P08988 (AACC4_SALSP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminoglycoside N(3')-acetyltransferase IV
EC=2.3.1.81

Alternative name(s):
ACC(3)-IV
Aminocyclitol 3-N-acetyltransferase type IV

Gene names

Name:

aacC4

Encoded on

Plasmid pWP7b

Organism

Salmonella sp.

Taxonomic identifier

599 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.
Catalytic activity	Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.
Sequence similarities	Belongs to the antibiotic N-acetyltransferase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Molecular function	Acyltransferase Transferase
Technical term	Plasmid
Gene Ontology (GO)
Biological_process	response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminoglycoside 3-N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Aminoglycoside N(3')-acetyltransferase IV		PRO_0000068548

Sequences

	Sequence		Length	Mass (Da)
	P08988 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 7E8CBBFC6DFC111E	FASTA	261	28,491
	10 20 30 40 50 60 MQYEWRKAEL IGQLLNLGVT PGGVLLVHSS FRSVRPLEDG PLGLIEALRA ALGPGGTLVM 70 80 90 100 110 120 PSWSGLDDEP FDPATSPVTP DLGVVSDTFW RLPNVKRSAH PFAFAAAGPQ AEQIISDPLP 130 140 150 160 170 180 LPPHSPASPV ARVHELDGQV LLLGVGHDAN TTLHLAELMA KVPYGVPRHC TILQDGKLVR 190 200 210 220 230 240 VDYLENDHCC ERFALADRWL KEKSLQKEGP VGHAFARLIR SRDIVATALG QLGRDPLIFL 250 260 HPPEGGMRRM RCRSPVDWLS S

References

[1]	"Genes for gentamicin-(3)-N-acetyltransferases III and IV: I. Nucleotide sequence of the AAC(3)-IV gene and possible involvement of an IS140 element in its expression." Braeu B., Pilz U., Piepersberg W. Mol. Gen. Genet. 193:179-187(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Piepersberg W. Submitted (SEP-1985) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X01385 Genomic DNA. Translation: CAA25642.1.
PIR	S09647.
3D structure databases
ProteinModelPortal	P08988.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003679. Amioglycoside_AcTrfase. [Graphical view]
Pfam	PF02522. Antibiotic_NAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AACC4_SALSP

Accession

Primary (citable) accession number: P08988

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program