Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-cell surface antigen CD2

Gene

Cd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface antigen CD2
Alternative name(s):
LFA-2
LFA-3 receptor
Lymphocyte antigen 37
Short name:
Ly-37
T-cell surface antigen T11/Leu-5
CD_antigen: CD2
Gene namesi
Name:Cd2
Synonyms:Ly-37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88320. Cd2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 203181ExtracellularSequence analysisAdd
BLAST
Transmembranei204 – 22926HelicalSequence analysisAdd
BLAST
Topological domaini230 – 344115CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • anchored component of plasma membrane Source: MGI
  • cell-cell junction Source: MGI
  • cell surface Source: MGI
  • cytoplasmic side of plasma membrane Source: MGI
  • external side of plasma membrane Source: MGI
  • extracellular region Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Chaini23 – 344322T-cell surface antigen CD2PRO_0000014602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi133 ↔ 197By similarity
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi140 ↔ 180By similarity
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP08920.
PaxDbiP08920.
PRIDEiP08920.

PTM databases

PhosphoSiteiP08920.

Expressioni

Gene expression databases

BgeeiP08920.
CleanExiMM_CD2.
ExpressionAtlasiP08920. baseline and differential.
GenevisibleiP08920. MM.

Interactioni

Subunit structurei

Interacts with CD2AP and PSTPIP1.2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: MGI
  • receptor binding Source: MGI

Protein-protein interaction databases

MINTiMINT-1769762.
STRINGi10090.ENSMUSP00000029456.

Structurei

3D structure databases

ProteinModelPortaliP08920.
SMRiP08920. Positions 24-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 12199Ig-like V-typeAdd
BLAST
Domaini122 – 20281Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi276 – 34368Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW98. Eukaryota.
ENOG410Y7BE. LUCA.
HOGENOMiHOG000276890.
HOVERGENiHBG000262.
InParanoidiP08920.
KOiK06449.
OMAiGTQVHQQ.
OrthoDBiEOG7KSX9X.
PhylomeDBiP08920.
TreeFamiTF335971.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR015632. CD2.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF05790. C2-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01870. CD2ANTIGEN.
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCKFLGSFF LLFSLSGKGA DCRDNETIWG VLGHGITLNI PNFQMTDDID
60 70 80 90 100
EVRWVRRGTL VAEFKRKKPP FLISETYEVL ANGSLKIKKP MMRNDSGTYN
110 120 130 140 150
VMVYGTNGMT RLEKDLDVRI LERVSKPMIH WECPNTTLTC AVLQGTDFEL
160 170 180 190 200
KLYQGETLLN SLPQKNMSYQ WTNLNAPFKC EAINPVSKES KMEVVNCPEK
210 220 230 240 250
GLSFYVTVGV GAGGLLLVLL VALFIFCICK RRKRNRRRKD EELEIKASRT
260 270 280 290 300
STVERGPKPH STPAAAAQNS VALQAPPPPG HHLQTPGHRP LPPGHRTREH
310 320 330 340
QQKKRPPPSG TQIHQQKGPP LPRPRVQPKP PCGSGDGVSL PPPN
Length:344
Mass (Da):38,415
Last modified:November 1, 1988 - v1
Checksum:iCFD12FCBD1444450
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991Y → T (PubMed:2894031).Curated
Sequence conflicti128 – 1281M → V (PubMed:2894031).Curated
Sequence conflicti128 – 1281M → V (PubMed:3257775).Curated
Sequence conflicti139 – 1391T → I in AAA37397 (PubMed:3257775).Curated
Sequence conflicti175 – 1751N → A (PubMed:2894031).Curated
Sequence conflicti175 – 1751N → S in AAA37393 (PubMed:3257775).Curated
Sequence conflicti175 – 1751N → S in AAA37397 (PubMed:3257775).Curated
Sequence conflicti191 – 1911K → N in CAA29500 (PubMed:2820751).Curated
Sequence conflicti192 – 1921M → T (PubMed:2894031).Curated
Sequence conflicti192 – 1921M → T (PubMed:3257775).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00023 mRNA. Translation: CAA68258.1.
X06143 mRNA. Translation: CAA29500.1.
M19807
, M19799, M19801, M19803, M19805 Genomic DNA. Translation: AAA37393.1.
M18934 mRNA. Translation: AAA37397.1.
BC053731 mRNA. Translation: AAH53731.1.
CCDSiCCDS17681.1.
PIRiI49585.
RefSeqiNP_038514.1. NM_013486.2.
UniGeneiMm.22842.

Genome annotation databases

EnsembliENSMUST00000029456; ENSMUSP00000029456; ENSMUSG00000027863.
GeneIDi12481.
KEGGimmu:12481.
UCSCiuc008qrf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00023 mRNA. Translation: CAA68258.1.
X06143 mRNA. Translation: CAA29500.1.
M19807
, M19799, M19801, M19803, M19805 Genomic DNA. Translation: AAA37393.1.
M18934 mRNA. Translation: AAA37397.1.
BC053731 mRNA. Translation: AAH53731.1.
CCDSiCCDS17681.1.
PIRiI49585.
RefSeqiNP_038514.1. NM_013486.2.
UniGeneiMm.22842.

3D structure databases

ProteinModelPortaliP08920.
SMRiP08920. Positions 24-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1769762.
STRINGi10090.ENSMUSP00000029456.

PTM databases

PhosphoSiteiP08920.

Proteomic databases

EPDiP08920.
PaxDbiP08920.
PRIDEiP08920.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029456; ENSMUSP00000029456; ENSMUSG00000027863.
GeneIDi12481.
KEGGimmu:12481.
UCSCiuc008qrf.1. mouse.

Organism-specific databases

CTDi914.
MGIiMGI:88320. Cd2.

Phylogenomic databases

eggNOGiENOG410IW98. Eukaryota.
ENOG410Y7BE. LUCA.
HOGENOMiHOG000276890.
HOVERGENiHBG000262.
InParanoidiP08920.
KOiK06449.
OMAiGTQVHQQ.
OrthoDBiEOG7KSX9X.
PhylomeDBiP08920.
TreeFamiTF335971.

Miscellaneous databases

PROiP08920.
SOURCEiSearch...

Gene expression databases

BgeeiP08920.
CleanExiMM_CD2.
ExpressionAtlasiP08920. baseline and differential.
GenevisibleiP08920. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR015632. CD2.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF05790. C2-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01870. CD2ANTIGEN.
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The murine homologue of the T lymphocyte CD2 antigen: molecular cloning, chromosome assignment and cell surface expression."
    Sewell W.A., Brown M.H., Fink P.J., Kozak C.A., Crumpton M.J.
    Eur. J. Immunol. 17:1015-1020(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B10.A.
  2. "Murine and human T11 (CD2) cDNA sequences suggest a common signal transduction mechanism."
    Clayton L.K., Sayre P.H., Novotny J., Reinherz E.L.
    Eur. J. Immunol. 17:1367-1370(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes."
    Diamond D.J., Clayton L.K., Sayre P.H., Reinherz E.L.
    Proc. Natl. Acad. Sci. U.S.A. 85:1615-1619(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
    Tissue: Liver.
  4. "Molecular cloning of the murine homologue of CD2. Homology of the molecule to its human counterpart T11."
    Yagita H., Okumura K., Nakauchi H.
    J. Immunol. 140:1321-1326(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hematopoietic.
  6. "A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts."
    Dustin M.L., Olszowy M.W., Holdorf A.D., Li J., Bromley S., Desai N., Widder P., Rosenberger F., van der Merwe P.A., Allen P.M., Shaw A.S.
    Cell 94:667-677(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD2AP.
  7. "The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse."
    Badour K., Zhang J., Shi F., McGavin M.K.H., Rampersad V., Hardy L.A., Field D., Siminovitch K.A.
    Immunity 18:141-154(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PSTPIP1.

Entry informationi

Entry nameiCD2_MOUSE
AccessioniPrimary (citable) accession number: P08920
Secondary accession number(s): Q61394
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: June 8, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.