P09013 (HXB5B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-B5b

Alternative name(s):
Homeobox protein Zf-54
Hox-B5-like

Gene names

Name:	hoxb5b
Synonyms:	zf54
ORF Names:	zgc:101134

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus.
Developmental stage	At the 10-somite stage, barely detectable in the paraxial mesoderm. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit at somite 1. Ref.6
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from mutant phenotype PubMed 11440248. Source: ZFIN cardioblast differentiation Inferred from mutant phenotype PubMed 19081079. Source: ZFIN cell fate specification Inferred from mutant phenotype PubMed 11440248. Source: ZFIN transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Homeobox protein Hox-B5b		PRO_0000200133
Regions
	DNA binding	201 – 260	60	Homeobox
	Motif	183 – 188	6	Antp-type hexapeptide
Experimental info
	Sequence conflict	47	1	Y → N in AAD15946. Ref.1
	Sequence conflict	161	1	H → R Ref.3
	Sequence conflict	161	1	H → R Ref.4
	Sequence conflict	198	1	G → K in CAA31291. Ref.5
	Sequence conflict	201 – 202	2	GK → EN in CAA31291. Ref.5
	Sequence conflict	213	1	T → A in CAA31291. Ref.5
	Sequence conflict	235	1	A → R in CAA31291. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P09013 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 07BD5B28FFEECFE6	FASTA	276	30,912
	10 20 30 40 50 60 MSSYFLNSFS GRYPNGSDYQ LLNYGTNGAM NASYRDSTSM HSGSFGYNYN GIDLSVNRPN 70 80 90 100 110 120 NGHFGAVGDN SRAFQNPSQE TRYRQSSCSL SSPDPLSCAT SDTLELKGSS PPSDQSTPTG 130 140 150 160 170 180 NSRLTNSNNL TSSNSTHFAD TDETNVSSET EEGAQTTTTS HTQKQESVAT STTTPNDGQT 190 200 210 220 230 240 PQIFPWMRKL HISHDMTGPD GKRARTAYTR YQTLELEKEF HFNRYLTRRR RIEIAHALCL 250 260 270 SERQIKIWFQ NRRMKWKKDN KLKSMSLATA GSAFQN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Zebrafish hox clusters and vertebrate genome evolution." Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K., Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M., Postlethwait J.H. Science 282:1711-1714(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	The Danio rerio sequencing project at the Sanger Institute Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB.
[3]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[4]	"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a." Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K. Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 101-203. Strain: Tuebingen.
[5]	"Primary structure, developmentally regulated expression and potential duplication of the zebrafish homeobox gene ZF-21." Njolstad P.R., Molven A., Hordvik I., Apold J., Fjose A. Nucleic Acids Res. 16:9097-9111(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-276.
[6]	"Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk." Prince V.E., Joly L., Ekker M., Ho R.K. Development 125:407-420(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 234-276, DEVELOPMENTAL STAGE. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF071253 Genomic DNA. Translation: AAD15946.1. AL645798 Genomic DNA. Translation: CAD44458.1. BC078285 mRNA. Translation: AAH78285.1. DQ060547 mRNA. Translation: AAY67925.1. X12803 Genomic DNA. Translation: CAA31291.1. Y14526 mRNA. Translation: CAA74861.1.
IPI	IPI00489481.
RefSeq	NP_571612.2. NM_131537.3.
UniGene	Dr.75783.
3D structure databases
ProteinModelPortal	P09013.
SMR	P09013. Positions 181-261.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000076161; ENSDARP00000070639; ENSDARG00000054030.
GeneID	58052.
KEGG	dre:58052.
Organism-specific databases
CTD	58052.
ZFIN	ZDB-GENE-000823-6. hoxb5b.
Phylogenomic databases
eggNOG	NOG236516.
GeneTree	ENSGT00700000104189.
HOGENOM	HOG000231178.
HOVERGEN	HBG016849.
InParanoid	P09013.
OrthoDB	EOG45MN66.
Gene expression databases
Bgee	P09013.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20892316.

Entry information

Entry name

HXB5B_DANRE

Accession

Primary (citable) accession number: P09013
Secondary accession number(s): O57359 , Q4PR96, Q6DC10, Q8JH53, Q9PWM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program