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P09013

- HXB5B_DANRE

UniProt

P09013 - HXB5B_DANRE

Protein

Homeobox protein Hox-B5b

Gene

hoxb5b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi201 – 26060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. brain development Source: ZFIN
    2. cardioblast differentiation Source: ZFIN
    3. cell fate specification Source: ZFIN
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B5b
    Alternative name(s):
    Homeobox protein Zf-54
    Hox-B5-like
    Gene namesi
    Name:hoxb5b
    Synonyms:zf54
    ORF Names:zgc:101134
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 12

    Organism-specific databases

    ZFINiZDB-GENE-000823-6. hoxb5b.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Homeobox protein Hox-B5bPRO_0000200133Add
    BLAST

    Expressioni

    Developmental stagei

    At the 10-somite stage, barely detectable in the paraxial mesoderm. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit at somite 1.1 Publication

    Gene expression databases

    BgeeiP09013.

    Structurei

    3D structure databases

    ProteinModelPortaliP09013.
    SMRiP09013. Positions 181-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi183 – 1886Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG236516.
    GeneTreeiENSGT00750000117269.
    HOGENOMiHOG000231178.
    HOVERGENiHBG016849.
    InParanoidiP09013.
    OrthoDBiEOG780RP4.
    PhylomeDBiP09013.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09013-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFLNSFS GRYPNGSDYQ LLNYGTNGAM NASYRDSTSM HSGSFGYNYN    50
    GIDLSVNRPN NGHFGAVGDN SRAFQNPSQE TRYRQSSCSL SSPDPLSCAT 100
    SDTLELKGSS PPSDQSTPTG NSRLTNSNNL TSSNSTHFAD TDETNVSSET 150
    EEGAQTTTTS HTQKQESVAT STTTPNDGQT PQIFPWMRKL HISHDMTGPD 200
    GKRARTAYTR YQTLELEKEF HFNRYLTRRR RIEIAHALCL SERQIKIWFQ 250
    NRRMKWKKDN KLKSMSLATA GSAFQN 276
    Length:276
    Mass (Da):30,912
    Last modified:February 1, 2005 - v2
    Checksum:i07BD5B28FFEECFE6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471Y → N in AAD15946. (PubMed:9831563)Curated
    Sequence conflicti161 – 1611H → R1 PublicationCurated
    Sequence conflicti161 – 1611H → R(PubMed:16174031)Curated
    Sequence conflicti198 – 1981G → K in CAA31291. (PubMed:2902580)Curated
    Sequence conflicti201 – 2022GK → EN in CAA31291. (PubMed:2902580)Curated
    Sequence conflicti213 – 2131T → A in CAA31291. (PubMed:2902580)Curated
    Sequence conflicti235 – 2351A → R in CAA31291. (PubMed:2902580)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071253 Genomic DNA. Translation: AAD15946.1.
    AL645798 Genomic DNA. Translation: CAD44458.1.
    BC078285 mRNA. Translation: AAH78285.1.
    DQ060547 mRNA. Translation: AAY67925.1.
    X12803 Genomic DNA. Translation: CAA31291.1.
    Y14526 mRNA. Translation: CAA74861.1.
    RefSeqiNP_571612.2. NM_131537.3.
    UniGeneiDr.75783.

    Genome annotation databases

    EnsembliENSDART00000076161; ENSDARP00000070639; ENSDARG00000054030.
    GeneIDi58052.
    KEGGidre:58052.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071253 Genomic DNA. Translation: AAD15946.1 .
    AL645798 Genomic DNA. Translation: CAD44458.1 .
    BC078285 mRNA. Translation: AAH78285.1 .
    DQ060547 mRNA. Translation: AAY67925.1 .
    X12803 Genomic DNA. Translation: CAA31291.1 .
    Y14526 mRNA. Translation: CAA74861.1 .
    RefSeqi NP_571612.2. NM_131537.3.
    UniGenei Dr.75783.

    3D structure databases

    ProteinModelPortali P09013.
    SMRi P09013. Positions 181-261.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000076161 ; ENSDARP00000070639 ; ENSDARG00000054030 .
    GeneIDi 58052.
    KEGGi dre:58052.

    Organism-specific databases

    CTDi 58052.
    ZFINi ZDB-GENE-000823-6. hoxb5b.

    Phylogenomic databases

    eggNOGi NOG236516.
    GeneTreei ENSGT00750000117269.
    HOGENOMi HOG000231178.
    HOVERGENi HBG016849.
    InParanoidi P09013.
    OrthoDBi EOG780RP4.
    PhylomeDBi P09013.
    TreeFami TF316310.

    Miscellaneous databases

    NextBioi 20892316.

    Gene expression databases

    Bgeei P09013.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    4. "Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a."
      Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K.
      Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 101-203.
      Strain: Tuebingen.
    5. "Primary structure, developmentally regulated expression and potential duplication of the zebrafish homeobox gene ZF-21."
      Njolstad P.R., Molven A., Hordvik I., Apold J., Fjose A.
      Nucleic Acids Res. 16:9097-9111(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-276.
    6. "Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk."
      Prince V.E., Joly L., Ekker M., Ho R.K.
      Development 125:407-420(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 234-276, DEVELOPMENTAL STAGE.
      Tissue: Embryo.

    Entry informationi

    Entry nameiHXB5B_DANRE
    AccessioniPrimary (citable) accession number: P09013
    Secondary accession number(s): O57359
    , Q4PR96, Q6DC10, Q8JH53, Q9PWM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3