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Protein

Pre-rRNA-processing protein SRD1

Gene

SRD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a direct or indirect role in pre-rRNA processing.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri168 – 19326GATA-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29333-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-rRNA-processing protein SRD1
Alternative name(s):
Suppressor of rRNA-processing defect protein 1
Gene namesi
Name:SRD1
Ordered Locus Names:YCR018C
ORF Names:YCR18C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome III

Organism-specific databases

CYGDiYCR018c.
EuPathDBiFungiDB:YCR018C.
SGDiS000000611. SRD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Pre-rRNA-processing protein SRD1PRO_0000083482Add
BLAST

Proteomic databases

PaxDbiP09007.

Interactioni

Protein-protein interaction databases

BioGridi30997. 9 interactions.
MINTiMINT-4478353.
STRINGi4932.YCR018C.

Structurei

3D structure databases

ProteinModelPortaliP09007.
SMRiP09007. Positions 167-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 GATA-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri168 – 19326GATA-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG311416.
GeneTreeiENSGT00530000068273.
InParanoidiP09007.
KOiK14858.
OMAiTSACNSE.
OrthoDBiEOG7ZPNX9.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00401. ZnF_GATA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09007-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYNNYDNSG SSFLTRVVKK SDMEKTLLLN REIDDWKSND KKKAYKERGR
60 70 80 90 100
VYASCSFIEV SFSQIRAVDV EKKIENAEQL RDLTRNIVKN KTSSLNEITP
110 120 130 140 150
SKNRVTSACN SERRTTSQEA NNLEGYHSCA QGTSRSASIT KKYSKKTTSR
160 170 180 190 200
PKREKRQTIL PNGEIKECSK CKDTWTIQWR SGPDQNRELC SPCGLAYGKR
210 220
LKKENEKKRQ AADKRIDRNN P
Length:221
Mass (Da):25,514
Last modified:March 15, 2004 - v2
Checksum:iD9519E6564546687
GO

Sequence cautioni

The sequence CAA29638.1 differs from that shown. Reason: Frameshift at position 218. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061T → I in CAA29638 (PubMed:2825123).Curated
Sequence conflicti192 – 1921P → R in CAA30298 (PubMed:2825123).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06322 Genomic DNA. Translation: CAA29638.1. Frameshift.
X07388 Genomic DNA. Translation: CAA30298.1. Sequence problems.
X59720 Genomic DNA. Translation: CAA42309.2.
BK006937 Genomic DNA. Translation: DAA07495.1.
PIRiS07396.
S19428.
RefSeqiNP_009944.2. NM_001178731.1.

Genome annotation databases

EnsemblFungiiYCR018C; YCR018C; YCR018C.
GeneIDi850377.
KEGGisce:YCR018C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06322 Genomic DNA. Translation: CAA29638.1. Frameshift.
X07388 Genomic DNA. Translation: CAA30298.1. Sequence problems.
X59720 Genomic DNA. Translation: CAA42309.2.
BK006937 Genomic DNA. Translation: DAA07495.1.
PIRiS07396.
S19428.
RefSeqiNP_009944.2. NM_001178731.1.

3D structure databases

ProteinModelPortaliP09007.
SMRiP09007. Positions 167-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30997. 9 interactions.
MINTiMINT-4478353.
STRINGi4932.YCR018C.

Proteomic databases

PaxDbiP09007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYCR018C; YCR018C; YCR018C.
GeneIDi850377.
KEGGisce:YCR018C.

Organism-specific databases

CYGDiYCR018c.
EuPathDBiFungiDB:YCR018C.
SGDiS000000611. SRD1.

Phylogenomic databases

eggNOGiNOG311416.
GeneTreeiENSGT00530000068273.
InParanoidiP09007.
KOiK14858.
OMAiTSACNSE.
OrthoDBiEOG7ZPNX9.

Enzyme and pathway databases

BioCyciYEAST:G3O-29333-MONOMER.

Miscellaneous databases

NextBioi965878.
PROiP09007.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00401. ZnF_GATA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Polymorphisms on the right arm of yeast chromosome III associated with Ty transposition and recombination events."
    Warmington J.R., Green R.P., Newlon C.S., Oliver S.G.
    Nucleic Acids Res. 15:8963-8982(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CN31C and S288c / GRF88.
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Valles G., Volckaerts G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 106 AND C-TERMINUS.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "SRD1, a Saccharomyces cerevisiae suppressor of the temperature-sensitive pre-rRNA processing defect of rrp1-1."
    Fabian G.R., Hess S.M., Hopper A.K.
    Genetics 124:497-504(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "SRD1, a S. cerevisiae gene affecting pre-rRNA processing contains a C2/C2 zinc finger motif."
    Hess S.M., Stanford D.R., Hopper A.K.
    Nucleic Acids Res. 22:1265-1271(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSRD1_YEAST
AccessioniPrimary (citable) accession number: P09007
Secondary accession number(s): D6VR26, P09008, Q06989
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: March 15, 2004
Last modified: June 24, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2100 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.