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Protein

Meiosis protein mei2

Gene

mei2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Crucial for commitment to meiosis but it is not sufficient itself for the commitment. May be a splicing regulator.

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • RNA binding Source: PomBase

GO - Biological processi

  • meiosis I Source: PomBase
  • positive regulation of meiotic cell cycle Source: PomBase
  • premeiotic DNA replication Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Meiosis, Stress response

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis protein mei2
Gene namesi
Name:mei2
ORF Names:SPAC27D7.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC27D7.03c.
PomBaseiSPAC27D7.03c. mei2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • Mei2 nuclear dot complex Source: PomBase
  • nuclear chromosome Source: PomBase
  • nucleus Source: PomBase
  • Tor2-Mei2-Ste11 complex Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 750750Meiosis protein mei2PRO_0000081626Add
BLAST

Post-translational modificationi

Inactivated by phosphorylation by ran1/pat1.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP08965.

Expressioni

Inductioni

By nitrogen starvation.

Interactioni

Subunit structurei

Binds rad24 when phosphorylated.

Protein-protein interaction databases

BioGridi278557. 37 interactions.
MINTiMINT-132219.

Structurei

3D structure databases

ProteinModelPortaliP08965.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini195 – 27076RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini293 – 36169RRM 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiP08965.
OMAiIMETESP.
OrthoDBiEOG7G4QPN.
PhylomeDBiP08965.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR007201. Rrm_2.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF04059. RRM_2. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08965-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMETESPLS ITSPSPSDST FQVDMEKTMH ALPSSLLDSP LLSTNEHYPP
60 70 80 90 100
KSTLLLSGPS PIRNIQLSAT KSSESNSIDY LTDTQNIFPN FVNNENNYQF
110 120 130 140 150
STAPLNPIDA CRVGERKVFT TGNVLLSADR QPLSTWQQNI SVLSESPPQN
160 170 180 190 200
GIQSYISSSE QAAQALTRKP SVTGFRSSSL NSNSDDIDIF SHASRYLFVT
210 220 230 240 250
NLPRIVPYAT LLELFSKLGD VKGIDTSSLS TDGICIVAFF DIRQAIQAAK
260 270 280 290 300
SLRSQRFFND RLLYFQFCQR SSIQKMINQG ATIQFLDDNE GQLLLNMQGG
310 320 330 340 350
SVLSILQLQS ILQTFGPLLI MKPLRSQNVS QIICEFYDTR DASFALDELD
360 370 380 390 400
GRIIHNCCLQ VAYYDAMADS VSTSSASSLS VPRGFSGMLN NNSEWNNSMT
410 420 430 440 450
MSSNQETPTA ASCAVSRIGS SYGMSNNFGS VPLGRTESSP AWGTSGYYDV
460 470 480 490 500
SSTSPVAPSD RNPSRQYNSI RYGLDVNPIA PPNSSRLKQR NSDLLNGINP
510 520 530 540 550
QWSPFSSNTG KVFDSPTGSL GMRRSLTVGA NASCSNPTNL SFASLTLHDS
560 570 580 590 600
KADSTLSASS LNPDLNLQRY TPTVEKHASD RNSVDYAQIA SGIDTRTTVM
610 620 630 640 650
IKNIPNKFTQ QMLRDYIDVT NKGTYDFLYL RIDFVNKCNV GYAFINFIEP
660 670 680 690 700
QSIITFGKAR VGTQWNVFHS EKICDISYAN IQGKDRLIEK FRNSCVMDEN
710 720 730 740 750
PAYRPKIFVS HGPNRGMEEP FPAPNNARRK LRSIASAQQI GLFPPTASKC
Length:750
Mass (Da):82,677
Last modified:November 1, 1988 - v1
Checksum:iA13D9E75F48D09DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07180 Genomic DNA. Translation: CAA30165.1.
CU329670 Genomic DNA. Translation: CAA15822.1.
PIRiS00391. COZPME.
RefSeqiNP_594609.1. NM_001020037.2.

Genome annotation databases

EnsemblFungiiSPAC27D7.03c.1; SPAC27D7.03c.1:pep; SPAC27D7.03c.
GeneIDi2542080.
KEGGispo:SPAC27D7.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07180 Genomic DNA. Translation: CAA30165.1.
CU329670 Genomic DNA. Translation: CAA15822.1.
PIRiS00391. COZPME.
RefSeqiNP_594609.1. NM_001020037.2.

3D structure databases

ProteinModelPortaliP08965.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278557. 37 interactions.
MINTiMINT-132219.

Proteomic databases

MaxQBiP08965.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC27D7.03c.1; SPAC27D7.03c.1:pep; SPAC27D7.03c.
GeneIDi2542080.
KEGGispo:SPAC27D7.03c.

Organism-specific databases

EuPathDBiFungiDB:SPAC27D7.03c.
PomBaseiSPAC27D7.03c. mei2.

Phylogenomic databases

InParanoidiP08965.
OMAiIMETESP.
OrthoDBiEOG7G4QPN.
PhylomeDBiP08965.

Miscellaneous databases

PROiP08965.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR007201. Rrm_2.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF04059. RRM_2. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The S.pombe mei2 gene encoding a crucial molecule for commitment to meiosis is under the regulation of cAMP."
    Watanabe Y., Iino Y., Furuhata K., Shimoda C., Yamamoto M.
    EMBO J. 7:761-767(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "14-3-3 protein interferes with the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p."
    Sato M., Watanabe Y., Akiyoshi Y., Yamamoto M.
    Curr. Biol. 12:141-145(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAD24.

Entry informationi

Entry nameiMEI2_SCHPO
AccessioniPrimary (citable) accession number: P08965
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

The expression of mei2 protein is negatively controlled by cAMP.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.