ID   HXB5B_DANRE             Reviewed;         276 AA.
AC   P09013; O57359; Q4PR96; Q6DC10; Q8JH53; Q9PWM0;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 2.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=Homeobox protein Hox-B5b;
DE   AltName: Full=Homeobox protein Zf-54;
DE   AltName: Full=Hox-B5-like;
GN   Name=hoxb5b; Synonyms=zf54; ORFNames=zgc:101134;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA   Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA   Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA   Postlethwait J.H.;
RT   "Zebrafish hox clusters and vertebrate genome evolution.";
RL   Science 282:1711-1714(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 101-203.
RC   STRAIN=Tuebingen;
RX   PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA   Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA   de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA   Richardson M.K.;
RT   "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT   rerio) hox complex with description of a novel member, hoxb13a.";
RL   Evol. Dev. 7:362-375(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-276.
RX   PubMed=2902580; DOI=10.1093/nar/16.19.9097;
RA   Njolstad P.R., Molven A., Hordvik I., Apold J., Fjose A.;
RT   "Primary structure, developmentally regulated expression and potential
RT   duplication of the zebrafish homeobox gene ZF-21.";
RL   Nucleic Acids Res. 16:9097-9111(1988).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 234-276, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=9425136; DOI=10.1242/dev.125.3.407;
RA   Prince V.E., Joly L., Ekker M., Ho R.K.;
RT   "Zebrafish hox genes: genomic organization and modified colinear expression
RT   patterns in the trunk.";
RL   Development 125:407-420(1998).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: At the 10-somite stage, barely detectable in the
CC       paraxial mesoderm. At the 20-somite stage, expressed within the
CC       developing CNS with an anterior expression limit at somite 1.
CC       {ECO:0000269|PubMed:9425136}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AF071253; AAD15946.1; -; Genomic_DNA.
DR   EMBL; AL645798; CAD44458.1; -; Genomic_DNA.
DR   EMBL; BC078285; AAH78285.1; -; mRNA.
DR   EMBL; DQ060547; AAY67925.1; -; mRNA.
DR   EMBL; X12803; CAA31291.1; -; Genomic_DNA.
DR   EMBL; Y14526; CAA74861.1; -; mRNA.
DR   RefSeq; NP_571612.2; NM_131537.3.
DR   AlphaFoldDB; P09013; -.
DR   SMR; P09013; -.
DR   STRING; 7955.ENSDARP00000070639; -.
DR   PaxDb; 7955-ENSDARP00000070639; -.
DR   GeneID; 58052; -.
DR   KEGG; dre:58052; -.
DR   AGR; ZFIN:ZDB-GENE-000823-6; -.
DR   CTD; 58052; -.
DR   ZFIN; ZDB-GENE-000823-6; hoxb5b.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; P09013; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P09013; -.
DR   TreeFam; TF316310; -.
DR   PRO; PR:P09013; -.
DR   Proteomes; UP000000437; Alternate scaffold 12.
DR   Proteomes; UP000000437; Chromosome 12.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IMP:ZFIN.
DR   GO; GO:0010002; P:cardioblast differentiation; IMP:ZFIN.
DR   GO; GO:0001708; P:cell fate specification; IMP:ZFIN.
DR   GO; GO:0007507; P:heart development; IGI:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   PANTHER; PTHR45659:SF2; HOMEOBOX PROTEIN HOX-B5; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..276
FT                   /note="Homeobox protein Hox-B5b"
FT                   /id="PRO_0000200133"
FT   DNA_BIND        201..260
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          63..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           183..188
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        71..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        47
FT                   /note="Y -> N (in Ref. 1; AAD15946)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        161
FT                   /note="H -> R (in Ref. 3 and 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        198
FT                   /note="G -> K (in Ref. 5; CAA31291)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        201..202
FT                   /note="GK -> EN (in Ref. 5; CAA31291)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        213
FT                   /note="T -> A (in Ref. 5; CAA31291)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        235
FT                   /note="A -> R (in Ref. 5; CAA31291)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   276 AA;  30912 MW;  07BD5B28FFEECFE6 CRC64;
     MSSYFLNSFS GRYPNGSDYQ LLNYGTNGAM NASYRDSTSM HSGSFGYNYN GIDLSVNRPN
     NGHFGAVGDN SRAFQNPSQE TRYRQSSCSL SSPDPLSCAT SDTLELKGSS PPSDQSTPTG
     NSRLTNSNNL TSSNSTHFAD TDETNVSSET EEGAQTTTTS HTQKQESVAT STTTPNDGQT
     PQIFPWMRKL HISHDMTGPD GKRARTAYTR YQTLELEKEF HFNRYLTRRR RIEIAHALCL
     SERQIKIWFQ NRRMKWKKDN KLKSMSLATA GSAFQN
//