T-cell surface antigen CD2 precursor

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P08920 (CD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 130. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
T-cell surface antigen CD2

Alternative name(s):
LFA-2
LFA-3 receptor
Lymphocyte antigen 37
Short name=Ly-37
T-cell surface antigen T11/Leu-5
CD_antigen=CD2

Gene names

Name:	Cd2
Synonyms:	Ly-37

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Subunit structure	Interacts with CD2AP and PSTPIP1. Ref.6 Ref.7
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	anchored to plasma membrane Inferred from direct assay PubMed 1383383. Source: MGI external side of plasma membrane Inferred from direct assay PubMed 12874832 PubMed 8125140. Source: MGI extracellular region Inferred from direct assay PubMed 1383383. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW internal side of plasma membrane Inferred from direct assay PubMed 1383383. Source: MGI
Molecular_function	eukaryotic cell surface binding Inferred from direct assay PubMed 1383383. Source: MGI protein homodimerization activity Inferred from direct assay PubMed 1383383. Source: MGI receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

Chain

23 – 344

322

T-cell surface antigen CD2

PRO_0000014602

Regions

Topological domain

23 – 203

181

Extracellular Potential

Transmembrane

204 – 229

Helical; Potential

Topological domain

230 – 344

115

Cytoplasmic Potential

Domain

23 – 121

Ig-like V-type

Domain

122 – 202

Ig-like C2-type

Compositional bias

276 – 343

Pro-rich

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

135

N-linked (GlcNAc...) Potential

Glycosylation

166

N-linked (GlcNAc...) Potential

Disulfide bond

133 ↔ 197

By similarity

Disulfide bond

140 ↔ 180

By similarity

Experimental info

Sequence conflict

Y → T Ref.3

Sequence conflict

128

M → V Ref.3

Sequence conflict

128

M → V Ref.4

Sequence conflict

139

T → I in AAA37397. Ref.4

Sequence conflict

175

N → A Ref.3

Sequence conflict

175

N → S in AAA37393. Ref.4

Sequence conflict

175

N → S in AAA37397. Ref.4

Sequence conflict

191

K → N in CAA29500. Ref.2

Sequence conflict

192

M → T Ref.3

Sequence conflict

192

M → T Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

P08920 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: CFD12FCBD1444450
Show »

FASTA

344

38,415

        10         20         30         40         50         60 
MKCKFLGSFF LLFSLSGKGA DCRDNETIWG VLGHGITLNI PNFQMTDDID EVRWVRRGTL 

        70         80         90        100        110        120 
VAEFKRKKPP FLISETYEVL ANGSLKIKKP MMRNDSGTYN VMVYGTNGMT RLEKDLDVRI 

       130        140        150        160        170        180 
LERVSKPMIH WECPNTTLTC AVLQGTDFEL KLYQGETLLN SLPQKNMSYQ WTNLNAPFKC 

       190        200        210        220        230        240 
EAINPVSKES KMEVVNCPEK GLSFYVTVGV GAGGLLLVLL VALFIFCICK RRKRNRRRKD 

       250        260        270        280        290        300 
EELEIKASRT STVERGPKPH STPAAAAQNS VALQAPPPPG HHLQTPGHRP LPPGHRTREH 

       310        320        330        340 
QQKKRPPPSG TQIHQQKGPP LPRPRVQPKP PCGSGDGVSL PPPN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The murine homologue of the T lymphocyte CD2 antigen: molecular cloning, chromosome assignment and cell surface expression." Sewell W.A., Brown M.H., Fink P.J., Kozak C.A., Crumpton M.J. Eur. J. Immunol. 17:1015-1020(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: B10.A.
[2]	"Murine and human T11 (CD2) cDNA sequences suggest a common signal transduction mechanism." Clayton L.K., Sayre P.H., Novotny J., Reinherz E.L. Eur. J. Immunol. 17:1367-1370(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes." Diamond D.J., Clayton L.K., Sayre P.H., Reinherz E.L. Proc. Natl. Acad. Sci. U.S.A. 85:1615-1619(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver.
[4]	"Molecular cloning of the murine homologue of CD2. Homology of the molecule to its human counterpart T11." Yagita H., Okumura K., Nakauchi H. J. Immunol. 140:1321-1326(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Hematopoietic.
[6]	"A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts." Dustin M.L., Olszowy M.W., Holdorf A.D., Li J., Bromley S., Desai N., Widder P., Rosenberger F., van der Merwe P.A., Allen P.M., Shaw A.S. Cell 94:667-677(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CD2AP.
[7]	"The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse." Badour K., Zhang J., Shi F., McGavin M.K.H., Rampersad V., Hardy L.A., Field D., Siminovitch K.A. Immunity 18:141-154(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PSTPIP1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y00023 mRNA. Translation: CAA68258.1. X06143 mRNA. Translation: CAA29500.1. M19807 , M19799, M19801, M19803, M19805 Genomic DNA. Translation: AAA37393.1. M18934 mRNA. Translation: AAA37397.1. BC053731 mRNA. Translation: AAH53731.1.
IPI	IPI00108001.
PIR	I49585.
RefSeq	NP_038514.1. NM_013486.2.
UniGene	Mm.22842.
3D structure databases
ProteinModelPortal	P08920.
SMR	P08920. Positions 24-199.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1769762.
PTM databases
PhosphoSite	P08920.
Proteomic databases
PRIDE	P08920.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000029456; ENSMUSP00000029456; ENSMUSG00000027863.
GeneID	12481.
KEGG	mmu:12481.
Organism-specific databases
CTD	914.
MGI	MGI:88320. Cd2.
Phylogenomic databases
eggNOG	NOG47564.
HOGENOM	HOG000276890.
HOVERGEN	HBG000262.
InParanoid	P08920.
KO	K06449.
OMA	GTQVHQQ.
OrthoDB	EOG4H9XMK.
Gene expression databases
ArrayExpress	P08920.
Bgee	P08920.
CleanEx	MM_CD2.
Genevestigator	P08920.
GermOnline	ENSMUSG00000027863. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR013783. Ig-like_fold. IPR008424. Ig_C2-set. IPR013106. Ig_V-set. IPR015631. SLAM_fam_rcpts. IPR015632. T-cell_sdhesion_molc_CD2. [Graphical view]
PANTHER	PTHR12080. PTHR12080. 1 hit. PTHR12080:SF10. PTHR12080:SF10. 1 hit.
Pfam	PF05790. C2-set. 1 hit. PF07686. V-set. 1 hit. [Graphical view]
PRINTS	PR01870. CD2ANTIGEN.
PROSITE	PS50835. IG_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	281378.
SOURCE	Search...

Entry information

Entry name

CD2_MOUSE

Accession

Primary (citable) accession number: P08920
Secondary accession number(s): Q61394

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	April 3, 2013
This is version 130 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents