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Protein

Gap junction beta-1 protein

Gene

gjb1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-1 protein
Alternative name(s):
Connexin-30
Short name:
Cx30
Gene namesi
Name:gjb1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865435. gjb1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 75ExtracellularSequence analysisAdd BLAST30
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 130CytoplasmicSequence analysisAdd BLAST32
Transmembranei131 – 153HelicalSequence analysisAdd BLAST23
Topological domaini154 – 191ExtracellularSequence analysisAdd BLAST38
Transmembranei192 – 214HelicalSequence analysisAdd BLAST23
Topological domaini215 – 264CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578531 – 264Gap junction beta-1 proteinAdd BLAST264

Expressioni

Tissue specificityi

Lung, liver, intestines, stomach and kidney.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009576.
KOiK07620.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR002267. Connexin32.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PRINTSiPR00206. CONNEXIN.
PR01138. CONNEXINB1.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P08983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWAGLYAIL SGVNRHSTSI GRIWLSVVFI FRIMVLVAAA ESVWGDEKSA
60 70 80 90 100
FTCNTQQPGC NSVCYDHFFP ISHIRLWALQ LIIVSTPALL VAMHVAHLQH
110 120 130 140 150
QEKKELRLSR HVKDQELAEV KKHKVKISGT LWWTYISSVF FRIIFEAAFM
160 170 180 190 200
YIFYLIYPGY SMIRLLKCDA YPCPNTVDCF VSRPTEKTIF TVFMLVASGV
210 220 230 240 250
CIVLNVAEVF FLIAQACTRR ARRHRDSGSI SKEHQQNEMN LLITGGSIIK
260
RSAGQEKGDH CSTS
Length:264
Mass (Da):29,995
Last modified:July 1, 1989 - v2
Checksum:i08082E1F1051A8B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00791 mRNA. Translation: CAA68745.1.
PIRiA31102.
RefSeqiNP_001095219.1. NM_001101749.1.
UniGeneiXl.1191.

Genome annotation databases

GeneIDi394373.
KEGGixla:394373.

Similar proteinsi

Entry informationi

Entry nameiCXB1_XENLA
AccessioniPrimary (citable) accession number: P08983
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: May 10, 2017
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families