrain boundary development Source: ZFIN
    6. midbrain-hindbrain boundary morphogenesis Source: ZFIN

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein engrailed-2a
    Short name:
    Homeobox protein en-2a
    Alternative name(s):
    Zf-En-2
    Gene namesi
    Name:eng2a
    Synonyms:eng-2, eng2, zf-en-2
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 7

    Organism-specific databases

    ZFINiZDB-GENE-980526-167. eng2a.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Homeobox protein engrailed-2aPRO_0000196073Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiP09015.

    Structurei

    3D structure databases

    ProteinModelPortaliP09015.
    SMRiP09015. Positions 175-234.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the engrailed homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG306728.
    GeneTreeiENSGT00750000117439.
    HOGENOMiHOG000247054.
    HOVERGENiHBG005975.
    InParanoidiP09015.
    OMAiERHEECE.
    OrthoDBiEOG7VTDN8.
    PhylomeDBiP09015.
    TreeFamiTF106461.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR019549. Homeobox-engrailed_C-terminal.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000747. Homeodomain_engrailed.
    IPR019737. Homoebox-engrailed_CS.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF10525. Engrail_1_C_sig. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00026. ENGRAILED.
    PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00033. ENGRAILED. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09015-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDENEQSARD VEQRGASDES NSAIRPLLQA PGNLQLPHRI TNFFIDNILR    50
    PDFGRKKEAN ITRYEDNHGA RENHNPTGPS TGQVGSTVPA EEASTTHTSS 100
    GGKEAEIESE EPLKPRGENV DQCLGSESDS SQSNSNGQTG QGMLWPAWVY 150
    CTRYSDRPSS GPRSRKPKKK AASKEDKRPR TAFTAEQLQR LKAEFQTNRY 200
    LTEQRRQSLA QELGLNESQI KIWFQNKRAK IKKASGVKNG LAIHLMAQGL 250
    YNHSTTSKED KSDSD 265
    Length:265
    Mass (Da):29,540
    Last modified:October 1, 1993 - v2
    Checksum:iAB4B08EF062D5AE0
    GO

    Sequence cautioni

    The sequence CAA30471.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti206 – 2061R → A in CAA30471. (PubMed:2896133)Curated
    Sequence conflicti265 – 2651D → H in CAA48491. (PubMed:1363539)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68151 Genomic DNA. Translation: CAA48254.1.
    X68446 mRNA. Translation: CAA48491.1.
    X07622 Genomic DNA. Translation: CAA30471.1. Different initiation.
    X59126 Genomic DNA. No translation available.
    PIRiA56557.
    S00562.
    RefSeqiNP_571119.2. NM_131044.2.
    UniGeneiDr.162132.
    Dr.162307.
    Dr.75073.

    Genome annotation databases

    EnsembliENSDART00000031700; ENSDARP00000028905; ENSDARG00000026599.
    GeneIDi30243.
    KEGGidre:30243.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68151 Genomic DNA. Translation: CAA48254.1 .
    X68446 mRNA. Translation: CAA48491.1 .
    X07622 Genomic DNA. Translation: CAA30471.1 . Different initiation.
    X59126 Genomic DNA. No translation available.
    PIRi A56557.
    S00562.
    RefSeqi NP_571119.2. NM_131044.2.
    UniGenei Dr.162132.
    Dr.162307.
    Dr.75073.

    3D structure databases

    ProteinModelPortali P09015.
    SMRi P09015. Positions 175-234.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000031700 ; ENSDARP00000028905 ; ENSDARG00000026599 .
    GeneIDi 30243.
    KEGGi dre:30243.

    Organism-specific databases

    CTDi 30243.
    ZFINi ZDB-GENE-980526-167. eng2a.

    Phylogenomic databases

    eggNOGi NOG306728.
    GeneTreei ENSGT00750000117439.
    HOGENOMi HOG000247054.
    HOVERGENi HBG005975.
    InParanoidi P09015.
    OMAi ERHEECE.
    OrthoDBi EOG7VTDN8.
    PhylomeDBi P09015.
    TreeFami TF106461.

    Miscellaneous databases

    NextBioi 20806696.
    PROi P09015.

    Gene expression databases

    Bgeei P09015.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR019549. Homeobox-engrailed_C-terminal.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000747. Homeodomain_engrailed.
    IPR019737. Homoebox-engrailed_CS.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF10525. Engrail_1_C_sig. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00026. ENGRAILED.
    PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00033. ENGRAILED. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and early embryonic expression of the zebrafish engrailed-2 gene."
      Fjose A., Njolstad P.R., Nornes S., Molven A., Krauss S.
      Mech. Dev. 39:51-62(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Coordinate embryonic expression of three zebrafish engrailed genes."
      Ekker M., Wegner J., Akimenko M.-A., Westerfield M.
      Development 116:1001-1010(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "A zebrafish engrailed-like homeobox sequence expressed during embryogenesis."
      Fjose A., Eiken H.G., Njolstad P.R., Molven A., Hordvik I.
      FEBS Lett. 231:355-360(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 162-265.
    4. "Conservation of engrailed-like homeobox sequences during vertebrate evolution."
      Holland P.W.H., Williams N.A.
      FEBS Lett. 277:250-252(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 182-244.

    Entry informationi

    Entry nameiHME2A_DANRE
    AccessioniPrimary (citable) accession number: P09015
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3