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Protein

T-cell surface antigen CD2

Gene

Cd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.1 Publication

GO - Molecular functioni

  • antigen binding Source: RGD
  • protein homodimerization activity Source: RGD
  • protein kinase binding Source: RGD
  • protein self-association Source: RGD
  • receptor binding Source: RGD
  • receptor tyrosine kinase binding Source: RGD

GO - Biological processi

  • cell-cell adhesion Source: RGD
  • heterotypic cell-cell adhesion Source: RGD
  • positive regulation of interferon-gamma secretion Source: RGD
  • positive regulation of interleukin-8 secretion Source: RGD
  • positive regulation of tumor necrosis factor production Source: RGD
  • T cell activation Source: RGD

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface antigen CD2
Alternative name(s):
LFA-2
LFA-3 receptor
OX-34 antigen1 Publication
T-cell surface antigen T11/Leu-5
CD_antigen: CD2
Gene namesi
Name:Cd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 2, Unplaced

Organism-specific databases

RGDi2297 Cd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 202ExtracellularSequence analysisAdd BLAST180
Transmembranei203 – 228HelicalSequence analysisAdd BLAST26
Topological domaini229 – 344CytoplasmicSequence analysisAdd BLAST116

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000001460323 – 344T-cell surface antigen CD2Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 196Combined sources2 Publications
Glycosylationi134N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi139 ↔ 179Combined sources2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP08921
PRIDEiP08921

PTM databases

iPTMnetiP08921
PhosphoSitePlusiP08921

Expressioni

Gene expression databases

BgeeiENSRNOG00000015821

Interactioni

Subunit structurei

Interacts with CD48 (PubMed:16803907). Interacts with CD58 (LFA-3) (By similarity). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LCKP0623911EBI-7175586,EBI-1348From Homo sapiens.

GO - Molecular functioni

  • protein homodimerization activity Source: RGD
  • protein kinase binding Source: RGD
  • protein self-association Source: RGD
  • receptor binding Source: RGD
  • receptor tyrosine kinase binding Source: RGD

Protein-protein interaction databases

IntActiP08921, 2 interactors
MINTiP08921
STRINGi10116.ENSRNOP00000021268

Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 31Combined sources5
Beta strandi36 – 38Combined sources3
Beta strandi49 – 56Combined sources8
Beta strandi59 – 67Combined sources9
Beta strandi71 – 74Combined sources4
Beta strandi77 – 79Combined sources3
Beta strandi85 – 89Combined sources5
Helixi92 – 94Combined sources3
Beta strandi96 – 104Combined sources9
Beta strandi109 – 120Combined sources12
Beta strandi127 – 131Combined sources5
Turni132 – 135Combined sources4
Beta strandi136 – 140Combined sources5
Beta strandi148 – 153Combined sources6
Beta strandi156 – 169Combined sources14
Beta strandi177 – 183Combined sources7
Beta strandi186 – 192Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A64X-ray2.00A/B23-121[»]
1A6PX-ray2.08A/B26-121[»]
1A7BX-ray3.10A/B/C/D23-121[»]
1CDCX-ray2.00A/B23-121[»]
1HNGX-ray2.80A/B23-198[»]
1T6WNMR-A23-121[»]
2DRUX-ray2.60A121-199[»]
ProteinModelPortaliP08921
SMRiP08921
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08921

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 121Ig-like V-typeAdd BLAST99
Domaini122 – 202Ig-like C2-typeAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 68CD58 binding region 1By similarityAdd BLAST13
Regioni99 – 113CD58 binding region 2By similarityAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi277 – 343Pro-richSequence analysisAdd BLAST67

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW98 Eukaryota
ENOG410Y7BE LUCA
GeneTreeiENSGT00390000009232
HOGENOMiHOG000276890
HOVERGENiHBG000262
InParanoidiP08921
KOiK06449
OMAiGTQVHQQ
OrthoDBiEOG091G0M7A
PhylomeDBiP08921

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015632 CD2
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR008424 Ig_C2-set
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF05790 C2-set, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01870 CD2ANTIGEN
SUPFAMiSSF48726 SSF48726, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCKFLGSFF LLFSLSSKGA DCRDSGTVWG ALGHGINLNI PNFQMTDDID
60 70 80 90 100
EVRWERGSTL VAEFKRKMKP FLKSGAFEIL ANGDLKIKNL TRDDSGTYNV
110 120 130 140 150
TVYSTNGTRI LNKALDLRIL EMVSKPMIYW ECSNATLTCE VLEGTDVELK
160 170 180 190 200
LYQGKEHLRS LRQKTMSYQW TNLRAPFKCK AVNRVSQESE MEVVNCPEKG
210 220 230 240 250
LPLYLIVGVS AGGLLLVFFG ALFIFCICKR KKRNRRRKGE ELEIKASRMS
260 270 280 290 300
TVERGPKPHS TQASAPASQN PVASQAPPPP GHHLQTPGHR PLPPSHRNRE
310 320 330 340
HQPKKRPPPS GTQVHQQKGP PLPRPRVQPK PPCGSGDVSL PPPN
Length:344
Mass (Da):38,413
Last modified:April 25, 2018 - v2
Checksum:iFE2CB45CBF2E5FA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112N → D in CAA28757 (PubMed:3102667).1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05111 mRNA Translation: CAA28757.1
AABR07012723 Genomic DNA No translation available.
CH474015 Genomic DNA Translation: EDL85525.1
BC088164 mRNA Translation: AAH88164.1
PIRiA33071 RWRTC2
RefSeqiNP_036962.1, NM_012830.1
UniGeneiRn.10328

Genome annotation databases

EnsembliENSRNOT00000021268; ENSRNOP00000021268; ENSRNOG00000015821
GeneIDi497761
KEGGirno:497761
UCSCiRGD:2297 rat

Similar proteinsi

Entry informationi

Entry nameiCD2_RAT
AccessioniPrimary (citable) accession number: P08921
Secondary accession number(s): F1M9W7, Q5I0M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 25, 2018
Last modified: April 25, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health