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Protein

Alpha-2A adrenergic receptor

Gene

ADRA2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei113Implicated in ligand binding1
Sitei200Implicated in catechol agonist binding and receptor activation1
Sitei204Implicated in catechol agonist binding and receptor activation1

GO - Molecular functioni

  • alpha-1B adrenergic receptor binding Source: BHF-UCL
  • alpha2-adrenergic receptor activity Source: BHF-UCL
  • alpha-2C adrenergic receptor binding Source: BHF-UCL
  • epinephrine binding Source: BHF-UCL
  • heterotrimeric G-protein binding Source: BHF-UCL
  • norepinephrine binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • thioesterase binding Source: BHF-UCL

GO - Biological processi

  • actin cytoskeleton organization Source: ProtInc
  • activation of MAPK activity by adrenergic receptor signaling pathway Source: BHF-UCL
  • activation of protein kinase activity Source: BHF-UCL
  • activation of protein kinase B activity Source: BHF-UCL
  • adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
  • adenylate cyclase-inhibiting adrenergic receptor signaling pathway Source: BHF-UCL
  • cellular response to hormone stimulus Source: BHF-UCL
  • epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway Source: BHF-UCL
  • glucose homeostasis Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • intestinal absorption Source: BHF-UCL
  • movement of cell or subcellular component Source: ProtInc
  • negative regulation of adenylate cyclase activity Source: BHF-UCL
  • negative regulation of adrenergic receptor signaling pathway Source: BHF-UCL
  • negative regulation of calcium ion-dependent exocytosis Source: BHF-UCL
  • negative regulation of calcium ion transmembrane transporter activity Source: BHF-UCL
  • negative regulation of calcium ion transport Source: BHF-UCL
  • negative regulation of cAMP biosynthetic process Source: BHF-UCL
  • negative regulation of epinephrine secretion Source: BHF-UCL
  • negative regulation of insulin secretion Source: BHF-UCL
  • negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: BHF-UCL
  • negative regulation of lipid catabolic process Source: BHF-UCL
  • negative regulation of norepinephrine secretion Source: BHF-UCL
  • phospholipase C-activating adrenergic receptor signaling pathway Source: BHF-UCL
  • platelet activation Source: InterPro
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of cytokine production Source: BHF-UCL
  • positive regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
  • positive regulation of MAP kinase activity Source: BHF-UCL
  • positive regulation of membrane protein ectodomain proteolysis Source: BHF-UCL
  • positive regulation of potassium ion transport Source: BHF-UCL
  • positive regulation of wound healing Source: BHF-UCL
  • Ras protein signal transduction Source: ProtInc
  • regulation of insulin secretion Source: Reactome
  • regulation of smooth muscle contraction Source: InterPro
  • regulation of vasoconstriction Source: InterPro
  • Rho protein signal transduction Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150594-MONOMER.
ReactomeiR-HSA-390696. Adrenoceptors.
R-HSA-392023. Adrenaline signalling through Alpha-2 adrenergic receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-5683826. Surfactant metabolism.
SignaLinkiP08913.
SIGNORiP08913.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2 adrenergic receptor subtype C10
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Gene namesi
Name:ADRA2A
Synonyms:ADRA2R, ADRAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:281. ADRA2A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 59Helical; Name=1By similarityAdd BLAST26
Topological domaini60 – 70CytoplasmicBy similarityAdd BLAST11
Transmembranei71 – 96Helical; Name=2By similarityAdd BLAST26
Topological domaini97 – 106ExtracellularBy similarity10
Transmembranei107 – 129Helical; Name=3By similarityAdd BLAST23
Topological domaini130 – 151CytoplasmicBy similarityAdd BLAST22
Transmembranei152 – 172Helical; Name=4By similarityAdd BLAST21
Topological domaini173 – 194ExtracellularBy similarityAdd BLAST22
Transmembranei195 – 217Helical; Name=5By similarityAdd BLAST23
Topological domaini218 – 374CytoplasmicBy similarityAdd BLAST157
Transmembranei375 – 395Helical; Name=6By similarityAdd BLAST21
Topological domaini396 – 409ExtracellularBy similarityAdd BLAST14
Transmembranei410 – 429Helical; Name=7By similarityAdd BLAST20
Topological domaini430 – 450CytoplasmicBy similarityAdd BLAST21

GO - Cellular componenti

  • basolateral plasma membrane Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • integral component of plasma membrane Source: BHF-UCL
  • plasma membrane Source: Reactome
  • receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi79D → N: No change in binding affinity. eliminates guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi113D → N: No binding to yohimbine. Increase in adenylate cyclase activity. 1 Publication1
Mutagenesisi130D → N: Lower affinity for agonists. Eliminates guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi200S → A: Lower affinity for agonists. No change in guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi204S → A: Lower affinity for agonists. Reduced guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi412F → N: 350-fold reduced affinity for alpha-2 antagonist yohimbine, 3000-fold increase for beta-antagonist alprenolol. 1 Publication1

Organism-specific databases

DisGeNETi150.
PharmGKBiPA35.

Chemistry databases

ChEMBLiCHEMBL1867.
DrugBankiDB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB00714. Apomorphine.
DB00964. Apraclonidine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB00865. Benzphetamine.
DB00217. Bethanidine.
DB00484. Brimonidine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB01136. Carvedilol.
DB00477. Chlorpromazine.
DB00575. Clonidine.
DB00363. Clozapine.
DB01151. Desipramine.
DB00633. Dexmedetomidine.
DB00320. Dihydroergotamine.
DB00449. Dipivefrin.
DB01142. Doxepin.
DB04855. Dronedarone.
DB06262. Droxidopa.
DB01363. Ephedra.
DB00751. Epinastine.
DB00668. Epinephrine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB06623. Flupirtine.
DB00629. Guanabenz.
DB01018. Guanfacine.
DB00589. Lisuride.
DB04948. Lofexidine.
DB00408. Loxapine.
DB08815. Lurasidone.
DB00934. Maprotiline.
DB01365. Mephentermine.
DB01577. Methamphetamine.
DB01403. Methotrimeprazine.
DB00968. Methyldopa.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB06711. Naphazoline.
DB01149. Nefazodone.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00935. Oxymetazoline.
DB01267. Paliperidone.
DB01186. Pergolide.
DB00925. Phenoxybenzamine.
DB00692. Phentolamine.
DB00397. Phenylpropanolamine.
DB00413. Pramipexole.
DB00457. Prazosin.
DB01608. Propericiazine.
DB00852. Pseudoephedrine.
DB01224. Quetiapine.
DB00734. Risperidone.
DB00268. Ropinirole.
DB00697. Tizanidine.
DB00797. Tolazoline.
DB00656. Trazodone.
DB00726. Trimipramine.
DB06694. Xylometazoline.
DB01392. Yohimbine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi25.

Polymorphism and mutation databases

BioMutaiADRA2A.
DMDMi1351829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690801 – 450Alpha-2A adrenergic receptorAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
Modified residuei331PhosphoserineBy similarity1
Modified residuei353Omega-N-methylarginineBy similarity1
Lipidationi442S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

EPDiP08913.
PaxDbiP08913.
PeptideAtlasiP08913.
PRIDEiP08913.

PTM databases

iPTMnetiP08913.
PhosphoSitePlusiP08913.

Expressioni

Gene expression databases

BgeeiENSG00000150594.
CleanExiHS_ADRA2A.
GenevisibleiP08913. HS.

Interactioni

GO - Molecular functioni

  • alpha-1B adrenergic receptor binding Source: BHF-UCL
  • alpha-2C adrenergic receptor binding Source: BHF-UCL
  • heterotrimeric G-protein binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • thioesterase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi106659. 8 interactors.
DIPiDIP-61452N.
IntActiP08913. 3 interactors.
STRINGi9606.ENSP00000280155.

Chemistry databases

BindingDBiP08913.

Structurei

Secondary structure

1450
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi119 – 128Combined sources10
Helixi130 – 139Combined sources10
Helixi140 – 142Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLLNMR-A118-149[»]
1HO9NMR-A118-149[»]
1HODNMR-A118-149[»]
1HOFNMR-A118-149[»]
ProteinModelPortaliP08913.
SMRiP08913.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08913.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP08913.
KOiK04138.
OrthoDBiEOG091G06VI.
PhylomeDBiP08913.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLQPDAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLLTVFG
60 70 80 90 100
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY
110 120 130 140 150
FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI
160 170 180 190 200
KAIIITVWVI SAVISFPPLI SIEKKGGGGG PQPAEPRCEI NDQKWYVISS
210 220 230 240 250
CIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDAVA APPGGTERRP
260 270 280 290 300
NGLGPERSAG PGGAEAEPLP TQLNGAPGEP APAGPRDTDA LDLEESSSSD
310 320 330 340 350
HAERPPGPRR PERGPRGKGK ARASQVKPGD SLPRRGPGAT GIGTPAAGPG
360 370 380 390 400
EERVGAAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLTAVG
410 420 430 440 450
CSVPRTLFKF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV
Length:450
Mass (Da):48,957
Last modified:February 1, 1996 - v3
Checksum:iA703CF262F04E8AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104A → T in AAA51664 (PubMed:2823383).Curated1
Sequence conflicti124L → P (PubMed:1849485).Curated1
Sequence conflicti157V → C in AAA51664 (PubMed:2823383).Curated1
Sequence conflicti333 – 365PRRGP…RWRGR → RGAGRGRRGSGRRLQGRGRS ASGLPRRRAGAGG in AAA51664 (PubMed:2823383).CuratedAdd BLAST33
Sequence conflicti333 – 365PRRGP…RWRGR → RGAGRGRRGSGRRLQGRGRS ASGLPRRRAGAGG in AAA51665 (PubMed:2568356).CuratedAdd BLAST33
Sequence conflicti368R → L in AAA51664 (PubMed:2823383).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014957251N → K Rare polymorphism; frequency in Caucasians 0.004 and in African-Americans 0.05; 40% increase in agonist-promoted Gi coupling. 3 PublicationsCorresponds to variant rs1800035dbSNPEnsembl.1
Natural variantiVAR_055908401C → S.Corresponds to variant rs35658213dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18415 Genomic DNA. Translation: AAA51664.1.
M23533 Genomic DNA. Translation: AAA51665.1.
AF281308 Genomic DNA. Translation: AAF91441.1.
AF316894 Genomic DNA. Translation: AAK01634.1.
DQ149926 Genomic DNA. Translation: AAZ73101.1.
AF284095 mRNA. Translation: AAK26743.1.
AF262016 Genomic DNA. Translation: AAG00447.2.
AY032736 Genomic DNA. Translation: AAK51162.1.
DQ285607 Genomic DNA. Translation: ABB72683.1.
EU332846 Genomic DNA. Translation: ABY87535.1.
AL158163 Genomic DNA. Translation: CAH72817.1.
BC035047 mRNA. Translation: AAH35047.1.
BC050414 mRNA. Translation: AAH50414.4.
PIRiA34169.
RefSeqiNP_000672.3. NM_000681.3.
UniGeneiHs.249159.

Genome annotation databases

EnsembliENST00000280155; ENSP00000280155; ENSG00000150594.
GeneIDi150.
KEGGihsa:150.
UCSCiuc001kzo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18415 Genomic DNA. Translation: AAA51664.1.
M23533 Genomic DNA. Translation: AAA51665.1.
AF281308 Genomic DNA. Translation: AAF91441.1.
AF316894 Genomic DNA. Translation: AAK01634.1.
DQ149926 Genomic DNA. Translation: AAZ73101.1.
AF284095 mRNA. Translation: AAK26743.1.
AF262016 Genomic DNA. Translation: AAG00447.2.
AY032736 Genomic DNA. Translation: AAK51162.1.
DQ285607 Genomic DNA. Translation: ABB72683.1.
EU332846 Genomic DNA. Translation: ABY87535.1.
AL158163 Genomic DNA. Translation: CAH72817.1.
BC035047 mRNA. Translation: AAH35047.1.
BC050414 mRNA. Translation: AAH50414.4.
PIRiA34169.
RefSeqiNP_000672.3. NM_000681.3.
UniGeneiHs.249159.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLLNMR-A118-149[»]
1HO9NMR-A118-149[»]
1HODNMR-A118-149[»]
1HOFNMR-A118-149[»]
ProteinModelPortaliP08913.
SMRiP08913.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106659. 8 interactors.
DIPiDIP-61452N.
IntActiP08913. 3 interactors.
STRINGi9606.ENSP00000280155.

Chemistry databases

BindingDBiP08913.
ChEMBLiCHEMBL1867.
DrugBankiDB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB00714. Apomorphine.
DB00964. Apraclonidine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB00865. Benzphetamine.
DB00217. Bethanidine.
DB00484. Brimonidine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB01136. Carvedilol.
DB00477. Chlorpromazine.
DB00575. Clonidine.
DB00363. Clozapine.
DB01151. Desipramine.
DB00633. Dexmedetomidine.
DB00320. Dihydroergotamine.
DB00449. Dipivefrin.
DB01142. Doxepin.
DB04855. Dronedarone.
DB06262. Droxidopa.
DB01363. Ephedra.
DB00751. Epinastine.
DB00668. Epinephrine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB06623. Flupirtine.
DB00629. Guanabenz.
DB01018. Guanfacine.
DB00589. Lisuride.
DB04948. Lofexidine.
DB00408. Loxapine.
DB08815. Lurasidone.
DB00934. Maprotiline.
DB01365. Mephentermine.
DB01577. Methamphetamine.
DB01403. Methotrimeprazine.
DB00968. Methyldopa.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB06711. Naphazoline.
DB01149. Nefazodone.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00935. Oxymetazoline.
DB01267. Paliperidone.
DB01186. Pergolide.
DB00925. Phenoxybenzamine.
DB00692. Phentolamine.
DB00397. Phenylpropanolamine.
DB00413. Pramipexole.
DB00457. Prazosin.
DB01608. Propericiazine.
DB00852. Pseudoephedrine.
DB01224. Quetiapine.
DB00734. Risperidone.
DB00268. Ropinirole.
DB00697. Tizanidine.
DB00797. Tolazoline.
DB00656. Trazodone.
DB00726. Trimipramine.
DB06694. Xylometazoline.
DB01392. Yohimbine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi25.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP08913.
PhosphoSitePlusiP08913.

Polymorphism and mutation databases

BioMutaiADRA2A.
DMDMi1351829.

Proteomic databases

EPDiP08913.
PaxDbiP08913.
PeptideAtlasiP08913.
PRIDEiP08913.

Protocols and materials databases

DNASUi150.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280155; ENSP00000280155; ENSG00000150594.
GeneIDi150.
KEGGihsa:150.
UCSCiuc001kzo.4. human.

Organism-specific databases

CTDi150.
DisGeNETi150.
GeneCardsiADRA2A.
H-InvDBHIX0190540.
HGNCiHGNC:281. ADRA2A.
MIMi104210. gene.
neXtProtiNX_P08913.
PharmGKBiPA35.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP08913.
KOiK04138.
OrthoDBiEOG091G06VI.
PhylomeDBiP08913.
TreeFamiTF316350.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150594-MONOMER.
ReactomeiR-HSA-390696. Adrenoceptors.
R-HSA-392023. Adrenaline signalling through Alpha-2 adrenergic receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-5683826. Surfactant metabolism.
SignaLinkiP08913.
SIGNORiP08913.

Miscellaneous databases

EvolutionaryTraceiP08913.
GeneWikiiAlpha-2A_adrenergic_receptor.
GenomeRNAii150.
PROiP08913.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150594.
CleanExiHS_ADRA2A.
GenevisibleiP08913. HS.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00558. ADRENRGCA2AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA2A_HUMAN
AccessioniPrimary (citable) accession number: P08913
Secondary accession number(s): B0LPF6
, Q2I8G2, Q2XN99, Q86TH8, Q9BZK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 189 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.