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Protein

Aminoglycoside N(3)-acetyltransferase IV

Gene

aacC4

Organism
Salmonella sp.
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3)-acetyltransferase IV (EC:2.3.1.81)
Alternative name(s):
ACC(3)-IV
Aminocyclitol 3-N-acetyltransferase type IV
Gene namesi
Name:aacC4
Encoded oniPlasmid pWP7b0 Publication
OrganismiSalmonella sp.
Taxonomic identifieri599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000685481 – 261Aminoglycoside N(3)-acetyltransferase IVAdd BLAST261

Structurei

3D structure databases

ProteinModelPortaliP08988.
SMRiP08988.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK19276.

Family and domain databases

InterProiView protein in InterPro
IPR003679. Amioglycoside_AcTrfase.
IPR028345. Antibiotic_NAT-like.
PANTHERiPTHR11104. PTHR11104. 1 hit.
PfamiView protein in Pfam
PF02522. Antibiotic_NAT. 1 hit.
SUPFAMiSSF110710. SSF110710. 1 hit.

Sequencei

Sequence statusi: Complete.

P08988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYEWRKAEL IGQLLNLGVT PGGVLLVHSS FRSVRPLEDG PLGLIEALRA
60 70 80 90 100
ALGPGGTLVM PSWSGLDDEP FDPATSPVTP DLGVVSDTFW RLPNVKRSAH
110 120 130 140 150
PFAFAAAGPQ AEQIISDPLP LPPHSPASPV ARVHELDGQV LLLGVGHDAN
160 170 180 190 200
TTLHLAELMA KVPYGVPRHC TILQDGKLVR VDYLENDHCC ERFALADRWL
210 220 230 240 250
KEKSLQKEGP VGHAFARLIR SRDIVATALG QLGRDPLIFL HPPEGGMRRM
260
RCRSPVDWLS S
Length:261
Mass (Da):28,491
Last modified:February 1, 1996 - v2
Checksum:i7E8CBBFC6DFC111E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01385 Genomic DNA. Translation: CAA25642.1.
PIRiS09647.

Genome annotation databases

KEGGiag:CAA25642.

Similar proteinsi

Entry informationi

Entry nameiAACC4_SALSP
AccessioniPrimary (citable) accession number: P08988
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1996
Last modified: October 25, 2017
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families