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Protein

39S ribosomal protein L3, mitochondrial

Gene

MRPL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. RNA binding Source: ProtInc
  3. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L3, mitochondrial
Short name:
L3mt
Short name:
MRP-L3
Gene namesi
Name:MRPL3
Synonyms:MRL3, RPML3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:10379. MRPL3.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial large ribosomal subunit Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Combined oxidative phosphorylation deficiency 91 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA mitochondrial disease characterized by failure to thrive, poor feeding, hypertrophic cardiomyopathy, hepatomegaly, and psychomotor retardation. Death in infancy has been observed in some cases.

See also OMIM:614582
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti317 – 3171P → R in COXPD9. 1 Publication
VAR_066676

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614582. phenotype.
Orphaneti319509. Combined oxidative phosphorylation defect type 9.
PharmGKBiPA30960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 34834839S ribosomal protein L3, mitochondrialPRO_0000077253Add
BLAST

Proteomic databases

MaxQBiP09001.
PaxDbiP09001.
PeptideAtlasiP09001.
PRIDEiP09001.

PTM databases

PhosphoSiteiP09001.

Expressioni

Gene expression databases

BgeeiP09001.
CleanExiHS_MRPL3.
ExpressionAtlasiP09001. baseline and differential.
GenevestigatoriP09001.

Organism-specific databases

HPAiHPA043665.

Interactioni

Protein-protein interaction databases

BioGridi116390. 31 interactions.
IntActiP09001. 4 interactions.
MINTiMINT-3006640.
STRINGi9606.ENSP00000264995.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40E1-348[»]
ProteinModelPortaliP09001.
SMRiP09001. Positions 97-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L3P family.Curated

Phylogenomic databases

eggNOGiCOG0087.
GeneTreeiENSGT00390000011422.
HOGENOMiHOG000100369.
HOVERGENiHBG002294.
InParanoidiP09001.
KOiK02906.
OrthoDBiEOG70GMFZ.
PhylomeDBiP09001.
TreeFamiTF105634.

Family and domain databases

InterProiIPR000597. Ribosomal_L3.
IPR019927. Ribosomal_L3_bac/org-type.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR11229. PTHR11229. 1 hit.
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
TIGRFAMsiTIGR03625. L3_bact. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P09001-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGWRLLTQV GAQVLGRLGD GLGAALGPGN RTHIWLFVRG LHGKSGTWWD
60 70 80 90 100
EHLSEENVPF IKQLVSDEDK AQLASKLCPL KDEPWPIHPW EPGSFRVGLI
110 120 130 140 150
ALKLGMMPLW TKDGQKHVVT LLQVQDCHVL KYTSKENCNG KMATLSVGGK
160 170 180 190 200
TVSRFRKATS ILEFYRELGL PPKQTVKIFN ITDNAAIKPG TPLYAAHFRP
210 220 230 240 250
GQYVDVTAKT IGKGFQGVMK RWGFKGQPAT HGQTKTHRRP GAVATGDIGR
260 270 280 290 300
VWPGTKMPGK MGNIYRTEYG LKVWRINTKH NIIYVNGSVP GHKNCLVKVK
310 320 330 340
DSKLPAYKDL GKNLPFPTYF PDGDEEELPE DLYDENVCQP GAPSITFA
Length:348
Mass (Da):38,633
Last modified:November 1, 1988 - v1
Checksum:i6DE6B5BD6BD72E32
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti261 – 2611M → T.
Corresponds to variant rs2291381 [ dbSNP | Ensembl ].
VAR_020108
Natural varianti317 – 3171P → R in COXPD9. 1 Publication
VAR_066676

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06323 mRNA. Translation: CAA29639.1.
CR456720 mRNA. Translation: CAG33001.1.
CH471052 Genomic DNA. Translation: EAW79209.1.
BC003375 mRNA. Translation: AAH03375.1.
CCDSiCCDS3071.1.
PIRiA27294. R5HUL3.
RefSeqiNP_009139.1. NM_007208.3.
UniGeneiHs.205163.

Genome annotation databases

EnsembliENST00000264995; ENSP00000264995; ENSG00000114686.
GeneIDi11222.
KEGGihsa:11222.
UCSCiuc003eoh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06323 mRNA. Translation: CAA29639.1.
CR456720 mRNA. Translation: CAG33001.1.
CH471052 Genomic DNA. Translation: EAW79209.1.
BC003375 mRNA. Translation: AAH03375.1.
CCDSiCCDS3071.1.
PIRiA27294. R5HUL3.
RefSeqiNP_009139.1. NM_007208.3.
UniGeneiHs.205163.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40E1-348[»]
ProteinModelPortaliP09001.
SMRiP09001. Positions 97-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116390. 31 interactions.
IntActiP09001. 4 interactions.
MINTiMINT-3006640.
STRINGi9606.ENSP00000264995.

PTM databases

PhosphoSiteiP09001.

Proteomic databases

MaxQBiP09001.
PaxDbiP09001.
PeptideAtlasiP09001.
PRIDEiP09001.

Protocols and materials databases

DNASUi11222.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264995; ENSP00000264995; ENSG00000114686.
GeneIDi11222.
KEGGihsa:11222.
UCSCiuc003eoh.3. human.

Organism-specific databases

CTDi11222.
GeneCardsiGC03M131181.
HGNCiHGNC:10379. MRPL3.
HPAiHPA043665.
MIMi607118. gene.
614582. phenotype.
neXtProtiNX_P09001.
Orphaneti319509. Combined oxidative phosphorylation defect type 9.
PharmGKBiPA30960.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0087.
GeneTreeiENSGT00390000011422.
HOGENOMiHOG000100369.
HOVERGENiHBG002294.
InParanoidiP09001.
KOiK02906.
OrthoDBiEOG70GMFZ.
PhylomeDBiP09001.
TreeFamiTF105634.

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

GeneWikiiMRPL3.
GenomeRNAii11222.
NextBioi42715.
PROiP09001.
SOURCEiSearch...

Gene expression databases

BgeeiP09001.
CleanExiHS_MRPL3.
ExpressionAtlasiP09001. baseline and differential.
GenevestigatoriP09001.

Family and domain databases

InterProiIPR000597. Ribosomal_L3.
IPR019927. Ribosomal_L3_bac/org-type.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR11229. PTHR11229. 1 hit.
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
TIGRFAMsiTIGR03625. L3_bact. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells."
    Ou J.-H., Yen T.S.B., Wang Y.-F., Kam W.K., Rutter W.
    Nucleic Acids Res. 15:8919-8934(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: VARIANT COXPD9 ARG-317.

Entry informationi

Entry nameiRM03_HUMAN
AccessioniPrimary (citable) accession number: P09001
Secondary accession number(s): Q6IBT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: January 7, 2015
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.