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P08987

- GTFB_STRMU

UniProt

P08987 - GTFB_STRMU

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Protein
Glucosyltransferase-I
Gene
gtfB, SMU_1004
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

Catalytic activityi

Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1).

GO - Molecular functioni

  1. dextransucrase activity Source: UniProtKB-EC
  2. glucosyltransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glucan biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-955-MONOMER.
SABIO-RKP08987.

Protein family/group databases

CAZyiGH70. Glycoside Hydrolase Family 70.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosyltransferase-I (EC:2.4.1.5)
Short name:
GTF-I
Alternative name(s):
Dextransucrase
Sucrose 6-glucosyltransferase
Gene namesi
Name:gtfB
Ordered Locus Names:SMU_1004
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Dental caries

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed prediction
Add
BLAST
Chaini35 – 14761442Glucosyltransferase-I
PRO_0000021385Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.1004.

Structurei

3D structure databases

ProteinModelPortaliP08987.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati159 – 17820Cell wall-binding 1
Add
BLAST
Repeati179 – 19921Cell wall-binding 2
Add
BLAST
Repeati1087 – 110620Cell wall-binding 3
Add
BLAST
Repeati1107 – 112620Cell wall-binding 4
Add
BLAST
Repeati1170 – 118920Cell wall-binding 5
Add
BLAST
Repeati1214 – 123421Cell wall-binding 6
Add
BLAST
Repeati1235 – 125420Cell wall-binding 7
Add
BLAST
Repeati1279 – 129921Cell wall-binding 8
Add
BLAST
Repeati1300 – 131920Cell wall-binding 9
Add
BLAST
Repeati1344 – 136421Cell wall-binding 10
Add
BLAST
Repeati1365 – 138420Cell wall-binding 11
Add
BLAST
Repeati1409 – 142921Cell wall-binding 12
Add
BLAST
Repeati1430 – 144920Cell wall-binding 13
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni200 – 1051852Catalytic; approximate
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG5263.
KOiK00689.
OMAiANGVQVK.
OrthoDBiEOG60PH6T.
PhylomeDBiP08987.

Family and domain databases

Gene3Di3.20.20.80. 3 hits.
InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view]
PfamiPF01473. CW_binding_1. 4 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 4 hits.
TIGRFAMsiTIGR04035. glucan_65_rpt. 6 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEiPS51170. CW. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08987-1 [UniParc]FASTAAdd to Basket

« Hide

MDKKVRYKLR KVKKRWVTVS VASAVMTLTT LSGGLVKADS NESKSQISND     50
SNTSVVTANE ESNVTTEVTS KQEAASSQTN HTVTTISSST SVVNPKEVVS 100
NPYTVGETAS NGEKLQNQTT TVDKTSEAAA NNISKQTTEA DTDVIDDSNA 150
ANLQILEKLP NVKEIDGKYY YYDNNGKVRT NFTLIADGKI LHFDETGAYT 200
DTSIDTVNKD IVTTRSNLYK KYNQVYDRSA QSFEHVDHYL TAESWYRPKY 250
ILKDGKTWTQ STEKDFRPLL MTWWPSQETQ RQYVNYMNAQ LGINKTYDDT 300
SNQLQLNIAA ATIQAKIEAK ITTLKNTDWL RQTISAFVKT QSAWNSDSEK 350
PFDDHLQNGA VLYDNEGKLT PYANSNYRIL NRTPTNQTGK KDPRYTADNT 400
IGGYEFLLAN DVDNSNPVVQ AEQLNWLHFL MNFGNIYAND PDANFDSIRV 450
DAVDNVDADL LQIAGDYLKA AKGIHKNDKA ANDHLSILEA WSDNDTPYLH 500
DDGDNMINMD NKLRLSLLFS LAKPLNQRSG MNPLITNSLV NRTDDNAETA 550
AVPSYSFIRA HDSEVQDLIR DIIKAEINPN VVGYSFTMEE IKKAFEIYNK 600
DLLATEKKYT HYNTALSYAL LLTNKSSVPR VYYGDMFTDD GQYMAHKTIN 650
YEAIETLLKA RIKYVSGGQA MRNQQVGNSE IITSVRYGKG ALKATDTGDR 700
TTRTSGVAVI EGNNPSLRLK ASDRVVVNMG AAHKNQAYRP LLLTTDNGIK 750
AYHSDQEAAG LVRYTNDRGE LIFTAADIKG YANPQVSGYL GVWVPVGAAA 800
DQDVRVAAST APSTDGKSVH QNAALDSRVM FEGFSNFQAF ATKKEEYTNV 850
VIAKNVDKFA EWGVTDFEMA PQYVSSTDGS FLDSVIQNGY AFTDRYDLGI 900
SKPNKYGTAD DLVKAIKALH SKGIKVMADW VPDQMYAFPE KEVVTATRVD 950
KFGKPVEGSQ IKSVLYVADS KSSGKDQQAK YGGAFLEELQ AKYPELFARK 1000
QISTGVPMDP SVKIKQWSAK YFNGTNILGR GAGYVLKDQA TNTYFNISDN 1050
KEINFLPKTL LNQDSQVGFS YDGKGYVYYS TSGYQAKNTF ISEGDKWYYF 1100
DNNGYMVTGA QSINGVNYYF LSNGLQLRDA ILKNEDGTYA YYGNDGRRYE 1150
NGYYQFMSGV WRHFNNGEMS VGLTVIDGQV QYFDEMGYQA KGKFVTTADG 1200
KIRYFDKQSG NMYRNRFIEN EEGKWLYLGE DGAAVTGSQT INGQHLYFRA 1250
NGVQVKGEFV TDRYGRISYY DSNSGDQIRN RFVRNAQGQW FYFDNNGYAV 1300
TGARTINGQH LYFRANGVQV KGEFVTDRHG RISYYDGNSG DQIRNRFVRN 1350
AQGQWFYFDN NGYAVTGART INGQHLYFRA NGVQVKGEFV TDRYGRISYY 1400
DSNSGDQIRN RFVRNAQGQW FYFDNNGYAV TGARTINGQH LYFRANGVQV 1450
KGEFVTDRYG RISYYDANSG ERVRIN 1476
Length:1,476
Mass (Da):165,847
Last modified:December 6, 2002 - v3
Checksum:i9C6E09F731B4CBCF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621S → T in strain: MT4239.
Natural varianti65 – 651T → I in strain: GS-5.
Natural varianti68 – 681V → A in strain: GS-5, MT4245, MT4251, MT4467 and MT8148.
Natural varianti78 – 781Q → P in strain: MT4251.
Natural varianti86 – 861I → S in strain: GS-5, MT4245, MT4251, MT4467 and MT8148.
Natural varianti89 – 891S → F in strain: MT4251.
Natural varianti168 – 1681K → N in strain: MT4251.
Natural varianti276 – 2761S → D in strain: GS-5, MT4467 and MT8148.
Natural varianti399 – 3991N → R in strain: MT4239.
Natural varianti474 – 4741I → T in strain: MT4239.
Natural varianti512 – 5121K → R in strain: MT8148.
Natural varianti519 – 5191F → Y in strain: MT8148.
Natural varianti701 – 7011T → I in strain: MT8148.
Natural varianti708 – 7081A → V in strain: MT8148.
Natural varianti938 – 9381F → L in strain: MT8148.
Natural varianti952 – 9576FGKPVE → YGTPVA in strain: GS-5, MT4239 and MT4467.
Natural varianti963 – 9642SV → NT in strain: GS-5, MT4239 and MT4467.
Natural varianti968 – 9703ADS → VDG in strain: GS-5, MT4239 and MT4467.
Natural varianti1086 – 10861A → T in strain: MT4239.
Natural varianti1158 – 11581S → N in strain: MT4239.
Natural varianti1163 – 11631H → Y in strain: MT4251.
Natural varianti1168 – 11681E → K in strain: MT8148.
Natural varianti1182 – 11821Y → C in strain: MT8148.
Natural varianti1234 – 12341A → P in strain: MT4239.
Natural varianti1263 – 12631R → H in strain: GS-5 and MT4467.
Natural varianti1263 – 12631R → P in strain: MT8148.
Natural varianti1264 – 12641Y → H in strain: GS-5, MT4239, MT4467 and MT8148.
Natural varianti1272 – 12721S → G in strain: GS-5, MT4239, MT4467 and MT8148.
Natural varianti1329 – 13291H → Y in strain: GS-5 and MT4467.
Natural varianti1394 – 13941Y → H in strain: GS-5, MT4239, MT4467 and MT8148.
Natural varianti1402 – 14021S → G in strain: GS-5, MT4239, MT4467 and MT8148.
Natural varianti1459 – 14591Y → H in strain: MT4467.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti570 – 5701R → A in AAA88588. 1 Publication
Sequence conflicti800 – 81718ADQDV…STDGK → LIKMFALRLARPHQQMA in AAA88588. 1 Publication
Add
BLAST
Sequence conflicti1310 – 13101H → L in AAA88588. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17361 Genomic DNA. Translation: AAA88588.1.
D88651 Genomic DNA. Translation: BAA26101.1.
D88654 Genomic DNA. Translation: BAA26105.1.
D88657 Genomic DNA. Translation: BAA26109.1.
D88660 Genomic DNA. Translation: BAA26113.1.
D89977 Genomic DNA. Translation: BAA26119.1.
AE014133 Genomic DNA. Translation: AAN58705.1.
PIRiB33135.
RefSeqiNP_721399.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58705; AAN58705; SMU_1004.
GeneIDi1028336.
KEGGismu:SMU_1004.
PATRICi19664129. VBIStrMut61772_0897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17361 Genomic DNA. Translation: AAA88588.1 .
D88651 Genomic DNA. Translation: BAA26101.1 .
D88654 Genomic DNA. Translation: BAA26105.1 .
D88657 Genomic DNA. Translation: BAA26109.1 .
D88660 Genomic DNA. Translation: BAA26113.1 .
D89977 Genomic DNA. Translation: BAA26119.1 .
AE014133 Genomic DNA. Translation: AAN58705.1 .
PIRi B33135.
RefSeqi NP_721399.1. NC_004350.2.

3D structure databases

ProteinModelPortali P08987.
ModBasei Search...

Protein-protein interaction databases

STRINGi 210007.SMU.1004.

Protein family/group databases

CAZyi GH70. Glycoside Hydrolase Family 70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58705 ; AAN58705 ; SMU_1004 .
GeneIDi 1028336.
KEGGi smu:SMU_1004.
PATRICi 19664129. VBIStrMut61772_0897.

Phylogenomic databases

eggNOGi COG5263.
KOi K00689.
OMAi ANGVQVK.
OrthoDBi EOG60PH6T.
PhylomeDBi P08987.

Enzyme and pathway databases

BioCyci SMUT210007:GC7Z-955-MONOMER.
SABIO-RK P08987.

Family and domain databases

Gene3Di 3.20.20.80. 3 hits.
InterProi IPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view ]
Pfami PF01473. CW_binding_1. 4 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 4 hits.
TIGRFAMsi TIGR04035. glucan_65_rpt. 6 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEi PS51170. CW. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the gtfB gene from Streptococcus mutans."
    Shiroza T., Ueda S., Kuramitsu H.K.
    J. Bacteriol. 169:4263-4270(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GS-5.
  2. "Molecular analyses of glucosyltransferase genes among strains of Streptococcus mutans."
    Fujiwara T., Terao Y., Hoshino T., Kawabata S., Ooshima T., Sobue S., Kimura S., Hamada S.
    FEMS Microbiol. Lett. 161:331-336(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MT4239 / Serotype c, MT4245 / Serotype e, MT4251 / Serotype f, MT4467 / Serotype e and MT8148 / Serotype c.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiGTFB_STRMU
AccessioniPrimary (citable) accession number: P08987
Secondary accession number(s): O69381
, O69384, O69387, O69390, O69396
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: December 6, 2002
Last modified: July 9, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

GTF-I synthesizes water-insoluble glucans (alpha 1,3-linked glucose and some 1,6 linkages), GTF-S synthesizes water-soluble glucans (alpha 1,6-glucose). GTF-SI synthesizes both forms of glucans.

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi