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P08913

- ADA2A_HUMAN

UniProt

P08913 - ADA2A_HUMAN

Protein

Alpha-2A adrenergic receptor

Gene

ADRA2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 168 (01 Oct 2014)
      Sequence version 3 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei113 – 1131Implicated in ligand binding
    Sitei200 – 2001Implicated in catechol agonist binding and receptor activation
    Sitei204 – 2041Implicated in catechol agonist binding and receptor activation

    GO - Molecular functioni

    1. alpha-1B adrenergic receptor binding Source: BHF-UCL
    2. alpha2-adrenergic receptor activity Source: BHF-UCL
    3. alpha-2C adrenergic receptor binding Source: BHF-UCL
    4. epinephrine binding Source: BHF-UCL
    5. heterotrimeric G-protein binding Source: BHF-UCL
    6. norepinephrine binding Source: BHF-UCL
    7. protein binding Source: BHF-UCL
    8. protein heterodimerization activity Source: BHF-UCL
    9. protein homodimerization activity Source: BHF-UCL
    10. protein kinase binding Source: BHF-UCL
    11. thioesterase binding Source: BHF-UCL

    GO - Biological processi

    1. actin cytoskeleton organization Source: ProtInc
    2. activation of MAPK activity by adrenergic receptor signaling pathway Source: BHF-UCL
    3. activation of protein kinase activity Source: BHF-UCL
    4. activation of protein kinase B activity Source: BHF-UCL
    5. acute inflammatory response Source: Ensembl
    6. adenylate cyclase-inhibiting adrenergic receptor signaling pathway Source: BHF-UCL
    7. blood coagulation Source: Reactome
    8. cellular component movement Source: ProtInc
    9. cellular response to hormone stimulus Source: BHF-UCL
    10. DNA replication Source: Ensembl
    11. energy reserve metabolic process Source: Reactome
    12. epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway Source: BHF-UCL
    13. fear response Source: Ensembl
    14. female pregnancy Source: Ensembl
    15. glucose homeostasis Source: BHF-UCL
    16. G-protein coupled receptor signaling pathway Source: BHF-UCL
    17. intestinal absorption Source: BHF-UCL
    18. negative regulation of adenylate cyclase activity Source: BHF-UCL
    19. negative regulation of adrenergic receptor signaling pathway Source: BHF-UCL
    20. negative regulation of calcium ion-dependent exocytosis Source: BHF-UCL
    21. negative regulation of calcium ion transmembrane transporter activity Source: BHF-UCL
    22. negative regulation of calcium ion transport Source: BHF-UCL
    23. negative regulation of cAMP biosynthetic process Source: BHF-UCL
    24. negative regulation of epinephrine secretion Source: BHF-UCL
    25. negative regulation of insulin secretion Source: BHF-UCL
    26. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: BHF-UCL
    27. negative regulation of lipid catabolic process Source: BHF-UCL
    28. negative regulation of norepinephrine secretion Source: BHF-UCL
    29. negative regulation of uterine smooth muscle contraction Source: Ensembl
    30. phospholipase C-activating adrenergic receptor signaling pathway Source: BHF-UCL
    31. platelet activation Source: Reactome
    32. positive regulation of cell migration Source: BHF-UCL
    33. positive regulation of cell proliferation Source: ProtInc
    34. positive regulation of cytokine production Source: BHF-UCL
    35. positive regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
    36. positive regulation of MAP kinase activity Source: BHF-UCL
    37. positive regulation of membrane protein ectodomain proteolysis Source: BHF-UCL
    38. positive regulation of potassium ion transport Source: BHF-UCL
    39. positive regulation of vasodilation Source: Ensembl
    40. positive regulation of wound healing Source: BHF-UCL
    41. Ras protein signal transduction Source: ProtInc
    42. regulation of insulin secretion Source: Reactome
    43. regulation of vasoconstriction Source: InterPro
    44. Rho protein signal transduction Source: ProtInc
    45. signal transduction Source: ProtInc
    46. small molecule metabolic process Source: Reactome
    47. thermoception Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16927. Adrenoceptors.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_19180. Adrenaline signalling through Alpha-2 adrenergic receptor.
    REACT_19231. G alpha (i) signalling events.
    REACT_19333. G alpha (z) signalling events.
    SignaLinkiP08913.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2A adrenergic receptor
    Alternative name(s):
    Alpha-2 adrenergic receptor subtype C10
    Alpha-2A adrenoreceptor
    Short name:
    Alpha-2A adrenoceptor
    Short name:
    Alpha-2AAR
    Gene namesi
    Name:ADRA2A
    Synonyms:ADRA2R, ADRAR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:281. ADRA2A.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. basolateral plasma membrane Source: BHF-UCL
    2. cytoplasm Source: BHF-UCL
    3. integral component of plasma membrane Source: BHF-UCL
    4. plasma membrane Source: Reactome
    5. receptor complex Source: BHF-UCL
    6. synapse Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi79 – 791D → N: No change in binding affinity. eliminates guanine nucleotide-sensitive agonist binding. 1 Publication
    Mutagenesisi113 – 1131D → N: No binding to yohimbine. Increase in adenylate cyclase activity. 1 Publication
    Mutagenesisi130 – 1301D → N: Lower affinity for agonists. Eliminates guanine nucleotide-sensitive agonist binding. 1 Publication
    Mutagenesisi200 – 2001S → A: Lower affinity for agonists. No change in guanine nucleotide-sensitive agonist binding. 1 Publication
    Mutagenesisi204 – 2041S → A: Lower affinity for agonists. Reduced guanine nucleotide-sensitive agonist binding. 1 Publication
    Mutagenesisi412 – 4121F → N: 350-fold reduced affinity for alpha-2 antagonist yohimbine, 3000-fold increase for beta-antagonist alprenolol. 2 Publications

    Organism-specific databases

    PharmGKBiPA35.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Alpha-2A adrenergic receptorPRO_0000069080Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
    Lipidationi442 – 4421S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP08913.
    PRIDEiP08913.

    PTM databases

    PhosphoSiteiP08913.

    Expressioni

    Gene expression databases

    BgeeiP08913.
    CleanExiHS_ADRA2A.
    GenevestigatoriP08913.

    Interactioni

    Protein-protein interaction databases

    BioGridi106659. 8 interactions.
    IntActiP08913. 3 interactions.
    STRINGi9606.ENSP00000280155.

    Structurei

    Secondary structure

    1
    450
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi119 – 12810
    Helixi130 – 13910
    Helixi140 – 1423

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HLLNMR-A118-149[»]
    1HO9NMR-A118-149[»]
    1HODNMR-A118-149[»]
    1HOFNMR-A118-149[»]
    ProteinModelPortaliP08913.
    SMRiP08913. Positions 39-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08913.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularBy similarityAdd
    BLAST
    Topological domaini60 – 7011CytoplasmicBy similarityAdd
    BLAST
    Topological domaini97 – 10610ExtracellularBy similarity
    Topological domaini130 – 15122CytoplasmicBy similarityAdd
    BLAST
    Topological domaini173 – 19422ExtracellularBy similarityAdd
    BLAST
    Topological domaini218 – 374157CytoplasmicBy similarityAdd
    BLAST
    Topological domaini396 – 40914ExtracellularBy similarityAdd
    BLAST
    Topological domaini430 – 45021CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5926Helical; Name=1By similarityAdd
    BLAST
    Transmembranei71 – 9626Helical; Name=2By similarityAdd
    BLAST
    Transmembranei107 – 12923Helical; Name=3By similarityAdd
    BLAST
    Transmembranei152 – 17221Helical; Name=4By similarityAdd
    BLAST
    Transmembranei195 – 21723Helical; Name=5By similarityAdd
    BLAST
    Transmembranei375 – 39521Helical; Name=6By similarityAdd
    BLAST
    Transmembranei410 – 42920Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP08913.
    KOiK04138.
    OrthoDBiEOG7J9VPT.
    PhylomeDBiP08913.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR002233. ADR_fam.
    IPR001946. ADRA2A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00558. ADRENRGCA2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08913-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLQPDAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLLTVFG    50
    NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY 100
    FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI 150
    KAIIITVWVI SAVISFPPLI SIEKKGGGGG PQPAEPRCEI NDQKWYVISS 200
    CIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDAVA APPGGTERRP 250
    NGLGPERSAG PGGAEAEPLP TQLNGAPGEP APAGPRDTDA LDLEESSSSD 300
    HAERPPGPRR PERGPRGKGK ARASQVKPGD SLPRRGPGAT GIGTPAAGPG 350
    EERVGAAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLTAVG 400
    CSVPRTLFKF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV 450
    Length:450
    Mass (Da):48,957
    Last modified:February 1, 1996 - v3
    Checksum:iA703CF262F04E8AC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1041A → T in AAA51664. (PubMed:2823383)Curated
    Sequence conflicti124 – 1241L → P(PubMed:1849485)Curated
    Sequence conflicti157 – 1571V → C in AAA51664. (PubMed:2823383)Curated
    Sequence conflicti333 – 36533PRRGP…RWRGR → RGAGRGRRGSGRRLQGRGRS ASGLPRRRAGAGG in AAA51664. (PubMed:2823383)CuratedAdd
    BLAST
    Sequence conflicti333 – 36533PRRGP…RWRGR → RGAGRGRRGSGRRLQGRGRS ASGLPRRRAGAGG in AAA51665. (PubMed:2568356)CuratedAdd
    BLAST
    Sequence conflicti368 – 3681R → L in AAA51664. (PubMed:2823383)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti251 – 2511N → K Rare polymorphism; frequency in Caucasians 0.004 and in African-Americans 0.05; 40% increase in agonist-promoted Gi coupling. 3 Publications
    Corresponds to variant rs1800035 [ dbSNP | Ensembl ].
    VAR_014957
    Natural varianti401 – 4011C → S.
    Corresponds to variant rs35658213 [ dbSNP | Ensembl ].
    VAR_055908

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18415 Genomic DNA. Translation: AAA51664.1.
    M23533 Genomic DNA. Translation: AAA51665.1.
    AF281308 Genomic DNA. Translation: AAF91441.1.
    AF316894 Genomic DNA. Translation: AAK01634.1.
    DQ149926 Genomic DNA. Translation: AAZ73101.1.
    AF284095 mRNA. Translation: AAK26743.1.
    AF262016 Genomic DNA. Translation: AAG00447.2.
    AY032736 Genomic DNA. Translation: AAK51162.1.
    DQ285607 Genomic DNA. Translation: ABB72683.1.
    EU332846 Genomic DNA. Translation: ABY87535.1.
    AL158163 Genomic DNA. Translation: CAH72817.1.
    BC035047 mRNA. Translation: AAH35047.1.
    BC050414 mRNA. Translation: AAH50414.4.
    PIRiA34169.
    RefSeqiNP_000672.3. NM_000681.3.
    UniGeneiHs.249159.

    Genome annotation databases

    EnsembliENST00000280155; ENSP00000280155; ENSG00000150594.
    GeneIDi150.
    KEGGihsa:150.
    UCSCiuc001kzo.3. human.

    Polymorphism databases

    DMDMi1351829.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18415 Genomic DNA. Translation: AAA51664.1 .
    M23533 Genomic DNA. Translation: AAA51665.1 .
    AF281308 Genomic DNA. Translation: AAF91441.1 .
    AF316894 Genomic DNA. Translation: AAK01634.1 .
    DQ149926 Genomic DNA. Translation: AAZ73101.1 .
    AF284095 mRNA. Translation: AAK26743.1 .
    AF262016 Genomic DNA. Translation: AAG00447.2 .
    AY032736 Genomic DNA. Translation: AAK51162.1 .
    DQ285607 Genomic DNA. Translation: ABB72683.1 .
    EU332846 Genomic DNA. Translation: ABY87535.1 .
    AL158163 Genomic DNA. Translation: CAH72817.1 .
    BC035047 mRNA. Translation: AAH35047.1 .
    BC050414 mRNA. Translation: AAH50414.4 .
    PIRi A34169.
    RefSeqi NP_000672.3. NM_000681.3.
    UniGenei Hs.249159.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HLL NMR - A 118-149 [» ]
    1HO9 NMR - A 118-149 [» ]
    1HOD NMR - A 118-149 [» ]
    1HOF NMR - A 118-149 [» ]
    ProteinModelPortali P08913.
    SMRi P08913. Positions 39-442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106659. 8 interactions.
    IntActi P08913. 3 interactions.
    STRINGi 9606.ENSP00000280155.

    Chemistry

    BindingDBi P08913.
    ChEMBLi CHEMBL2331074.
    DrugBanki DB00321. Amitriptyline.
    DB00182. Amphetamine.
    DB00964. Apraclonidine.
    DB00865. Benzphetamine.
    DB00217. Bethanidine.
    DB00484. Brimonidine.
    DB00575. Clonidine.
    DB04840. Debrisoquin.
    DB00633. Dexmedetomidine.
    DB00449. Dipivefrin.
    DB00751. Epinastine.
    DB00696. Ergotamine.
    DB00800. Fenoldopam.
    DB00629. Guanabenz.
    DB00226. Guanadrel Sulfate.
    DB01170. Guanethidine.
    DB01018. Guanfacine.
    DB04948. Lofexidine.
    DB00968. Methyldopa.
    DB06148. Mianserin.
    DB00370. Mirtazapine.
    DB00368. Norepinephrine.
    DB00935. Oxymetazoline.
    DB00692. Phentolamine.
    DB00397. Phenylpropanolamine.
    DB00852. Pseudoephedrine.
    DB00697. Tizanidine.
    DB00656. Trazodone.
    DB01392. Yohimbine.
    GuidetoPHARMACOLOGYi 25.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P08913.

    Polymorphism databases

    DMDMi 1351829.

    Proteomic databases

    PaxDbi P08913.
    PRIDEi P08913.

    Protocols and materials databases

    DNASUi 150.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280155 ; ENSP00000280155 ; ENSG00000150594 .
    GeneIDi 150.
    KEGGi hsa:150.
    UCSCi uc001kzo.3. human.

    Organism-specific databases

    CTDi 150.
    GeneCardsi GC10P112826.
    H-InvDB HIX0190540.
    HGNCi HGNC:281. ADRA2A.
    MIMi 104210. gene.
    neXtProti NX_P08913.
    PharmGKBi PA35.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG249628.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P08913.
    KOi K04138.
    OrthoDBi EOG7J9VPT.
    PhylomeDBi P08913.
    TreeFami TF316350.

    Enzyme and pathway databases

    Reactomei REACT_16927. Adrenoceptors.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_19180. Adrenaline signalling through Alpha-2 adrenergic receptor.
    REACT_19231. G alpha (i) signalling events.
    REACT_19333. G alpha (z) signalling events.
    SignaLinki P08913.

    Miscellaneous databases

    EvolutionaryTracei P08913.
    GeneWikii Alpha-2A_adrenergic_receptor.
    GenomeRNAii 150.
    NextBioi 595.
    PROi P08913.
    SOURCEi Search...

    Gene expression databases

    Bgeei P08913.
    CleanExi HS_ADRA2A.
    Genevestigatori P08913.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR002233. ADR_fam.
    IPR001946. ADRA2A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF24. PTHR24248:SF24. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00558. ADRENRGCA2AR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor."
      Kobilka B.K., Matsui H., Kobilka T.S., Yang-Feng T.L., Francke U., Caron M.G., Lefkowitz R.J., Regan J.W.
      Science 238:650-656(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Platelet.
    2. "Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation."
      Fraser C.M., Arakawa S., McCombie W.R., Venter J.C.
      J. Biol. Chem. 264:11754-11761(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs."
      Guyer C.A., Horstman D.A., Wilson A.L., Clark J.D., Kragoe E.J. Jr., Limbird L.E.
      J. Biol. Chem. 265:17307-17317(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 333-365.
    4. "An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling."
      Small K.M., Forbes S.L., Brown K.M., Liggett S.B.
      J. Biol. Chem. 275:38518-38523(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-251.
    5. "Complex haplotypes derived from noncoding polymorphisms of the intronless alpha-2A-adrenergic gene diversify receptor expression."
      Small K.M., Brown K.M., Seman C.A., Theiss C.T., Liggett S.B.
      Proc. Natl. Acad. Sci. U.S.A. 103:5472-5477(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-251.
    6. "Cloning and expression of human alpha-2A adrenergic receptor in SY5Y cells."
      Mao Z.-M., Tang K., Li B.-M., Jing N.-H.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    7. "A search for genetic variability in the human alpha-2 adrenergic receptor on chromosome 10."
      Castellano M., Giacche' M., Rossi F., Rivadossi F., Perani C., Beschi M., Agabiti Rosei E.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. "Human alpha-2A adrenergic receptor gene and the genotype of -1296 nucleotide and motionsickness."
      Liu L., Yuan L.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    9. SeattleSNPs variation discovery resource
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-251.
    10. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    11. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PNS and Testis.
    13. "Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR."
      Chhajlani V., Rangel N., Uhlen S., Wikberg J.E.S.
      FEBS Lett. 280:241-244(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-209.
    14. "A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists."
      Suryanarayana S., Daunt D.A., von Zastrow M., Kobilka B.K.
      J. Biol. Chem. 266:15488-15492(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF PHE-412.
    15. "Site-directed mutagenesis of alpha 2a-adrenergic receptors: Identification of amino acids involved in ligand binding and receptor activation by agonists."
      Wang C.-D., Buck M.A., Fraser C.M.
      Mol. Pharmacol. 40:168-179(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF ASPARTIC ACID AND SERINE RESIDUES.
    16. "Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi."
      Li C., Fan Y., Lan T.H., Lambert N.A., Wu G.
      J. Biol. Chem. 287:42784-42794(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    17. "NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix."
      Chung D.A., Zuiderweg E.R.P., Fowler C.B., Soyer O.S., Mosberg H.I., Neubig R.R.
      Biochemistry 41:3596-3604(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 118-149, PROBABLE MEMBRANE TOPOLOGY.

    Entry informationi

    Entry nameiADA2A_HUMAN
    AccessioniPrimary (citable) accession number: P08913
    Secondary accession number(s): B0LPF6
    , Q2I8G2, Q2XN99, Q86TH8, Q9BZK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 168 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3