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P08988

- AACC4_SALSP

UniProt

P08988 - AACC4_SALSP

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Protein

Aminoglycoside N(3')-acetyltransferase IV

Gene

aacC4

Organism
Salmonella sp.
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3')-acetyltransferase IV (EC:2.3.1.81)
Alternative name(s):
ACC(3)-IV
Aminocyclitol 3-N-acetyltransferase type IV
Gene namesi
Name:aacC4
Encoded oniPlasmid pWP7b0 Publication
OrganismiSalmonella sp.
Taxonomic identifieri599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Aminoglycoside N(3')-acetyltransferase IVPRO_0000068548Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP08988.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08988-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQYEWRKAEL IGQLLNLGVT PGGVLLVHSS FRSVRPLEDG PLGLIEALRA
60 70 80 90 100
ALGPGGTLVM PSWSGLDDEP FDPATSPVTP DLGVVSDTFW RLPNVKRSAH
110 120 130 140 150
PFAFAAAGPQ AEQIISDPLP LPPHSPASPV ARVHELDGQV LLLGVGHDAN
160 170 180 190 200
TTLHLAELMA KVPYGVPRHC TILQDGKLVR VDYLENDHCC ERFALADRWL
210 220 230 240 250
KEKSLQKEGP VGHAFARLIR SRDIVATALG QLGRDPLIFL HPPEGGMRRM
260
RCRSPVDWLS S
Length:261
Mass (Da):28,491
Last modified:February 1, 1996 - v2
Checksum:i7E8CBBFC6DFC111E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01385 Genomic DNA. Translation: CAA25642.1.
PIRiS09647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01385 Genomic DNA. Translation: CAA25642.1 .
PIRi S09647.

3D structure databases

ProteinModelPortali P08988.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003679. Amioglycoside_AcTrfase.
[Graphical view ]
Pfami PF02522. Antibiotic_NAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes for gentamicin-(3)-N-acetyltransferases III and IV: I. Nucleotide sequence of the AAC(3)-IV gene and possible involvement of an IS140 element in its expression."
    Braeu B., Pilz U., Piepersberg W.
    Mol. Gen. Genet. 193:179-187(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Piepersberg W.
    Submitted (SEP-1985) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiAACC4_SALSP
AccessioniPrimary (citable) accession number: P08988
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3