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Protein

Myosin-1

Gene

MYO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cell division.

Miscellaneous

Present with 2140 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi180 – 187ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

  • actomyosin contractile ring assembly Source: SGD
  • actomyosin contractile ring contraction Source: SGD
  • cell separation after cytokinesis Source: SGD
  • microtubule-based movement Source: InterPro

Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31084-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Type II myosin
Gene namesi
Name:MYO1
Ordered Locus Names:YHR023W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR023W
SGDiS000001065 MYO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234841 – 1928Myosin-1Add BLAST1928

Proteomic databases

MaxQBiP08964
PaxDbiP08964
PRIDEiP08964

PTM databases

iPTMnetiP08964

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi36454, 217 interactors
DIPiDIP-808N
IntActiP08964, 39 interactors
MINTiP08964
STRINGi4932.YHR023W

Structurei

3D structure databases

ProteinModelPortaliP08964
SMRiP08964
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 71Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST64
Domaini75 – 791Myosin motorPROSITE-ProRule annotationAdd BLAST717
Domaini794 – 823IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni460 – 529Actin-bindingBy similarityAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili856 – 1911Sequence analysisAdd BLAST1056

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00900000140837
HOGENOMiHOG000248744
InParanoidiP08964
KOiK10352
OMAiRSKWDDE
OrthoDBiEOG092C04K7

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 3 hits
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR008989 Myosin_S1_N
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P08964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGGQSCSSN MIVWIPDEKE VFVKGELMST DINKNKFTGQ EEQIGIVHPL
60 70 80 90 100
DSTEVSNLVQ VRISDVFPVN PSTFDKVENM SELTHLNEPS VLYNLEKRYD
110 120 130 140 150
CDLIYTYSGL FLVAINPYHN LNLYSEDHIN LYHNKHNRLS KSRLDENSHE
160 170 180 190 200
KLPPHIFAIA EEAYENLLSE GKDQSILVTG ESGAGKTENT KKILQYLASI
210 220 230 240 250
TSGSPSNIAP VSGSSIVESF EMKILQSNPI LESFGNAQTV RNNNSSRFGK
260 270 280 290 300
FIKIEFNEHG MINGAHIEWY LLEKSRIVHQ NSKERNYHIF YQLLSGLDDS
310 320 330 340 350
ELKNLRLKSR NVKDYKILSN SNQDIIPGIN DVENFKELLS ALNIIGFSKD
360 370 380 390 400
QIRWIFQVVA IILLIGNIEF VSDRAEQASF KNDVSAICSN LGVDEKDFQT
410 420 430 440 450
AILRPRSKAG KEWVSQSKNS QQAKFILNAL SRNLYERLFG YIVDMINKNL
460 470 480 490 500
DHGSATLNYI GLLDIAGFEI FENNSFEQLC INYTNEKLQQ FFNNHMFVLE
510 520 530 540 550
QSEYLKENIQ WDYIDYGKDL QLTIDLIESK GPPTGVLPLL DEEAVLPKST
560 570 580 590 600
DESFYSKLIS TWDQNSSKFK RSRLKNGFIL KHYAGDVEYT VEGWLSKNKD
610 620 630 640 650
PLNDNLLSLL SSSQNDIISK LFQPEGEKSS SAGVEANISN QEVKKSARTS
660 670 680 690 700
TFKTTSSRHR EQQITLLNQL ASTHPHFVRC IIPNNVKKVK TFNRRLILDQ
710 720 730 740 750
LRCNGVLEGI RLAREGYPNR IAFQEFFQRY RILYPENSTT TTFSSKLKAS
760 770 780 790 800
TKQNCEFLLT SLQLDTKVYK IGNTKLFFKA GVLADLEKQK DVKLNNIMIK
810 820 830 840 850
LTATIRGYTV RKEITYHLQK LKKTRVIGNT FRLYNRLVKE DPWFNLFIRI
860 870 880 890 900
KPLLTSSNDM TRTKKFNEQI NKLKNDLQEM ESKKKFLEEK NQKTVNELEN
910 920 930 940 950
TQDLLNQEKE NLRKNESLLN RVKTSSETLQ KQFDDLVSEK DEISREKLEV
960 970 980 990 1000
AQNLEEAHQK IQGLQETIRE REATLEKLHS KNNELIKQIS DLNCDISKEQ
1010 1020 1030 1040 1050
SSQSLIKESK LKLENEIKRL KDVINSKEEE IKSFNDKLSS SEEDLDIKLV
1060 1070 1080 1090 1100
TLEKNCNIAM SRLQSLVTEN SDLRSKNENF KKEKAALNNQ LKNKESELLK
1110 1120 1130 1140 1150
MKEKIDNHKK ELATFSKQRD DAVSEHGKIT AELKETRIQL TEYKSNYQKI
1160 1170 1180 1190 1200
KEEYSNFQRE TKEQEQKKRN SLVESLNDSK IKELEARLSQ EISLNQYLNK
1210 1220 1230 1240 1250
RISGNSVETN ISSTRRSTSY SDDPLDKEDI IKKYYDLQLA FTEITRNLEN
1260 1270 1280 1290 1300
EIEEKKNLIS RLRFTETRLA SSSFEDQKIK AQMKKLKKLI QDMDPSIPLD
1310 1320 1330 1340 1350
SILNEPLDNC PDKESDINKL MLEVDYLKRQ LDIETRAHYD AENAISALHS
1360 1370 1380 1390 1400
KFRKIQGESS LSSSDIYKLK FEASEERVKS LEDKLKTMPL RDRTNLPVGD
1410 1420 1430 1440 1450
IIKNRDSISK YEEEIRYYKL ENYKLQEILN ESNGKLSQLT LDLRQSKSKE
1460 1470 1480 1490 1500
ALLSEQLDRL QKDLESTERQ KELLSSTIKQ QKQQFENCMD DLQGNELRLR
1510 1520 1530 1540 1550
EHIHALKQAE EDVKNMASII EKLKTQNKQK EKLIWEREME RNDSDMQLQE
1560 1570 1580 1590 1600
TLLELKRVQD VKKILSDDLA HLKERLSAVE DRSQYTDEIN RLKEELNCSL
1610 1620 1630 1640 1650
KAETNLKKEF ATLKYKLETS TNDSEAKISD LLKQLDHYTK VVEMLNNEKD
1660 1670 1680 1690 1700
AISLAEKELY QKYEALNTEC ESLKGKIVSL TKIKQELESD LNQKTDALQI
1710 1720 1730 1740 1750
SNAALSSSTQ KNKEITEKIK YLEETLQLQM EQNSRNGELV KTLQASCNGY
1760 1770 1780 1790 1800
KDKFDDEKQK NIDLYEENQT LQKLNTDLQL QLKNLHERLS DTTEKNAWLS
1810 1820 1830 1840 1850
KIHELENMVS LETDLKYEEM KKNKSLERAV EELQTKNSQQ TDVIELANKN
1860 1870 1880 1890 1900
RSEFEEATLK YEAQISDLEK YISQQELEMK KSIRDNSSYR DKVQEMAQEI
1910 1920
EFWKSRYEST MIGSKNIDSN NAQSKIFS
Length:1,928
Mass (Da):223,636
Last modified:February 1, 1995 - v3
Checksum:i6F54C7611F43DC9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36K → I in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti46I → T in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti46I → T in CAA29550 (PubMed:3322809).Curated1
Sequence conflicti59V → S in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti59V → S in CAA29550 (PubMed:3322809).Curated1
Sequence conflicti86L → F in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti330Missing in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti330Missing in CAA29550 (PubMed:3322809).Curated1
Sequence conflicti343N → S in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti343N → S in CAA29550 (PubMed:3322809).Curated1
Sequence conflicti421 – 426QQAKFI → TKLSSL in CAA37894 (PubMed:2263482).Curated6
Sequence conflicti515D → S in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti529 – 535SKGPPTG → ARGHDR in CAA37894 (PubMed:2263482).Curated7
Sequence conflicti529 – 535SKGPPTG → ARGHDR in CAA29550 (PubMed:3322809).Curated7
Sequence conflicti541D → V in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti541D → V in CAA29550 (PubMed:3322809).Curated1
Sequence conflicti550 – 551TD → LM in CAA37894 (PubMed:2263482).Curated2
Sequence conflicti573R → A in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti582H → D in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti588 – 599EYTVE…LSKNK → NTLWKAGYPKT in CAA37894 (PubMed:2263482).CuratedAdd BLAST12
Sequence conflicti599Missing in CAA29550 (PubMed:3322809).Curated1
Sequence conflicti627 – 632EKSSSA → GKNLLVC in CAA37894 (PubMed:2263482).Curated6
Sequence conflicti627 – 632EKSSSA → GKNLLVC in CAA29550 (PubMed:3322809).Curated6
Sequence conflicti695R → S in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti695R → S in CAA29550 (PubMed:3322809).Curated1
Sequence conflicti736 – 742ENSTTTT → RKFNHHD in CAA29550 (PubMed:3322809).Curated7
Sequence conflicti756E → R in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti756E → R in CAA29550 (PubMed:3322809).Curated1
Sequence conflicti773 – 784NTKLF…AGVLA → ILTVFQKLEYWS in CAA37894 (PubMed:2263482).CuratedAdd BLAST12
Sequence conflicti793 – 794KL → NV in CAA37894 (PubMed:2263482).Curated2
Sequence conflicti896N → T in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti900N → NSQITKINTNITETPQSTYI GERPKRVICGN in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti906N → I in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti911N → K in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti915 – 930NESLL…SETLQ → RIAIKILKPAINIT in CAA37894 (PubMed:2263482).CuratedAdd BLAST16
Sequence conflicti934 – 939DDLVSE → MTLFL in CAA37894 (PubMed:2263482).Curated6
Sequence conflicti951 – 958AQNLEEAH → RKILKKLD in CAA37894 (PubMed:2263482).Curated8
Sequence conflicti1002S → C in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1049L → D in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1056C → S in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1060M → I in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1085A → E in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1123V → C in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1133L → S in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1144 – 1146KSN → NLI in CAA37894 (PubMed:2263482).Curated3
Sequence conflicti1159 – 1168RETKEQEQKK → TRKKEEQDKE in CAA37894 (PubMed:2263482).Curated10
Sequence conflicti1179 – 1204SKIKE…KRISG → ELKVKEWKARCHRKYLKSIL KQKNIR in CAA37894 (PubMed:2263482).CuratedAdd BLAST26
Sequence conflicti1224P → S in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1228E → Q in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1253E → Q in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1311 – 1323PDKES…KLMLE → LTKSLILTNGNAS in CAA37894 (PubMed:2263482).CuratedAdd BLAST13
Sequence conflicti1400D → H in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1454 – 1554SEQLD…ETLLE → P in CAA37894 (PubMed:2263482).CuratedAdd BLAST101
Sequence conflicti1568D → V in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1630 – 1646DLLKQ…VEMLN → SEAARSLYKSGGNVD in CAA37894 (PubMed:2263482).CuratedAdd BLAST17
Sequence conflicti1699 – 1705Missing in CAA37894 (PubMed:2263482).Curated7
Sequence conflicti1725 – 1737TLQLQ…NSRNG → NTTANGTKFKEW in CAA37894 (PubMed:2263482).CuratedAdd BLAST13
Sequence conflicti1754 – 1757FDDE → LMM in CAA37894 (PubMed:2263482).Curated4
Sequence conflicti1777D → E in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1788R → T in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1825S → D in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1882S → W in CAA37894 (PubMed:2263482).Curated1
Sequence conflicti1902 – 1904FWK → NSGKRLDADDL in CAA37894 (PubMed:2263482).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53947 Genomic DNA Translation: CAA37894.1
U10399 Genomic DNA Translation: AAB68872.1
X06187 Genomic DNA Translation: CAA29550.1
BK006934 Genomic DNA Translation: DAA06714.1
PIRiS46773
RefSeqiNP_011888.1, NM_001179153.1

Genome annotation databases

EnsemblFungiiYHR023W; YHR023W; YHR023W
GeneIDi856418
KEGGisce:YHR023W

Similar proteinsi

Entry informationi

Entry nameiMYO1_YEAST
AccessioniPrimary (citable) accession number: P08964
Secondary accession number(s): D3DKX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1995
Last modified: April 25, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health