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P08910 (ABHD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Abhydrolase domain-containing protein 2

EC=3.1.1.-
Alternative name(s):
Lung alpha/beta hydrolase 2
Protein PHPS1-2
Gene names
Name:ABHD2
Synonyms:LABH2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in smooth muscle cells migration By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

Caution

Was originally (Ref.1) thought to be a G-coupled receptor.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
Serine esterase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

response to wounding

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Abhydrolase domain-containing protein 2
PRO_0000212457

Regions

Transmembrane10 – 3021Helical; Signal-anchor for type II membrane protein; Potential

Sites

Active site2071Charge relay system By similarity
Active site3451Charge relay system By similarity
Active site3761Charge relay system By similarity

Natural variations

Natural variant2531R → Q. Ref.4
Corresponds to variant rs17851730 [ dbSNP | Ensembl ].
VAR_031203

Experimental info

Sequence conflict271Y → C in BAD96803. Ref.3
Sequence conflict3881E → G in BAD96561. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P08910 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: 747C6AB2C99B3CC2

FASTA42548,315
        10         20         30         40         50         60 
MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG LSRFLLKSCP 

        70         80         90        100        110        120 
LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF ITMSDGATST FDLFEPLAEH 

       130        140        150        160        170        180 
CVGDDITMVI CPGIANHSEK QYIRTFVDYA QKNGYRCAVL NHLGALPNIE LTSPRMFTYG 

       190        200        210        220        230        240 
CTWEFGAMVN YIKKTYPLTQ LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL 

       250        260        270        280        290        300 
RAQETFMQWD QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL 

       310        320        330        340        350        360 
MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE SLLTIPKSLS 

       370        380        390        400        410        420 
EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY ANAICQWERN KLQCSDTEQV 


EADLE 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family."
Rapiejko P.J., George S.T., Malbon C.C.
Nucleic Acids Res. 16:8721-8721(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Cloning of an androgen-regulated a/b hydrolase."
Utleg A., White J., Lin B.
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastric carcinoma and Liver.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-253.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X12433 mRNA. Translation: CAA30976.1.
AF546700 mRNA. Translation: AAQ12021.1.
AK222841 mRNA. Translation: BAD96561.1.
AK223083 mRNA. Translation: BAD96803.1.
BC019248 mRNA. Translation: AAH19248.1.
BC090052 mRNA. Translation: AAH90052.1.
CCDSCCDS10348.1.
PIRA31026.
RefSeqNP_008942.3. NM_007011.7.
NP_690888.1. NM_152924.4.
XP_005254889.1. XM_005254832.1.
XP_005254890.1. XM_005254833.1.
UniGeneHs.122337.

3D structure databases

ProteinModelPortalP08910.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116242. 1 interaction.

PTM databases

PhosphoSiteP08910.

Polymorphism databases

DMDM123504.

Proteomic databases

MaxQBP08910.
PaxDbP08910.
PRIDEP08910.

Protocols and materials databases

DNASU11057.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000352732; ENSP00000268129; ENSG00000140526.
ENST00000355100; ENSP00000347217; ENSG00000140526.
ENST00000565973; ENSP00000455639; ENSG00000140526.
GeneID11057.
KEGGhsa:11057.
UCSCuc002bnj.2. human.

Organism-specific databases

CTD11057.
GeneCardsGC15P089631.
HGNCHGNC:18717. ABHD2.
HPAHPA005999.
MIM612196. gene.
neXtProtNX_P08910.
PharmGKBPA38658.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0429.
HOGENOMHOG000230852.
HOVERGENHBG080812.
InParanoidP08910.
KOK13697.
OMAFSGHVQT.
PhylomeDBP08910.
TreeFamTF313195.

Gene expression databases

ArrayExpressP08910.
BgeeP08910.
CleanExHS_ABHD2.
GenevestigatorP08910.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR012020. AB-Hydro_YheT.
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000952. UPF0017_hydro-like_CS.
[Graphical view]
PfamPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS01133. UPF0017. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSABHD2. human.
GeneWikiABHD2.
GenomeRNAi11057.
NextBio42013.
PROP08910.
SOURCESearch...

Entry information

Entry nameABHD2_HUMAN
AccessionPrimary (citable) accession number: P08910
Secondary accession number(s): Q53G48 expand/collapse secondary AC list , Q53GU0, Q5FVD9, Q8TC79
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM