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P08962

- CD63_HUMAN

UniProt

P08962 - CD63_HUMAN

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Protein
CD63 antigen
Gene
CD63, MLA1, TSPAN30
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.5 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. cell migration Source: UniProtKB
  3. cell-matrix adhesion Source: UniProtKB
  4. cellular protein localization Source: MGI
  5. endosome to melanosome transport Source: UniProtKB
  6. pigment granule maturation Source: UniProtKB
  7. platelet activation Source: Reactome
  8. platelet degranulation Source: Reactome
  9. positive regulation of integrin-mediated signaling pathway Source: UniProtKB
  10. positive regulation of receptor internalization Source: UniProtKB
  11. protein transport Source: UniProtKB-KW
  12. regulation of rubidium ion transport Source: MGI
  13. regulation of vascular endothelial growth factor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
CD63 antigen
Alternative name(s):
Granulophysin
Lysosomal-associated membrane protein 3
Short name:
LAMP-3
Melanoma-associated antigen ME491
OMA81H
Ocular melanoma-associated antigen
Tetraspanin-30
Short name:
Tspan-30
CD_antigen: CD63
Gene namesi
Name:CD63
Synonyms:MLA1, TSPAN30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:1692. CD63.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosomemultivesicular body. Melanosome
Note: Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies.10 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1110Cytoplasmic Reviewed prediction
Transmembranei12 – 3221Helical; Reviewed prediction
Add
BLAST
Topological domaini33 – 5119Extracellular Reviewed prediction
Add
BLAST
Transmembranei52 – 7221Helical; Reviewed prediction
Add
BLAST
Topological domaini73 – 819Cytoplasmic Reviewed prediction
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Topological domaini103 – 203101Extracellular Reviewed prediction
Add
BLAST
Transmembranei204 – 22421Helical; Reviewed prediction
Add
BLAST
Topological domaini225 – 23814Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. endosome membrane Source: MGI
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of plasma membrane Source: ProtInc
  5. intrinsic component of plasma membrane Source: UniProtKB
  6. late endosome membrane Source: UniProtKB
  7. lysosomal membrane Source: UniProtKB
  8. melanosome Source: UniProtKB-SubCell
  9. multivesicular body, internal vesicle Source: UniProtKB
  10. plasma membrane Source: Reactome
  11. platelet dense granule membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26231.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 238237CD63 antigen
PRO_0000219216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...)2 Publications
Glycosylationi150 – 1501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP08962.
PaxDbiP08962.
PRIDEiP08962.

PTM databases

PhosphoSiteiP08962.

Expressioni

Tissue specificityi

Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.1 Publication

Gene expression databases

ArrayExpressiP08962.
BgeeiP08962.
CleanExiHS_CD63.
GenevestigatoriP08962.

Organism-specific databases

HPAiCAB026356.
HPA010088.

Interactioni

Subunit structurei

Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1. Interacts with CD9. Identified in a complex with CD9 and ITGB3. Interacts with PMEL. Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TIMP1P010335EBI-762053,EBI-712536

Protein-protein interaction databases

BioGridi107405. 16 interactions.
IntActiP08962. 16 interactions.
MINTiMINT-2981823.
STRINGi9606.ENSP00000257857.

Structurei

3D structure databases

ProteinModelPortaliP08962.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268658.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
InParanoidiP08962.
KOiK06497.
OMAiMITFAVF.
PhylomeDBiP08962.
TreeFamiTF316345.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P08962-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAVEGGMKCV KFLLYVLLLA FCACAVGLIA VGVGAQLVLS QTIIQGATPG    50
SLLPVVIIAV GVFLFLVAFV GCCGACKENY CLMITFAIFL SLIMLVEVAA 100
AIAGYVFRDK VMSEFNNNFR QQMENYPKNN HTASILDRMQ ADFKCCGAAN 150
YTDWEKIPSM SKNRVPDSCC INVTVGCGIN FNEKAIHKEG CVEKIGGWLR 200
KNVLVVAAAA LGIAFVEVLG IVFACCLVKS IRSGYEVM 238
Length:238
Mass (Da):25,637
Last modified:January 23, 2007 - v2
Checksum:i85AC8E235C6E425F
GO
Isoform 2 (identifier: P08962-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-45: Missing.

Show »
Length:215
Mass (Da):23,430
Checksum:iC4469E42BCC8C4F7
GO
Isoform 3 (identifier: P08962-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Note: Gene prediction based on EST data.

Show »
Length:156
Mass (Da):17,271
Checksum:iD5A714579CDE49EF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282Missing in isoform 3.
VSP_046996Add
BLAST
Alternative sequencei23 – 4523Missing in isoform 2.
VSP_045300Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361Q → E AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07982 mRNA. Translation: CAA30792.1.
M59907 mRNA. Translation: AAA63235.1.
M58485 mRNA. No translation available.
S93788 mRNA. Translation: AAB21617.1.
X62654 Genomic DNA. Translation: CAA44519.1.
AF508304 mRNA. Translation: AAM34259.1.
AK311893 mRNA. Translation: BAG34834.1.
CR542096 mRNA. Translation: CAG46893.1.
BT007073 mRNA. Translation: AAP35736.1.
BT020137 mRNA. Translation: AAV38939.1.
BT020138 mRNA. Translation: AAV38940.1.
AC009779 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96827.1.
BC002349 mRNA. Translation: AAH02349.1.
BC013017 mRNA. Translation: AAH13017.1.
CCDSiCCDS58242.1. [P08962-3]
CCDS58243.1. [P08962-2]
CCDS8890.1. [P08962-1]
PIRiI38016.
RefSeqiNP_001244318.1. NM_001257389.1. [P08962-1]
NP_001244319.1. NM_001257390.1. [P08962-1]
NP_001244320.1. NM_001257391.1. [P08962-1]
NP_001244321.1. NM_001257392.1. [P08962-2]
NP_001244329.1. NM_001257400.1. [P08962-3]
NP_001244330.1. NM_001257401.1. [P08962-3]
NP_001254627.1. NM_001267698.1. [P08962-1]
NP_001771.1. NM_001780.5. [P08962-1]
UniGeneiHs.445570.

Genome annotation databases

EnsembliENST00000257857; ENSP00000257857; ENSG00000135404. [P08962-1]
ENST00000546939; ENSP00000447356; ENSG00000135404. [P08962-3]
ENST00000549117; ENSP00000447730; ENSG00000135404. [P08962-1]
ENST00000550776; ENSP00000448091; ENSG00000135404. [P08962-3]
ENST00000552692; ENSP00000449337; ENSG00000135404. [P08962-1]
ENST00000552754; ENSP00000446807; ENSG00000135404. [P08962-2]
GeneIDi967.
KEGGihsa:967.
UCSCiuc001shn.4. human. [P08962-1]
uc009znz.4. human.

Polymorphism databases

DMDMi116026.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07982 mRNA. Translation: CAA30792.1 .
M59907 mRNA. Translation: AAA63235.1 .
M58485 mRNA. No translation available.
S93788 mRNA. Translation: AAB21617.1 .
X62654 Genomic DNA. Translation: CAA44519.1 .
AF508304 mRNA. Translation: AAM34259.1 .
AK311893 mRNA. Translation: BAG34834.1 .
CR542096 mRNA. Translation: CAG46893.1 .
BT007073 mRNA. Translation: AAP35736.1 .
BT020137 mRNA. Translation: AAV38939.1 .
BT020138 mRNA. Translation: AAV38940.1 .
AC009779 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96827.1 .
BC002349 mRNA. Translation: AAH02349.1 .
BC013017 mRNA. Translation: AAH13017.1 .
CCDSi CCDS58242.1. [P08962-3 ]
CCDS58243.1. [P08962-2 ]
CCDS8890.1. [P08962-1 ]
PIRi I38016.
RefSeqi NP_001244318.1. NM_001257389.1. [P08962-1 ]
NP_001244319.1. NM_001257390.1. [P08962-1 ]
NP_001244320.1. NM_001257391.1. [P08962-1 ]
NP_001244321.1. NM_001257392.1. [P08962-2 ]
NP_001244329.1. NM_001257400.1. [P08962-3 ]
NP_001244330.1. NM_001257401.1. [P08962-3 ]
NP_001254627.1. NM_001267698.1. [P08962-1 ]
NP_001771.1. NM_001780.5. [P08962-1 ]
UniGenei Hs.445570.

3D structure databases

ProteinModelPortali P08962.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107405. 16 interactions.
IntActi P08962. 16 interactions.
MINTi MINT-2981823.
STRINGi 9606.ENSP00000257857.

PTM databases

PhosphoSitei P08962.

Polymorphism databases

DMDMi 116026.

Proteomic databases

MaxQBi P08962.
PaxDbi P08962.
PRIDEi P08962.

Protocols and materials databases

DNASUi 967.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257857 ; ENSP00000257857 ; ENSG00000135404 . [P08962-1 ]
ENST00000546939 ; ENSP00000447356 ; ENSG00000135404 . [P08962-3 ]
ENST00000549117 ; ENSP00000447730 ; ENSG00000135404 . [P08962-1 ]
ENST00000550776 ; ENSP00000448091 ; ENSG00000135404 . [P08962-3 ]
ENST00000552692 ; ENSP00000449337 ; ENSG00000135404 . [P08962-1 ]
ENST00000552754 ; ENSP00000446807 ; ENSG00000135404 . [P08962-2 ]
GeneIDi 967.
KEGGi hsa:967.
UCSCi uc001shn.4. human. [P08962-1 ]
uc009znz.4. human.

Organism-specific databases

CTDi 967.
GeneCardsi GC12M056119.
HGNCi HGNC:1692. CD63.
HPAi CAB026356.
HPA010088.
MIMi 155740. gene.
neXtProti NX_P08962.
PharmGKBi PA26231.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG268658.
HOGENOMi HOG000230651.
HOVERGENi HBG107306.
InParanoidi P08962.
KOi K06497.
OMAi MITFAVF.
PhylomeDBi P08962.
TreeFami TF316345.

Miscellaneous databases

ChiTaRSi CD63. human.
GeneWikii CD63.
GenomeRNAii 967.
NextBioi 4044.
PROi P08962.
SOURCEi Search...

Gene expression databases

ArrayExpressi P08962.
Bgeei P08962.
CleanExi HS_CD63.
Genevestigatori P08962.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression."
    Hotta H., Ross A.H., Huebner K., Isobe M., Wendeborn S., Chao M.V., Ricciardi R.P., Tsujimoto Y., Croce C.M., Koprowski H.
    Cancer Res. 48:2955-2962(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Characterization of three abundant mRNAs from human ovarian granulosa cells."
    Rapp G., Freudenstein J., Klaudiny J., Mucha J., Wempe F., Zimmer M., Scheit K.H.
    DNA Cell Biol. 9:479-485(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Ovary.
  3. "CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells."
    Metzelaar M.J., Wigngaard P.L., Peters P.J., Sixma J.J., Nieuwenhuis H.K., Clevers H.C.
    J. Biol. Chem. 266:3239-3245(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  4. "An ocular melanoma-associated antigen. Molecular characterization."
    Wang M.X., Earley J.J. Jr., Shields J.A., Donoso L.A.
    Arch. Ophthalmol. 110:399-404(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences."
    Hotta H., Miyamoto H., Hara I., Takahashi N., Homma M.
    Biochem. Biophys. Res. Commun. 185:436-442(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Melanocyte variant of lysosome-associated membrane protein-3 (LAMP3; also CD63 and melanoma associated antigen ME419) mRNA."
    Ancans J., Suzuki I., Thody A.J.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Skin.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  10. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Muscle.
  13. "The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin."
    Nishibori M., Cham B., McNicol A., Shalev A., Jain N., Gerrard J.M.
    J. Clin. Invest. 91:1775-1782(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-38 (ISOFORM 1), SUBCELLULAR LOCATION, LACK OF EXPRESSION IN HERMANSKY-PUDLAK SYNDROME.
    Tissue: Platelet.
  14. "Isolation and amino terminal sequencing of a novel melanoma-associated antigen."
    Ross A.H., Dietzschold B., Jackson D.M., Earley J.J., Ghrist B.F.D., Atkinson B., Koprowski H.
    Arch. Biochem. Biophys. 242:540-548(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21 (ISOFORMS 1/2).
  15. "The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells."
    Kobayashi T., Vischer U.M., Rosnoblet C., Lebrand C., Lindsay M., Parton R.G., Kruithof E.K.O., Gruenberg J.
    Mol. Biol. Cell 11:1829-1843(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  16. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-130.
  17. "LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells."
    Gruetzkau A., Smorodchenko A., Lippert U., Kirchhof L., Artuc M., Henz B.M.
    Cytometry 61:62-68(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  18. "Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein."
    Jung K.K., Liu X.W., Chirco R., Fridman R., Kim H.R.
    EMBO J. 25:3934-3942(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TIMP1 AND ITGB1.
  19. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Placenta.
  20. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-130.
    Tissue: Liver.
  21. "Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets."
    Israels S.J., McMillan-Ward E.M.
    Thromb. Res. 125:152-158(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CD9, IDENTIFICATION IN A COMPLEX WITH ITGB3.
  22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  23. "CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin."
    Doyle E.L., Ridger V., Ferraro F., Turmaine M., Saftig P., Cutler D.F.
    Blood 118:4265-4273(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CELL-CELL ADHESION, SUBCELLULAR LOCATION.
  24. "The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis."
    van Niel G., Charrin S., Simoes S., Romao M., Rochin L., Saftig P., Marks M.S., Rubinstein E., Raposo G.
    Dev. Cell 21:708-721(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MELANOCYTE DEVELOPMENT, SUBCELLULAR LOCATION, INTERACTION WITH PMEL.
  25. "Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-beta1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo."
    Tugues S., Honjo S., Konig C., Padhan N., Kroon J., Gualandi L., Li X., Barkefors I., Thijssen V.L., Griffioen A.W., Claesson-Welsh L.
    J. Biol. Chem. 288:19060-19071(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KDR.
  26. "TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling."
    Lee S.Y., Kim J.M., Cho S.Y., Kim H.S., Shin H.S., Jeon J.Y., Kausar R., Jeong S.Y., Lee Y.S., Lee M.A.
    Biochem. J. 459:565-576(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CD63 AND ITGB1.

Entry informationi

Entry nameiCD63_HUMAN
AccessioniPrimary (citable) accession number: P08962
Secondary accession number(s): F8VZE2
, Q5TZP3, Q8N6Z9, Q9UCG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.
This antigen is associated with early stages of melanoma tumor progression.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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