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P09013 (HXB5B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B5b
Alternative name(s):
Homeobox protein Zf-54
Hox-B5-like
Gene names
Name:hoxb5b
Synonyms:zf54
ORF Names:zgc:101134
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus.

Developmental stage

At the 10-somite stage, barely detectable in the paraxial mesoderm. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit at somite 1. Ref.6

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Homeobox protein Hox-B5b
PRO_0000200133

Regions

DNA binding201 – 26060Homeobox
Motif183 – 1886Antp-type hexapeptide

Experimental info

Sequence conflict471Y → N in AAD15946. Ref.1
Sequence conflict1611H → R Ref.3
Sequence conflict1611H → R Ref.4
Sequence conflict1981G → K in CAA31291. Ref.5
Sequence conflict201 – 2022GK → EN in CAA31291. Ref.5
Sequence conflict2131T → A in CAA31291. Ref.5
Sequence conflict2351A → R in CAA31291. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P09013 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 07BD5B28FFEECFE6

FASTA27630,912
        10         20         30         40         50         60 
MSSYFLNSFS GRYPNGSDYQ LLNYGTNGAM NASYRDSTSM HSGSFGYNYN GIDLSVNRPN 

        70         80         90        100        110        120 
NGHFGAVGDN SRAFQNPSQE TRYRQSSCSL SSPDPLSCAT SDTLELKGSS PPSDQSTPTG 

       130        140        150        160        170        180 
NSRLTNSNNL TSSNSTHFAD TDETNVSSET EEGAQTTTTS HTQKQESVAT STTTPNDGQT 

       190        200        210        220        230        240 
PQIFPWMRKL HISHDMTGPD GKRARTAYTR YQTLELEKEF HFNRYLTRRR RIEIAHALCL 

       250        260        270 
SERQIKIWFQ NRRMKWKKDN KLKSMSLATA GSAFQN 

« Hide

References

« Hide 'large scale' references
[1]"Zebrafish hox clusters and vertebrate genome evolution."
Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K., Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M., Postlethwait J.H.
Science 282:1711-1714(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[3]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[4]"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a."
Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K.
Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 101-203.
Strain: Tuebingen.
[5]"Primary structure, developmentally regulated expression and potential duplication of the zebrafish homeobox gene ZF-21."
Njolstad P.R., Molven A., Hordvik I., Apold J., Fjose A.
Nucleic Acids Res. 16:9097-9111(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-276.
[6]"Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk."
Prince V.E., Joly L., Ekker M., Ho R.K.
Development 125:407-420(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 234-276, DEVELOPMENTAL STAGE.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF071253 Genomic DNA. Translation: AAD15946.1.
AL645798 Genomic DNA. Translation: CAD44458.1.
BC078285 mRNA. Translation: AAH78285.1.
DQ060547 mRNA. Translation: AAY67925.1.
X12803 Genomic DNA. Translation: CAA31291.1.
Y14526 mRNA. Translation: CAA74861.1.
RefSeqNP_571612.2. NM_131537.3.
UniGeneDr.75783.

3D structure databases

ProteinModelPortalP09013.
SMRP09013. Positions 181-261.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000076161; ENSDARP00000070639; ENSDARG00000054030.
GeneID58052.
KEGGdre:58052.

Organism-specific databases

CTD58052.
ZFINZDB-GENE-000823-6. hoxb5b.

Phylogenomic databases

eggNOGNOG236516.
GeneTreeENSGT00750000117269.
HOGENOMHOG000231178.
HOVERGENHBG016849.
InParanoidP09013.
OrthoDBEOG780RP4.
PhylomeDBP09013.
TreeFamTF316310.

Gene expression databases

BgeeP09013.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20892316.

Entry information

Entry nameHXB5B_DANRE
AccessionPrimary (citable) accession number: P09013
Secondary accession number(s): O57359 expand/collapse secondary AC list , Q4PR96, Q6DC10, Q8JH53, Q9PWM0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 2005
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries