Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P08988 (AACC4_SALSP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminoglycoside N(3')-acetyltransferase IV

EC=2.3.1.81
Alternative name(s):
ACC(3)-IV
Aminocyclitol 3-N-acetyltransferase type IV
Gene names
Name:aacC4
Encoded onPlasmid pWP7b
OrganismSalmonella sp.
Taxonomic identifier599 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activity

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

Sequence similarities

Belongs to the antibiotic N-acetyltransferase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Molecular functionAcyltransferase
Transferase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionaminoglycoside 3-N-acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Aminoglycoside N(3')-acetyltransferase IV
PRO_0000068548

Sequences

Sequence LengthMass (Da)Tools
P08988 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 7E8CBBFC6DFC111E

FASTA26128,491
        10         20         30         40         50         60 
MQYEWRKAEL IGQLLNLGVT PGGVLLVHSS FRSVRPLEDG PLGLIEALRA ALGPGGTLVM 

        70         80         90        100        110        120 
PSWSGLDDEP FDPATSPVTP DLGVVSDTFW RLPNVKRSAH PFAFAAAGPQ AEQIISDPLP 

       130        140        150        160        170        180 
LPPHSPASPV ARVHELDGQV LLLGVGHDAN TTLHLAELMA KVPYGVPRHC TILQDGKLVR 

       190        200        210        220        230        240 
VDYLENDHCC ERFALADRWL KEKSLQKEGP VGHAFARLIR SRDIVATALG QLGRDPLIFL 

       250        260 
HPPEGGMRRM RCRSPVDWLS S 

« Hide

References

[1]"Genes for gentamicin-(3)-N-acetyltransferases III and IV: I. Nucleotide sequence of the AAC(3)-IV gene and possible involvement of an IS140 element in its expression."
Braeu B., Pilz U., Piepersberg W.
Mol. Gen. Genet. 193:179-187(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Piepersberg W.
Submitted (SEP-1985) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01385 Genomic DNA. Translation: CAA25642.1.
PIRS09647.

3D structure databases

ProteinModelPortalP08988.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAACC4_SALSP
AccessionPrimary (citable) accession number: P08988
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families