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P09001

- RM03_HUMAN

UniProt

P09001 - RM03_HUMAN

Protein

39S ribosomal protein L3, mitochondrial

Gene

MRPL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Nov 1988)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. RNA binding Source: ProtInc
    3. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: ProtInc

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L3, mitochondrial
    Short name:
    L3mt
    Short name:
    MRP-L3
    Gene namesi
    Name:MRPL3
    Synonyms:MRL3, RPML3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:10379. MRPL3.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Combined oxidative phosphorylation deficiency 9 (COXPD9) [MIM:614582]: A mitochondrial disease characterized by failure to thrive, poor feeding, hypertrophic cardiomyopathy, hepatomegaly, and psychomotor retardation. Death in infancy has been observed in some cases.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti317 – 3171P → R in COXPD9. 1 Publication
    VAR_066676

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi614582. phenotype.
    Orphaneti319509. Combined oxidative phosphorylation defect type 9.
    PharmGKBiPA30960.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 34834839S ribosomal protein L3, mitochondrialPRO_0000077253Add
    BLAST

    Proteomic databases

    MaxQBiP09001.
    PaxDbiP09001.
    PeptideAtlasiP09001.
    PRIDEiP09001.

    PTM databases

    PhosphoSiteiP09001.

    Expressioni

    Gene expression databases

    ArrayExpressiP09001.
    BgeeiP09001.
    CleanExiHS_MRPL3.
    GenevestigatoriP09001.

    Organism-specific databases

    HPAiHPA043665.

    Interactioni

    Protein-protein interaction databases

    BioGridi116390. 25 interactions.
    IntActiP09001. 4 interactions.
    MINTiMINT-3006640.
    STRINGi9606.ENSP00000264995.

    Structurei

    3D structure databases

    ProteinModelPortaliP09001.
    SMRiP09001. Positions 97-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L3P family.Curated

    Phylogenomic databases

    eggNOGiCOG0087.
    HOGENOMiHOG000100369.
    HOVERGENiHBG002294.
    InParanoidiP09001.
    KOiK02906.
    OrthoDBiEOG70GMFZ.
    PhylomeDBiP09001.
    TreeFamiTF105634.

    Family and domain databases

    InterProiIPR000597. Ribosomal_L3.
    IPR019927. Ribosomal_L3_bac/org-type.
    IPR019926. Ribosomal_L3_CS.
    IPR009000. Transl_B-barrel.
    [Graphical view]
    PANTHERiPTHR11229. PTHR11229. 1 hit.
    PfamiPF00297. Ribosomal_L3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 1 hit.
    TIGRFAMsiTIGR03625. L3_bact. 1 hit.
    PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P09001-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGWRLLTQV GAQVLGRLGD GLGAALGPGN RTHIWLFVRG LHGKSGTWWD    50
    EHLSEENVPF IKQLVSDEDK AQLASKLCPL KDEPWPIHPW EPGSFRVGLI 100
    ALKLGMMPLW TKDGQKHVVT LLQVQDCHVL KYTSKENCNG KMATLSVGGK 150
    TVSRFRKATS ILEFYRELGL PPKQTVKIFN ITDNAAIKPG TPLYAAHFRP 200
    GQYVDVTAKT IGKGFQGVMK RWGFKGQPAT HGQTKTHRRP GAVATGDIGR 250
    VWPGTKMPGK MGNIYRTEYG LKVWRINTKH NIIYVNGSVP GHKNCLVKVK 300
    DSKLPAYKDL GKNLPFPTYF PDGDEEELPE DLYDENVCQP GAPSITFA 348
    Length:348
    Mass (Da):38,633
    Last modified:November 1, 1988 - v1
    Checksum:i6DE6B5BD6BD72E32
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti261 – 2611M → T.
    Corresponds to variant rs2291381 [ dbSNP | Ensembl ].
    VAR_020108
    Natural varianti317 – 3171P → R in COXPD9. 1 Publication
    VAR_066676

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06323 mRNA. Translation: CAA29639.1.
    CR456720 mRNA. Translation: CAG33001.1.
    CH471052 Genomic DNA. Translation: EAW79209.1.
    BC003375 mRNA. Translation: AAH03375.1.
    CCDSiCCDS3071.1.
    PIRiA27294. R5HUL3.
    RefSeqiNP_009139.1. NM_007208.3.
    UniGeneiHs.205163.

    Genome annotation databases

    EnsembliENST00000264995; ENSP00000264995; ENSG00000114686.
    GeneIDi11222.
    KEGGihsa:11222.
    UCSCiuc003eoh.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06323 mRNA. Translation: CAA29639.1 .
    CR456720 mRNA. Translation: CAG33001.1 .
    CH471052 Genomic DNA. Translation: EAW79209.1 .
    BC003375 mRNA. Translation: AAH03375.1 .
    CCDSi CCDS3071.1.
    PIRi A27294. R5HUL3.
    RefSeqi NP_009139.1. NM_007208.3.
    UniGenei Hs.205163.

    3D structure databases

    ProteinModelPortali P09001.
    SMRi P09001. Positions 97-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116390. 25 interactions.
    IntActi P09001. 4 interactions.
    MINTi MINT-3006640.
    STRINGi 9606.ENSP00000264995.

    PTM databases

    PhosphoSitei P09001.

    Proteomic databases

    MaxQBi P09001.
    PaxDbi P09001.
    PeptideAtlasi P09001.
    PRIDEi P09001.

    Protocols and materials databases

    DNASUi 11222.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264995 ; ENSP00000264995 ; ENSG00000114686 .
    GeneIDi 11222.
    KEGGi hsa:11222.
    UCSCi uc003eoh.3. human.

    Organism-specific databases

    CTDi 11222.
    GeneCardsi GC03M131181.
    HGNCi HGNC:10379. MRPL3.
    HPAi HPA043665.
    MIMi 607118. gene.
    614582. phenotype.
    neXtProti NX_P09001.
    Orphaneti 319509. Combined oxidative phosphorylation defect type 9.
    PharmGKBi PA30960.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0087.
    HOGENOMi HOG000100369.
    HOVERGENi HBG002294.
    InParanoidi P09001.
    KOi K02906.
    OrthoDBi EOG70GMFZ.
    PhylomeDBi P09001.
    TreeFami TF105634.

    Miscellaneous databases

    GeneWikii MRPL3.
    GenomeRNAii 11222.
    NextBioi 42715.
    PROi P09001.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P09001.
    Bgeei P09001.
    CleanExi HS_MRPL3.
    Genevestigatori P09001.

    Family and domain databases

    InterProi IPR000597. Ribosomal_L3.
    IPR019927. Ribosomal_L3_bac/org-type.
    IPR019926. Ribosomal_L3_CS.
    IPR009000. Transl_B-barrel.
    [Graphical view ]
    PANTHERi PTHR11229. PTHR11229. 1 hit.
    Pfami PF00297. Ribosomal_L3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 1 hit.
    TIGRFAMsi TIGR03625. L3_bact. 1 hit.
    PROSITEi PS00474. RIBOSOMAL_L3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells."
      Ou J.-H., Yen T.S.B., Wang Y.-F., Kam W.K., Rutter W.
      Nucleic Acids Res. 15:8919-8934(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: VARIANT COXPD9 ARG-317.

    Entry informationi

    Entry nameiRM03_HUMAN
    AccessioniPrimary (citable) accession number: P09001
    Secondary accession number(s): Q6IBT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: November 1, 1988
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3