SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P08923

- LTK_MOUSE

UniProt

P08923 - LTK_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Leukocyte tyrosine kinase receptor
Gene
Ltk
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei540 – 5401ATP By similarity
Active sitei639 – 6391Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi512 – 5209ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: UniProtKB
  3. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. cellular response to retinoic acid Source: Ensembl
  3. negative regulation of apoptotic process Source: UniProtKB
  4. phosphatidylinositol 3-kinase signaling Source: UniProtKB
  5. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
  6. positive regulation of neuron projection development Source: Ensembl
  7. protein phosphorylation Source: UniProtKB
  8. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte tyrosine kinase receptor (EC:2.7.10.1)
Gene namesi
Name:Ltk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96840. Ltk.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein 1 Publication
Isoform A : Endoplasmic reticulum
Note: Retained in the endoplasmic reticulum.1 Publication
Isoform B : Endoplasmic reticulum
Note: Retained in the endoplasmic reticulum.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 421405Extracellular Reviewed prediction
Add
BLAST
Transmembranei422 – 44625Helical; Reviewed prediction
Add
BLAST
Topological domaini447 – 888442Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 888872Leukocyte tyrosine kinase receptor
PRO_0000016739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi377 – 3771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi409 – 4091N-linked (GlcNAc...) Reviewed prediction
Modified residuei672 – 6721Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP08923.
PRIDEiP08923.

PTM databases

PhosphoSiteiP08923.

Expressioni

Tissue specificityi

Subsets of lymphoid and neuronal cells.

Gene expression databases

ArrayExpressiP08923.
BgeeiP08923.
CleanExiMM_LTK.
GenevestigatoriP08923.

Interactioni

Subunit structurei

Homodimer when bound to ligand Inferred. Part of a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2 By similarity. Isoform A binds calnexin.

Structurei

3D structure databases

ProteinModelPortaliP08923.
SMRiP08923. Positions 498-789.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini506 – 782277Protein kinase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00750000117362.
HOGENOMiHOG000231766.
HOVERGENiHBG052371.
InParanoidiA2AQ22.
KOiK05118.
OMAiAEGGQGC.
OrthoDBiEOG7GN2KT.
TreeFamiTF351636.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR026984. LTK.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PANTHERiPTHR24416:SF138. PTHR24416:SF138. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform D (identifier: P08923-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGCSHRLLLW LGAAGTILCS NSEFQTPFLT PSLLPVLVLN SQEQKVTPTP    50
SKLEPASLPN PLGTRGPWVF NTCGASGRSG PTQTQCDGAY TGSSVMVTVG 100
AAGPLKGVQL WRVPDTGQYL ISAYGAAGGK GAQNHLSRAH GIFLSAVFFL 150
RRGEPVYILV GQQGQDACPG GSPESQLVCL GESGEHATTY GTERIPGWRR 200
WAGGGGGGGG ATSIFRLRAG EPEPLLVAAG GGGRSYRRRP DRGRTQAVPE 250
RLETRAAAPG SGGRGGAAGG GSGWTSRAHS PQAGRSPREG AEGGEGCAEA 300
WAALRWAAAG GFGGGGGACA AGGGGGGYRG GDTSESDLLW ADGEDGTSFV 350
HPSGELYLQP LAVTEGHGEV EIRKHPNCSH CPFKDCQWQA ELWTAECTCP 400
EGTELAVDNV TCMDLPTTAS PLILMGAVVA ALALSLLMMC AVLILVNQKC 450
QGLWGTRLPG PELELSKLRS SAIRTAPNPY YCQVGLSPAQ PWPLPPGLTE 500
VSPANVTLLR ALGHGAFGEV YEGLVTGLPG DSSPLPVAIK TLPELCSHQD 550
ELDFLMEALI ISKFSHQNIV RCVGLSFRSA PRLILLELMS GGDMKSFLRH 600
SRPHPGQLAP LTMQDLLQLA QDIAQGCHYL EENHFIHRDI AARNCLLSCS 650
GASRVAKIGD FGMARDIYQA SYYRKGGRTL LPVKWMPPEA LLEGLFTSKT 700
DSWSFGVLLW EIFSLGYMPY PGHTNQEVLD FIATGNRMDP PRNCPGPVYR 750
IMTQCWQHQP ELRPDFGSIL ERIQYCTQDP DVLNSPLPVE PGPILEEEEA 800
SRLGNRSLEG LRSPKPLELS SQNLKSWGGG LLGSWLPSGL KTLKPRCLQP 850
QNIWNPTYGS WTPRGPQGED TGIEHCNGSS SSSIPGIQ 888

Note: May be produced by alternative promoter usage.

Length:888
Mass (Da):94,471
Last modified:July 27, 2011 - v3
Checksum:i7D204A474DEF0AC6
GO
Isoform A (identifier: P08923-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.
     252-252: L → M
     271-331: Missing.

Note: May be produced by alternative promoter usage. Starts at a CUG codon.

Show »
Length:576
Mass (Da):62,749
Checksum:i3598526F13E50B4E
GO
Isoform B (identifier: P08923-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.
     252-252: L → M

Note: May be produced by alternative promoter usage. Starts at a CUG codon.

Show »
Length:637
Mass (Da):68,323
Checksum:i72225A1464E47365
GO
Isoform C (identifier: P08923-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-331: Missing.

Show »
Length:827
Mass (Da):88,897
Checksum:i906AFE379E266FD6
GO

Sequence cautioni

The sequence CAA30793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti746 – 7461G → E.1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 251251Missing in isoform A and isoform B.
VSP_002950Add
BLAST
Alternative sequencei252 – 2521L → M in isoform A and isoform B.
VSP_002951
Alternative sequencei271 – 33161Missing in isoform A and isoform C.
VSP_002952Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261T → A in AAA39451. 1 Publication
Sequence conflicti113 – 1131V → A in AAA39451. 1 Publication
Sequence conflicti789 – 7891V → M in CAA36848. 1 Publication
Sequence conflicti789 – 7891V → M in AAA39451. 1 Publication
Sequence conflicti875 – 8751H → Q in CAA36848. 1 Publication
Sequence conflicti875 – 8751H → Q in AAA39451. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52621 mRNA. Translation: CAA36848.1.
M90470 mRNA. Translation: AAA39451.1.
AL844536 Genomic DNA. Translation: CAM18081.1.
X07984 mRNA. Translation: CAA30793.1. Different initiation.
CCDSiCCDS16608.1. [P08923-1]
CCDS16609.1. [P08923-4]
CCDS50674.1. [P08923-2]
PIRiI58378.
S12792.
RefSeqiNP_976220.2. NM_203345.2. [P08923-1]
NP_996824.1. NM_206941.1. [P08923-3]
NP_996825.2. NM_206942.2. [P08923-4]
UniGeneiMm.1740.

Genome annotation databases

EnsembliENSMUST00000028759; ENSMUSP00000028759; ENSMUSG00000027297. [P08923-1]
ENSMUST00000082130; ENSMUSP00000080774; ENSMUSG00000027297. [P08923-4]
ENSMUST00000182203; ENSMUSP00000138201; ENSMUSG00000027297. [P08923-2]
GeneIDi17005.
KEGGimmu:17005.
UCSCiuc008lug.1. mouse. [P08923-3]
uc008lui.1. mouse. [P08923-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52621 mRNA. Translation: CAA36848.1 .
M90470 mRNA. Translation: AAA39451.1 .
AL844536 Genomic DNA. Translation: CAM18081.1 .
X07984 mRNA. Translation: CAA30793.1 . Different initiation.
CCDSi CCDS16608.1. [P08923-1 ]
CCDS16609.1. [P08923-4 ]
CCDS50674.1. [P08923-2 ]
PIRi I58378.
S12792.
RefSeqi NP_976220.2. NM_203345.2. [P08923-1 ]
NP_996824.1. NM_206941.1. [P08923-3 ]
NP_996825.2. NM_206942.2. [P08923-4 ]
UniGenei Mm.1740.

3D structure databases

ProteinModelPortali P08923.
SMRi P08923. Positions 498-789.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P08923.

Proteomic databases

PaxDbi P08923.
PRIDEi P08923.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028759 ; ENSMUSP00000028759 ; ENSMUSG00000027297 . [P08923-1 ]
ENSMUST00000082130 ; ENSMUSP00000080774 ; ENSMUSG00000027297 . [P08923-4 ]
ENSMUST00000182203 ; ENSMUSP00000138201 ; ENSMUSG00000027297 . [P08923-2 ]
GeneIDi 17005.
KEGGi mmu:17005.
UCSCi uc008lug.1. mouse. [P08923-3 ]
uc008lui.1. mouse. [P08923-1 ]

Organism-specific databases

CTDi 4058.
MGIi MGI:96840. Ltk.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00750000117362.
HOGENOMi HOG000231766.
HOVERGENi HBG052371.
InParanoidi A2AQ22.
KOi K05118.
OMAi AEGGQGC.
OrthoDBi EOG7GN2KT.
TreeFami TF351636.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 3474.

Miscellaneous databases

NextBioi 291120.
PROi P08923.
SOURCEi Search...

Gene expression databases

ArrayExpressi P08923.
Bgeei P08923.
CleanExi MM_LTK.
Genevestigatori P08923.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR026984. LTK.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view ]
PANTHERi PTHR24416:SF138. PTHR24416:SF138. 1 hit.
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator."
    Bernards A., de la Monte S.
    EMBO J. 9:2279-2287(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Strain: BALB/c.
  2. "Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain."
    Haase V.H., Snijders A.J., Cooke S.M., Teng M.N., Kaul D., le Beau M.M., Bruns G.A., Bernards A.
    Oncogene 6:2319-2325(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Strain: BALB/c.
  3. "Four tissue-specific mouse ltk mRNAs predict tyrosine kinases that differ upstream of their transmembrane segment."
    Snijders A.J., Haase V.H., Bernards A.
    Oncogene 8:27-35(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain."
    Ben-Neriah Y., Bauskin A.R.
    Nature 333:672-676(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 260-888 (ISOFORM A).
  6. "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin."
    Snijders A.J., Ho S.C., Haase V.H., Pillai S., Bernards A.
    J. Biol. Chem. 272:1297-1301(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CALNEXIN (ISOFORM A).
  7. "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus."
    Li N., Nakamura K., Jiang Y., Tsurui H., Matsuoka S., Abe M., Ohtsuji M., Nishimura H., Kato K., Kawai T., Atsumi T., Koike T., Shirai T., Ueno H., Hirose S.
    Hum. Mol. Genet. 13:171-179(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLU-746.
    Strain: NZB.

Entry informationi

Entry nameiLTK_MOUSE
AccessioniPrimary (citable) accession number: P08923
Secondary accession number(s): A2AQ22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi