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P09015

- HME2A_DANRE

UniProt

P09015 - HME2A_DANRE

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Protein

Homeobox protein engrailed-2a

Gene

eng2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi176 – 23560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: ZFIN
  2. apoptotic process involved in morphogenesis Source: ZFIN
  3. cell fate specification Source: ZFIN
  4. midbrain development Source: ZFIN
  5. midbrain-hindbrain boundary development Source: ZFIN
  6. midbrain-hindbrain boundary morphogenesis Source: ZFIN
  7. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein engrailed-2a
Short name:
Homeobox protein en-2a
Alternative name(s):
Zf-En-2
Gene namesi
Name:eng2a
Synonyms:eng-2, eng2, zf-en-2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-980526-167. eng2a.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Homeobox protein engrailed-2aPRO_0000196073Add
BLAST

Expressioni

Gene expression databases

BgeeiP09015.

Structurei

3D structure databases

ProteinModelPortaliP09015.
SMRiP09015. Positions 175-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the engrailed homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG306728.
GeneTreeiENSGT00760000119211.
HOGENOMiHOG000247054.
HOVERGENiHBG005975.
InParanoidiP09015.
OMAiERHEECE.
OrthoDBiEOG7VTDN8.
PhylomeDBiP09015.
TreeFamiTF106461.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000747. Homeodomain_engrailed.
IPR019737. Homoebox-engrailed_CS.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00026. ENGRAILED.
PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09015-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDENEQSARD VEQRGASDES NSAIRPLLQA PGNLQLPHRI TNFFIDNILR
60 70 80 90 100
PDFGRKKEAN ITRYEDNHGA RENHNPTGPS TGQVGSTVPA EEASTTHTSS
110 120 130 140 150
GGKEAEIESE EPLKPRGENV DQCLGSESDS SQSNSNGQTG QGMLWPAWVY
160 170 180 190 200
CTRYSDRPSS GPRSRKPKKK AASKEDKRPR TAFTAEQLQR LKAEFQTNRY
210 220 230 240 250
LTEQRRQSLA QELGLNESQI KIWFQNKRAK IKKASGVKNG LAIHLMAQGL
260
YNHSTTSKED KSDSD
Length:265
Mass (Da):29,540
Last modified:October 1, 1993 - v2
Checksum:iAB4B08EF062D5AE0
GO

Sequence cautioni

The sequence CAA30471.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2061R → A in CAA30471. (PubMed:2896133)Curated
Sequence conflicti265 – 2651D → H in CAA48491. (PubMed:1363539)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68151 Genomic DNA. Translation: CAA48254.1.
X68446 mRNA. Translation: CAA48491.1.
X07622 Genomic DNA. Translation: CAA30471.1. Different initiation.
X59126 Genomic DNA. No translation available.
PIRiA56557.
S00562.
RefSeqiNP_571119.2. NM_131044.2.
UniGeneiDr.162132.
Dr.162307.
Dr.75073.

Genome annotation databases

EnsembliENSDART00000031700; ENSDARP00000028905; ENSDARG00000026599.
GeneIDi30243.
KEGGidre:30243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68151 Genomic DNA. Translation: CAA48254.1 .
X68446 mRNA. Translation: CAA48491.1 .
X07622 Genomic DNA. Translation: CAA30471.1 . Different initiation.
X59126 Genomic DNA. No translation available.
PIRi A56557.
S00562.
RefSeqi NP_571119.2. NM_131044.2.
UniGenei Dr.162132.
Dr.162307.
Dr.75073.

3D structure databases

ProteinModelPortali P09015.
SMRi P09015. Positions 175-234.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000031700 ; ENSDARP00000028905 ; ENSDARG00000026599 .
GeneIDi 30243.
KEGGi dre:30243.

Organism-specific databases

CTDi 30243.
ZFINi ZDB-GENE-980526-167. eng2a.

Phylogenomic databases

eggNOGi NOG306728.
GeneTreei ENSGT00760000119211.
HOGENOMi HOG000247054.
HOVERGENi HBG005975.
InParanoidi P09015.
OMAi ERHEECE.
OrthoDBi EOG7VTDN8.
PhylomeDBi P09015.
TreeFami TF106461.

Miscellaneous databases

NextBioi 20806696.
PROi P09015.

Gene expression databases

Bgeei P09015.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000747. Homeodomain_engrailed.
IPR019737. Homoebox-engrailed_CS.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00026. ENGRAILED.
PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and early embryonic expression of the zebrafish engrailed-2 gene."
    Fjose A., Njolstad P.R., Nornes S., Molven A., Krauss S.
    Mech. Dev. 39:51-62(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Coordinate embryonic expression of three zebrafish engrailed genes."
    Ekker M., Wegner J., Akimenko M.-A., Westerfield M.
    Development 116:1001-1010(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "A zebrafish engrailed-like homeobox sequence expressed during embryogenesis."
    Fjose A., Eiken H.G., Njolstad P.R., Molven A., Hordvik I.
    FEBS Lett. 231:355-360(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 162-265.
  4. "Conservation of engrailed-like homeobox sequences during vertebrate evolution."
    Holland P.W.H., Williams N.A.
    FEBS Lett. 277:250-252(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 182-244.

Entry informationi

Entry nameiHME2A_DANRE
AccessioniPrimary (citable) accession number: P09015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3