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P08988

- AACC4_SALSP

UniProt

P08988 - AACC4_SALSP

Protein

Aminoglycoside N(3')-acetyltransferase IV

Gene

aacC4

Organism
Salmonella sp.
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

    Catalytic activityi

    Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

    GO - Molecular functioni

    1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminoglycoside N(3')-acetyltransferase IV (EC:2.3.1.81)
    Alternative name(s):
    ACC(3)-IV
    Aminocyclitol 3-N-acetyltransferase type IV
    Gene namesi
    Name:aacC4
    Encoded oniPlasmid pWP7b0 Publication
    OrganismiSalmonella sp.
    Taxonomic identifieri599 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Aminoglycoside N(3')-acetyltransferase IVPRO_0000068548Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP08988.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR003679. Amioglycoside_AcTrfase.
    [Graphical view]
    PfamiPF02522. Antibiotic_NAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08988-1 [UniParc]FASTAAdd to Basket

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    MQYEWRKAEL IGQLLNLGVT PGGVLLVHSS FRSVRPLEDG PLGLIEALRA    50
    ALGPGGTLVM PSWSGLDDEP FDPATSPVTP DLGVVSDTFW RLPNVKRSAH 100
    PFAFAAAGPQ AEQIISDPLP LPPHSPASPV ARVHELDGQV LLLGVGHDAN 150
    TTLHLAELMA KVPYGVPRHC TILQDGKLVR VDYLENDHCC ERFALADRWL 200
    KEKSLQKEGP VGHAFARLIR SRDIVATALG QLGRDPLIFL HPPEGGMRRM 250
    RCRSPVDWLS S 261
    Length:261
    Mass (Da):28,491
    Last modified:February 1, 1996 - v2
    Checksum:i7E8CBBFC6DFC111E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01385 Genomic DNA. Translation: CAA25642.1.
    PIRiS09647.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01385 Genomic DNA. Translation: CAA25642.1 .
    PIRi S09647.

    3D structure databases

    ProteinModelPortali P08988.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003679. Amioglycoside_AcTrfase.
    [Graphical view ]
    Pfami PF02522. Antibiotic_NAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes for gentamicin-(3)-N-acetyltransferases III and IV: I. Nucleotide sequence of the AAC(3)-IV gene and possible involvement of an IS140 element in its expression."
      Braeu B., Pilz U., Piepersberg W.
      Mol. Gen. Genet. 193:179-187(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Piepersberg W.
      Submitted (SEP-1985) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiAACC4_SALSP
    AccessioniPrimary (citable) accession number: P08988
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3