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P08962

- CD63_HUMAN

UniProt

P08962 - CD63_HUMAN

Protein

CD63 antigen

Gene

CD63

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.5 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. cell-matrix adhesion Source: UniProtKB
    3. cell migration Source: UniProtKB
    4. cellular protein localization Source: MGI
    5. endosome to melanosome transport Source: UniProtKB
    6. pigment granule maturation Source: UniProtKB
    7. platelet activation Source: Reactome
    8. platelet degranulation Source: Reactome
    9. positive regulation of integrin-mediated signaling pathway Source: UniProtKB
    10. positive regulation of receptor internalization Source: UniProtKB
    11. protein transport Source: UniProtKB-KW
    12. regulation of rubidium ion transport Source: MGI
    13. regulation of vascular endothelial growth factor signaling pathway Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD63 antigen
    Alternative name(s):
    Granulophysin
    Lysosomal-associated membrane protein 3
    Short name:
    LAMP-3
    Melanoma-associated antigen ME491
    OMA81H
    Ocular melanoma-associated antigen
    Tetraspanin-30
    Short name:
    Tspan-30
    CD_antigen: CD63
    Gene namesi
    Name:CD63
    Synonyms:MLA1, TSPAN30
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:1692. CD63.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosomemultivesicular body. Melanosome
    Note: Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies.

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. endosome membrane Source: MGI
    3. extracellular vesicular exosome Source: UniProtKB
    4. integral component of plasma membrane Source: ProtInc
    5. intrinsic component of plasma membrane Source: UniProtKB
    6. late endosome membrane Source: UniProtKB
    7. lysosomal membrane Source: UniProtKB
    8. melanosome Source: UniProtKB-SubCell
    9. multivesicular body, internal vesicle Source: UniProtKB
    10. plasma membrane Source: Reactome
    11. platelet dense granule membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26231.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 238237CD63 antigenPRO_0000219216Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi130 – 1301N-linked (GlcNAc...)2 Publications
    Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).1 Publication

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP08962.
    PaxDbiP08962.
    PRIDEiP08962.

    PTM databases

    PhosphoSiteiP08962.

    Expressioni

    Tissue specificityi

    Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.1 Publication

    Gene expression databases

    ArrayExpressiP08962.
    BgeeiP08962.
    CleanExiHS_CD63.
    GenevestigatoriP08962.

    Organism-specific databases

    HPAiCAB026356.
    HPA010088.

    Interactioni

    Subunit structurei

    Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1. Interacts with CD9. Identified in a complex with CD9 and ITGB3. Interacts with PMEL. Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TIMP1P010335EBI-762053,EBI-712536

    Protein-protein interaction databases

    BioGridi107405. 16 interactions.
    IntActiP08962. 16 interactions.
    MINTiMINT-2981823.
    STRINGi9606.ENSP00000257857.

    Structurei

    3D structure databases

    ProteinModelPortaliP08962.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1110CytoplasmicSequence Analysis
    Topological domaini33 – 5119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini73 – 819CytoplasmicSequence Analysis
    Topological domaini103 – 203101ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 23814CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268658.
    HOGENOMiHOG000230651.
    HOVERGENiHBG107306.
    InParanoidiP08962.
    KOiK06497.
    OMAiMITFAVF.
    PhylomeDBiP08962.
    TreeFamiTF316345.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P08962-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVEGGMKCV KFLLYVLLLA FCACAVGLIA VGVGAQLVLS QTIIQGATPG    50
    SLLPVVIIAV GVFLFLVAFV GCCGACKENY CLMITFAIFL SLIMLVEVAA 100
    AIAGYVFRDK VMSEFNNNFR QQMENYPKNN HTASILDRMQ ADFKCCGAAN 150
    YTDWEKIPSM SKNRVPDSCC INVTVGCGIN FNEKAIHKEG CVEKIGGWLR 200
    KNVLVVAAAA LGIAFVEVLG IVFACCLVKS IRSGYEVM 238
    Length:238
    Mass (Da):25,637
    Last modified:January 23, 2007 - v2
    Checksum:i85AC8E235C6E425F
    GO
    Isoform 2 (identifier: P08962-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         23-45: Missing.

    Show »
    Length:215
    Mass (Da):23,430
    Checksum:iC4469E42BCC8C4F7
    GO
    Isoform 3 (identifier: P08962-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-82: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:156
    Mass (Da):17,271
    Checksum:iD5A714579CDE49EF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 361Q → E AA sequence (PubMed:7682577)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8282Missing in isoform 3. CuratedVSP_046996Add
    BLAST
    Alternative sequencei23 – 4523Missing in isoform 2. 1 PublicationVSP_045300Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07982 mRNA. Translation: CAA30792.1.
    M59907 mRNA. Translation: AAA63235.1.
    M58485 mRNA. No translation available.
    S93788 mRNA. Translation: AAB21617.1.
    X62654 Genomic DNA. Translation: CAA44519.1.
    AF508304 mRNA. Translation: AAM34259.1.
    AK311893 mRNA. Translation: BAG34834.1.
    CR542096 mRNA. Translation: CAG46893.1.
    BT007073 mRNA. Translation: AAP35736.1.
    BT020137 mRNA. Translation: AAV38939.1.
    BT020138 mRNA. Translation: AAV38940.1.
    AC009779 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96827.1.
    BC002349 mRNA. Translation: AAH02349.1.
    BC013017 mRNA. Translation: AAH13017.1.
    CCDSiCCDS58242.1. [P08962-3]
    CCDS58243.1. [P08962-2]
    CCDS8890.1. [P08962-1]
    PIRiI38016.
    RefSeqiNP_001244318.1. NM_001257389.1. [P08962-1]
    NP_001244319.1. NM_001257390.1. [P08962-1]
    NP_001244320.1. NM_001257391.1. [P08962-1]
    NP_001244321.1. NM_001257392.1. [P08962-2]
    NP_001244329.1. NM_001257400.1. [P08962-3]
    NP_001244330.1. NM_001257401.1. [P08962-3]
    NP_001254627.1. NM_001267698.1. [P08962-1]
    NP_001771.1. NM_001780.5. [P08962-1]
    UniGeneiHs.445570.

    Genome annotation databases

    EnsembliENST00000257857; ENSP00000257857; ENSG00000135404. [P08962-1]
    ENST00000546939; ENSP00000447356; ENSG00000135404. [P08962-3]
    ENST00000549117; ENSP00000447730; ENSG00000135404. [P08962-1]
    ENST00000550776; ENSP00000448091; ENSG00000135404. [P08962-3]
    ENST00000552692; ENSP00000449337; ENSG00000135404. [P08962-1]
    ENST00000552754; ENSP00000446807; ENSG00000135404. [P08962-2]
    GeneIDi967.
    KEGGihsa:967.
    UCSCiuc001shn.4. human. [P08962-1]
    uc009znz.4. human.

    Polymorphism databases

    DMDMi116026.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07982 mRNA. Translation: CAA30792.1 .
    M59907 mRNA. Translation: AAA63235.1 .
    M58485 mRNA. No translation available.
    S93788 mRNA. Translation: AAB21617.1 .
    X62654 Genomic DNA. Translation: CAA44519.1 .
    AF508304 mRNA. Translation: AAM34259.1 .
    AK311893 mRNA. Translation: BAG34834.1 .
    CR542096 mRNA. Translation: CAG46893.1 .
    BT007073 mRNA. Translation: AAP35736.1 .
    BT020137 mRNA. Translation: AAV38939.1 .
    BT020138 mRNA. Translation: AAV38940.1 .
    AC009779 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96827.1 .
    BC002349 mRNA. Translation: AAH02349.1 .
    BC013017 mRNA. Translation: AAH13017.1 .
    CCDSi CCDS58242.1. [P08962-3 ]
    CCDS58243.1. [P08962-2 ]
    CCDS8890.1. [P08962-1 ]
    PIRi I38016.
    RefSeqi NP_001244318.1. NM_001257389.1. [P08962-1 ]
    NP_001244319.1. NM_001257390.1. [P08962-1 ]
    NP_001244320.1. NM_001257391.1. [P08962-1 ]
    NP_001244321.1. NM_001257392.1. [P08962-2 ]
    NP_001244329.1. NM_001257400.1. [P08962-3 ]
    NP_001244330.1. NM_001257401.1. [P08962-3 ]
    NP_001254627.1. NM_001267698.1. [P08962-1 ]
    NP_001771.1. NM_001780.5. [P08962-1 ]
    UniGenei Hs.445570.

    3D structure databases

    ProteinModelPortali P08962.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107405. 16 interactions.
    IntActi P08962. 16 interactions.
    MINTi MINT-2981823.
    STRINGi 9606.ENSP00000257857.

    PTM databases

    PhosphoSitei P08962.

    Polymorphism databases

    DMDMi 116026.

    Proteomic databases

    MaxQBi P08962.
    PaxDbi P08962.
    PRIDEi P08962.

    Protocols and materials databases

    DNASUi 967.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257857 ; ENSP00000257857 ; ENSG00000135404 . [P08962-1 ]
    ENST00000546939 ; ENSP00000447356 ; ENSG00000135404 . [P08962-3 ]
    ENST00000549117 ; ENSP00000447730 ; ENSG00000135404 . [P08962-1 ]
    ENST00000550776 ; ENSP00000448091 ; ENSG00000135404 . [P08962-3 ]
    ENST00000552692 ; ENSP00000449337 ; ENSG00000135404 . [P08962-1 ]
    ENST00000552754 ; ENSP00000446807 ; ENSG00000135404 . [P08962-2 ]
    GeneIDi 967.
    KEGGi hsa:967.
    UCSCi uc001shn.4. human. [P08962-1 ]
    uc009znz.4. human.

    Organism-specific databases

    CTDi 967.
    GeneCardsi GC12M056119.
    HGNCi HGNC:1692. CD63.
    HPAi CAB026356.
    HPA010088.
    MIMi 155740. gene.
    neXtProti NX_P08962.
    PharmGKBi PA26231.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG268658.
    HOGENOMi HOG000230651.
    HOVERGENi HBG107306.
    InParanoidi P08962.
    KOi K06497.
    OMAi MITFAVF.
    PhylomeDBi P08962.
    TreeFami TF316345.

    Miscellaneous databases

    ChiTaRSi CD63. human.
    GeneWikii CD63.
    GenomeRNAii 967.
    NextBioi 4044.
    PROi P08962.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08962.
    Bgeei P08962.
    CleanExi HS_CD63.
    Genevestigatori P08962.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression."
      Hotta H., Ross A.H., Huebner K., Isobe M., Wendeborn S., Chao M.V., Ricciardi R.P., Tsujimoto Y., Croce C.M., Koprowski H.
      Cancer Res. 48:2955-2962(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Characterization of three abundant mRNAs from human ovarian granulosa cells."
      Rapp G., Freudenstein J., Klaudiny J., Mucha J., Wempe F., Zimmer M., Scheit K.H.
      DNA Cell Biol. 9:479-485(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Ovary.
    3. "CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells."
      Metzelaar M.J., Wigngaard P.L., Peters P.J., Sixma J.J., Nieuwenhuis H.K., Clevers H.C.
      J. Biol. Chem. 266:3239-3245(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    4. "An ocular melanoma-associated antigen. Molecular characterization."
      Wang M.X., Earley J.J. Jr., Shields J.A., Donoso L.A.
      Arch. Ophthalmol. 110:399-404(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences."
      Hotta H., Miyamoto H., Hara I., Takahashi N., Homma M.
      Biochem. Biophys. Res. Commun. 185:436-442(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Melanocyte variant of lysosome-associated membrane protein-3 (LAMP3; also CD63 and melanoma associated antigen ME419) mRNA."
      Ancans J., Suzuki I., Thody A.J.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Skin.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    10. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Muscle.
    13. "The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin."
      Nishibori M., Cham B., McNicol A., Shalev A., Jain N., Gerrard J.M.
      J. Clin. Invest. 91:1775-1782(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-38 (ISOFORM 1), SUBCELLULAR LOCATION, LACK OF EXPRESSION IN HERMANSKY-PUDLAK SYNDROME.
      Tissue: Platelet.
    14. "Isolation and amino terminal sequencing of a novel melanoma-associated antigen."
      Ross A.H., Dietzschold B., Jackson D.M., Earley J.J., Ghrist B.F.D., Atkinson B., Koprowski H.
      Arch. Biochem. Biophys. 242:540-548(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21 (ISOFORMS 1/2).
    15. "The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells."
      Kobayashi T., Vischer U.M., Rosnoblet C., Lebrand C., Lindsay M., Parton R.G., Kruithof E.K.O., Gruenberg J.
      Mol. Biol. Cell 11:1829-1843(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    16. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-130.
    17. "LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells."
      Gruetzkau A., Smorodchenko A., Lippert U., Kirchhof L., Artuc M., Henz B.M.
      Cytometry 61:62-68(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    18. "Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein."
      Jung K.K., Liu X.W., Chirco R., Fridman R., Kim H.R.
      EMBO J. 25:3934-3942(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TIMP1 AND ITGB1.
    19. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Placenta.
    20. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-130.
      Tissue: Liver.
    21. "Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets."
      Israels S.J., McMillan-Ward E.M.
      Thromb. Res. 125:152-158(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CD9, IDENTIFICATION IN A COMPLEX WITH ITGB3.
    22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. "CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin."
      Doyle E.L., Ridger V., Ferraro F., Turmaine M., Saftig P., Cutler D.F.
      Blood 118:4265-4273(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CELL-CELL ADHESION, SUBCELLULAR LOCATION.
    24. "The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis."
      van Niel G., Charrin S., Simoes S., Romao M., Rochin L., Saftig P., Marks M.S., Rubinstein E., Raposo G.
      Dev. Cell 21:708-721(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN MELANOCYTE DEVELOPMENT, SUBCELLULAR LOCATION, INTERACTION WITH PMEL.
    25. "Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-beta1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo."
      Tugues S., Honjo S., Konig C., Padhan N., Kroon J., Gualandi L., Li X., Barkefors I., Thijssen V.L., Griffioen A.W., Claesson-Welsh L.
      J. Biol. Chem. 288:19060-19071(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KDR.
    26. "TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling."
      Lee S.Y., Kim J.M., Cho S.Y., Kim H.S., Shin H.S., Jeon J.Y., Kausar R., Jeong S.Y., Lee Y.S., Lee M.A.
      Biochem. J. 459:565-576(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CD63 AND ITGB1.

    Entry informationi

    Entry nameiCD63_HUMAN
    AccessioniPrimary (citable) accession number: P08962
    Secondary accession number(s): F8VZE2
    , Q5TZP3, Q8N6Z9, Q9UCG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 152 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.
    This antigen is associated with early stages of melanoma tumor progression.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3