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P09001

- RM03_HUMAN

UniProt

P09001 - RM03_HUMAN

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Protein

39S ribosomal protein L3, mitochondrial

Gene

MRPL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. RNA binding Source: ProtInc
  3. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L3, mitochondrial
Short name:
L3mt
Short name:
MRP-L3
Gene namesi
Name:MRPL3
Synonyms:MRL3, RPML3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:10379. MRPL3.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial large ribosomal subunit Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Combined oxidative phosphorylation deficiency 9 (COXPD9) [MIM:614582]: A mitochondrial disease characterized by failure to thrive, poor feeding, hypertrophic cardiomyopathy, hepatomegaly, and psychomotor retardation. Death in infancy has been observed in some cases.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti317 – 3171P → R in COXPD9. 1 Publication
VAR_066676

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614582. phenotype.
Orphaneti319509. Combined oxidative phosphorylation defect type 9.
PharmGKBiPA30960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 34834839S ribosomal protein L3, mitochondrialPRO_0000077253Add
BLAST

Proteomic databases

MaxQBiP09001.
PaxDbiP09001.
PeptideAtlasiP09001.
PRIDEiP09001.

PTM databases

PhosphoSiteiP09001.

Expressioni

Gene expression databases

BgeeiP09001.
CleanExiHS_MRPL3.
ExpressionAtlasiP09001. baseline and differential.
GenevestigatoriP09001.

Organism-specific databases

HPAiHPA043665.

Interactioni

Protein-protein interaction databases

BioGridi116390. 31 interactions.
IntActiP09001. 4 interactions.
MINTiMINT-3006640.
STRINGi9606.ENSP00000264995.

Structurei

3D structure databases

ProteinModelPortaliP09001.
SMRiP09001. Positions 97-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L3P family.Curated

Phylogenomic databases

eggNOGiCOG0087.
GeneTreeiENSGT00390000011422.
HOGENOMiHOG000100369.
HOVERGENiHBG002294.
InParanoidiP09001.
KOiK02906.
OrthoDBiEOG70GMFZ.
PhylomeDBiP09001.
TreeFamiTF105634.

Family and domain databases

InterProiIPR000597. Ribosomal_L3.
IPR019927. Ribosomal_L3_bac/org-type.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR11229. PTHR11229. 1 hit.
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
TIGRFAMsiTIGR03625. L3_bact. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09001-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGWRLLTQV GAQVLGRLGD GLGAALGPGN RTHIWLFVRG LHGKSGTWWD
60 70 80 90 100
EHLSEENVPF IKQLVSDEDK AQLASKLCPL KDEPWPIHPW EPGSFRVGLI
110 120 130 140 150
ALKLGMMPLW TKDGQKHVVT LLQVQDCHVL KYTSKENCNG KMATLSVGGK
160 170 180 190 200
TVSRFRKATS ILEFYRELGL PPKQTVKIFN ITDNAAIKPG TPLYAAHFRP
210 220 230 240 250
GQYVDVTAKT IGKGFQGVMK RWGFKGQPAT HGQTKTHRRP GAVATGDIGR
260 270 280 290 300
VWPGTKMPGK MGNIYRTEYG LKVWRINTKH NIIYVNGSVP GHKNCLVKVK
310 320 330 340
DSKLPAYKDL GKNLPFPTYF PDGDEEELPE DLYDENVCQP GAPSITFA
Length:348
Mass (Da):38,633
Last modified:November 1, 1988 - v1
Checksum:i6DE6B5BD6BD72E32
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti261 – 2611M → T.
Corresponds to variant rs2291381 [ dbSNP | Ensembl ].
VAR_020108
Natural varianti317 – 3171P → R in COXPD9. 1 Publication
VAR_066676

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06323 mRNA. Translation: CAA29639.1.
CR456720 mRNA. Translation: CAG33001.1.
CH471052 Genomic DNA. Translation: EAW79209.1.
BC003375 mRNA. Translation: AAH03375.1.
CCDSiCCDS3071.1.
PIRiA27294. R5HUL3.
RefSeqiNP_009139.1. NM_007208.3.
UniGeneiHs.205163.

Genome annotation databases

EnsembliENST00000264995; ENSP00000264995; ENSG00000114686.
GeneIDi11222.
KEGGihsa:11222.
UCSCiuc003eoh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06323 mRNA. Translation: CAA29639.1 .
CR456720 mRNA. Translation: CAG33001.1 .
CH471052 Genomic DNA. Translation: EAW79209.1 .
BC003375 mRNA. Translation: AAH03375.1 .
CCDSi CCDS3071.1.
PIRi A27294. R5HUL3.
RefSeqi NP_009139.1. NM_007208.3.
UniGenei Hs.205163.

3D structure databases

ProteinModelPortali P09001.
SMRi P09001. Positions 97-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116390. 31 interactions.
IntActi P09001. 4 interactions.
MINTi MINT-3006640.
STRINGi 9606.ENSP00000264995.

PTM databases

PhosphoSitei P09001.

Proteomic databases

MaxQBi P09001.
PaxDbi P09001.
PeptideAtlasi P09001.
PRIDEi P09001.

Protocols and materials databases

DNASUi 11222.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264995 ; ENSP00000264995 ; ENSG00000114686 .
GeneIDi 11222.
KEGGi hsa:11222.
UCSCi uc003eoh.3. human.

Organism-specific databases

CTDi 11222.
GeneCardsi GC03M131181.
HGNCi HGNC:10379. MRPL3.
HPAi HPA043665.
MIMi 607118. gene.
614582. phenotype.
neXtProti NX_P09001.
Orphaneti 319509. Combined oxidative phosphorylation defect type 9.
PharmGKBi PA30960.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0087.
GeneTreei ENSGT00390000011422.
HOGENOMi HOG000100369.
HOVERGENi HBG002294.
InParanoidi P09001.
KOi K02906.
OrthoDBi EOG70GMFZ.
PhylomeDBi P09001.
TreeFami TF105634.

Miscellaneous databases

GeneWikii MRPL3.
GenomeRNAii 11222.
NextBioi 42715.
PROi P09001.
SOURCEi Search...

Gene expression databases

Bgeei P09001.
CleanExi HS_MRPL3.
ExpressionAtlasi P09001. baseline and differential.
Genevestigatori P09001.

Family and domain databases

InterProi IPR000597. Ribosomal_L3.
IPR019927. Ribosomal_L3_bac/org-type.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view ]
PANTHERi PTHR11229. PTHR11229. 1 hit.
Pfami PF00297. Ribosomal_L3. 1 hit.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 1 hit.
TIGRFAMsi TIGR03625. L3_bact. 1 hit.
PROSITEi PS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells."
    Ou J.-H., Yen T.S.B., Wang Y.-F., Kam W.K., Rutter W.
    Nucleic Acids Res. 15:8919-8934(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: VARIANT COXPD9 ARG-317.

Entry informationi

Entry nameiRM03_HUMAN
AccessioniPrimary (citable) accession number: P09001
Secondary accession number(s): Q6IBT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3