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Protein

Monoacylglycerol lipase ABHD2

Gene

ABHD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).By similarity1 Publication

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.1 Publication

Enzyme regulationi

Acylglycerol lipase activity is activated upon binding to progesterone.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei207NucleophileBy similarity1
Active sitei345Charge relay systemBy similarity1
Active sitei376Charge relay systemBy similarity1

GO - Molecular functioni

  • acylglycerol lipase activity Source: UniProtKB
  • hormone binding Source: UniProtKB
  • steroid hormone receptor activity Source: UniProtKB

GO - Biological processi

  • acrosome reaction Source: Ensembl
  • acylglycerol catabolic process Source: UniProtKB
  • negative regulation of cell migration Source: Ensembl
  • response to progesterone Source: UniProtKB
  • response to wounding Source: Ensembl
  • sperm capacitation Source: UniProtKB
  • steroid hormone mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140526-MONOMER.

Protein family/group databases

ESTHERihuman-ABHD2. abh_upf0017.

Chemistry databases

SwissLipidsiSLP:000001546.

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase ABHD2Curated (EC:3.1.1.231 Publication)
Alternative name(s):
2-arachidonoylglycerol hydrolaseCurated
Abhydrolase domain-containing protein 2Curated
Lung alpha/beta hydrolase 2By similarity
Protein PHPS1-21 Publication
Gene namesi
Name:ABHD2Imported
Synonyms:LABH2By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:18717. ABHD2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicCurated9
Transmembranei10 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini31 – 425ExtracellularCuratedAdd BLAST395

GO - Cellular componenti

  • acrosomal vesicle Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • sperm flagellum Source: UniProtKB
  • sperm plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11057.
OpenTargetsiENSG00000140526.
PharmGKBiPA38658.

Polymorphism and mutation databases

BioMutaiABHD2.
DMDMi123504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124571 – 425Monoacylglycerol lipase ABHD2Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi136N-linked (GlcNAc...)PROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP08910.
PaxDbiP08910.
PeptideAtlasiP08910.
PRIDEiP08910.

PTM databases

iPTMnetiP08910.
PhosphoSitePlusiP08910.
SwissPalmiP08910.

Expressioni

Tissue specificityi

Present in sperm (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000140526.
CleanExiHS_ABHD2.
ExpressionAtlasiP08910. baseline and differential.
GenevisibleiP08910. HS.

Organism-specific databases

HPAiHPA005999.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000268129.

Structurei

3D structure databases

ProteinModelPortaliP08910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 382AB hydrolase-1Sequence analysisAdd BLAST255

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1838. Eukaryota.
COG0429. LUCA.
GeneTreeiENSGT00530000062981.
HOGENOMiHOG000230852.
HOVERGENiHBG080812.
InParanoidiP08910.
KOiK13697.
OMAiYPQTQLV.
OrthoDBiEOG091G08XK.
PhylomeDBiP08910.
TreeFamiTF313195.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000952. AB_hydrolase_4_CS.
IPR012020. ABHD4.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01133. UPF0017. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG
60 70 80 90 100
LSRFLLKSCP LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF
110 120 130 140 150
ITMSDGATST FDLFEPLAEH CVGDDITMVI CPGIANHSEK QYIRTFVDYA
160 170 180 190 200
QKNGYRCAVL NHLGALPNIE LTSPRMFTYG CTWEFGAMVN YIKKTYPLTQ
210 220 230 240 250
LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL RAQETFMQWD
260 270 280 290 300
QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL
310 320 330 340 350
MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE
360 370 380 390 400
SLLTIPKSLS EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY
410 420
ANAICQWERN KLQCSDTEQV EADLE
Length:425
Mass (Da):48,315
Last modified:November 1, 1988 - v1
Checksum:i747C6AB2C99B3CC2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27Y → C in BAD96803 (Ref. 3) Curated1
Sequence conflicti388E → G in BAD96561 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031203253R → Q.1 PublicationCorresponds to variant rs17851730dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12433 mRNA. Translation: CAA30976.1.
AF546700 mRNA. Translation: AAQ12021.1.
AK222841 mRNA. Translation: BAD96561.1.
AK223083 mRNA. Translation: BAD96803.1.
BC019248 mRNA. Translation: AAH19248.1.
BC090052 mRNA. Translation: AAH90052.1.
CCDSiCCDS10348.1.
PIRiA31026.
RefSeqiNP_008942.3. NM_007011.7.
NP_690888.1. NM_152924.4.
XP_005254889.1. XM_005254832.1.
XP_005254890.1. XM_005254833.1.
XP_011519467.1. XM_011521165.1.
UniGeneiHs.122337.

Genome annotation databases

EnsembliENST00000352732; ENSP00000268129; ENSG00000140526.
ENST00000565973; ENSP00000455639; ENSG00000140526.
GeneIDi11057.
KEGGihsa:11057.
UCSCiuc002bnk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12433 mRNA. Translation: CAA30976.1.
AF546700 mRNA. Translation: AAQ12021.1.
AK222841 mRNA. Translation: BAD96561.1.
AK223083 mRNA. Translation: BAD96803.1.
BC019248 mRNA. Translation: AAH19248.1.
BC090052 mRNA. Translation: AAH90052.1.
CCDSiCCDS10348.1.
PIRiA31026.
RefSeqiNP_008942.3. NM_007011.7.
NP_690888.1. NM_152924.4.
XP_005254889.1. XM_005254832.1.
XP_005254890.1. XM_005254833.1.
XP_011519467.1. XM_011521165.1.
UniGeneiHs.122337.

3D structure databases

ProteinModelPortaliP08910.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000268129.

Chemistry databases

SwissLipidsiSLP:000001546.

Protein family/group databases

ESTHERihuman-ABHD2. abh_upf0017.

PTM databases

iPTMnetiP08910.
PhosphoSitePlusiP08910.
SwissPalmiP08910.

Polymorphism and mutation databases

BioMutaiABHD2.
DMDMi123504.

Proteomic databases

MaxQBiP08910.
PaxDbiP08910.
PeptideAtlasiP08910.
PRIDEiP08910.

Protocols and materials databases

DNASUi11057.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352732; ENSP00000268129; ENSG00000140526.
ENST00000565973; ENSP00000455639; ENSG00000140526.
GeneIDi11057.
KEGGihsa:11057.
UCSCiuc002bnk.2. human.

Organism-specific databases

CTDi11057.
DisGeNETi11057.
GeneCardsiABHD2.
HGNCiHGNC:18717. ABHD2.
HPAiHPA005999.
MIMi612196. gene.
neXtProtiNX_P08910.
OpenTargetsiENSG00000140526.
PharmGKBiPA38658.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1838. Eukaryota.
COG0429. LUCA.
GeneTreeiENSGT00530000062981.
HOGENOMiHOG000230852.
HOVERGENiHBG080812.
InParanoidiP08910.
KOiK13697.
OMAiYPQTQLV.
OrthoDBiEOG091G08XK.
PhylomeDBiP08910.
TreeFamiTF313195.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140526-MONOMER.

Miscellaneous databases

ChiTaRSiABHD2. human.
GeneWikiiABHD2.
GenomeRNAii11057.
PROiP08910.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140526.
CleanExiHS_ABHD2.
ExpressionAtlasiP08910. baseline and differential.
GenevisibleiP08910. HS.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000952. AB_hydrolase_4_CS.
IPR012020. ABHD4.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01133. UPF0017. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABHD2_HUMAN
AccessioniPrimary (citable) accession number: P08910
Secondary accession number(s): Q53G48
, Q53GU0, Q5FVD9, Q8TC79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a G-coupled receptor.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.