P08923 (LTK_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 134.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Leukocyte tyrosine kinase receptor EC=2.7.10.1 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 888 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport By similarity. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subunit structure | Homodimer when bound to ligand Probable. Part of a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2 By similarity. Isoform A binds calnexin. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein Ref.6. Isoform A: Endoplasmic reticulum. Note: Retained in the endoplasmic reticulum. Ref.6 Isoform B: Endoplasmic reticulum. Note: Retained in the endoplasmic reticulum. Ref.6 |
| Tissue specificity | Subsets of lymphoid and neuronal cells. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 1 protein kinase domain. |
| Sequence caution | The sequence CAA30793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. |
Ontologies
Alternative products
| This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select] Note: Additional isoforms seem to exist. | ||||||
| Isoform D (identifier: P08923-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: May be produced by alternative promoter usage. | ||||||
| Isoform A (identifier: P08923-2) The sequence of this isoform differs from the canonical sequence as follows: 1-251: Missing. 252-252: L → M 271-331: Missing. | ||||||
| Note: May be produced by alternative promoter usage. Starts at a CUG codon. | ||||||
| Isoform B (identifier: P08923-3) The sequence of this isoform differs from the canonical sequence as follows: 1-251: Missing. 252-252: L → M | ||||||
| Note: May be produced by alternative promoter usage. Starts at a CUG codon. | ||||||
| Isoform C (identifier: P08923-4) The sequence of this isoform differs from the canonical sequence as follows: 271-331: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 16 | 16 | Potential | ||||||
| Chain | 17 – 888 | 872 | Leukocyte tyrosine kinase receptor | PRO_0000016739 | |||||
Regions | |||||||||
| Topological domain | 17 – 421 | 405 | Extracellular Potential | ||||||
| Transmembrane | 422 – 446 | 25 | Helical; Potential | ||||||
| Topological domain | 447 – 888 | 442 | Cytoplasmic Potential | ||||||
| Domain | 506 – 782 | 277 | Protein kinase | ||||||
| Nucleotide binding | 512 – 520 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 639 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 540 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 668 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 672 | 1 | Phosphotyrosine; by autocatalysis By similarity | ||||||
| Modified residue | 673 | 1 | Phosphotyrosine By similarity | ||||||
| Glycosylation | 377 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 409 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 251 | 251 | Missing in isoform A and isoform B. | VSP_002950 | |||||
| Alternative sequence | 252 | 1 | L → M in isoform A and isoform B. | VSP_002951 | |||||
| Alternative sequence | 271 – 331 | 61 | Missing in isoform A and isoform C. | VSP_002952 | |||||
| Natural variant | 746 | 1 | G → E. Ref.7 | ||||||
Experimental info | |||||||||
| Sequence conflict | 26 | 1 | T → A in AAA39451. Ref.3 | ||||||
| Sequence conflict | 113 | 1 | V → A in AAA39451. Ref.3 | ||||||
| Sequence conflict | 789 | 1 | V → M in CAA36848. Ref.2 | ||||||
| Sequence conflict | 789 | 1 | V → M in AAA39451. Ref.3 | ||||||
| Sequence conflict | 875 | 1 | H → Q in CAA36848. Ref.2 | ||||||
| Sequence conflict | 875 | 1 | H → Q in AAA39451. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator." Bernards A., de la Monte S. EMBO J. 9:2279-2287(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). Strain: BALB/c. |
| [2] | "Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain." Haase V.H., Snijders A.J., Cooke S.M., Teng M.N., Kaul D., le Beau M.M., Bruns G.A., Bernards A. Oncogene 6:2319-2325(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). Strain: BALB/c. |
| [3] | "Four tissue-specific mouse ltk mRNAs predict tyrosine kinases that differ upstream of their transmembrane segment." Snijders A.J., Haase V.H., Bernards A. Oncogene 8:27-35(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D). |
| [4] | "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.  Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [5] | "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain." Ben-Neriah Y., Bauskin A.R. Nature 333:672-676(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 260-888 (ISOFORM A). |
| [6] | "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin." Snijders A.J., Ho S.C., Haase V.H., Pillai S., Bernards A. J. Biol. Chem. 272:1297-1301(1997) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CALNEXIN (ISOFORM A). |
| [7] | "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus." Li N., Nakamura K., Jiang Y., Tsurui H., Matsuoka S., Abe M., Ohtsuji M., Nishimura H., Kato K., Kawai T., Atsumi T., Koike T., Shirai T., Ueno H., Hirose S. Hum. Mol. Genet. 13:171-179(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLU-746. Strain: NZB. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X52621 mRNA. Translation: CAA36848.1. M90470 mRNA. Translation: AAA39451.1. AL844536 Genomic DNA. Translation: CAM18081.1. X07984 mRNA. Translation: CAA30793.1. Different initiation. |
| IPI | IPI00108002. IPI00229958. IPI00229960. IPI00828801. |
| PIR | I58378. S12792. |
| RefSeq | NP_976220.2. NM_203345.2. NP_996824.1. NM_206941.1. NP_996825.2. NM_206942.2. |
| UniGene | Mm.1740. |
3D structure databases | |
| ProteinModelPortal | P08923. |
| SMR | P08923. Positions 498-789. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P08923. |
Proteomic databases | |
| PaxDb | P08923. |
| PRIDE | P08923. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000028759; ENSMUSP00000028759; ENSMUSG00000027297. ENSMUST00000082130; ENSMUSP00000080774; ENSMUSG00000027297. |
| GeneID | 17005. |
| KEGG | mmu:17005. |
Organism-specific databases | |
| CTD | 4058. |
| MGI | MGI:96840. Ltk. |
Phylogenomic databases | |
| eggNOG | COG0515. |
| GeneTree | ENSGT00700000104172. |
| HOGENOM | HOG000231766. |
| HOVERGEN | HBG052371. |
| InParanoid | A2AQ22. |
| KO | K05118. |
| OMA | PAQSWPL. |
| OrthoDB | EOG4DR9BP. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.1. 3474. |
Gene expression databases | |
| ArrayExpress | P08923. |
| Bgee | P08923. |
| CleanEx | MM_LTK. |
| Genevestigator | P08923. |
| GermOnline | ENSMUSG00000027297. Mus musculus. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR026984. LTK. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR002011. Tyr_kinase_rcpt_2_CS. [Graphical view] |
| PANTHER | PTHR24416:SF138. PTHR24416:SF138. 1 hit. |
| Pfam | PF07714. Pkinase_Tyr. 1 hit. [Graphical view] |
| PRINTS | PR00109. TYRKINASE. |
| SMART | SM00219. TyrKc. 1 hit. [Graphical view] |
| SUPFAM | SSF56112. Kinase_like. 1 hit. |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 291120. |
| SOURCE | Search... |
Entry information
| Entry name | LTK_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P08923 Secondary accession number(s): A2AQ22 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |