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P08910

- ABHD2_HUMAN

UniProt

P08910 - ABHD2_HUMAN

Protein

Abhydrolase domain-containing protein 2

Gene

ABHD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1988)
      Previous versions | rss
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    Functioni

    May play a role in smooth muscle cells migration.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei207 – 2071Charge relay systemBy similarity
    Active sitei345 – 3451Charge relay systemBy similarity
    Active sitei376 – 3761Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of cell migration Source: Ensembl
    2. response to wounding Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abhydrolase domain-containing protein 2 (EC:3.1.1.-)
    Alternative name(s):
    Lung alpha/beta hydrolase 2
    Protein PHPS1-2
    Gene namesi
    Name:ABHD2
    Synonyms:LABH2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:18717. ABHD2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38658.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Abhydrolase domain-containing protein 2PRO_0000212457Add
    BLAST

    Proteomic databases

    MaxQBiP08910.
    PaxDbiP08910.
    PRIDEiP08910.

    PTM databases

    PhosphoSiteiP08910.

    Expressioni

    Gene expression databases

    ArrayExpressiP08910.
    BgeeiP08910.
    CleanExiHS_ABHD2.
    GenevestigatoriP08910.

    Organism-specific databases

    HPAiHPA005999.

    Interactioni

    Protein-protein interaction databases

    BioGridi116242. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP08910.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0429.
    HOGENOMiHOG000230852.
    HOVERGENiHBG080812.
    InParanoidiP08910.
    KOiK13697.
    OMAiFSGHVQT.
    PhylomeDBiP08910.
    TreeFamiTF313195.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR012020. AB-Hydro_YheT.
    IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000952. UPF0017_hydro-like_CS.
    [Graphical view]
    PfamiPF00561. Abhydrolase_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS01133. UPF0017. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08910-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG    50
    LSRFLLKSCP LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF 100
    ITMSDGATST FDLFEPLAEH CVGDDITMVI CPGIANHSEK QYIRTFVDYA 150
    QKNGYRCAVL NHLGALPNIE LTSPRMFTYG CTWEFGAMVN YIKKTYPLTQ 200
    LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL RAQETFMQWD 250
    QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL 300
    MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE 350
    SLLTIPKSLS EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY 400
    ANAICQWERN KLQCSDTEQV EADLE 425
    Length:425
    Mass (Da):48,315
    Last modified:November 1, 1988 - v1
    Checksum:i747C6AB2C99B3CC2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271Y → C in BAD96803. 1 PublicationCurated
    Sequence conflicti388 – 3881E → G in BAD96561. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti253 – 2531R → Q.1 Publication
    Corresponds to variant rs17851730 [ dbSNP | Ensembl ].
    VAR_031203

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12433 mRNA. Translation: CAA30976.1.
    AF546700 mRNA. Translation: AAQ12021.1.
    AK222841 mRNA. Translation: BAD96561.1.
    AK223083 mRNA. Translation: BAD96803.1.
    BC019248 mRNA. Translation: AAH19248.1.
    BC090052 mRNA. Translation: AAH90052.1.
    CCDSiCCDS10348.1.
    PIRiA31026.
    RefSeqiNP_008942.3. NM_007011.7.
    NP_690888.1. NM_152924.4.
    XP_005254889.1. XM_005254832.1.
    XP_005254890.1. XM_005254833.1.
    UniGeneiHs.122337.

    Genome annotation databases

    EnsembliENST00000352732; ENSP00000268129; ENSG00000140526.
    ENST00000355100; ENSP00000347217; ENSG00000140526.
    ENST00000565973; ENSP00000455639; ENSG00000140526.
    GeneIDi11057.
    KEGGihsa:11057.
    UCSCiuc002bnj.2. human.

    Polymorphism databases

    DMDMi123504.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12433 mRNA. Translation: CAA30976.1 .
    AF546700 mRNA. Translation: AAQ12021.1 .
    AK222841 mRNA. Translation: BAD96561.1 .
    AK223083 mRNA. Translation: BAD96803.1 .
    BC019248 mRNA. Translation: AAH19248.1 .
    BC090052 mRNA. Translation: AAH90052.1 .
    CCDSi CCDS10348.1.
    PIRi A31026.
    RefSeqi NP_008942.3. NM_007011.7.
    NP_690888.1. NM_152924.4.
    XP_005254889.1. XM_005254832.1.
    XP_005254890.1. XM_005254833.1.
    UniGenei Hs.122337.

    3D structure databases

    ProteinModelPortali P08910.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116242. 1 interaction.

    PTM databases

    PhosphoSitei P08910.

    Polymorphism databases

    DMDMi 123504.

    Proteomic databases

    MaxQBi P08910.
    PaxDbi P08910.
    PRIDEi P08910.

    Protocols and materials databases

    DNASUi 11057.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000352732 ; ENSP00000268129 ; ENSG00000140526 .
    ENST00000355100 ; ENSP00000347217 ; ENSG00000140526 .
    ENST00000565973 ; ENSP00000455639 ; ENSG00000140526 .
    GeneIDi 11057.
    KEGGi hsa:11057.
    UCSCi uc002bnj.2. human.

    Organism-specific databases

    CTDi 11057.
    GeneCardsi GC15P089631.
    HGNCi HGNC:18717. ABHD2.
    HPAi HPA005999.
    MIMi 612196. gene.
    neXtProti NX_P08910.
    PharmGKBi PA38658.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0429.
    HOGENOMi HOG000230852.
    HOVERGENi HBG080812.
    InParanoidi P08910.
    KOi K13697.
    OMAi FSGHVQT.
    PhylomeDBi P08910.
    TreeFami TF313195.

    Miscellaneous databases

    ChiTaRSi ABHD2. human.
    GeneWikii ABHD2.
    GenomeRNAii 11057.
    NextBioi 42013.
    PROi P08910.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08910.
    Bgeei P08910.
    CleanExi HS_ABHD2.
    Genevestigatori P08910.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR012020. AB-Hydro_YheT.
    IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000952. UPF0017_hydro-like_CS.
    [Graphical view ]
    Pfami PF00561. Abhydrolase_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005211. Ab_hydro_YheT. 1 hit.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS01133. UPF0017. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family."
      Rapiejko P.J., George S.T., Malbon C.C.
      Nucleic Acids Res. 16:8721-8721(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Cloning of an androgen-regulated a/b hydrolase."
      Utleg A., White J., Lin B.
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Gastric carcinoma and Liver.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-253.
      Tissue: Testis.

    Entry informationi

    Entry nameiABHD2_HUMAN
    AccessioniPrimary (citable) accession number: P08910
    Secondary accession number(s): Q53G48
    , Q53GU0, Q5FVD9, Q8TC79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: November 1, 1988
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally thought to be a G-coupled receptor.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3