P08910 (ABHD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Abhydrolase domain-containing protein 2
EC=3.1.1.-

Alternative name(s):
Lung alpha/beta hydrolase 2
Protein PHPS1-2

Gene names

Name:	ABHD2
Synonyms:	LABH2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in smooth muscle cells migration By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
Caution	Was originally (Ref.1) thought to be a G-coupled receptor.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase Serine esterase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cell migration Inferred from electronic annotation. Source: Compara response to wounding Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB
Molecular_function	carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	Abhydrolase domain-containing protein 2		PRO_0000212457
Regions
	Transmembrane	10 – 30	21	Helical; Signal-anchor for type II membrane protein; Potential
Sites
	Active site	207	1	Charge relay system By similarity
	Active site	345	1	Charge relay system By similarity
	Active site	376	1	Charge relay system By similarity
Natural variations
	Natural variant	253	1	R → Q. Ref.4 Corresponds to variant rs17851730 [ dbSNP | Ensembl ].		VAR_031203
Experimental info
	Sequence conflict	27	1	Y → C in BAD96803. Ref.3
	Sequence conflict	388	1	E → G in BAD96561. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P08910 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: 747C6AB2C99B3CC2	FASTA	425	48,315
	10 20 30 40 50 60 MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG LSRFLLKSCP 70 80 90 100 110 120 LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF ITMSDGATST FDLFEPLAEH 130 140 150 160 170 180 CVGDDITMVI CPGIANHSEK QYIRTFVDYA QKNGYRCAVL NHLGALPNIE LTSPRMFTYG 190 200 210 220 230 240 CTWEFGAMVN YIKKTYPLTQ LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL 250 260 270 280 290 300 RAQETFMQWD QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL 310 320 330 340 350 360 MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE SLLTIPKSLS 370 380 390 400 410 420 EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY ANAICQWERN KLQCSDTEQV EADLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family." Rapiejko P.J., George S.T., Malbon C.C. Nucleic Acids Res. 16:8721-8721(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Cloning of an androgen-regulated a/b hydrolase." Utleg A., White J., Lin B. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Gastric carcinoma and Liver.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-253. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X12433 mRNA. Translation: CAA30976.1. AF546700 mRNA. Translation: AAQ12021.1. AK222841 mRNA. Translation: BAD96561.1. AK223083 mRNA. Translation: BAD96803.1. BC019248 mRNA. Translation: AAH19248.1. BC090052 mRNA. Translation: AAH90052.1.
IPI	IPI00031707.
PIR	A31026.
RefSeq	NP_008942.3. NM_007011.7. NP_690888.1. NM_152924.4.
UniGene	Hs.122337.
3D structure databases
ProteinModelPortal	P08910.
ModBase	Search...
PTM databases
PhosphoSite	P08910.
Polymorphism databases
DMDM	123504.
Proteomic databases
PaxDb	P08910.
PRIDE	P08910.
Protocols and materials databases
DNASU	11057.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000352732; ENSP00000268129; ENSG00000140526. ENST00000355100; ENSP00000347217; ENSG00000140526. ENST00000565973; ENSP00000455639; ENSG00000140526.
GeneID	11057.
KEGG	hsa:11057.
UCSC	uc002bnj.2. human.
Organism-specific databases
CTD	11057.
GeneCards	GC15P089631.
HGNC	HGNC:18717. ABHD2.
HPA	HPA005999.
MIM	612196. gene.
neXtProt	NX_P08910.
PharmGKB	PA38658.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0429.
HOGENOM	HOG000230852.
HOVERGEN	HBG080812.
InParanoid	P08910.
KO	K13697.
OMA	YPQTQLV.
OrthoDB	EOG4PK27S.
PhylomeDB	P08910.
Gene expression databases
ArrayExpress	P08910.
Bgee	P08910.
CleanEx	HS_ABHD2.
Genevestigator	P08910.
GermOnline	ENSG00000140526. Homo sapiens.
Family and domain databases
InterPro	IPR012020. AB-Hydro_YheT. IPR000073. AB_hydrolase_1. IPR000952. UPF0017_hydro-like_CS. [Graphical view]
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PIRSF	PIRSF005211. Ab_hydro_YheT. 1 hit.
PROSITE	PS01133. UPF0017. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ABHD2. human.
GenomeRNAi	11057.
NextBio	42013.
SOURCE	Search...

Entry information

Entry name

ABHD2_HUMAN

Accession

Primary (citable) accession number: P08910
Secondary accession number(s): Q53G48 , Q53GU0, Q5FVD9, Q8TC79

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.