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P08910

- ABHD2_HUMAN

UniProt

P08910 - ABHD2_HUMAN

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Protein

Abhydrolase domain-containing protein 2

Gene

ABHD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in smooth muscle cells migration.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei207 – 2071Charge relay systemBy similarity
Active sitei345 – 3451Charge relay systemBy similarity
Active sitei376 – 3761Charge relay systemBy similarity

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of cell migration Source: Ensembl
  2. response to wounding Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 2 (EC:3.1.1.-)
Alternative name(s):
Lung alpha/beta hydrolase 2
Protein PHPS1-2
Gene namesi
Name:ABHD2
Synonyms:LABH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:18717. ABHD2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Abhydrolase domain-containing protein 2PRO_0000212457Add
BLAST

Proteomic databases

MaxQBiP08910.
PaxDbiP08910.
PRIDEiP08910.

PTM databases

PhosphoSiteiP08910.

Expressioni

Gene expression databases

BgeeiP08910.
CleanExiHS_ABHD2.
ExpressionAtlasiP08910. baseline and differential.
GenevestigatoriP08910.

Organism-specific databases

HPAiHPA005999.

Interactioni

Protein-protein interaction databases

BioGridi116242. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP08910.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0429.
GeneTreeiENSGT00530000062981.
HOGENOMiHOG000230852.
HOVERGENiHBG080812.
InParanoidiP08910.
KOiK13697.
OMAiFSGHVQT.
PhylomeDBiP08910.
TreeFamiTF313195.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR012020. AB-Hydro_YheT.
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000952. UPF0017_hydro-like_CS.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01133. UPF0017. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08910 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG
60 70 80 90 100
LSRFLLKSCP LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF
110 120 130 140 150
ITMSDGATST FDLFEPLAEH CVGDDITMVI CPGIANHSEK QYIRTFVDYA
160 170 180 190 200
QKNGYRCAVL NHLGALPNIE LTSPRMFTYG CTWEFGAMVN YIKKTYPLTQ
210 220 230 240 250
LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL RAQETFMQWD
260 270 280 290 300
QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL
310 320 330 340 350
MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE
360 370 380 390 400
SLLTIPKSLS EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY
410 420
ANAICQWERN KLQCSDTEQV EADLE
Length:425
Mass (Da):48,315
Last modified:November 1, 1988 - v1
Checksum:i747C6AB2C99B3CC2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271Y → C in BAD96803. 1 PublicationCurated
Sequence conflicti388 – 3881E → G in BAD96561. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti253 – 2531R → Q.1 Publication
Corresponds to variant rs17851730 [ dbSNP | Ensembl ].
VAR_031203

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12433 mRNA. Translation: CAA30976.1.
AF546700 mRNA. Translation: AAQ12021.1.
AK222841 mRNA. Translation: BAD96561.1.
AK223083 mRNA. Translation: BAD96803.1.
BC019248 mRNA. Translation: AAH19248.1.
BC090052 mRNA. Translation: AAH90052.1.
CCDSiCCDS10348.1.
PIRiA31026.
RefSeqiNP_008942.3. NM_007011.7.
NP_690888.1. NM_152924.4.
XP_005254889.1. XM_005254832.1.
XP_005254890.1. XM_005254833.1.
UniGeneiHs.122337.

Genome annotation databases

EnsembliENST00000352732; ENSP00000268129; ENSG00000140526.
ENST00000355100; ENSP00000347217; ENSG00000140526.
ENST00000565973; ENSP00000455639; ENSG00000140526.
GeneIDi11057.
KEGGihsa:11057.
UCSCiuc002bnj.2. human.

Polymorphism databases

DMDMi123504.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12433 mRNA. Translation: CAA30976.1 .
AF546700 mRNA. Translation: AAQ12021.1 .
AK222841 mRNA. Translation: BAD96561.1 .
AK223083 mRNA. Translation: BAD96803.1 .
BC019248 mRNA. Translation: AAH19248.1 .
BC090052 mRNA. Translation: AAH90052.1 .
CCDSi CCDS10348.1.
PIRi A31026.
RefSeqi NP_008942.3. NM_007011.7.
NP_690888.1. NM_152924.4.
XP_005254889.1. XM_005254832.1.
XP_005254890.1. XM_005254833.1.
UniGenei Hs.122337.

3D structure databases

ProteinModelPortali P08910.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116242. 1 interaction.

PTM databases

PhosphoSitei P08910.

Polymorphism databases

DMDMi 123504.

Proteomic databases

MaxQBi P08910.
PaxDbi P08910.
PRIDEi P08910.

Protocols and materials databases

DNASUi 11057.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000352732 ; ENSP00000268129 ; ENSG00000140526 .
ENST00000355100 ; ENSP00000347217 ; ENSG00000140526 .
ENST00000565973 ; ENSP00000455639 ; ENSG00000140526 .
GeneIDi 11057.
KEGGi hsa:11057.
UCSCi uc002bnj.2. human.

Organism-specific databases

CTDi 11057.
GeneCardsi GC15P089631.
HGNCi HGNC:18717. ABHD2.
HPAi HPA005999.
MIMi 612196. gene.
neXtProti NX_P08910.
PharmGKBi PA38658.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0429.
GeneTreei ENSGT00530000062981.
HOGENOMi HOG000230852.
HOVERGENi HBG080812.
InParanoidi P08910.
KOi K13697.
OMAi FSGHVQT.
PhylomeDBi P08910.
TreeFami TF313195.

Miscellaneous databases

ChiTaRSi ABHD2. human.
GeneWikii ABHD2.
GenomeRNAii 11057.
NextBioi 42013.
PROi P08910.
SOURCEi Search...

Gene expression databases

Bgeei P08910.
CleanExi HS_ABHD2.
ExpressionAtlasi P08910. baseline and differential.
Genevestigatori P08910.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR012020. AB-Hydro_YheT.
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000952. UPF0017_hydro-like_CS.
[Graphical view ]
Pfami PF00561. Abhydrolase_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS01133. UPF0017. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family."
    Rapiejko P.J., George S.T., Malbon C.C.
    Nucleic Acids Res. 16:8721-8721(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Cloning of an androgen-regulated a/b hydrolase."
    Utleg A., White J., Lin B.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastric carcinoma and Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-253.
    Tissue: Testis.

Entry informationi

Entry nameiABHD2_HUMAN
AccessioniPrimary (citable) accession number: P08910
Secondary accession number(s): Q53G48
, Q53GU0, Q5FVD9, Q8TC79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: October 29, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a G-coupled receptor.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3