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Protein

Homeobox protein engrailed-2a

Gene

eng2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi176 – 235HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: ZFIN
  • apoptotic process involved in morphogenesis Source: ZFIN
  • axonogenesis involved in innervation Source: ZFIN
  • cell fate specification Source: ZFIN
  • midbrain development Source: ZFIN
  • midbrain-hindbrain boundary development Source: ZFIN
  • midbrain-hindbrain boundary morphogenesis Source: ZFIN
  • regulation of transcription, DNA-templated Source: InterPro

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein engrailed-2a
Short name:
Homeobox protein en-2a
Alternative name(s):
Zf-En-2
Gene namesi
Name:eng2a
Synonyms:eng-2, eng2, zf-en-2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-980526-167 en2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001960731 – 265Homeobox protein engrailed-2aAdd BLAST265

Proteomic databases

PaxDbiP09015
PRIDEiP09015

Expressioni

Gene expression databases

BgeeiENSDARG00000026599
ExpressionAtlasiP09015 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000028905

Structurei

3D structure databases

ProteinModelPortaliP09015
SMRiP09015
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the engrailed homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0493 Eukaryota
ENOG4111P06 LUCA
GeneTreeiENSGT00910000144043
HOGENOMiHOG000247054
HOVERGENiHBG005975
InParanoidiP09015
OMAiKDAGTCC
OrthoDBiEOG091G0XBB
PhylomeDBiP09015
TreeFamiTF106461

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR019549 Homeobox-engrailed_C-terminal
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000747 Homeobox_engrailed
IPR020479 Homeobox_metazoa
IPR019737 Homoebox-engrailed_CS
IPR000047 HTH_motif
PfamiView protein in Pfam
PF10525 Engrail_1_C_sig, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00026 ENGRAILED
PR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00033 ENGRAILED, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P09015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDENEQSARD VEQRGASDES NSAIRPLLQA PGNLQLPHRI TNFFIDNILR
60 70 80 90 100
PDFGRKKEAN ITRYEDNHGA RENHNPTGPS TGQVGSTVPA EEASTTHTSS
110 120 130 140 150
GGKEAEIESE EPLKPRGENV DQCLGSESDS SQSNSNGQTG QGMLWPAWVY
160 170 180 190 200
CTRYSDRPSS GPRSRKPKKK AASKEDKRPR TAFTAEQLQR LKAEFQTNRY
210 220 230 240 250
LTEQRRQSLA QELGLNESQI KIWFQNKRAK IKKASGVKNG LAIHLMAQGL
260
YNHSTTSKED KSDSD
Length:265
Mass (Da):29,540
Last modified:October 1, 1993 - v2
Checksum:iAB4B08EF062D5AE0
GO

Sequence cautioni

The sequence CAA30471 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206R → A in CAA30471 (PubMed:2896133).Curated1
Sequence conflicti265D → H in CAA48491 (PubMed:1363539).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68151 Genomic DNA Translation: CAA48254.1
X68446 mRNA Translation: CAA48491.1
X07622 Genomic DNA Translation: CAA30471.1 Different initiation.
X59126 Genomic DNA No translation available.
PIRiA56557
S00562
RefSeqiNP_571119.2, NM_131044.2
UniGeneiDr.162132
Dr.162307
Dr.75073

Genome annotation databases

EnsembliENSDART00000031700; ENSDARP00000028905; ENSDARG00000026599
GeneIDi30243
KEGGidre:30243

Similar proteinsi

Entry informationi

Entry nameiHME2A_DANRE
AccessioniPrimary (citable) accession number: P09015
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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